Article
Clinical Neurology
David J. Seiffge, Duncan Wilson, Gareth Ambler, Gargi Banerjee, Isabel Charlotte Hostettler, Henry Houlden, Clare Shakeshaft, Hannah Cohen, Tarek A. Yousry, Rustam Al-Shahi Salman, Gregory Lip, Martin M. Brown, Keith Muir, H. R. Jager, David J. Werring
Summary: The study investigated the impact of small vessel disease (SVD) on anticoagulant-associated intracerebral haemorrhage (ICH). It found that medium-to-high severity SVD is associated with ICH in patients on anticoagulants and independently predicts ICH in patients with atrial fibrillation (AF) taking anticoagulants. The absence of SVD identifies patients at low risk of ICH, indicating that anticoagulation alone may not be the sole cause of ICH.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Clinical Neurology
Yuji Shiga, Shiro Aoki, Naohisa Hosomi, Ryota Nomura, Masahiro Nakamori, Tomohisa Nezu, Keisuke Tachiyama, Teppei Kamimura, Naoto Kinoshita, Ryo Shimomura, Yuki Hayashi, Hayato Matsushima, Eiji Imamura, Hiroki Ueno, Shinichi Wakabayashi, Kazuhiko Nakano, Tatsuo Kohriyama, Hirofumi Maruyama
Summary: This study identified an association between the presence of cnm-positive S. mutans and DWI hyperintensities in patients with acute ICH.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Natalia Cullell, Cristina Gallego-Fabrega, Jara Carcel-Marquez, Elena Muino, Laia Llucia-Carol, Miquel Lledos, Jesus M. Martin-Campos, Jessica Molina, Laura Casas, Marta Almeria, Israel Fernandez-Cadenas, Jerzy Krupinski
Summary: This study used proteome-wide association study (PWAS) and co-localization analysis to identify the association of ICA1L protein with small vessel strokes (SVS) and intracerebral haemorrhages (ICH), and found that the protein expression levels of ICA1L in the brain have a causal relationship with these two diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Simon Fandler-Hoefler, Lena Obergottsberger, Gareth Ambler, Sebastian Eppinger, Gerit Wuensch, Markus Kneihsl, David Seiffge, Gargi Banerjee, Duncan Wilson, Philip Nash, Hans Rudolf Jaeger, Christian Enzinger, David J. Werring, Thomas Gattringer
Summary: Assessing the risk of recurrent intracerebral hemorrhage (ICH) is important, and MRI-based cerebral small vessel disease (SVD) markers can help determine the etiology of ICH and evaluate the risk of recurrence. The highest recurrence risk was found in patients with probable cerebral amyloid angiopathy (CAA), while the risk was low for arteriolosclerosis and negligible for cryptogenic ICH.
Article
Clinical Neurology
Ghil Schwarz, Gargi Banerjee, Isabel Charlotte Hostettler, Gareth Ambler, David J. Seiffge, Tenzin S. Brookes, Duncan Wilson, Hannah Cohen, Tarek Yousry, Rustam Al-Shahi Salman, Gregory Y. H. Lip, Martin M. Brown, Keith W. Muir, Henry Houlden, Rolf Jager, David J. Werring, Julie Staals
Summary: Total SVD score is associated with non-lobar ICH location, while CAA score is not significantly associated with lobar ICH location.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Review
Clinical Neurology
Zicheng Cheng, Wenyuan Zhang, Zhenxiang Zhan, Lingfan Xia, Zhao Han
Summary: In patients with spontaneous intracerebral hemorrhage, cerebral small vessel disease markers and the total burden of the disease are associated with functional outcome, mortality, stroke recurrence, and hematoma expansion.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Yunke Li, Sung-Min Cho, Radhika Avadhani, Hassan Ali, Yi Hao, Santosh B. Murthy, Joshua N. Goldstein, Fan Xia, Xin Hu, Natalie L. Ullman, Issam Awad, Daniel Hanley, Wendy C. Ziai
Summary: This study analyzed the long-term outcomes of patients with spontaneous supratentorial intracerebral hemorrhage (ICH) treated with minimally invasive surgery (MIS). The study found that following successful reduction of the hematoma by MIS, patients with lower total burden of cerebral small vessel disease (CSVD), absence of lacunes, and absence of severe white matter hyperintensities had significantly lower odds of poor functional outcomes.
