Article
Engineering, Biomedical
Can Liu, Lei Fan, Zhenming Tian, Huiquan Wen, Lei Zhou, Pengfei Guan, Yian Luo, Chuncheung Chan, Guoxin Tan, Chengyun Ning, Limin Rong, Bin Liu
Summary: Conductive scaffolds have shown therapeutic effects for patients with peripheral nerve injuries. The development of biocompatible electroconductive hydrogels has been proposed in this study, which can promote nerve repair and functional recovery.
BIOACTIVE MATERIALS
(2021)
Article
Multidisciplinary Sciences
W. Grabowska, R. King, S. Roll, I. V. Habermann, S. Hoerder, K. Hahn, S. N. Willich, S. Schroeder, B. Brinkhaus, J. Dietzel
Summary: This study aimed to assess the reliability of DPNCheck for repeated sural nerve conduction parameters. A post hoc analysis was conducted using data from a randomized controlled trial, which found moderate to good reliability of DPNCheck for nerve velocity and amplitude, but weak correlation with Total Neuropathy Score clinical. Given the limitations of this analysis, further long-term, pre-specified studies are needed to fully determine the suitability of DPNCheck for monitoring DPN progression.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
David Gonzalez, Miguel L. Allende
Summary: Wallerian degeneration is a genetically conserved mechanism where peripheral nervous system axons have a higher capacity to regenerate. The use of zebrafish larvae and time-lapse microscopy allows for monitoring of the regenerative process of peripheral nerves.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Xianchen Zhang, Fulong Zhang
Summary: Diabetes peripheral neuropathy (DPN) is often symptomless in its early stage, but irreversible once symptoms and obvious defects appear. Diagnosis of neuropathy relies on physical examinations, questionnaires, nerve conduction studies, skin biopsies, etc. However, diagnosing DPN remains challenging, and early diagnosis and immediate intervention are crucial in preventing the development and progression of diabetic neuropathy. The clear peripheral nerve imaging, intuitive lesion detection, and quantitative evaluation provided by MRI have made it advantageous in diagnosing, classifying, and following-up DPN. With advancements in magnetic resonance technology, more studies have been conducted on the detection of DPN. This article reviews the research field of MRI in DPN.
Article
Clinical Neurology
A. G. Kristensen, S. Gylfadottir, M. Itani, S. Kuwabara, T. Kroigard, K. S. Khan, N. B. Finnerup, H. Andersen, T. S. Jensen, S. Sindrup, H. Tankisi
Summary: The present study aimed to investigate the pathophysiology of diabetic polyneuropathy (DPN) and evaluate the diagnostic value of sensory and motor axonal excitability testing in type 2 diabetics. The results showed subtle changes in excitability in the examined patient group, with weak correlations between motor excitability parameters and clinical scores. This suggests that axonal excitability testing may not be useful for early DPN diagnosis and mechanism understanding.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Manal Mohammed Hashem, Ahmed Esmael, Abdelfattah Kasem Nassar, Mohammed El-Sherif
Summary: The study found that diabetics treated with metformin have lower levels of vitamin B12 and higher levels of homocysteine, which are associated with more severe diabetic peripheral neuropathy.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Haifa Maalmi, Alexander Strom, Agnese Petrera, Stefanie M. Hauck, Klaus Strassburger, Oliver Kuss, Oana-Patricia Zaharia, Gidon J. Boenhof, Wolfgang Rathmann, Sandra Trenkamp, Volker Burkart, Julia Szendroedi, Dan Ziegler, Michael Roden, Christian Herder
Summary: No established blood-based biomarker exists for monitoring diabetic sensorimotor polyneuropathy (DSPN) and evaluating treatment response. This study found that higher serum levels of neurofilament light chain (NFL) were associated with prevalent DSPN and nerve dysfunction in individuals recently diagnosed with diabetes. The findings suggest that NFL could be a potential biomarker for DSPN.
Article
Endocrinology & Metabolism
Yuichiro Iwamoto, Shuhei Nakanishi, Takashi Itoh, Erina Nakao, Toshitomo Sugisaki, Takashi Kusano, Mana Ohnishi, Haruka Takenouchi, Hideyuki Iwamoto, Junpei Sanada, Yoshiro Fushimi, Yukino Katakura, Shoji Hemmi, Tomohiko Kimura, Fuminori Tatsumi, Masashi Shimoda, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
Summary: This study investigated the association between Baba's diabetic neuropathy classification (BDC) and diabetic microvascular and macrovascular complications. The results showed a significant correlation between BDC and the severity of diabetic retinopathy, nephropathy, history of myocardial infarction or cerebral infarction, carotid IMT, and ABI. These findings suggest that BDC may be useful in predicting the presence of various diabetic complications and support further investigation into other diabetes-related complications in patients with severe diabetic polyneuropathy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Engineering, Biomedical
Qinfeng Yang, Shenghui Su, Shencai Liu, Sheng Yang, Jing Xu, Yixiu Zhong, Yusheng Yang, Liangjie Tian, Zilin Tan, Jian Wang, Zhiqiang Yu, Zhanjun Shi, Fangguo Liang
Summary: An electroconductive hydrogel loaded with bone marrow stem cell-derived exosomes was designed to treat diabetic peripheral nerve injury, resulting in functional recovery and pain relief. This system showed potential for nerve regeneration, functional restoration, and pain relief in patients with diabetic peripheral nerve injury.
