Review
Endocrinology & Metabolism
Lindsey Mountcastle, Melissa Zajdel, Taylor Robinson, Krystyna R. Keller, Shani Gelles, Alicia A. Livinski, Bijal Kikani, Dawn E. Lea, Laura M. Koehly
Summary: Despite the high burden and unique stressors of caregiving for a child with a congenital, chromosomal, or genetic disorder, there has been limited research on the physiological impact of this type of caregiving. A review of 15 studies found inconsistent links between caregiving and the regulation or dysregulation of the HPA axis, possibly due to variations in disease contexts, study designs, and biomarker measurement. Future research should focus on standardizing measurement and study designs, increasing participant diversity, and exploring moderators of the links between caregiving and the HPA axis.
FRONTIERS IN NEUROENDOCRINOLOGY
(2023)
Review
Immunology
Anne C. S. Ramos, Luciana M. Oliveira, Yvanna L. D. C. O. Santos, Marlon C. S. Dantas, Cristiani I. B. Walker, Ana M. C. Faria, Lilian L. Bueno, Silvio S. Dolabella, Ricardo T. Fujiwara
Summary: This systematic review aimed to investigate the role of Immunoglobulin-A (IgA) as a mediator of protective immunity against gastrointestinal helminths. The results showed consistent associations between higher IgA levels and lower parasitological parameters in mice, rats, and sheep. However, the role of IgA in other host species remained uncertain, highlighting the need for further research.
IMMUNOLOGY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Katsuhiro Nakanishi, Noriko Mogi, Yuki Kikuchi, Minami Matsuda, Takeshi Matsuoka, Kotome Shiina, Shota Morikane, Kohta Kurohane, Yasuo Niwa, Hirokazu Kobayashi, Yasuyuki Imai
Summary: The study demonstrates that plant-derived secretory component can enhance protease-resistance of SIgA, potentially contributing to its oral application. The reconstituted SIgA with plant-derived SC showed increased resistance to pepsin and trypsin, suggesting a promising alternative for efficient production of orally applicable SIgA.
PLANT MOLECULAR BIOLOGY
(2021)
Article
Immunology
Laia Marques-Feixa, Agueda Castro-Quintas, Helena Palma-Gudiel, Soledad Romero, Astrid Morer, Marta Rapado-Castro, Maria Martin, Inaki Zorrilla, Hilario Blasco-Fontecilla, Maite Ramirez, Maria Mayoral, Iria Mendez, Nerea San Martin-Gonzalez, Maria Rodrigo-Yanguas, Jose Luis Monsterin-Garcia, Lourdes Fananas
Summary: This study investigates the behavior of s-IgA in children and adolescents facing acute psychosocial stress, finding that the response of s-IgA varies depending on developmental stage and history of childhood maltreatment. Interestingly, children without maltreatment do not show changes in s-IgA levels after stress, while those with maltreatment show a similar response to adolescents, with an increase in s-IgA levels after the psychosocial stressor.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Sport Sciences
Flavia Campos, Julio C. Molina Correa, Vinicius C. M. Canevari, Braulio H. M. Branco, Leonardo Andreato, Solange de Paula Ramos
Summary: This study aimed to evaluate the relationship between training loads, stress, and immune-endocrine markers during a precompetitive period in Brazilian jiu-jitsu athletes. The results showed that increased training loads were recorded in technical-tactical training sessions, and athletes reported higher physical loads during the first four weeks. The study also found an increased perception of stress and cortisol levels, while salivary testosterone and salivary immunoglobulin A levels decreased at four weeks. Additionally, the study found that training did not result in significant fatigue or underperformance, and reducing physical training loads appeared to reduce stress symptoms and improve recovery.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Mark D. Owen, Charlotte Sacks, Siva Bathina, Robyn A. Emmins, Alan J. Dickson
Summary: Improved understanding of expression of recombinant immunoglobulin (IgG)-based therapies can decrease manufacturing process costs and bring down costs to patients. Deletion of C-terminal Lysine (C-Lys) from IgG molecules has been shown to greatly impact yield. This study set out to characterise structural components of IgG C-terminal variants which modulate protein expression by examination of the consequences of mutations at the C-terminal of IgG on expression and by the use of fluorescent C-terminal fragment fusion proteins.
