期刊
JOURNAL OF CLINICAL VIROLOGY
卷 71, 期 -, 页码 59-62出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jcv.2015.08.003
关键词
BK virus; Caveolar-dependent Endocytosis; Statins; Cellular receptor; Renal transplantation
类别
资金
- NIH [DK088018, DK098159]
BK virus (BKV) causes BKV nephritis in renal transplant patients and contributes significantly to the increase of probability of graft loss. BKV, being latent in the urogenital tract, is likely to be transported with the donor kidney to recipients and following reactivation replicates in the nucleus of renal epithelial tubular cells. BKV daughter viruses are released and enter other renal epithelial cells to spread infection. There are still a lot of unknown factors about the mechanism and kinetics of BKV infection. The treatment of BKV infection, with exception of reduction in immunosuppression which increases the risk of allograft rejection, is almost exclusively limited to application of anti-viral drugs with rather inconsistent results. The shortcomings of anti-viral therapies demand the understanding of early steps of infection of permissive cells by BK virus in hope that adequate interventional therapies preventing infection of cells with BK virus could be developed. This review describes the BKV entry in target human cells, intracellular trafficking pathways of BKV particles and potential therapeutic implications based on understanding of mechanisms of BKV infection of renal cells. (C) 2015 The Authors. Published by Elsevier B.V.
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