Article
Clinical Neurology
Jose Fidel Baizabal-Carvallo, Marlene Alonso-Juarez, Joseph Jankovic
Summary: This study reviewed the medical records and video recordings of 155 TS patients and found that 26.5% of them had OM tics. Compared to classic tardive dyskinesia, OM tics have different manifestations and are more commonly associated with oromandibular and eye-rolling movements. Therefore, it is important to differentiate between the two.
JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Roberto Cadeddu, Daniel E. Knutson, Laura J. Mosher, Stefanos Loizou, Karen Odeh, Janet L. Fisher, James M. Cook, Marco Bortolato
Summary: This study found that a novel drug targeting GABA(A) receptors, DK-I-56-1, effectively reduced tic-like jerks and PPI deficits in mouse models of Tourette syndrome, and prevented the adverse effects of dopamine. The drug showed similar effects to dopaminergic antagonists but did not elicit extrapyramidal symptoms.
Review
Clinical Neurology
James Peters, Nirosen Vijiaratnam, Heather Angus-Leppan
Summary: This study reviewed the clinical spectrum of tic disorders induced by AED, including the types of AED implicated and the characteristics of the symptoms. The analysis revealed that multiple AEDs can induce tic disorders, suggesting that the cause is unlikely to be solely related to alterations in a single neurotransmitter, but rather a network imbalance influenced by various factors.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Tamara Pringsheim, Christos Ganos, Christelle Nilles, Andrea E. E. Cavanna, Donald L. L. Gilbert, Erica Greenberg, Andreas Hartmann, Tammy Hedderly, Isobel Heyman, Holan Liang, Irene Malaty, Osman Malik, Nanette Mol Debes, Kirsten Muller Vahl, Alexander Munchau, Tara Murphy, Peter Nagy, Tamsin Owen, Renata Rizzo, Liselotte Skov, Jeremy Stern, Natalia Szejko, Yulia Worbe, Davide Martino
Summary: In 2020, there was a significant increase in referrals for young people with rapid onset of severe tic-like behaviors. A working group was formed to develop clinical criteria for the diagnosis of functional tic-like behaviors (FTLBs) to aid in recognition and diagnosis by healthcare professionals.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Payton Beeler, Nicholas O. Jensen, Soyoung Kim, Amy Robichaux-Viehoever, Bradley L. Schlaggar, Deanna J. Greene, Kevin J. Black, Rajan K. Chakrabarty
Summary: The study confirms the fractal nature of tics, indicating correlation between neighboring time scales. The fractal dimension is correlated with tic severity and serves as a sensitive parameter for examining the effects of tic suppression conditions. This finding opens up new possibilities for utilizing the fractal nature of tics as a tool for assessing and treating tic disorders.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2022)
Article
Clinical Neurology
Jose Fidel Baizabal-Carvallo, Marlene Alonso-Juarez, Joseph Jankovic
Summary: Tics are rapid, recurrent, non-rhythmic movements or emitted sounds. This study compared tics associated with Tourette syndrome (TS) and secondary tic disorders (STD). It found that patients with TS had a younger age at onset, more severe and complex tics, and involvement of cranial-cervical muscles. Simple phonic tics showed the highest diagnostic accuracy for TS, but there was overlap in tic types and comorbidities between TS and STD patients.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Review
Psychology, Developmental
Veit Roessner, Heike Eichele, Jeremy S. Stern, Liselotte Skov, Renata Rizzo, Nanette Mol Debes, Peter Nagy, Andrea E. Cavanna, Cristiano Termine, Christos Ganos, Alexander Muenchau, Natalia Szejko, Danielle Cath, Kirsten R. Mueller-Vahl, Cara Verdellen, Andreas Hartmann, Aribert Rothenberger, Pieter J. Hoekstra, Kerstin J. Plessen
Summary: The first European guidelines for Tourette Syndrome (TS) were published in 2011 by the European Society for the Study of Tourette Syndrome (ESSTS). The updated part on pharmacological treatment emphasizes the importance of psychoeducation and behavioral approaches as first-line treatments. Pharmacological treatment, particularly with dopamine blocking agents like aripiprazole, is indicated in some patients, especially when behavioral approaches are not effective or feasible. Treatment should be individualized based on the patient's needs, preferences, and co-existing conditions.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Article
Health Care Sciences & Services
Jesjeet Singh Gill
Summary: This case report describes a young male with Tourette syndrome and comorbid major depressive disorder and ADHD who experienced troublesome side effects due to his existing medications. The patient's symptoms were effectively controlled and improved by switching risperidone to cariprazine and increasing the antidepressant dose.
