期刊
BRAIN AND LANGUAGE
卷 125, 期 3, 页码 245-252出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bandl.2013.02.005
关键词
Apraxia of speech; Aphasia; Atrophy; Broca's area; Premotor cortex; Hypometabolism
资金
- NIDCD [R01-DC010367]
Progressive apraxia of speech (AOS) can result from neurodegenerative disease and can occur in isolation or in the presence of agrammatic aphasia. We aimed to determine the neuroanatomical and metabolic correlates of progressive ADS and aphasia. Thirty-six prospectively recruited subjects with progressive ADS or agrammatic aphasia, or both, underwent the Western Aphasia Battery (WAB) and Token Test to assess aphasia, an ADS rating scale (ASRS), 3T MRI and 18-F fluorodeoxyglucose (FDG) PET. Correlations between clinical measures and imaging were assessed. The only region that correlated to ASRS was left superior premotor volume. In contrast, WAB and Token Test correlated with hypometabolism and volume of a network of left hemisphere regions, including pars triangularis, pars opercularis, pars orbitalis, middle frontal gyrus, superior temporal gyrus, precentral gyrus and inferior parietal lobe. Progressive agrammatic aphasia and ADS have non-overlapping regional correlations, suggesting that these are dissociable clinical features that have different neuroanatomical underpinnings. (c) 2013 Elsevier Inc. All rights reserved.
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