Article
Radiology, Nuclear Medicine & Medical Imaging
Young Hee Sung, Joong-Seok Kim, Sang-Won Yoo, Na-Young Shin, Yoonho Nam, Tae-Beom Ahn, Dallah Yoo, Kyung Mi Lee, Hyug-Gi Kim, Seong-Beom Koh, Jinhee Kim, Ilsoo Kim, Do-Young Kwon, Younghen Lee, Chulhan Kim, Sun Ju Chung, Sungyang Jo, Seung Hyun Lee, Sang Joon Kim, Minjae Kim, Chul Hyoung Lyoo, Min Seok Baek, Suk Yun Kang, Suk Ki Chang, Sang-Won Jo, Seun Ah Lee, Hyeo-il Ma, Young Eun Kim, Eun Soo Kim, Yun Joong Kim, Hyun Sook Kim, Min-Hee Woo, Hye Jeong Choi, Eung Yeop Kim
Summary: This study compared the diagnostic performance of susceptibility map-weighted imaging (SMwI) using different MRI machines with N-3-fluoropropyl-2-beta-carbomethoxy-3-beta-(4-iodophenyl)nortropane (F-18-FP-CIT) PET in the diagnosis of neurodegenerative parkinsonism. The results showed that SMwI had a high diagnostic sensitivity, specificity, and accuracy, and there was no significant difference between the results of SMwI and F-18-FP-CIT PET. The study demonstrated the generalisability of SMwI for determining nigrostriatal degeneration in patients with parkinsonism in a multi-centre setting.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pyeong Hwa Kim, Da Hyun Lee, Chong Hyun Suh, Minjae Kim, Woo Hyun Shim, Sang Joon Kim
Summary: Loss of nigral hyperintensity on SWI can accurately differentiate idiopathic Parkinson's disease or primary parkinsonism from a healthy/disease control group. However, the proportion of non-diagnostic scans is not negligible and must be considered.
EUROPEAN RADIOLOGY
(2021)
Article
Clinical Neurology
Sonoko Oshima, Yasutaka Fushimi, Tomohisa Okada, Satoshi Nakajima, Yusuke Yokota, Atsushi Shima, John Grinstead, Sinyeob Ahn, Nobukatsu Sawamoto, Ryosuke Takahashi, Yuji Nakamoto
Summary: The study assessed a new MRI imaging technique that can visualize neuromelanin in the substantia nigra with high resolution in a short scan time, showing potential for evaluating Parkinson's disease.
MOVEMENT DISORDERS
(2021)
Article
Neurosciences
Young Hee Sung, Young Noh, Eung Yeop Kim
Summary: Thin-section neuromelanin-sensitive MRI provides insights into the affected regions of the substantia nigra pars compacta in early-stage Parkinson's disease, with specific areas (nigrosome 1 and 2) showing significant spatial differences between patients and healthy subjects.
HUMAN BRAIN MAPPING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marieke van der Pluijm, Clifford Cassidy, Melissa Zandstra, Elon Wallert, Kora de Bruin, Jan Booij, Lieuwe de Haan, Guillermo Horga, Elsmarieke van de Giessen
Summary: NM-MRI is a highly reproducible measure, with the GRE sequence showing the highest contrast and lowest variability for CR measurements.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Biochemistry & Molecular Biology
Bok-Seok Kim, Taeik Jang, Sung-Eun Yoo, Jae Moon Lee, Eunhee Kim
Summary: The impairment of protein clearance mechanisms in dopaminergic neurons leads to the accumulation of alpha-synuclein, contributing to the pathogenesis of Parkinson's disease. Fas-associated factor 1 (FAF1) was found to disrupt alpha-synuclein clearance through the autophagy-lysosome pathway, indicating a novel role as a negative regulator of autophagic alpha-synuclein clearance. This disturbance ultimately leads to alpha-synuclein accumulation and autophagy dysregulation in PD model mice.