BIOACTIVE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Jae-Min Lee, You Jung Choi, Myung Chul Yoo, Seung Geun Yeo
Summary: Peripheral facial nerve injury causes changes in neuroactive substances that affect nerve cell damage, survival, growth, and regeneration. This review explores the biomolecules involved in peripheral facial nerve damage and their impact on the central nervous system (CNS), aiming to identify potential strategies for treating facial nerve injury and functional recovery. By identifying the biomolecules in the CNS that change after peripheral nerve damage, this review could contribute to the development of effective treatment strategies for peripheral facial palsy.
Review
Neurosciences
Lili Zhao, Weixiao Huang, Sheng Yi
Summary: Single-cell RNA sequencing enables the classification and transcriptional profiling of individual cells, leading to a better understanding of cellular diversity. In the peripheral nervous system (PNS), this technique has identified multiple cell types including neurons, glial cells, ependymal cells, immune cells, and vascular cells. Subtypes of neurons and glial cells have also been recognized in different physiological and pathological states. This article summarizes the heterogeneity of cells in the PNS and describes cellular variability during development and regeneration, which provides insights into the complex cellular architecture of the PNS and serves as a basis for future genetic manipulation.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Neurosciences
Tianhao Yu, Yingxi Xu, Muhammad Arslan Ahmad, Rabia Javed, Haruo Hagiwara, Xiaohong Tian
Summary: Autologous nerve grafts are widely accepted as the gold standard for peripheral nerve repair, but their usability is reduced by inherent drawbacks. Exosomes, as key players in intercellular communication, have shown promising potential in treating peripheral nerve injury and enhancing the repairing capacity of nerve grafts.
CURRENT NEUROPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lars B. Dahlin
Summary: Appropriate animal models are crucial for studying the biology and physiology of neurons and other cells under normal and stress conditions. Understanding the activation of genes and factors in nerve regeneration is important for conditions like nerve injuries and neuropathy. Advanced technology and bioinformatics are necessary for a comprehensive understanding of different cell types and their behavior in neuropathies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Fangguo Liang, Yusheng Yang, Yuyong Chen, Jiajun Xie, Shencai Liu, Zilin Tan, Liangjie Tian, Zhiqiang Yu, Zhanjun Shi, Peigen Xie, Hong Ding, Qinfeng Yang
Summary: In this study, an electroconductive hydrogel loaded with sustained-release analgesic microspheres was designed as a promising therapeutic approach for diabetic peripheral nerve injury. In vitro and in vivo experiments demonstrated that this treatment strategy can enhance nerve regeneration, functional recovery, and pain relief in diabetic patients.
