Article
Biotechnology & Applied Microbiology
Megan A. Holborn, Graeme Ford, Sarah Turner, Juanita Mellet, Jeanne van Rensburg, Fourie Joubert, Michael S. Pepper
Summary: This paper describes a database of genes and variants (NCGR) that collects and compares genetic findings associated with NESHIE and CP. Furthermore, it demonstrates how NCGR can be used to prioritize genes and variants with potential clinical relevance to the genetic susceptibility and pathogenesis of NESHIE.
Article
Computer Science, Information Systems
Dalal Bakheet, Noura Alotaibi, Daniel Konn, Brigitte Vollmer, Koushik Maharatna
Summary: This study investigated the use of EEG signal analysis to predict cerebral palsy in infants with hypoxic-ischemic encephalopathy. By analyzing entropy features and graph-theoretic parameters, it was found that these characteristics could successfully distinguish between infants with CP and those with normal neurology. The study concluded that these features could be potential biomarkers for cerebral cellular damage and be used for early CP prediction in clinical settings.
Review
Biochemistry & Molecular Biology
Yue Zhou, Luqiang Sun, Haichuan Wang
Summary: The prevalence of neonatal hypoxic-ischemic encephalopathy (HIE) is increasing, leading to the need for effective treatments and preventions. Research has focused on understanding the underlying pathology and the potential of dietary interventions, such as a ketogenic diet (KD). The KD has shown promising effects in animal models and brain injury patients, including potential neuroprotection and improvement of mitochondrial function.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Pediatrics
Ipsita Goswami, Daphne Kamino, Elysa Widjaja, Melissa Paniccia, Nicholas Mitsakakis, Aideen Moore, Emily W. Y. Tam
Summary: This study compares the longitudinal changes in heart rate variability (HRV) during therapeutic hypothermia in neonates with different subtypes of hypoxic-ischemic brain injury. The results show that neonates with watershed injury and mixed pattern injury have significant suppression of HRV during the first 48 hours of hypothermia therapy.
PEDIATRIC RESEARCH
(2022)
Article
Multidisciplinary Sciences
Tim Hermans, Katherine Carkeek, Anneleen Dereymaeker, Katrien Jansen, Gunnar Naulaers, Sabine Van Huffel, Maarten De Vos
Summary: In neonates with hypoxic ischemic encephalopathy, the use of wavelet coherence between EEG power and rSO2 is a promising method for assessing neurovascular coupling. However, fluctuations in SpO2 limit the reliability of previous methods. To address this issue, partial wavelet coherence is proposed to eliminate the influence of SpO2. Furthermore, the study investigates the additional value of novel NVC biomarkers compared to traditional EEG and NIRS biomarkers for identifying brain injury.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Sergi Gomez-Quintana, Alison O'Shea, Andreea Factor, Emanuel Popovici, Andriy Temko
Summary: The study proposes a method that combines AI decision support with healthcare professionals to provide intuitive interpretation of neonatal EEG by acoustic detection of seizures. The survey results demonstrated that this method reduces the burden of reviewing EEG data and achieves accuracy comparable to experienced neurophysiologists.
SCIENTIFIC REPORTS
(2022)
Article
Behavioral Sciences
Tayla R. Penny, Yen Pham, Amy E. Sutherland, Madeleine J. Smith, Joohyung Lee, Graham Jenkin, Michael C. Fahey, Suzanne L. Miller, Courtney A. McDonald
Summary: This study identified specific cognitive and motor deficits tests in a neonatal hypoxic ischemic rat model. Due to high variability in the model, significant impairment is not always observed in individual tests, but by combining outcomes, long-term behavioral burden can be measured.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Review
Pediatrics
Dianne G. Kleuskens, Filipe Goncalves Costa, Kim V. Annink, Agnes van den Hoogen, Thomas Alderliesten, Floris Groenendaal, Manon J. N. Benders, Jeroen Dudink
Summary: Cerebral hyperperfusion is a major complication in neonates with HIE, typically occurring within 10-30 minutes after the hypoxic-ischemic event and persisting up to 10 days and even 1 month after birth. This process is characterized by angiogenesis and cerebral vasodilation, mediated by endogenous pathways.