STROKE AND VASCULAR NEUROLOGY
(2023)
Article
Clinical Neurology
Chaofan Sui, Hongwei Wen, Shengpei Wang, Mengmeng Feng, Haotian Xin, Yian Gao, Jing Li, Lingfei Guo, Changhu Liang
Summary: CSVD patients with cerebral microbleeds (CMBs) have extensive white matter microstructural deterioration. Using DTI-derived diffusivity and anisotropy metrics, we found that CSVD patients with CMBs showed significant FA decrease and AD, RD, and MD increases in cognitive and sensorimotor-related white matter tracts.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Wenhua Zhang, Ying Zhou, Jianan Wang, Xiaoxian Gong, Zhicai Chen, Xuting Zhang, Jinsong Cai, Siyan Chen, Lei Fang, Jianzhong Sun, Min Lou
Summary: This study established a new index mALPS to measure glymphatic function, showing that mALPS index could represent glymphatic clearance function and had correlations with imaging markers in cerebral small vessel disease (CSVD) patients.
Article
Clinical Neurology
Cindy W. W. Yoon, Joung-Ho Rha, Hee-Kwon Park, Soo-Hyun Park, Soonwook Kwon, Byeong C. Kim, Young Chul Youn, Jee Hyang Jeong, Hyun Jeong Han, Seong Hye Choi
Summary: Sex plays an important role in the progression of cerebral microbleeds (CMBs). Women have a significantly greater increase in the number of CMBs after 2 years compared to men.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Sacha Posener, Ghazi Hmeydia, Joseph Benzakoun, Catherine Oppenheim, Jean-Claude Baron, Guillaume Turc
Summary: This systematic review and meta-analysis examined the prevalence, associated factors, and presumed causes of remote diffusion-weighted imaging lesions (RDWILs) in patients with spontaneous intracerebral hemorrhage (ICH). The results showed that RDWILs were detected in approximately 25% of acute ICH patients and were associated with neuroimaging features of microangiopathy, atrial fibrillation, clinical severity, elevated blood pressure, ICH volume, and the presence of subarachnoid or intraventricular hemorrhage. RDWILs were also associated with poor functional outcome at 3 months. Further studies are needed to investigate the impact of specific ICH treatment strategies on reducing RDWILs and improving outcomes.
Article
Immunology
Xiang-hua Ye, Jian-li Zhang, Yu-jia Jin, Dan Shen, Xiao-di Hao, Jia-wen Li, Jia-wei Zhong, Lu-hang Jin, Lu-sha Tong, Feng Gao
Summary: Insulin resistance was found to be associated with the occurrence of remote diffusion-weighted imaging lesions (R-DWILs) in patients with intracerebral hemorrhage (ICH).
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Yiyi Chen, Jie Xu, Yuesong Pan, Hongyi Yan, Jing Jing, Yingying Yang, Xing Wang, Huijuan Wan, Ying Gao, Shangrong Han, Xi Zhong, Chenhui Liu, Jingtao Pi, Zhengyang Li, Biyang Luo, Guangyao Wang, Yilong Zhao, Nan Wang, Jinxi Lin, Xia Meng, Xingquan Zhao, Liping Liu, Wei Li, Yong Jiang, Zixiao Li, Xinmiao Zhang, Xiaomeng Yang, Ruijun Ji, Chunjuan Wang, Hao Li, Penglian Wang, Huaguang Zheng, Weizhong Ji, Xueli Cai, Songdi Wu, Xinsheng Han, Yongjun Wang, Yilong Wang
Summary: The study found that in patients with ischemic stroke or transient ischemic attack, TMAO and choline levels were associated with white matter hyperintensities, especially with periventricular white matter hyperintensities, but not with lacunes or cerebral microbleeds.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Laurent Puy, Adrian R. R. Parry-Jones, Else Charlotte Sandset, Dar Dowlatshahi, Wendy Ziai, Charlotte Cordonnier
Summary: Intracerebral haemorrhage (ICH) is a serious condition caused by the rupture of a cerebral vessel and the entry of blood into the brain parenchyma. It is a major cause of stroke-related mortality and dependency, with limited treatment options available. This Primer provides a comprehensive overview of the epidemiology, pathophysiology, diagnosis, and treatment of ICH, highlighting the importance of prevention and management of haematoma expansion and long-term vascular risk.