JOURNAL OF BIOTECHNOLOGY
(2023)
Article
Biochemical Research Methods
Angel Puerta, Daniel Garcia-Lopez, Paula Tejedor-Matellanes, Laura Gomez-Ruiz, Rebeca de la Cruz-Rodriguez, Mercedes de Frutos
Summary: This article studied the analysis of Immunoglobulin A (IgA) in human milk and colostrum using capillary gel electrophoresis (CGE), and developed tailor-made gel buffers for efficient analysis of IgA forms within less than 10 minutes.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Multidisciplinary Sciences
Aaron Gupta, Patrick Smith, Stylianos Bournazos, Jeffrey Ravetch
Summary: This article describes the development of a mouse model that can tolerate long-term administration of human antibody treatment. By incorporating the human IgG1 heavy chain and full expression of human Fc receptors, this model allows for in vivo testing of human monoclonal antibodies with relevant receptors and maintains therapeutic activity even in the late stages of treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Clinical Neurology
M. Alcantara, E. Sarpong, C. Barnett, H. Katzberg, V. Bril
Summary: The study results suggest that patients with generalized MG can be successfully transitioned to IVIG and from IVIG to SCIG in chronic treatment, leading to reductions in impairments, use of other medications, and improvement in overall status with Ig therapy.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Psychology, Biological
Linda McAuliffe, Bradley J. Wright, Agnes Hazi, Glynda J. Kinsella
Summary: The study investigated the relationship between perceived stress and pre-clinical indices of ill-health among dementia caregivers, finding that social support may play a moderating role in this relationship.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Public, Environmental & Occupational Health
Maria Stanfors, Josephine Jacobs
Summary: This study examines the association between unpaid caregiving, employment, and self-reported stress among men and women aged 45-74 in Sweden. The results show that women are overall more stressed than men, especially among intensive caregivers who also have a job. There is no caregiver effect on stress among men, while women experience a net effect of 6-9%. The combination of employment and intensive caregiving is stressful for women, possibly due to less leisure and sleep time.
SSM-POPULATION HEALTH
(2023)
Article
Physiology
Angie Henriquez Martinez, Laura C. Avila, Maria A. Pulido, Yeferzon A. Ardila, Veronica Akle, Natasha I. Bloch
Summary: The study found that stress affects young and old zebrafish differently. Only young fish showed significant changes in anxiety-like behavior after exposure to chronic stress, while their regeneration ability was not affected. On the other hand, older fish regenerated their caudal fin slower compared to young fish, but their behavior remained unaffected after stress exposure. The expression of the stress-related gene candidate sam2 increased in the brain of older individuals exposed to stress.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Endocrinology & Metabolism
Agueda Castro-Quintas, Helena Palma-Gudiel, Nerea San Martin-Gonzalez, Javier R. Caso, Juan C. Leza, Lourdes Fananas
Summary: Mucosal secretory immunoglobulin A (s-IgA) is an important component of human first line defense. This review investigates the reactivity of s-IgA to psychosocial stress in subjects under the age of 18. The findings suggest that s-IgA levels increase in children older than 9 years old when exposed to stress, and that s-IgA follows a circadian rhythm which is altered under stress conditions. These results indicate that s-IgA could be a potential psychosocial stress biomarker in pediatric and child-juvenile psychiatric populations, although further studies are needed to validate its role.