FRONTIERS IN PEDIATRICS
(2021)
Article
Computer Science, Artificial Intelligence
Mark E. O'Sullivan, Gordon Lightbody, Sean R. Mathieson, William P. Marnane, Geraldine B. Boylan, John M. O'Toole
Summary: The study aims to develop and evaluate algorithms for detecting neonatal EEG artefacts and assessing their application in automated EEG grading of neonatal hypoxic-ischemic encephalopathy (HIE). The study used machine learning and deep learning methods, with a deep learning convolutional neural network achieving the best performance for artefact detection. The inclusion of artefact detection in the grading algorithm slightly improved its accuracy.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Article
Pediatrics
Sijin Chen, Xilong Liu, Jie Lin, Yingjie Mei, Kan Deng, Qiao Xue, Xiaoyan Song, Yikai Xu
Summary: This study evaluated the cerebral amide proton transfer signal intensity in neonates with hypoxic-ischemic encephalopathy (HIE) with normal and abnormal conventional MRI findings. The results showed significantly increased amide proton transfer signal intensity in both the HIE/MRI- and HIE/MRI+ groups, suggesting that this imaging technique plays an important role in detecting HIE.
FRONTIERS IN PEDIATRICS
(2022)
Article
Neurosciences
Jin-Xiang Liu, Chang-Le Fang, Kun Zhang, Rui-Fang Ma, Hong-Su Zhou, Li Chen, Qiu-Lin Wang, Yu-Xuan Lu, Ting-Hua Wang, Liu-Lin Xiong
Summary: This study aimed to evaluate the feasibility of Transcranial Doppler Ultrasonography (TCD) in assessing neonatal hypoxic-ischemic encephalopathy (NHIE) modeling. Results showed that TCD scans revealed obvious alterations in cerebral blood flow in neonatal hypoxic-ischemic (HI) rats. Cerebral infarct was further validated by TTC staining and damage to nervous tissues was revealed by Nissl staining.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Pediatrics
John D. E. Barks, Yiqing Liu, Ian A. Dopp, Faye S. Silverstein
Summary: The study showed that AZ improves sensorimotor function, survival, brain tissue preservation, and composite scores in two neonatal rat models of inflammation-amplified HI brain injury. The benefits of AZ treatment increased with higher doses and decreased with longer initiation delays. The findings support further evaluation of AZ as a candidate treatment for neonatal neuroprotection, even with a 2-hour delay in initiation.
PEDIATRIC RESEARCH
(2022)
Article
Pediatrics
Jia Li, Guofei Zhang, Xiaorong Wang, Cuozhen Qiangba, Xiaoyan Song, Rouyi Lin, Chantao Huang, Xiaoying Yang, Shuyao Ning, Jian Zhang, Haiyan Liao, Siyuan Xie, Zhen Suo, Haiying Qi, Zhen Yu, Runling Shi, Yanli Yao
Summary: In high-altitude areas, the incidence of neonatal hypoxic-ischemic encephalopathy (HIE) is high and the brain injury is severe. Therapeutic hypothermia (TH) is limited and often delayed. EEG shows distinct patterns attributable to altitude hypoxia. TH is relatively safe.
Review
Pediatrics
Valerie Y. Chock, Anoop Rao, Krisa P. Van Meurs
Summary: Neonates with hypoxic ischemic encephalopathy (HIE) are at significant risk for adverse outcomes. Neuromonitoring provides critical diagnostic and prognostic information. Various modalities such as cEEG, aEEG, NIRS, and heart rate variability can be used for continuous monitoring, while cranial ultrasound and evoked potentials are used for serial bedside monitoring. Integrated use of these techniques, along with therapeutic hypothermia, can predict imaging outcomes and long-term neurodevelopment.
FRONTIERS IN PEDIATRICS
(2023)
Article
Pediatrics
Akihito Takeuchi, Takushi Inoue, Makoto Nakamura, Misao Kageyama, Tomoyuki Akiyama, Katsuhiro Kobayashi
Summary: The study reported the presence of pathological FOs in the high-gamma band in a newborn patient with severe hypoxic-ischemic encephalopathy, which is rare. The findings suggest that neonatal seizures may exhibit FOs with higher frequencies, and further research is needed to elucidate the pathophysiology.