Article
Nutrition & Dietetics
Chang-Chun Wu, Lee-Chin Wong, Chia-Jui Hsu, Chianne-Wen Yang, Ying-Chieh Tsai, Feng-Shiang Cheng, Hsiao-Yun Hu, Wang-Tso Lee
Summary: The study suggests that probiotics may not reduce tics in children with Tourette syndrome, but they may benefit comorbidities such as attention deficit and hyperactivity disorder. Further research is needed to clarify the effects of probiotics on the comorbidities of Tourette syndrome children.
Review
Psychology, Developmental
Natalia Szejko, Sally Robinson, Andreas Hartmann, Christos Ganos, Nanette M. Debes, Liselotte Skov, Martina Haas, Renata Rizzo, Jeremy Stern, Alexander Munchau, Virginie Czernecki, Andrea Dietrich, Tara L. Murphy, Davide Martino, Zsanett Tarnok, Tammy Hedderly, Kirsten R. Muller-Vahl, Danielle C. Cath
Summary: This article presents an updated version 2.0 of European clinical guidelines for Tourette syndrome and other tic disorders, focusing on assessment. The guidelines were developed through thorough literature screening, national guidelines supplementation, and expert discussions within ESSTS. Diagnostic changes between DSM-IV and DSM-5 classifications, recommendations for rating scales, and new information on differential diagnoses are highlighted. Additionally, a recent survey among ESSTS members on assessment in TS is discussed.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Article
Clinical Neurology
Kirsten R. Muller-Vahl, Carolin Fremer, Chan Beals, Jelena Ivkovic, Henrik Loft, Christoph Schindler
Summary: Lu AG06466 did not show efficacy in reducing tics and premonitory urges in patients with Tourette syndrome, but the treatment was generally safe.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Jose Fidel Baizabal-Carvallo, Joseph Jankovic
Summary: This study aimed to characterize the frequency and features of blocking tics in patients with Tourette syndrome (TS). The results showed that approximately 6% of patients had blocking phenomena, with phonic tic intrusion causing speech arrest being the most common. Variables such as shoulder tics, leg tics, copropraxia, dystonic tics, simple phonic tics, and number of phonic tics per patient were statistically related to blocking phenomena. The presence of dystonic tics and a higher number of phonic tics were associated with blocking phenomena.
JOURNAL OF MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Justyna Kaczynska, Piotr Janik
Summary: This study evaluated the prevalence, age of onset, and clinical correlates of blocking tics (BTs) in patients with Gilles de la Tourette syndrome (GTS). BTs represent early and common symptoms of GTS, associated with a more severe form of the syndrome.
FRONTIERS IN NEUROLOGY
(2021)
Article
Behavioral Sciences
Lina Schubert, Julius Verrel, Amelie Behm, Tobias Baeumer, Christian Beste, Alexander Muenchau
Summary: The study found that associations between urges and tics in patients with Gilles de la Tourette syndrome are complex and heterogeneous, with some individuals not showing the expected positive correlation, and even displaying negative associations. While most patients demonstrated a positive relationship between urges and tics, there were substantial inter-individual differences in these associations.