FRONTIERS IN NEUROENDOCRINOLOGY
(2023)
Review
Medicine, Research & Experimental
Xintian Wang, Jun Zhang, Yan Wu, Yuncong Xu, Jinxu Zheng
Summary: Secretory immunoglobulin A (SIgA) is essential for the first-line defense against pathogens and antigens in mucosal immunity, particularly in the respiratory system. This review explores the relationship between SIgA and various respiratory diseases, including COPD, asthma, tuberculosis, idiopathic pulmonary fibrosis, COVID-19, and lung cancer, aiming to provide new insights for the prevention, diagnosis, and treatment of these lung diseases.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Immunology
Albert Bondt, Kelly A. Dingess, Max Hoek, Danique M. H. van Rijswijck, Albert J. R. Heck
Summary: The study shows that the total pool of sIgA1 in milk is dominated by a small number of clones, with little overlap between donors and minimal changes over time.
Mothers provide protection to newborns through transfer of antibodies via breastfeeding.
The new method can visualize the transfer of immunoglobulin clonal repertoires from mother to infant and monitor changes over time in response to maternal physiology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rehabilitation
Niall Russell, Stephen Gallagher, Rachel M. Msetfi, Sara Hayes, Robert W. Motl, Susan Coote
Summary: This study aimed to gain insight into the experiences of people with MS taking part in a behavior change group physical activity intervention. The results showed that MS identity played a significant role in the acceptance of exercise, and psychological and social factors were important in participants' experience of the program. The findings support the effectiveness of the intervention in promoting physical activity and improving psychological outcomes.
PHYSIOTHERAPY THEORY AND PRACTICE
(2023)
Article
Public, Environmental & Occupational Health
Adam O'Riordan, Siobhan Howard, Tracey M. Keogh, Stephen Gallagher
Summary: This study examines the association between Type D personality and cardiovascular reactivity to acute stress in a healthy sample and investigates its predictive utility. The results show that Type D personality is associated with lower systolic blood pressure reactivity to stress in women, independent of negative affect, social inhibition, anxiety, and depression.
PSYCHOLOGY & HEALTH
(2023)
Review
Psychology, Clinical
Adam O'Riordan, Siobhan Howard, Stephen Gallagher
Summary: Novel research shows that a lower cardiovascular reaction to stress is associated with negative outcomes. This review examined the prospective outcomes predicted by blunted cardiovascular reactivity and identified the levels of blunted reactivity that predict these outcomes. The findings suggest that blunted reactivity predicts adverse cardiovascular health in cardiac samples and outcomes related to motivational and behavioral dysregulation in healthy samples. The threshold levels of blunted reactivity that predict these outcomes were identified.
HEALTH PSYCHOLOGY REVIEW
(2023)
Article
Immunology
Gallagher Stephen, Howard Siobhan, Orla. T. Muldoon, Anna. C. Whittaker
Summary: This study found that social cohesion is predictive of antibody response to COVID-19 vaccines, and this association is mediated by feelings of loneliness.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Substance Abuse
Heather Wardle, Alexey Kolesnikov, Ingo Fielder, Nathan Critchlow, Kate Hunt
Summary: Understanding how the gambling industry generates revenue is crucial for policy-making on consumer protection. The study found that gambling expenditure is unequal, with those with elevated Problem Gambling Severity Index scores contributing a significant share of spending. Different gambling activities vary in their reliance on problem gamblers, highlighting the need to reduce dependence on those harmed.
INTERNATIONAL GAMBLING STUDIES
(2023)
Article
Psychology, Biological
Siobhan Howard, Stephen Gallagher, Annie T. Ginty, Anna C. Whittaker
Summary: Life event stress is associated with reduced cardiovascular reactivity to acute psychological stress, regardless of the individual's personal relevance to the stress tasks. This study provides evidence against the argument that blunted reactivity to stress is a result of the context of the stressors.
Article
Geriatrics & Gerontology
Paul Doody, Janet M. Lord, Carolyn A. Greig, Anna C. Whittaker
Summary: Frailty is a multi-dimensional and dynamic condition characterized by declines in reserve and function across multiple physiologic systems, and it is projected to become a serious public health challenge in economically developed societies. This review provides a comprehensive overview of frailty, including its pathophysiology, definition(s), impact, prevalence, management, and prevention, and discusses limitations and future research directions.
