Article
Agriculture, Dairy & Animal Science
Maciej Przewozny, Magdalena Senderska-Plonowska, Anna Rzasa, Heliodor Wierzbicki, Jacek Borkowski, Jan-Hein Swagemakers, Agnieszka Zak-Bochenek, Tadeusz Stefaniak
Summary: The study analyzes the changes in acute phase proteins in the serum of patients from the equine clinic who underwent various orthopedic procedures. The concentrations of these proteins were found to change before clinical symptoms appeared, potentially aiding in early recognition and complication prevention.
Article
Immunology
Nathella Pavan Kumar, Kadar Moideen, Arul Nancy, Vijay Viswanathan, Kannan Thiruvengadam, Shanmugam Sivakumar, Syed Hissar, Hardy Kornfeld, Subash Babu
Summary: The study demonstrates that acute phase proteins can serve as accurate predictors of treatment failure in pulmonary tuberculosis, with high sensitivity and specificity in distinguishing between treatment failure and cure. These markers hold promise for rapid prognostic testing for adverse treatment outcomes in PTB in the future.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Engineering, Electrical & Electronic
Zhongjie Ren, Ke Cui, Yifeng Sun
Summary: The paper introduces a pipeline anti-vandalism monitoring system based on TDM interferometric fiber optic sensor array, utilizing high sensitivity for continuous monitoring of buried pipelines. This system reduces costs, accelerates construction processes, and effectively achieves vandalism alarms with over 90% accuracy within 1 ms.
OPTICAL FIBER TECHNOLOGY
(2021)
Article
Energy & Fuels
Ya-Rong Zheng, Jerome Vernieres, Zhenbin Wang, Ke Zhang, Degenhart Hochfilzer, Kevin Krempl, Ting-Wei Liao, Francesco Presel, Thomas Altantzis, Jarmo Fatermans, Soren Bertelsen Scott, Niklas Morch Secher, Choongman Moon, Pei Liu, Sara Bals, Sandra Van Aert, Ang Cao, Megha Anand, Jens K. Norskov, Jakob Kibsgaard, Ib Chorkendorff
Summary: This study presents a low-iridium mass-selected iridium-tantalum oxide catalyst with high intrinsic activity for acid environments, aiming to improve the efficiency of hydrogen production in water electrolysers. By carefully evaluating oxygen production, the researchers demonstrate that the catalyst exhibits higher activity compared to commercial IrO2.
Article
Computer Science, Information Systems
Alexander Schaum, Roberto Bernal-Jaquez, G. Sanchez-Gonzalez
Summary: This article addresses the problem of designing a system for monitoring the spread of dengue in a mixed population of humans and mosquitos using a model-based observer approach. The model has been validated with real data and a continuous-discrete extended Kalman Filter is designed for monitoring and prediction, showing potential for future automated monitoring schemes.
Article
Biochemistry & Molecular Biology
Subhadip Choudhuri, Imran Hussain Chowdhury, Avijit Saha, Bhaskar Mitra, Rinini Dastidar, Pijush Kanti Roy
Summary: The study reveals a significant association between increased positive to negative acute phase reactants ratio and monocyte immune activation in dengue patients, indicating intense immune activation and susceptibility to hemostatic derangement in secondary dengue infection patients.
Article
Biochemistry & Molecular Biology
Irwin Puc, Tzu-Chuan Ho, Ko-Lun Yen, Amrita Vats, Jih-Jin Tsai, Po-Lin Chen, Yu-Wen Chien, Yu-Chih Lo, Guey Chuen Perng
Summary: The clinical presentations of dengue fever are varied and nonspecific, making its progression and outcomes difficult to predict. This study classified dengue patients into different severity groups and analyzed 23 cytokines to identify potential biomarkers for effective intervention strategies. IL-10 was found to be a potential diagnostic marker for dengue fever, while CD121b showed promise in predicting severe dengue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Leena Liljedahl, Johan Malmstrom, Bjorg Kristjansdottir, Sofia Waldemarson, Karin Sundfeldt
Summary: Ovarian cancer is a lethal disease often discovered late. A targeted assay has shown success in identifying different subtypes of ovarian cancer, potentially leading to improved early diagnostics and survival rates.