Article
Clinical Neurology
Simon Morand-Beaulieu, Michael J. Crowley, Heidi Grantz, James F. Leckman, Lawrence Scahill, Denis G. Sukhodolsky
Summary: Comprehensive Behavioral Intervention for Tics (CBIT) is an effective treatment for Tourette syndrome (TS), but its underlying brain mechanisms are not well understood. This study found no association between EEG coherence during a Go/NoGo task and CBIT outcome, suggesting that the brain processes involved in motor response inhibition may not play a role in CBIT.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Madison S. Pilato, Alexandra Urban, Rafeed Alkawadri, Niravkumar Barot, James F. Castellano, Vijayalakshmi Rajasekaran, Anto Bagic, Joanna S. Fong-Isariyawongse
Summary: This study described the EEG findings in COVID-19 patients and found that neurologic manifestations are common in severe cases. COVID-19 patients with epilepsy may have an increased risk of neurological manifestations and abnormal EEG.
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2022)
Review
Clinical Neurology
Niravkumar Barot, Kavita Batra, Jerry Zhang, Mary Lou Klem, James Castellano, Jorge Gonzalez-Martinez, Anto Bagic
Summary: MRgLITT is an effective and safe intervention for drug-resistant epilepsy with different disease etiologies. The seizure freedom outcome is overall comparable between extratemporal and temporal lobe epilepsy; and highest with patients having hypothalamic hamartomas.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Ricardo Bruna, David Lopez-Sanz, Fernando Maestu, Ann D. Cohen, Anto Bagic, Ted Huppert, Tae Kim, Rebecca E. Roush, Betz Snitz, James T. Becker
Summary: This study investigated the mechanisms behind Alzheimer's disease and found that patients with amnestic MCI showed a slowing of brain activity, which was not observed in individuals without subjective complaints. This raises interesting questions about this particular group of individuals and the underlying brain mechanisms behind their cognitive impairment.
CLINICAL EEG AND NEUROSCIENCE
(2023)
Article
Neuroimaging
Xiyuan Jiang, Shuai Ye, Abbas Sohrabpour, Anto Bagic, Bin He
Summary: The study demonstrated the capability of the fast spatiotemporal iteratively reweighted edge sparsity minimization (FAST-IRES) algorithm in locating and estimating epilepsy sources from MEG measurements, providing important information for pre-surgical planning in focal drug-resistant epilepsy patients.
NEUROIMAGE-CLINICAL
(2022)
Article
Neurosciences
Ricardo Bruna, Fernando Maestu, David Lopez-Sanz, Anto Bagic, Ann D. Cohen, Yue-Fang Chang, Yu Cheng, Jack Doman, Ted Huppert, Tae Kim, Rebecca E. Roush, Beth E. Snitz, James T. Becker
Summary: The study found that older females had higher phase locking values in networks affected during the asymptomatic phase of neurodegenerative disorders, similar to individuals with mild cognitive impairment. This suggests that women may experience brain functional changes earlier in life than men, potentially explaining the higher prevalence of dementia among women.
BRAIN CONNECTIVITY
(2022)
Article
Clinical Neurology
Vasileios Kokkinos, Alexandra Urban, Birgit Frauscher, Mirela Simon, Helweh Hussein, Alan Bush, Ziv Williams, Anto Bagic, R. Mark Richardson
Summary: This study investigates the localization of barques across the hippocampal longitudinal axis. By analyzing data from 51 epilepsy patients, the study found that barques predominantly occur in the posterior hippocampus and are related to barque activity in the anterior hippocampus. Statistical parametric mapping confirmed significant differences in barque activity between the anterior and posterior hippocampus. The findings have important implications for the interpretation of intracranial electroencephalogram in epilepsy surgery evaluations involving the hippocampus.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Haiteng Jiang, Vasileios Kokkinos, Shuai Ye, Alexandra Urban, Anto Bagic, Mark Richardson, Bin He
Summary: This study developed a new method to localize the seizure onset zone (SOZ) and predict seizure outcome using short-time resting-state SEEG data. They found that greater differences in resting-state information flow between SOZ and non-SOZ regions are associated with favorable seizure outcome.
Article
Clinical Neurology
Stephanie M. Ahrens, Kristen H. Arredondo, Anto I. Bagic, Shasha Bai, Kevin E. Chapman, Michael A. Ciliberto, Dave F. Clarke, Mariah Eisner, Nathan B. Fountain, Jay R. Gavvala, M. Scott Perry, Kyle C. Rossi, Lily C. Wong-Kisiel, Susan T. Herman, Adam P. Ostendorf
Summary: This study investigates the influence of geographic region and other center characteristics on presurgical testing for drug-resistant epilepsy, finding significant regional differences and potential disparities in access to surgical treatment.
