Article
Cell Biology
Erik Axel Andersson, Eridan Rocha-Ferreira, Henrik Hagberg, Carina Mallard, Carl Joakim Ek
Summary: The study investigated the impact of GMH on the BBB using a rat model, showing that GMH causes temporary dysfunction in the BBB that normalizes within 5 days. Tight-junction proteins were identified as potential biomarkers for GMH.
Article
Biochemistry & Molecular Biology
Taliha Nadeem, Apoorva Bommareddy, Lolade Bolarinwa, Henar Cuervo
Summary: Germinal matrix-intraventricular hemorrhage (GM-IVH) is a devastating neurological complication in premature infants. Previous studies have suggested increased angiogenesis and paucity of pericytes as key factors contributing to GM-IVH pathogenesis. In this study, we comprehensively analyzed the vascular endothelium and pericytes in the mouse GM during development. Our findings show that the mouse GM has greater vascular area and vascular branching compared to the developing cortex. Additionally, we found distinct phenotypical and likely functional characteristics of pericytes in the developing mouse GM compared to other brain regions. These findings provide insights into the mechanisms underlying the susceptibility of the GM vasculature to hemorrhage.
Article
Pediatrics
Elizabeth J. Snyder, Sumit Pruthi, Marta Hernanz-Schulman
Summary: The study describes the imaging characteristics and diagnostic pitfalls of posterior GMH in extremely premature infants. Unlike traditional preterm infants, extremely preterm infants show a more fetal pattern of germinal matrix distribution, leading to different distribution and size of GMH injury. It is important to be aware of the differences in diagnosis and imaging findings in extremely preterm infants.
PEDIATRIC RADIOLOGY
(2022)
Article
Clinical Neurology
Sruthi Ramagiri, Shelei Pan, Dakota DeFreitas, Peter H. Yang, Dhvanii K. Raval, David F. Wozniak, Prabagaran Esakky, Jennifer M. Strahle
Summary: Posthemorrhagic hydrocephalus is a common complication of intraventricular hemorrhage in infants. This study develops an animal model of intraventricular hemorrhage and demonstrates that administration of the iron chelator deferoxamine at the time of hemorrhage can prevent hydrocephalus and reduce iron levels in the choroid plexus. This treatment strategy may be clinically relevant for preventing neurological sequelae after intraventricular hemorrhage.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Clinical Neurology
Bokun Cheng, Deep R. Sharma, Ajeet Kumar, Hardik Sheth, Alex Agyemang, Michael Aschner, Xusheng Zhang, Praveen Ballabh
Summary: Cheng et al. demonstrate that IVH in premature newborns leads to decreased neurogenesis, cortical interneurons, Sonic Hedgehog levels, and cognitive function. The activation of Sonic Hedgehog signaling can reverse these changes, suggesting a novel therapeutic approach for IVH survivors. This study highlights the disruption in cortical interneurons in IVH and proposes a new strategy to restore cortical interneurons and cognitive function in infants with IVH.
Article
Multidisciplinary Sciences
Lilian M. N. Kebaya, Kevin Stubbs, Marcus Lo, Sarah Al-Saoud, Bradley Karat, Keith St Lawrence, Sandrine de Ribaupierre, Emma G. Duerden
Summary: Germinal Matrix-Intraventricular Hemorrhage (GMH-IVH) is a significant cause of adverse neurodevelopment in preterm infants. Reliable biomarkers are needed to aid in the early detection of posthemorrhagic ventricular dilatation (PHVD) and subsequent neurodevelopment. In a prospective cohort study, 3-dimensional (3D) cUS and functional near-infrared spectroscopy (fNIRS) were used to monitor neonates with GMH-IVH. Larger ventricle volumes (VV) were associated with decreased functional connectivity (sFC) in infants with severe GMH-IVH.
SCIENTIFIC REPORTS
(2023)
Review
Pediatrics
Miltiadis Badagionis, Theodoros N. Sergentanis, Panagiota Pervanidou, Emmanouil Kalampokas, Nikolaos Vlahos, Makarios Eleftheriades
Summary: This systematic review and meta-analysis examines the association between exposure to preeclampsia during pregnancy and the occurrence of cerebral palsy in offspring. The study found no significant association between preeclampsia and cerebral palsy, but the association became statistically significant when adjusting for variables other than gestational age.