NATURE REVIEWS DISEASE PRIMERS
(2023)
Article
Geriatrics & Gerontology
Mangmang Xu, Baojin Li, Di Zhong, Yajun Cheng, Qian Wu, Shuting Zhang, Shihong Zhang, Bo Wu, Ming Liu
Summary: Severe periventricular white matter hyperintensities, cerebral microbleeds, or cumulative cerebral small vessel disease burden have important influences on the long-term outcome of primary intracerebral hemorrhage. Cerebral microbleeds and periventricular white matter hyperintensities were significantly associated with poor functional outcome, while periventricular white matter hyperintensities and lobar cerebral microbleed severity were associated with stroke recurrence. However, the cumulative cerebral small vessel disease score was associated with both poor functional outcome and stroke recurrence.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Ghil Schwarz, Gargi Banerjee, Isabel C. Hostettler, Gareth Ambler, David J. Seiffge, Hatice Ozkan, Simone Browning, Robert Simister, Duncan Wilson, Hannah Cohen, Tarek Yousry, Rustam Al-Shahi Salman, Gregory Y. H. Lip, Martin M. Brown, Keith W. Muir, Henry Houlden, Rolf Jager, David J. Werring
Summary: This study found associations between putative biomarkers of parenchymal CAA and putative biomarkers of leptomeningeal CAA, and suggested that CT biomarkers may help in diagnosing CAA, but MRI still plays an important role in ICH survivors with suspected CAA.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Psychology, Clinical
Emily M. Briceno, Miguel Arce Renteria, Alden L. Gross, Richard N. Jones, Christopher Gonzalez, Rebeca Wong, David R. Weir, Kenneth M. Langa, Jennifer J. Manly
Summary: This study presents a cultural neuropsychological approach to prestatistical harmonization of cognitive data across the United States and Mexico. By comparing linguistic and cultural equivalence, the researchers identified confident and tentative linking items. Results showed that a significant proportion of the linking items exhibited measurement differences across cohorts. The study highlights the importance of multidisciplinary and multilingual teams in identifying differences in cognitive construct measurement that may not be detected by statistical procedures alone.
Review
Clinical Neurology
Jonathan G. Best, Aaron Jesuthasan, David J. Werring
Summary: Balancing the risks of recurrent ischemia and antithrombotic-associated bleeding, particularly intracranial hemorrhage (ICH), is a key challenge in secondary prevention of ischemic stroke and transient ischemic attack. This review explores the connection between neuroimaging markers of cerebral small vessel disease (CSVD) and antithrombotic and thrombolytic-associated ICH, focusing on cerebral microbleeds (CMB). The presence of CMB has the potential to enhance ICH risk prediction and guide clinical decision making.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Robert Hurford, Rekha Siripurapu, Hedley C. A. Emsley, Joanna Lovett, David Werring, Martin Martin Nicholas Punter
Summary: This article introduces a practical method for identifying uncommon causes of ischemic stroke and proposes a structured approach to investigate them, highlighting diagnostic 'red flags'. This is crucial for proper management and prognosis prediction of patients.
PRACTICAL NEUROLOGY
(2023)
Article
Clinical Neurology
Nicolas Raposo, Maria Clara Zanon Zotin, David J. Seiffge, Qi Li, Martina B. Goeldlin, Andreas Charidimou, Ashkan Shoamanesh, Hans Rolf Jager, Charlotte Cordonnier, Catharina Jm Klijn, Eric E. Smith, Steven M. Greenberg, David J. Werring, Anand Viswanathan
Summary: The study developed a new classification system called CLAS-ICH for subtyping intracerebral hemorrhage (ICH) based on recent advances in neuroimaging. The system assigns scores to each category to determine the underlying causes of ICH. The system was validated in two cohorts and demonstrated reliability and consistency.