Article
Clinical Neurology
Christopher W. Beatty, Stephanie M. Ahrens, Kristen H. Arredondo, Anto Bagic, Shasha Bai, Kevin E. Chapman, Michael A. Ciliberto, Dave F. Clarke, Mariah Eisner, Nathan B. Fountain, Jay R. Gavvala, M. S. Perry, Kyle C. Rossi, Lily C. Wong-Kisiel, Susan T. Herman, Adam P. Ostendorf
Summary: This study examines the variations in evaluation and treatment choices for epilepsy surgery, highlighting the need for comparative trials in the surgical management of drug-resistant epilepsy.
Letter
Clinical Neurology
Anto Bagic, Susan Bowyer, Michael Funke, Ismail Mohamed, Jeffrey R. Tenney, Wenbo Zhang, Andrew Zillgitt
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2023)
Letter
Clinical Neurology
Abid Y. Qureshi, Robert D. Stevens
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Health Care Sciences & Services
Gustavo Sudre, Anto Bagic, James T. Becker, John P. Ford
Summary: In this study, using neuroimaging data and a whole-head Elekta Neuromag 306 sensor system, a set of features strongly correlated with brain function were derived. These features can serve as a noninvasive quantitative tool for clinicians to screen and monitor cognitive function in at-risk individuals. The set of features were able to effectively differentiate between participants with normative and nonnormative brain function, and accurately predict participants' Mini-Mental Test score.
JMIR FORMATIVE RESEARCH
(2023)
Editorial Material
Clinical Neurology
Anto I. Bagic, Susan M. Bowyer, Richard C. Burgess, Michael E. Funke, Andrea Lowden, Ismail S. Mohamed, Tony Wilson, Wenbo Zhang, Andrew J. Zillgitt, Jeffrey R. Tenney
Summary: One of the major challenges in modern epileptology is the underutilization of epilepsy surgery for patients with medication-resistant epilepsy. Magnetoencephalography (MEG) is a clinically validated method that can improve surgical candidate identification and pre-surgical planning, but its usage in USA epilepsy centers is limited. The current MEG sensor technology, which employs SQUIDs, has limitations and advancements, such as optically pumped magnetometers (OPMs), are eagerly awaited. However, there are currently no OPM devices ready for practical clinical use.
Article
Psychology, Mathematical
Arish Alreja, Michael J. Ward, Qianli Ma, Brian E. Russ, Stephan Bickel, Nelleke C. Van Wouwe, Jorge A. Gonzalez-Martinez, Joseph S. Neimat, Taylor J. Abel, Anto Bagic, Lisa S. Parker, R. Mark Richardson, Charles E. Schroeder, Louis-Philippe Morency, Avniel Singh Ghuman
Summary: By collecting eye tracking and other behavioral measurements from patient-participants in their hospital rooms, we have a unique opportunity to study natural behavior for basic and clinical translational research. This approach allows us to study the neurobiology of natural social behavior and understand the disorders of the participants and clinician-patient interactions.
BEHAVIOR RESEARCH METHODS
(2023)
Article
Clinical Neurology
Elisaveta Sokolov, Nathaniel D. Sisterson, Helweh Hussein, Cheryl Plummer, Danielle Corson, Arun R. Antony, Joseph M. Mettenburg, Gena R. Ghearing, Jullie W. Pan, Alexandra Urban, Anto Bagic, R. Mark Richardson, Vasileios Kokkinos
Summary: The study highlights the value of intracranial monitoring in equalizing seizure outcomes in difficult-to-treat TLE patients undergoing ATL. Intracranial monitoring approaches showed similar outcomes in patients with TLE+ hypothesis, while sEEG performed well in patients with bilateral or poorly lateralized TLE. Importance of modifying primary hypothesis based on iEEG data was also emphasized.