Article
Neuroimaging
Samantha Tan, Septian Hartono, Thomas Welton, Chu Ning Ann, Soo Lee Lim, Tong San Koh, Huihua Li, Fiona Setiawan, Samuel Ng, Nicole Chia, Saifeng Liu, E. Mark Haacke, Eng King Tan, Louis Chew Seng Tan, Ling Ling Chan
Summary: QSM and DKI are complementary tools that provide valuable insights into the complex pathological changes in early Parkinson's disease, particularly in relation to iron deposition and microstructural alterations. These technologies have the potential to be clinically useful for early diagnosis and assessment of PD.
NEUROIMAGE-CLINICAL
(2021)
Review
Psychiatry
Julia Schulz, Juliana Zimmermann, Christian Sorg, Aurore Menegaux, Felix Brandl
Summary: This scoping review focuses on four dopamine MRI methods used in patients with schizophrenia, comparing them to other disorders with similar symptoms or dopamine abnormalities. The review also discusses current issues and outlines future research questions.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Xingxing Jian, Guihu Zhao, He Chen, Yanhui Wang, Jinchen Li, Lu Xie, Bin Li
Summary: This study utilized transcriptomics analysis to identify several hub DEGs between PD patients and normal controls, showing high correlations among these genes. A Cox model with an eight-gene signature was constructed to predict PD progression and survival successfully in an independent dataset, highlighting the clinical significance of these findings.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Neurosciences
Qingguo Ren, Yihua Wang, Shanshan Leng, Xiaomin Nan, Bin Zhang, Xinyan Shuai, Jianyuan Zhang, Xiaona Xia, Ye Li, Yaqiong Ge, Xiangshui Meng, Cuiping Zhao
Summary: Radiomic features based on magnitude images can reflect the Hoehn-Yahr stage of PD to some extent. The LASSO logistic regression model showed good prediction efficacy in both the training and validation sets.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Wenyue Liu, Changpeng Wang, Tingting He, Minghong Su, Yuan Lu, Guanyu Zhang, Thomas F. Munte, Lirong Jin, Zheng Ye
Summary: In Parkinson's disease, damage to the substantia nigra may lead to deficits in sequential working memory, mediated by dysfunction in the basal ganglia. Patients showed poorer performance in a digitordering task and smaller SNs compared to healthy controls. The study suggests that SN integrity is crucial for sequencing performance in PD patients.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Alexandra Sobczak, Stefan Repplinger, Eva M. Bauch, Norbert Brueggemann, Christina Lohse, Hermann Hinrichs, Lars Buentjen, Juergen Voges, Tino Zaehle, Nico Bunzeck
Summary: The results from intracranial electroencephalography recordings show that anticipating both positive and negative social feedback accelerates response times in healthy young and older adults, while the effect in operated Parkinson's Disease (PD) patients may be influenced by small sample size. The behavioral effect in non-operated PD patients is not modulated by medication status, indicating that processes other than dopaminergic neuromodulation play a role in driving invigoration by social incentives.
Article
Neurosciences
Mojtaba Jokar, Zhijia Jin, Pei Huang, Ying Wang, Youmin Zhang, Yan Li, Zenghui Cheng, Yu Liu, Rongbiao Tang, Xiaofeng Shi, Jihua Min, Fangtao Liu, Shengdi Chen, Naying He, E. Mark Haacke, Fuhua Yan
Summary: This study developed a comprehensive imaging biomarker for diagnosing Parkinson's disease by using a template-based, automatic segmentation method to detect the features of neuromelanin and iron in the substantia nigra. The combination of the N1 sign with other quantitative measures significantly improved the accuracy of Parkinson's disease diagnosis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Na Wang, Xue-ling Liu, Ling Li, Chuan-tao Zuo, Jian Wang, Pu-yeh Wu, Yong Zhang, Fengtao Liu, YuXin Li
Summary: The study found that alterations in STS correspond well with dopamine uptake on PET in patients with esPD. Evaluating STS can effectively differentiate the disease.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Cell Biology
Kujin Kwon, Hwapyeong Cho, Soyeon Lee, Eun Jeong Cho, Weonjin Yu, Catherine Yen Li Kok, Hyunsoo Shawn Je, Jae-Ick Kim, Hyung Joon Cho, Taejoon Kwon
Summary: Progressive iron accumulation in the substantia nigra is a major risk factor for neurodegenerative diseases. The study examined how neurons in the substantia nigra respond to age-related iron accumulation, with results showing an increase in stress response genes in older animals. This research provides insights into the neuronal response to excessive iron accumulation in relation to age-related neurodegenerative diseases.