Article
Virology
Ankit Kumar Sahu, Praveen Aggarwal, Meera Ekka, Jamshed Nayer, Sanjeev Bhoi, Akshay Kumar, Kalpana Luthra
Summary: This study demonstrates that elevated serum chymase levels at admission can serve as a biomarker for predicting the development of severe dengue during the course of illness. The accuracy and reliability of this marker is significantly higher than that of platelet count at admission. Monitoring chymase levels can provide a more accurate assessment of disease severity in dengue patients.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Mathematics
Alla Yu Vladova
Summary: Extensive but remote oil and gas fields in Canada and Russia require long pipelines, which are affected by the deepening of seasonal thawing caused by global warming and local anthropogenic effects. In order to improve the accuracy of temperature monitoring and separate anthropogenic heat losses from seasonal fluctuations, a short-term prediction approach using a transformed multidimensional dataset is proposed. The Prophet model is used for forecasting, with linear and nonlinear functions defining trend and seasonal components, while abnormal days can be defined by an analyst.
Article
Gastroenterology & Hepatology
Tadeusz Sebzda, Jan Gnus, Barbara Dziadkowiec, Miroslaw Latka, Jakub Gburek
Summary: The study aimed to use biomarkers for early diagnosis of tumor progression. By analyzing the serum of 185 patients with colorectal adenocarcinoma, it was found that the increased values of CB, TSA, and ATA parameters are associated with the tumor biology, invasion, and metastasis of colorectal cancer. The combination of CB-TSA-ATA three parameters has potential value in early diagnosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Parasitology
Juliane Hartke, Friederike Reuss, Isabelle Marie Kramer, Axel Magdeburg, Isra Deblauwe, Reshma Tuladhar, Ishan Gautam, Meghnath Dhimal, Ruth Mueller
Summary: Vector-borne diseases are increasing globally and are expected to worsen due to human-induced climate change. This has a particularly severe impact on resource-limited regions, where current surveillance programs are inadequate for monitoring the expansion of potential vector species. To address this, we utilized a field barcoding pipeline based on DNA nanopore sequencing to enhance entomological capacity in Nepal, a country with endemic vector-borne diseases. Our results confirmed the effectiveness of the barcoding pipeline for different mosquito life stages and storage methods. Additionally, an online workshop successfully facilitated knowledge transfer to Nepalese scientific experts from various disciplines, providing an opportunity for sustainable implementation of low-cost portable sequencing solutions in Nepal.
PARASITES & VECTORS
(2022)
Letter
Medicine, General & Internal
Arie R. Gafson, Xiaotong Jiang, Changyu Shen, Raj Kapoor, Henrik Zetterberg, Robert J. Fox, Shibeshih Belachew
Summary: This cohort study examines the serum neurofilament light concentration as a biomarker in relation to disability progression in multiple sclerosis, without considering the presence of acute inflammation.
Review
Oncology
Karolina Joanna Zietara, Jan Lejman, Katarzyna Wojciechowska, Monika Lejman
Summary: B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a common hematological malignancy in children. The disease is caused by the uncontrolled proliferation of precursor cells in the bone marrow. Molecules such as microRNA (miRNA) play a role in the development of BCP-ALL. miRNA is a short non-coding RNA that regulates gene expression. It affects both pre- and post-translational processes. The stability of miRNA and its presence in circulation are useful for diagnosis and prognosis of pediatric leukemias. miRNA is gaining attention for its biomarker potential and easy detection.