FRONTIERS IN PEDIATRICS
(2021)
Article
Clinical Neurology
D. N. Manners, G. Rizzo, C. La Morgia, C. Tonon, C. Testa, P. Barboni, E. Malucelli, M. L. Valentino, L. Caporali, D. Strobbe, V. Carelli, R. Lodi
AMERICAN JOURNAL OF NEURORADIOLOGY
(2015)
Article
Clinical Neurology
Valerio Carelli, Olimpia Musumeci, Leonardo Caporali, Claudia Zanna, Chiara La Morgia, Valentina Del Dotto, Anna Maria Porcelli, Michela Rugolo, Maria Lucia Valentino, Luisa Iommarini, Alessandra Maresca, Piero Barboni, Michele Carbonelli, Costantino Trombetta, Enza Maria Valente, Simone Patergnani, Carlotta Giorgi, Paolo Pinton, Giovanni Rizzo, Caterina Tonon, Raffaele Lodi, Patrizia Avoni, Rocco Liguori, Agostino Baruzzi, Antonio Toscano, Massimo Zeviani
ANNALS OF NEUROLOGY
(2015)
Article
Neurosciences
Stefano Zanigni, Rossana Terlizzi, Caterina Tonon, Claudia Testa, David Neil Manners, Sabina Capellari, Roberto Gallassi, Roberto Poda, Laura Ludovica Gramegna, Giovanna Calandra-Buonaura, Luisa Sambati, Pietro Cortelli, Raffaele Lodi
BRAIN RESEARCH BULLETIN
(2015)
Article
Clinical Neurology
Stefano Zanigni, Claudia Testa, Giovanna Calandra-Buonaura, Luisa Sambati, Maria Guarino, Anna Gabellini, Stefania Evangelisti, Pietro Cortelli, Raffaele Lodi, Caterina Tonon
PARKINSONISM & RELATED DISORDERS
(2015)
Article
Clinical Neurology
Claudia Testa, Giovanna Calandra-Buonaura, Stefania Evangelisti, Giulia Giannini, Federica Provini, Stefano Ratti, Annagrazia Cecere, Lia Talozzi, David Neil Manners, Raffaele Lodi, Caterina Tonon, Pietro Cortelli
PARKINSONISM & RELATED DISORDERS
(2019)
Review
Immunology
Vincenzo Di Nunno, Giacomo Nuvola, Mirta Mosca, Ilaria Maggio, Lidia Gatto, Alicia Tosoni, Raffaele Lodi, Enrico Franceschi, Alba Ariela Brandes
Summary: Immune checkpoint inhibitors show potential in the treatment of brain metastases, particularly for melanoma. The clinical role of immune checkpoint inhibitors for brain metastases from other solid malignancies remains uncertain at present.
Article
Biophysics
Marco Barbieri, Philip K. Lee, Leonardo Brizi, Enrico Giampieri, Francesco Solera, Gastone Castellani, Brian A. Hargreaves, Claudia Testa, Raffaele Lodi, Daniel Remondini
Summary: Magnetic resonance fingerprinting (MRF) is a fast quantitative MRI method. This study proposes a deep learning approach using a fully connected network (FCN) for MRF and compares it with the traditional dictionary-based approach. The results show that the FCN approach outperforms the dictionary-based approach in terms of scalability capabilities. The study also explores optimal training procedures to improve accuracy and robustness to noise and undersampling artifacts.
NMR IN BIOMEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Viscardo P. Fabbri, Mattia Riefolo, Tiziana Lazzarotto, Liliana Gabrielli, Giovanna Cenacchi, Carmine Gallo, Raffaele Aspide, Guido Frascaroli, Rocco Liguori, Raffaele Lodi, Caterina Tonon, Antonietta D'Errico, Maria Pia Foschini
Summary: The study described 33 cases of brain autopsies performed during two waves of the COVID-19 pandemic, comparing SARS-CoV-2 infection status and pathological findings.
Review
Medicine, General & Internal
Christian di Noia, James T. Grist, Frank Riemer, Maria Lyasheva, Miriana Fabozzi, Mauro Castelli, Raffaele Lodi, Caterina Tonon, Leonardo Rundo, Fulvio Zaccagna
Summary: Given the increasing clinical needs, artificial intelligence (AI) techniques have been widely used to predict survival in patients with brain tumors. This review focuses on the current applications of AI, particularly in magnetic resonance imaging (MRI), for survival assessment. The study identifies machine learning, deep learning, and radiomics-based methods as effective approaches for classifying patients and quantifying survival intervals. While classification tasks achieve high accuracy, quantification remains challenging but shows promising results.
Proceedings Paper
Computer Science, Artificial Intelligence
Rita Morisi, Giorgio Gnecco, Nico Lanconelli, Stefano Zanigni, David Neil Manners, Claudia Testa, Stefania Evangelisti, Laura Ludovica Gramegna, Claudio Bianchini, Pietro Cortelli, Caterina Tonon, Raffaele Lodi
PATTERN RECOGNITION AND IMAGE ANALYSIS (IBPRIA 2015)
(2015)