Article
Rehabilitation
Eunyoung Kang, Pooja Jethani, Erin R. Foster
Summary: This study evaluates the feasibility of person-centered goal setting in individuals with Parkinson's disease and explores the characteristics of the goals formulated. The findings suggest that person-centered goal setting is feasible and effective in guiding individuals with Parkinson's disease to formulate personally meaningful goals, highlighting the diverse cognitive rehabilitation needs of these individuals.
DISABILITY AND REHABILITATION
(2023)
Meeting Abstract
Psychology, Developmental
Kevin J. Black
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Meeting Abstract
Psychology, Developmental
Ann Iverson, Emily C. Bihun, Amanda L. Arbuckle, David Song, Kevin J. Black
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Psychiatry
Peristera Paschou, Yin Jin, Kirsten Mueller-Vahl, Harald E. Moeller, Renata Rizzo, Pieter J. Hoekstra, Veit Roessner, Nanette Mol Debes, Yulia Worbe, Andreas Hartmann, Pablo Mir, Danielle Cath, Irene Neuner, Heike Eichele, Chencheng Zhang, Katarzyna Lewandowska, Alexander Munchau, Julius Verrel, Richard Musil, Tim J. Silk, Colleen A. Hanlon, Emily D. Bihun, Valerie Brandt, Andrea Dietrich, Natalie Forde, Christos Ganos, Deanna J. Greene, Chunguang Chu, Michel J. Grothe, Tamara Hershey, Piotr Janik, Jonathan M. Koller, Juan Francisco Martin-Rodriguez, Karsten Mueller, Stefano Palmucci, Adriana Prato, Shukti Ramkiran, Federica Saia, Natalia Szejko, Renzo Torrecuso, Zeynep Tumer, Anne Uhlmann, Tanja Veselinovic, Tomasz Wolanczyk, Jade-Jocelyne Zouki, Pritesh Jain, Apostolia Topaloudi, Mary Kaka, Zhiyu Yang, Petros Drineas, Sophia Thomopoulos, Tonya White, Dick J. Veltman, Lianne Schmaal, Dan J. Stein, Jan Buitelaar, Barbara Franke, Odile van den Heuvel, Neda Jahanshad, Paul M. Thompson, Kevin J. Black
Summary: TS is characterized by multiple motor and vocal tics and high comorbidity rates with other neuropsychiatric disorders. The ENIGMA-TS working group aims to understand brain structure and function in TS and related disorders through collaborative efforts and transdiagnostic approaches.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
David Mataix-Cols, Kayoko Isomura, Gustaf Brander, Isabell Brikell, Paul Lichtenstein, Zheng Chang, Henrik Larsson, Ralf Kuja-Halkola, Kevin J. Black, Anna Sidorchuk, Lorena Fernandez de la Cruz
Summary: A Swedish study found that 20% of children with tic disorders continued to have chronic tic disorders into adulthood, with childhood psychiatric comorbidities and family history of psychiatric disorders being the strongest risk factors for tic disorder persistence.
MOVEMENT DISORDERS
(2023)
Article
Medicine, General & Internal
Ann M. Iverson, Amanda L. Arbuckle, David Y. Song, Emily C. Bihun, Kevin J. Black
Summary: Median nerve stimulation (MNS) at 10-12 Hz was found to improve tic frequency and intensity in individuals with Tourette syndrome and other chronic tic disorders, with minimal side effects. Participants used a transcutaneous electrical nerve stimulation (TENS) unit to administer MNS and reported improvements in tic symptoms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Ann M. Iverson, Amanda L. Arbuckle, Keisuke Ueda, David Y. Y. Song, Emily C. Bihun, Jonathan M. Koller, Michael Wallendorf, Kevin J. Black
Summary: A prior study found that rhythmic 12 Hz stimulation of the median nerve improved tics in Tourette syndrome (TS), but the cortical entrainment hypothesis could not explain this benefit. A replication study with 32 TS patients showed that both rhythmic and arrhythmic 12 Hz median nerve stimulation improved tic symptoms, but the two treatments did not differ significantly. The study suggests that another electrophysiological mechanism, or a placebo effect, may explain the improvement.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rehabilitation
Chang Dae Lee, Erin R. R. Foster, Yael Goverover
Summary: This study aims to explore the associations between subjective memory complaints (SMCs), depressive symptoms, cognitive ability (CA), and instrumental activities of daily living (IADL) performance, and investigate the role of depressive symptoms in these associations. The results showed that SMCs were significantly and positively associated with cognitive decline and limitations in IADL performance, and depressive symptoms mediated these associations.
