Article
Biochemistry & Molecular Biology
Silvia S. Barbieri, Leonardo Sandrini, Laura Musazzi, Maurizio Popoli, Alessandro Ieraci
Summary: Anxiety disorders are common mental health diseases, with stress being a major risk factor. The study found that apocynin can prevent the development of anxiety-like phenotype, reduce histone acetylation decrease, and block the upregulation of specific biochemical molecules.
Article
Biochemistry & Molecular Biology
Caren Aline Ramson da Fonseca, Angelica Schiavom dos Reis, Mikaela Peglow Pinz, Thiago Jacobsen Peglow, Ricardo Frederico Schumacher, Gelson Perin, Amanda Weege da Silveira Martins, William Borges Domingues, Vinicius Farias Campos, Mauro Pereira Soares, Juliano Alex Roehrs, Cristiane Luchese, Ethel Antunes Wilhelm
Summary: The study investigated the suppressive effect of bis (3-amino-2-pyridine) diselenide (BAPD) on comorbidity of psychiatric disorders and atopic dermatitis in mice, showing improvements in skin condition, reductions in scratching behavior, and anxiolytic and antidepressant effects through regulating inflammation and oxidative stress. Data demonstrated the potential benefits of BAPD in treating this complex condition.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Saki Watanabe, Alzahra J. Al Omran, Amy S. Shao, Zeyu Zhang, Chen Xue, Jifeng Zhang, Junji Watanabe, Jing Liang
Summary: Social isolation leads to anxiety, cognitive decline, and reduced ATP levels in mice. Treatment with DHM can ameliorate these changes by restoring mitochondrial capacity to generate ATP.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Psychology, Biological
Renally de Lima Moura, Larissa Maria Gomes Dutra, Maria da Vitoria Santos do Nascimento, Jose Carlos Nascimento de Oliveira, Vanessa Bordin Viera, Bruno Silva Dantas, Roberto Germano Costa, Marcelo Sobral da Silva, Ariosvaldo Nunes de Medeiros, Yuri Mangueira do Nascimento, Josean Fechine Tavares, Juliana Kessia Barbosa Soares
Summary: The aim of this research was to evaluate the effect of cactus flour on anxious-like behavior and cerebral lipid peroxidation in elderly rats. The results showed that cactus flour could alleviate anxiety symptoms and reduce brain lipid peroxidation. This suggests that cactus pear may play a positive role in preventing and treating anxiety in the aging phase.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Psychology, Multidisciplinary
Sonja Biglbauer, Anita Lauri Korajlija
Summary: This study aimed to examine the differences between socially anxious and non-anxious individuals on social media. The results showed that although there was no significant difference in the time spent on social media, their usage patterns were different. Less active use increased the risk of social anxiety, and offline social support was a significant correlate of social anxiety.
COMPUTERS IN HUMAN BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Dmitry A. Smagin, Irina L. Kovalenko, Anna G. Galyamina, Irina V. Belozertseva, Nikolay V. Tamkovich, Konstantin O. Baranov, Natalia N. Kudryavtseva
Summary: Chronic social defeat stress in male mice leads to the development of anxiety and a depression-like state, as well as downregulation of serotonergic genes in the midbrain raphe nuclei. Chronic lithium chloride treatment has dual effects on anxiety behavior and serotonergic gene expression in these mice, with an anxiolytic-like effect on social communication and an anxiogenic-like effect on elevated plus-maze and social interaction tests.
Article
Environmental Sciences
Diogo Ferreira Bicca, Cristiano Chiapinotto Spiazzi, Juliana Bernera Ramalho, Melina Bucco Soares, Francielli Weber Santos Cibin
Summary: The study revealed that subchronic low dose of GBH could affect behavior and oxidative stress in mouse hippocampus. Quercetin treatment partly or fully improved these effects, but caution is needed regarding the potential independent effects of continuous quercetin supplementation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
History & Philosophy Of Science
Troy Jollimore
Summary: Anxiety, often seen as negative, can actually serve as a positive alert for potential problems or threats. Friends' proxy anxiety can also contribute to our well-being by playing a similar role in our functioning. Friends are in a good position to help regulate deficient or excessive anxieties due to their close but relatively objective perspective.
Article
Neurosciences
Parul, Akanksha Mishra, Sonu Singh, Seema Singh, Virendra Tiwari, Swati Chaturvedi, Muhammad Wahajuddin, Gautam Palit, Shubha Shukla
Summary: Long-term psychological and physical stress can lead to oxidative stress and neuroinflammation, affecting neural stem cell dynamics, monoamine levels, and behavioral functions.
BRAIN RESEARCH BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Lei Wang, Thilina U. Jayawardena, Jimin Hyun, Kaiqiang Wang, Xiaoting Fu, Jiachao Xu, Xin Gao, Youngjin Park, You-Jin Jeon
Summary: Fucoidans isolated from brown seaweeds, such as Turbinaria ornata, have been found to have antioxidant and photoprotective effects. In this study, the fucoidan TO-F10 was shown to protect Vero cells and zebrafish from oxidative stress and photodamage induced by AAPH and UVB irradiation, respectively. These findings suggest that TO-F10 has potential as an ingredient in the cosmetic industry.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Celia Andres Juan, Jose Manuel Perez de la Lastra, Francisco J. Plou, Eduardo Perez-Lebena
Summary: Living species are constantly exposed to oxidants, leading to oxidative stress and disease. The induction of oxidative stress is caused by an imbalance between radical species and antioxidant defense systems, which can damage cellular biomolecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xing Wen, Qihan Huang, Minghui Zhu, Jun Lu
Summary: Cisplatin is an effective chemotherapy drug for solid tumors but also causes various side effects, especially nephrotoxicity. Previous studies have shown a correlation between selenoenzymes and cisplatin-induced renal damage. This study established mouse models with different selenium intake levels and found that selenium deficiency increased sensitivity to cisplatin-induced damage, while selenium supplementation protected against renal injury.
