期刊
BRAIN AND COGNITION
卷 75, 期 3, 页码 255-260出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bandc.2011.01.001
关键词
Fragile X premutation carrier; Adult; Women; Parietal lobe; Magnitude; Numerical; Spatial
资金
- National Institute of Health (NIH) NIA [RL1 AG032119]
- National Institute of Health (NIH) NINDS [RL1 NS062412]
- National Institute of Health (NIH) NIDA [TL1 DA024854]
- National Institute of Dental and Craniofacial Research (NIDCR) [UL1 DE019583]
The high frequency of the fragile X premutation in the general population and its emerging neurocognitive implications highlight the need to investigate the effects of the premutation on lifespan cognitive development. Until recently, cognitive function in fragile X premutation carriers (fXPCs) was presumed to be unaffected by the mutation. Here we show that young adult female fXPCs show subtle, yet significant, age- and FMR1 gene mutation-modulated cognitive impairments as tested by a quantitative magnitude comparison task. Our results begin to define the neurocognitive endophenotype associated with the premutation in adults, who are at risk for developing a neurodegenerative disorder associated with the fragile X premutation. Results from the present study may potentially be applied toward the design of early interventions wherein we might be able to target premutation carriers most at risk for degeneration for preventive treatment. (C) 2011 Elsevier Inc. All rights reserved.
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