PHYSICAL & OCCUPATIONAL THERAPY IN GERIATRICS
(2023)
Article
Multidisciplinary Sciences
Jaclyn M. Martindale, Harini Sarva, Davide Martino, Donald L. Gilbert, Christos Ganos, Tamara Pringsheim, Kevin Black, Irene A. Malaty
Summary: Based on expert opinion and literature review, this study discusses the barriers to the implementation of practice guidelines in the clinical care of patients with persistent tic disorders. The objectives are to identify divergences from existing guidelines and to identify categories of barriers leading to these gaps in clinical care.
Article
Rehabilitation
Janet L. Poole, Susan L. Murphy, Erin R. Foster, Alix G. Sleight, Toni Van Denend, Arash Asher, Kristine Carandang, Marcia Finlayson, Donald Fogelberg, Heather S. L. Jim, Aileen Ledingham, Tanya Packer, Matthew Plow, Katherine Preissner, Stephen Wechsler, Daniel Whibley
Summary: Fatigue is a burdensome symptom that affects various aspects of daily life. Occupational practitioners have historically played vital roles in managing fatigue. A workshop was organized by the American Occupational Therapy Foundation to develop research ideas and proposals for fatigue management. Four main topics were discussed, including implementation science, treatment taxonomy, trial design, and phenotyping.
OTJR-OCCUPATIONAL THERAPY JOURNAL OF RESEARCH
(2023)
Article
Rehabilitation
Pooja M. Jethani, Joan Toglia, Erin R. Foster
Summary: This study examines the impact of Parkinson's disease (PD) on cognitive self-efficacy (CSE), which is one's belief in their ability to control their cognitive performance. The results show that non-demented PD patients have lower CSE scores compared to healthy individuals, particularly in managing cognitive symptoms. Greater depressive symptoms and higher medication dosage are associated with lower CSE in PD patients. Rehabilitation professionals should consider assessing and intervening on CSE during treatment sessions.
OTJR-OCCUPATIONAL THERAPY JOURNAL OF RESEARCH
(2023)
Article
Rehabilitation
Eunyoung Kang, Julie Chen, Erin R. Foster
Summary: Telehealth delivery of a goal setting and goal management system called MyGoals is feasible to support goal setting and goal management for adults with chronic conditions. The system showed good credibility, expectancy, satisfaction, client engagement, person-centeredness, and change objective achievement. Interview data provided suggestions for improvements to MyGoals.
OTJR-OCCUPATIONAL THERAPY JOURNAL OF RESEARCH
(2023)
Article
Behavioral Sciences
Raul Alfaro, Jessica G. Nicanor-Carreon, Tasha Doty, Heather Lugar, Tamara Hershey, Marta Yanina Pepino
Summary: Wolfram syndrome is associated with impairment in smell identification and taste function, but odor-induced taste enhancement is preserved in the presence of reduced olfactory intensity.
Meeting Abstract
Clinical Neurology
Kevin J. Black, Amanda Arbuckle, Emily C. Bihun, David Song, Jonathan M. Koller, Amy Robichaux Viehoever, Keisuke Ueda
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES
(2022)
Article
Multidisciplinary Sciences
Payton Beeler, Nicholas O. Jensen, Soyoung Kim, Amy Robichaux-Viehoever, Bradley L. Schlaggar, Deanna J. Greene, Kevin J. Black, Rajan K. Chakrabarty
Summary: The study confirms the fractal nature of tics, indicating correlation between neighboring time scales. The fractal dimension is correlated with tic severity and serves as a sensitive parameter for examining the effects of tic suppression conditions. This finding opens up new possibilities for utilizing the fractal nature of tics as a tool for assessing and treating tic disorders.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2022)