Article
Clinical Neurology
Vishal Venkatraman, Stephen C. Harward, Srijan Bhasin, Kylie Calderon, Sage L. Atkins, Beiyu Liu, Hui-Jie Lee, Shein-Chung Chow, Herbert E. Fuchs, Eric M. Thompson
Summary: The study found significant differences in the ratios of HC:VI, HC:ER, and HC:FOHR between patients with high-grade IVH and low-grade IVH. Similarly, there were significant differences in HC:VI, HC:ER, and HC:FOHR between those who did and did not have CSF diversion. Routine ultrasound assessments of both head circumference and ventricle size are important clinical tools in infants with IVH of prematurity.
CHILDS NERVOUS SYSTEM
(2023)
Article
Cell Biology
Pilar Alves-Martinez, Isabel Atienza-Navarro, Maria Vargas-Soria, Maria Jose Carranza-Naval, Carmen Infante-Garcia, Isabel Benavente-Fernandez, Angel Del Marco, Simon Lubian-Lopez, Monica Garcia-Alloza
Summary: Germinal matrix-intraventricular hemorrhage (GM-IVH) is a common intracranial hemorrhage in preterm infants, resulting in neurological disabilities. This study demonstrates the neuroprotective effects of caffeine in GM-IVH, including reduced brain atrophy, improved neuronal wellbeing, preserved neurogenesis, and decreased inflammation. Caffeine treatment also leads to significant improvements in learning and memory abilities.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Clinical Neurology
Maria Argyropoulou, Vasileios G. Xydis, Aikaterini Drougia, Anastasia S. Giantsouli, Vasileios Giapros, Loukas G. Astrakas
Summary: Moderate and late preterm infants exhibit changes in brain functional connectivity and microstructural abnormalities. Low-grade intraventricular hemorrhage in these infants is associated with structural and functional abnormalities in specific brain regions related to language and cognition. Topological and functional properties of mature brain connectivity are present in these infants.
Editorial Material
Clinical Neurology
Emanuele La Corte, Micol Babini, Mariella Lefosse, Francesca Nicolini, Mino Zucchelli
Summary: Intraventricular hemorrhage and subsequent post hemorrhagic hydrocephalus are serious complications in premature infants, leading to neurodevelopmental delay, epilepsy, and cognitive impairment. Temporary cerebrospinal fluid diversion procedures may be a therapeutic option for such infants.
WORLD NEUROSURGERY
(2021)
Article
Pediatrics
Minoo Ashoori, John M. O'Toole, Ken D. O'Halloran, Gunnar Naulaers, Liesbeth Thewissen, Jan Miletin, Po-Yin Cheung, Afif EL-Khuffash, David Van Laere, Zbynek Stranak, Eugene M. Dempsey, Fiona B. McDonald
Summary: This study aimed to test the potential utility of applying machine learning methods to detect brain injury in extremely preterm infants using regional cerebral (rcSO(2)) and peripheral oxygen saturation (SpO(2)) signals. The analysis of a subset of infants in a clinical trial showed that data-driven desaturation (PRD) in rcSO(2) could better predict brain injury compared to a threshold-based approach.
Review
Clinical Neurology
Aswin Chari, Conor Mallucci, Andrew Whitelaw, Kristian Aquilina
Summary: Advances in medical care have resulted in more premature babies surviving into the neonatal period. GMH, IVH, and PHVD are crucial factors for the long-term cognitive and developmental outcomes in these infants. Current neurosurgical management includes early diagnosis, intervention thresholds, temporising measures, and definitive CSF diversion for PHVD. Techniques such as DRIFT and neuroendoscopic lavage are being reviewed for optimizing outcomes in premature infants.
CHILDS NERVOUS SYSTEM
(2021)
Article
Pediatrics
Misun Hwang, Luis O. Tierradentro-Garcia, Syed H. Hussaini, Stephanie C. Cajigas-Loyola, Summer L. Kaplan, Hansel J. Otero, Richard D. Bellah
Summary: Neurosonography has become an essential tool for diagnosis and serial monitoring of preterm brain injury. It offers distinct advantages such as cost-effectiveness, diagnostic utility, and convenience. Advances in neurosonography techniques provide new functional insights into the brain and prompt an updated review of the topic.