Article
Environmental Sciences
Maxime Lepretre, Arnaud Chaumot, Rayan Aboud, Nicolas Delorme, Anabelle Espeyte, Arnaud Salvador, Sophie Ayciriex, Jean Armengaud, Marina Coquery, Olivier Geffard, Davide Degli-Esposti
Summary: Mass spectrometry in multiple reaction monitoring (MRM) mode enables selective and multiplexed quantification of peptides derived from proteins. This study evaluates the feasibility of using dynamic MRM (dMRM) tools to investigate proteomes in sentinel species and demonstrates their potential for discovering new protein biomarkers. A dMRM assay was developed to capture the functional proteome of a freshwater crustacean and assess the effects of metal exposure. Metal-specific signatures were identified as potential biomarkers for tracking metal levels in freshwater ecosystems. This study highlights the potential of dMRM for identifying and developing biomarkers in sentinel species.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Immunology
Daniela Michlmayr, Paulina Andrade, Eduardo J. M. Nascimento, Allan Parker, Parnal Narvekar, Hansi J. Dean, Eva Harris
Summary: This study analyzed the specific and cross-reactive memory B cell responses to dengue virus in individuals who received a tetravalent vaccine candidate. The results showed that tetravalent vaccination induced type-specific memory B cells, demonstrating a significant contribution from all 4 components of the vaccine to the DENV-specific memory B cell response.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Jana L. Jacobs, William Bain, Asma Naqvi, Brittany Staines, Priscila M. S. Castanha, Haopu Yang, Valerie F. Boltz, Simon Barratt-Boyes, Ernesto T. A. Marques, Stephanie L. Mitchell, Barbara Methe, Tolani F. Olonisakin, Ghady Haidar, Thomas W. Burke, Elizabeth Petzold, Thomas Denny, Chris W. Woods, Bryan J. McVerry, Janet S. Lee, Simon C. Watkins, Claudette M. St Croix, Alison Morris, Mary F. Kearney, Mark S. Ladinsky, Pamela J. Bjorkman, Georgios D. Kitsios, John W. Mellors
Summary: This study found that SARS-CoV-2 vRNA was detected in the plasma of COVID-19 patients, with the highest rates in ICU patients. Higher levels of vRNA were associated with more severe disease, patient outcomes, and specific inflammatory biomarkers.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Ludmila Lobkowicz, Democrito de Barros Miranda-Filho, Ulisses Ramos Montarroyos, Celina Maria Turchi Martelli, Thalia Velho Barreto de Araujo, Wayner Vieira De Souza, Luciana Caroline Albuquerque Bezerra, Rafael Dhalia, Ernesto T. A. Marques, Nuria Sanchez Clemente, Jayne Webster, Aisling Vaughan, Emily L. Webb, Elizabeth B. Brickley, Ricardo Arraes de Alencar Ximenes
Summary: The co-circulation of arthropod-borne viruses, including Zika and Chikungunya, is increasingly common. This study investigated the geographic and temporal distribution of these infections during pregnancy and found that clinical symptoms alone may not be sufficient for differentiating Zika and Chikungunya infections. Laboratory diagnostics remain important in these cases.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Immunology
Priscila M. S. Castanha, Dylan J. Tuttle, Georgios D. Kitsios, Jana L. Jacobs, Ulisses Braga-Neto, Matthew Duespohl, Sanjay Rathod, Michelle M. Marti, Sarah Wheeler, Asma Naqvi, Brittany Staines, John Mellors, Alison Morris, Bryan J. McVerry, Faraaz Shah, Caitlin Schaefer, Bernard J. C. Macatangay, Barbara Methe, Christian A. Fernandez, Simon M. Barratt-Boyes, Donald Burke, Ernesto T. A. Marques
Summary: This study reveals that the classical pathway mediates complement overactivation in response to increased levels of circulating immune complexes, leading to the severity of COVID-19. Early non-neutralizing IgG responses play a crucial role in complement overactivation.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biochemical Research Methods
Yanlong Zhu, Stephane Esnault, Ying Ge, Nizar N. Jarjour, Allan R. Brasier
Summary: Airway remodeling in patients with asthma is associated with leukocyte numbers and remodeling markers. Patients with lower FEV1 have distinct dynamic responses to allergens.
CLINICAL PROTEOMICS
(2022)
Article
Biochemistry & Molecular Biology
Yanlong Zhu, Stephane Esnault, Ying Ge, Nizar N. Jarjour, Allan R. Brasier
Summary: This study analyzed metabolites in bronchoalveolar fluid (BALF) during a bronchial antigen challenge and identified distinct metabolic responses, providing insight into pathogenic and protective subtypes in allergic asthma.