ANNALS OF NEUROLOGY
(2023)
Letter
Clinical Neurology
Philip S. Nash, F. Humphries, L. Benjamin, D. J. Werring
JOURNAL OF NEUROLOGY
(2023)
Letter
Clinical Neurology
Yang Du, Wenpeng Zhang, Martina Locatelli, Robert J. Simister, H. Rolf Jaeger, David J. Werring
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Melinda B. Roaldsen, Agnethe Eltoft, Tom Wilsgaard, Hanne Christensen, Stefan T. Engelter, Bent Indredavik, Dalius Jatuzis, Guntis Karelis, Janika Korv, Erik Lundstrom, Jesper Petersson, Jukka Putaala, Mary-Helen Soyland, Arnstein Tveiten, Andrew Bivard, Stein Harald Johnsen, Michael Mazya, David J. Werring, Teddy Y. Wu, Gian Marco De Marchis, Thompson G. Robinson, Ellisiv B. Mathiesen
Summary: This study aimed to determine whether intravenous thrombolysis with tenecteplase within 4-5 hours of awakening could improve functional outcome in patients with ischaemic wake-up stroke selected with non-contrast CT. The results showed that treatment with tenecteplase was not associated with better functional outcome at 90 days, and the bleeding complications were similar between the treatment groups.
Article
Genetics & Heredity
Fang Chen, Xingyan Wang, Seon-Kyeong Jang, Bryan C. Quach, J. Dylan Weissenkampen, Chachrit Khunsriraksakul, Lina Yang, Renan Sauteraud, Christine M. Albert, Nicholette D. D. Allred, Donna K. Arnett, Allison E. Ashley-Koch, Kathleen C. Barnes, R. Graham Barr, Diane M. Becker, Lawrence F. Bielak, Joshua C. Bis, John Blangero, Meher Preethi Boorgula, Daniel Chasman, Sameer Chavan, Yii-Der Chen, Lee-Ming Chuang, Adolfo Correa, Joanne E. Curran, Sean P. David, Lisa de Las Fuentes, Ranjan Deka, Ravindranath Duggirala, Jessica D. Faul, Melanie E. Garrett, Sina A. Gharib, Xiuqing Guo, Michael E. Hall, Nicola L. Hawley, Jiang He, Brian D. Hobbs, John E. Hokanson, Chao A. Hsiung, Shih-Jen Hwang, Thomas M. Hyde, Marguerite R. Irvin, Andrew E. Jaffe, Eric O. Johnson, Robert Kaplan, Sharon L. R. Kardia, Joel D. Kaufman, Tanika N. Kelly, Joel E. Kleinman, Charles Kooperberg, I-Te Lee, Daniel Levy, Sharon M. Lutz, Ani W. Manichaikul, Lisa W. Martin, Olivia Marx, Stephen T. McGarvey, Ryan L. Minster, Matthew Moll, Karine A. Moussa, Take Naseri, Kari E. North, Elizabeth C. Oelsner, Juan M. Peralta, Patricia A. Peyser, Bruce M. Psaty, Nicholas Rafaels, Laura M. Raffield, Muagututi'a Sefuiva Reupena, Stephen S. Rich, Jerome Rotter, David A. Schwartz, Aladdin H. Shadyab, Wayne H-H Sheu, Mario Sims, Jennifer A. Smith, Xiao Sun, Kent D. Taylor, Marilyn J. Telen, Harold Watson, Daniel E. Weeks, David R. Weir, Lisa R. Yanek, Kendra A. Young, Kristin L. Young, Wei Zhao, Dana B. Hancock, Bibo Jiang, Scott Vrieze, Dajiang J. Liu
Summary: Most TWASs conducted so far have focused on European ancestry and lacked diversity. To address this limitation, researchers aggregated GWAS summary statistics, whole-genome sequences, and eQTL data from diverse ancestries. They developed a new approach called TESLA, which integrates eQTL datasets with multi-ancestry GWAS, improving power and identifying more genes associated with tobacco use phenotypes compared to alternative TWAS methods. The study also suggests potential drug repurposing options for treating nicotine addiction.