PEDIATRIC RADIOLOGY
(2022)
Review
Clinical Neurology
Jaewoo Chung, Sang Koo Lee, Chun -Sung Cho, Young Jin Kim, Jung Ho Ko, Jung -Ho Yun, Jin-Shup So, In-Ho Jung
Summary: Germinal matrix-intraventricular hemorrhage (GM-IVH) is a devastating neurological complication in preterm infants, with high mortality and neurodevelopmental disability rates. Pharmacological management of GM-IVH is still lacking strong evidence due to limited well-designed studies, except for recombinant human erythropoietin administration in certain situations. Further high-quality collaborative research studies are needed to improve outcomes for preterm infants with GM-IVH.
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Joy Armistead, Nehal Patel, Xiaoli Wu, Richard Hemming, Biswajit Chowdhury, Gagandeep Singh Basra, Marc R. Del Bigio, Hao Ding, Barbara Triggs-Raine
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2015)
Review
Neurosciences
Hassan Marzban, Marc R. Del Bigio, Jayed Alizadeh, Seek Ghayami, Robby M. Zechariah, Mojgan Rastegar
FRONTIERS IN CELLULAR NEUROSCIENCE
(2015)
Letter
Clinical Neurology
Carly Scramstad, Michael J. Ellis, Marc R. Del Bigio
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2017)
Article
Clinical Neurology
Marc R. Del Bigio, Johannes A. Hainfellner, Catriona A. McLean, Suzanne Z. Powell, Beata Sikorska, Hitoshi Takahashi, Joachim Weis, John H. Xuereb
Article
Clinical Neurology
P. Frosk, S. M. Phillips, M. R. Del Bigio, B. N. Chodirker
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2014)
Article
Neurosciences
Marc A. Ranson, Marc R. Del Bigio
Article
Multidisciplinary Sciences
Karen Bailey, Maryam Rahimi Balaei, Ashraf Mannan, Marc R. Del Bigio, Hassan Marzban
Article
Genetics & Heredity
Jessica N. Hartley, Louise R. Simard, Valentina Ly, Marc R. Del Bigio, Patrick Frosk
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2019)
Article
Oncology
Jessica S. Jarmasz, Hannah Stirton, James R. Davie, Marc R. Del Bigio
CLINICAL EPIGENETICS
(2019)
Article
Substance Abuse
Jessica S. Jarmasz, Hannah Stirton, Duaa Basalah, James R. Davie, Sterling K. Clarren, Susan J. Astley, Marc R. Del Bigio
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2019)
Article
Clinical Neurology
Robert Hammond, Chris Dunham, Deborah McFadden, Marc Del Bigio, Mari Perez-Rosendahl, Harry V. Vinters
Summary: Post-mortem examination of the nervous system culminates in brain cutting, which relies on expertise to recognize subtle abnormalities. Some Canadian jurisdictions have imposed restrictions on tissue retention due to aberrant practices. Surveying Canadian neuropathologists, most believe that cutting and sampling a brain before full fixation leads to a loss of diagnostic accuracy and academic deliverables.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Thatchawan Thanasupawat, Aleksandra Glogowska, Christopher Pascoe, Sai Nivedita Krishnan, Maliha Munir, Farhana Begum, Jason Beiko, Jerry Krcek, Marc R. Del Bigio, Marshall Pitz, Yaoqing Shen, Victor Spicer, Kevin M. Coombs, John Wilkins, Sabine Hombach-Klonisch, Thomas Klonisch
Summary: Researchers used patient-derived cell models and high-throughput analysis to characterize the proteomic profiles of malignant gliomas, identifying specific protein markers for different types of gliomas and validating their presence in disease cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Domenico L. Di Curzio, Xiaoyan Mao, Aidan Baker, Marc R. Del Bigio
FLUIDS AND BARRIERS OF THE CNS
(2018)
Article
Public, Environmental & Occupational Health
Jayantha C. Herath, Saman Kalikias, Susan M. Phillips, Marc R. Del Bigio
CANADIAN JOURNAL OF PUBLIC HEALTH-REVUE CANADIENNE DE SANTE PUBLIQUE
(2014)
Article
Medicine, Research & Experimental
Xiaoyan Mao, Marc R. Del Bigio
JOURNAL OF NEGATIVE RESULTS IN BIOMEDICINE
(2015)