Article
Immunology
Franciane Mouradian Emidio Teixeira, Luana de Mendonca Oliveira, Anna Julia Pietrobon, Erika Machado de Salles, Maria Regina D'Imperio Lima, Isabelle Freire Tabosa Viana, Roberto Dias Lins, Paula Ordonhez Rigato, Ernesto Torres de Azevedo Marques, Alberto Jose da Silva Duarte, Maria Notomi Sato
Summary: Neonatal immunization with a LAMP-1/p55Gag DNA vaccine can enhance antibody production and contribute to the development of new vaccine approaches for other emerging pathogens in early life.
Article
Immunology
Eduardo J. M. Nascimento, Brooke Norwood, Eloi Kpamegan, Allan Parker, Jesuina Fernandes, Erick Perez-Guzman, Vianney Tricou, Ralph Braun, Mayuri Sharma, Hansi J. Dean
Summary: Antibodies produced after TAK-003 vaccination are functional in fixing and activating the complement system on all dengue virus serotypes, which may contribute to the efficacy of TAK-003.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Editorial Material
Virology
Allan R. Brasier
Article
Biochemistry & Molecular Biology
Dianhua Qiao, Melissa Skibba, Xiaofang Xu, Allan R. Brasier
Summary: Epithelial mesenchymal plasticity (EMP) is a complex cellular reprogramming event that plays a major role in tissue homeostasis. Recently, the unfolded protein response (UPR) was found to trigger EMP through the IRE1 alpha-XBP1s axis, enhancing glucose shunting to protein N glycosylation. By identifying the genomic targets of XBP1s using CUT&RUN, it was discovered that XBP1s peaks were located near various promoters of genes controlling Rho-GTPase signaling, N-linked glycosylation, and ER-Golgi transport. Moreover, the IRE1 alpha-XBP1s pathway was shown to regulate mesenchymal transcription factors and hexosamine biosynthesis in EMP by recruiting activated RNA Pol II to GC-rich promoters.
NUCLEIC ACIDS RESEARCH
(2023)
Editorial Material
Medicine, Research & Experimental
Allan R. Brasier
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Review
Medicine, Research & Experimental
Allan. R. R. Brasier, Shannon. L. L. Casey, Peggy Hatfield, Patrick. W. W. Kelly, Whitney. A. A. Sweeney, Marin Schweizer, Bo Liu, Elizabeth. S. S. Burnside
Summary: This study proposes a model for developing leadership in translational teams (TTs) from team formation to dissemination and implementation. It identifies the stable impact of leadership behaviors on team development and emphasizes the importance of ongoing reflection, evaluation, and practice to enhance leadership skills. The study also provides a comprehensive multi-level evaluation framework to track the growth of TT leadership skills.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Review
Medicine, Research & Experimental
Allan R. Brasier, Shannon L. Casey, Felice Resnik, Betsy Rolland, Elizabeth S. Burnside
Summary: Successful translation involves the application of research and product development to advance healthcare interventions. Training in team skills and attitudes can enhance translational team performance. Interdisciplinary teams undergo developmental phases, with each phase promoting knowledge generation and translation. Antecedents of stage-dependent competencies and assessment rubrics can guide training interventions for improving performance in the clinical context.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Review
Medicine, Research & Experimental
Allan R. Brasier, Elizabeth S. Burnside, Betsy Rolland
Summary: A translational team is a type of interdisciplinary team that aims to improve human health. Understanding how to promote team performance in the areas of affect, communication, management, collaborative problem-solving, and leadership is essential. This study conducted a literature review to identify key competencies that enhance team performance and develop strategies for training interventions.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Letter
Medicine, General & Internal
Denis Y. Logunov, David M. Livermore, David A. Ornelles, Wibke Bayer, Ernesto Marques, Cecil Czerkinsky, Inna V. Dolzhikova, Hildegund C. J. Ertl