MATERIALS TODAY BIO
(2023)
Review
Biochemistry & Molecular Biology
Marwa El Soury, Benedetta Elena Fornasari, Giacomo Carta, Federica Zen, Kirsten Haastert-Talini, Giulia Ronchi
Summary: Peripheral nerves are easily prone to injuries and require supportive strategies to stimulate nerve growth and functional recovery. The impact of diet on health and body function is crucial, with balanced nutrition being essential for the health of the central and peripheral nervous systems. Many dietary supplements have shown to play a significant role in peripheral nerve development and regeneration, emphasizing the importance of tailored dietary plans for patients with nerve injuries in promoting nerve regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Anand Krishnan, Arul Duraikannu, Douglas W. Zochodne
EUROPEAN JOURNAL OF NEUROSCIENCE
(2016)
Article
Neurosciences
Jose A. Martinez, Masaki Kobayashi, Anand Krishnan, Christine Webber, Kimberly Christie, GuiFang Guo, Vandana Singh, Douglas W. Zochodne
EXPERIMENTAL NEUROLOGY
(2015)
Article
Biochemistry & Molecular Biology
Anand Krishnan, K. Dhanya, Saneesh P. S. Babu, Sankar Jagadeeshan, Manu Prasad, S. Asha Nair
JOURNAL OF CELLULAR BIOCHEMISTRY
(2017)
Article
Neurosciences
Anand Krishnan, Kaylynn Purdy, Ambika Chandrasekhar, Jose Martinez, Chu Cheng, Douglas W. Zochodne
MOLECULAR NEUROBIOLOGY
(2018)
Article
Clinical Neurology
Anand Krishnan, Sudha Bhavanam, Douglas Zochodne
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2018)
Review
Neurosciences
Arul Duraikannu, Anand Krishnan, Ambika Chandrasekhar, Douglas W. Zochodne
FRONTIERS IN CELLULAR NEUROSCIENCE
(2019)
Review
Oncology
Maricris Bautista, Anand Krishnan
FRONTIERS IN ONCOLOGY
(2020)
Article
Neurosciences
Ambika Chandrasekhar, Prashanth Komirishetty, Aparna Areti, Anand Krishnan, Douglas W. Zochodne
Summary: This study reveals a crucial role of dual specificity phosphatases (DUSPs) in supporting axon plasticity and survival. Knockdown of DUSP 1 and 4 impairs neurite outgrowth in sensory neurons, rendering them more sensitive to axonopathy and accelerating neurofilament breakdown and axon degeneration.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Neurosciences
Anand Krishnan, Shubham Dwivedi, Ambika Chandrasekhar, Aparna Areti, Douglas W. Zochodne
Summary: This study introduces a novel rapid screening model for nerve regeneration therapeutics, focusing on adult neurons. The model incubates sensory ganglia for 24 hours prior to dissociation, revealing unique events that promote axon growth. It provides a platform for rapid screening of drug candidates and offers opportunities to study novel intrinsic molecular changes in neurons and glial cells aimed at improving the pace of axon growth.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2021)
Article
Psychology, Biological
Zeinab Momeni, Maricris Bautista, Joseph Neapetung, Rylan Urban, Yasuhiko Yamamoto, Anand Krishnan, Veronica A. Campanucci
Summary: The study demonstrates that diabetes may impair hippocampal synaptic plasticity through RAGE signaling. Experiments show that RAGE-dependent decrease in long-term potentiation and increase in paired-pulse facilitation, as well as alterations in AMPA-induced currents and reactive oxygen species production.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Chemistry, Multidisciplinary
C. Christopher Almquist, Nicole Removski, Thayalan Rajeshkumar, Benjamin S. Gelfand, Laurent Maron, Warren E. Piers
Summary: This study reports the activation of ammonia through coordination to molybdenum centers. Experimental results show that (B(2)Pz(4)Py)Mo-II-NH3 loses dihydrogen at room temperature, resulting in the formation of the dinuclear compound (B(2)Pz(4)Py)Mo-N-Mo(B(2)Pz(4)Py). Mechanistic details were supported through experimental observations and density functional theory calculations, revealing the under-appreciated role of bridging nitrido intermediates in the process.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Cell Biology
Hussain Elhasasna, Raymond Khan, Kalpana K. Bhanumathy, Frederick S. Vizeacoumar, Prachi Walke, Maricris Bautista, Dinesh K. Dahiya, Vincent Maranda, Hardikkumar Patel, Amrutha Balagopal, Nezeka Alli, Anand Krishnan, Andrew Freywald, Franco J. Vizeacoumar
Summary: Neuroendocrine prostate cancer (NEPC) is a highly aggressive form of prostate tumors and often occurs as an adaptive response to androgen deprivation therapy. Overexpression of MYCN oncogene and loss of TP53 and RB1 activities are associated with NEPC. Fludarabine phosphate has been identified as a drug that can selectively inhibit the proliferation of N-MYC overexpressing NEPC cells by inducing reactive oxygen species (ROS).
Review
Cell Biology
Bhadrapriya Sivakumar, Anand Krishnan
Summary: Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a unique member of the neurotrophic factors (NTFs) family, with distinct structure and functions. It is widely expressed in developing and mature tissues, including the central and peripheral nervous system tissues. Research has shown that MANF protects neurons from complications associated with endoplasmic reticulum (ER) stress by restoring ER homeostasis and regulating unfolded protein response. This review focuses on MANF signaling in neurodegenerative conditions, particularly in experimental models of Parkinson's disease, Alzheimer's disease, and stroke, and also discusses its potential roles in other neurodegenerative conditions.
Review
Oncology
Shubham Dwivedi, Anand Krishnan
AMERICAN JOURNAL OF CANCER RESEARCH
(2020)
Article
Medicine, Research & Experimental
Eugene L. Asahchop, William G. Branton, Anand Krishnan, Patricia A. Chen, Dong Yang, Linglong Kong, Douglas W. Zochodne, Bruce Brew, M. Gill John, D. Christopher Power