期刊
JOURNAL OF CLINICAL VIROLOGY
卷 66, 期 -, 页码 19-23出版社
ELSEVIER
DOI: 10.1016/j.jcv.2015.02.017
关键词
Polyomavirus; STL polyomavirus; MALDI-TOF mass spectrometry; Gastroenteriti
类别
资金
- Ministry of Science and Technology of People's Republic of China [2011ZX10004-001]
- Bill & Melinda Gates Foundation award [OPP1016839]
- Institute of Pathogen Biology, CAMSPUMC [2013IPB102]
Background: Over the past 7 years, eleven novel human polyomaviruses (HPyVs) have been identified. The frequent discovery of human polyomaviruses (HPyVs) in the gastrointestinal tract and stool samples suggests a potential involvement in gastroenteritis. Objective: In this study we want to explore the prevalence of STL polyomavirus (STLPyV) in China and delineate the clinical role played by STLPyV. Study design: Stool samples from 508 hospitalized children with diarrhea and 271 healthy children were screened to detect STLPyV. Human polyomavirus 12(HPyV12), New Jersey polyomavirus (NJPyV-2013) and six common enteric viruses (including rotaviruses, adenovirus, norovirus GI and GII, astrovirus and sapovirus) were also screened in this study. Results: 348 of the 508 (68.5%) specimens from the hospitalized children with diarrhea contained at least 1 common enteric virus. STLPyV was identified in 11 specimens in the case group (2.2%), among which 4 specimens were negative for those common enteric viruses. STLPyV was not more prevalent among the case group than the control group (2.2% versus 3.0%; p = 0.50, chi(2) test). In case group, when common enteric viruses' positive and negative groups were compared, the difference in detection rate of STLPyV was not statistically significant (2.5% versus 2.0%; p = 0.98, chi(2) test). Two whole genome sequences of STLPyV were obtained. Conclusions: We are the first to report the prevalence of STLPyV in Chinese children and obtained whole genome sequences of STLPyV strains isolated in China. Our results of phylogenetic analysis support the hypothesis that STLPyV is geographically widespread. (C) 2015 Elsevier B.V. All rights reserved.
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