Article
Neurosciences
Sebastian C. Coleman, Zelekha A. Seedat, Anna C. Whittaker, Agatha Lenartowicz, Karen J. Mullinger
Summary: Post-task responses (PTRs) are transitional responses occurring between the end of a stimulus/task and a period of rest. They are not limited to motor networks but are widespread in regions recruited during the task and exhibit unique properties such as scaling with cognitive load and correlating significantly with behavior. PTRs are believed to inhibit task-positive network activity to enable a transition to rest, but further investigation is needed to uncover their role in neuroscience and pathology.
Article
Psychology, Clinical
Tracey M. Keogh, Siobhan Howard, Stephen Gallagher
Summary: Blunted cardiovascular reactivity is associated with a distinct behavioural profile of greater exposure to early life adversity, coupled with higher levels of behavioural disengagement and symptoms of depression. This study demonstrates how these behavioural clusters relate to health and behavioural outcomes during MIDUS 2.
BRITISH JOURNAL OF HEALTH PSYCHOLOGY
(2023)
Review
Geriatrics & Gerontology
Len De Nys, Esther F. Ofosu, Gemma C. Ryde, Jenni Connelly, Anna C. Whittaker
Summary: Age-related changes in cortisol and DHEA(S) levels can be improved by regular physical activity (PA) among older adults aged 65 years and older. A systematic review of observational studies and randomized controlled trials showed that PA beneficially reduces cortisol and increases DHEA(S) levels, with no significant differences between different genders, exercise modalities, or health states. These findings suggest that older adults should engage in regular PA of their choice to improve cortisol and/or DHEA(S) levels.
JOURNAL OF AGING AND PHYSICAL ACTIVITY
(2023)
Review
Geriatrics & Gerontology
Esther Frema Ofosu, Len de Nys, Jenni Connelly, Gemma Cathrine Ryde, Anna C. Whittaker
Summary: This systematic review and meta-analysis explore the benefits of physical activity (PA) on anxiety symptoms in older adults aged 65 years and above. The study found that PA is effective in managing anxiety symptoms, supported by both randomized controlled trials (RCTs) and non-RCTs. Subgroup analysis showed significant effects for all types, session times, frequency, and intervention periods of PA compared to control groups, but the optimal intensity and mode of PA remain unclear.
JOURNAL OF AGING AND PHYSICAL ACTIVITY
(2023)
Article
Immunology
Anna C. Whittaker, Len De Nys, Ryan C. Brindle, Mark T. Drayson
Summary: This study found that physical activity and sleep quality are associated with the maintenance of immunity in older adults. Physical activity is related to antibody levels against common pathogens such as pneumococcus and meningococcus, while sleep duration is related to antibody levels against pneumococcus.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Alice Maclean, Kate Hunt, Ashley Brown, Jane A. Evered, Anna Dowrick, Andrea Fokkens, Rachel Grob, Susan Law, Louise Locock, Michelle Marcinow, Lorraine Smith, Anna Urbanowicz, Nientke Verheij, Cervantee Wild
Summary: This study analyzes people's accounts of their need for and experiences of healthcare for long Covid (LC) symptoms, highlighting both positive and negative experiences in seeking appropriate care. The findings emphasize the importance of collective recognition as a crucial step in individual candidacy, and underscore the significance of believing and learning from patient experiences.
SSM-QUALITATIVE RESEARCH IN HEALTH
(2023)
Article
Substance Abuse
Nathan Critchlow, Kate Hunt, Heather Wardle, Martine Stead
Summary: This study examines the changes in expenditure on gambling advertising during national COVID-19 lockdowns and finds that the expenditure decreased significantly during the first lockdown, which is consistent with the overall reduction in gambling behavior. However, the expenditure increased during the second and third lockdowns, suggesting a potential correlation with increased gambling behavior.
JOURNAL OF GAMBLING STUDIES
(2023)
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)