Article
Environmental Sciences
Ozge Temiz
Summary: The study investigated the toxic effects of emamectin benzoate (EMB) in male mice, showing dose-dependent neurotoxic effects and changes in various biomarkers and enzyme activities in the brain tissue.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ken Ichiro Tanaka, Sachie Shiota, Okina Sakakibara, Mikako Shimoda, Ayaka Takafuji, Misaki Takabatake, Yoshito Kadota, Takashige Kawakami, Shinya Suzuki, Masahiro Kawahara
Summary: Metallothionein plays an important role in the development of chronic obstructive pulmonary disease (COPD) by suppressing elastase-induced lung injury through the inhibition of reactive oxygen species production.
Article
Biochemistry & Molecular Biology
Xuanyou Liu, Yichao Xiao, Qingyi Zhu, Yuqi Cui, Hong Hao, Meifang Wang, Peter J. Cowan, Ronald J. Korthuis, Guangfu Li, Qinghua Sun, Zhenguo Liu
Summary: PM exposure increased inflammatory cytokine levels and oxidative stress in both male and female mice, but to a greater extent in males. Circulating EPC levels were significantly decreased in males but remained unchanged in females, with antioxidants effectively preventing these effects in male mice. Female mice, despite ovariectomy, showed no significant impact on circulating EPC levels with PM exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Samira Salem, Essaid Leghouchi, Rachid Soulimani, Jaouad Bouayed
Summary: The study found that Parmelia caperata (PC) showed better anti-edematous activity compared to Lobaria pulmonaria (LP) in a mouse carrageenan-induced inflammatory model, while also significantly improving the endogenous antioxidant status of the liver.
INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
(2021)
Article
Environmental Sciences
Imen Dridi, Rachid Soulimani, Jaouad Bouayed
Summary: The study found that male offspring mice exposed to contaminated European eels during pregnancy and lactation exhibited depression-like behavior at different stages of life, with increased immobility in behavioral tests and elevated antioxidant enzyme activity in the hippocampus in middle-aged animals. This suggests a chronic depressive phenotype in offspring exposed to pollutants, with limited oxidative metabolism disturbances in their brains at middle age.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Zeyneb Chouit, Dounia Djellal, Souhila Haddad, Mourad Hanfer, Messaoud Hachemi, Zhoura Lakroun, Smail Chafaa, Hamadi Fetoui, Mohamed Kebieche, Rachid Soulimani
Summary: The study found that chronic exposure to cadmium may cause changes in neurobehavioral and cognitive abilities in rats, affect mitochondrial function in the brain, increase oxidative stress, and enhance the apoptosis signaling pathway.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Virology
Jaouad Bouayed, Torsten Bohn
Summary: The interaction between humans and SARS-CoV-2 can lead to various outcomes, including changes in human behavior that may facilitate the virus transmission. Some individuals infected with COVID-19 have displayed odd and irresponsible behaviors, potentially aiding in the spread of the virus.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Immunology
Jaouad Bouayed, Feng Q. Hefeng, Mahesh S. Desai, Bin Zhou, Tsuriel Rashi, Rachid Soulimani, Torsten Bohn
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Letter
Virology
Jaouad Bouayed, Torsten Bohn
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Nutrition & Dietetics
Rachid Soulimani, Amadou Dicko, Elie Baudelaire, Jaouad Bouayed
Summary: Rosa canina, Salix alba, Scrophularia nodosa, and Hedera helix have anti-inflammatory effects on LPS-stimulated peripheral blood mononuclear cells. Fine powders with superfine particle sizes have stronger inhibitory effects on inflammatory factors produced by cells, and they contain higher concentrations of phenolic compounds.
INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
(2023)
Article
Virology
Guillaume Schmitt, Sary Labdouni, Rachid Soulimani, Catherine Delamare, Jaouad Bouayed
Summary: The hormonal and physiological changes during pregnancy make pregnant women more vulnerable to COVID-19. A retrospective study found vitamin D deficiency in COVID-19-positive pregnant women, with more severe deficiency in those with mild symptoms. Additionally, pregnant women with COVID-19 showed lower levels of oxidative stress markers, which may explain the milder course of the disease.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Editorial Material
Immunology
Jaouad Bouayed
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Plant Sciences
Mariam Hammoud, Ali Chokr, Hiba N. Rajha, Carl Safi, Martijn van Walsem, Lambertus A. M. van den Broek, Esperance Debs, Richard G. Maroun, Nicolas Louka, Hassan Rammal
Summary: The study utilized IR technology to enhance the extraction efficiency of polyphenols from Eryngium creticum leaves, while maintaining the quantity and quality of the extracts. Additionally, the extracts exhibited antibacterial and antibiofilm properties.
Article
Biochemistry & Molecular Biology
Amal Lassoued, Noureddine Khalloufi, Wiem Saidani, Abdelhafidh Khazri, Neziha Ghanem-Boughanmi, Jaouad Bouayed, Mossadok Ben-Attia
Summary: Freshwater salinisation is a threat to the survival of freshwater species. This study investigated the effects of increased water salinity on the bivalve Unio ravoisieri. High salt concentration was found to significantly disrupt oxidative metabolism and increase neurotoxicity in the organism. The findings suggest that cat activity could be used as a sensitive marker to evaluate the impact of freshwater salinisation on freshwater species.
CHEMISTRY AND ECOLOGY
(2023)
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)