Article
Clinical Neurology
Joan Marti-Fabregas, Pol G. Camps-Renom, Jonathan G. Best, Anna Ramos-Pachon, Marina Guasch-Jimenez, Alejandro Martinez-Domeno, Daniel M. Guisado-Alonso, Beatriz M. Gomez-Anson, Gareth Ambler, Duncan Wilson, Keon-Joo Lee, Jae-Sung Lim, Hee-Joon Bae, Masayuki Shiozawa, Masatoshi Koga, Kazunori G. Toyoda, Michael G. Hennerici, Hugues Chabriat, Eric Jouvent, Debbie Yuen Kwun Wong, Henry Mak, Kui Kai Lau, Young Dae Kim, Tae-Jin Song, Ji-Hoe Heo, Sebastian Eppinger, Thomas Gattringer, Ender Uysal, Derya Selcuk Demirelli, Natan Bornstein, Einor Ben Assayag, Hen A. Hallevi, Jeremy A. Molad, Masashi Nishihara, Jun Tanaka, Hideo Hara, Yusuke B. Yakushiji, Shelagh B. Coutts, Eric A. Smith, Alexandros A. Polymeris, Benjamin Wagner, David A. Seiffge, Philippe A. Lyrer, Nils T. Peters, Stefan T. Engelter, Rustam Al-Shahi Salman, Hans Rudolf Jager, Gregory Y. H. Lip, Martina Goeldlin, Leonidas Panos, Christopher Charles G. Karayiannis, Thanh G. K. Phan, Velandai K. Srikanth, Nicolas Christ, Sarah Gunkel, Felix W. Fluri, Thomas W. Leung, Yannie O. Y. Soo, Winnie Chu, Jill Abrigo, Carmen Barbato, Simone Browning, Robert Simister, Anne-Marie Mendyk, Regis Bordet, Saima Hilal, Bibek Gyanwali, Christopher Chen, Simon Jung, Dilek Necioglu Orken, David Werring, Luis Prats-Sanchez
Summary: This study aimed to investigate the risk of future cerebrovascular events in patients with ischemic stroke (IS) or transient ischemic attack (TIA) and cortical superficial siderosis (cSS), as well as the benefits and safety of antithrombotic drugs for secondary prevention. The study found that cSS was associated with an increased risk of stroke, and the risk of IS was higher than that of intracranial hemorrhage (ICrH) in patients receiving antiplatelet or anticoagulant treatment alone, while the risk of ICrH was higher than that of IS in patients receiving both treatments. Therefore, the study suggests that using antiplatelet or anticoagulant drugs alone is safe in patients with cSS, but combined antithrombotic therapy might be hazardous.
Review
Clinical Neurology
Aikaterini Theodorou, Lina Palaiodimou, Konark Malhotra, Christina Zompola, Aristeidis H. Katsanos, Ashkan Shoamanesh, Efstathios Boviatsis, Efthimios Dardiotis, Martha Spilioti, Simona Sacco, David J. Werring, Charlotte Cordonnier, Andrei Alexandrov, George R. Paraskevas, Georgios Tsivgoulis
Summary: This study conducted a systematic review and meta-analysis on the clinical, neuroimaging, genetic, and cerebrospinal fluid biomarker characteristics of patients with cerebral amyloid angiopathy-related inflammation (CAA-ri). The results showed that cognitive decline was the most common clinical feature, while hyperintense T2/fluid-attenuated inversion recovery white matter lesions and lobar cerebral microbleeds were the most prevalent neuroimaging findings. 34% of patients with CAA-ri had the ApoE epsilon 4/epsilon 4 genotype.
Article
Clinical Neurology
Simon Fandler-Hoefler, Thomas Gattringer, Christian Enzinger, David J. Werring
Summary: This study found that patients with probable CAA who were diagnosed using the Boston v2.0 criteria had a lower risk of ICH recurrence compared to those diagnosed using the v1.5 criteria.
Letter
Medicine, General & Internal
David J. Werring, Gargi Banerjee
Review
Clinical Neurology
Kitti Thiankhaw, Hatice Ozkan, Gareth Ambler, David J. Werring
Summary: In patients with ischaemic stroke, there is a strong association between IADE and CSVD markers, such as lacunes, cerebral microbleeds, and white matter hyperintensities.
JOURNAL OF NEUROLOGY
(2023)