期刊
BRAIN AND LANGUAGE
卷 114, 期 2, 页码 72-79出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bandl.2009.11.006
关键词
Language; Sentence comprehension; Children; Functional magnetic resonance imaging (fMRI); Individual differences; Inter-subject variability
资金
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [RO1 HD046500]
- National Institutes of Health NCRR [P41RR09784]
- Center for Advanced MR Techniques at Stanford
The purpose of this study was to explore changes in activation of the cortical network that serves auditory sentence comprehension in children in response to increasing demands of complex sentences. A further goal is to study how individual differences in children's receptive language abilities are associated with such changes in cortical responses. Fourteen children, 10-16 years old, participated in an event-related functional magnetic resonance imaging experiment using a cross modal sentence-picture verification paradigm. We manipulated sentence difficulty and length in a 2 x 2 factorial design. Task-related activation covered large regions of the left and right superior temporal cortex, inferior parietal lobe, precuneous, cingulate, middle frontal gyrus and precentral gyrus. Sentence difficulty, independent of length, led to increased activation in the left temporal-parietal junction and right superior temporal gyrus. Changes in activation in frontal regions positively correlated with age-standardized receptive vocabulary scores and negatively correlated with reaction time on a receptive grammar test outside the scanner. Thus, individual differences in language skills were associated with changes in the network in response to changing task demands. These preliminary findings in a small sample of typically developing children suggest that the investigation of individual differences may prove useful in elucidating the underlying neural mechanisms of language disorders in children. (C) 2009 Elsevier Inc. All rights reserved.
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