Review
Neurosciences
Qian Wang, Fang-Yu Chen, Zhuo-Min Ling, Wen-Feng Su, Ya-Yu Zhao, Gang Chen, Zhong-Ya Wei
Summary: Peripheral neuropathy is a common neurological issue with limited treatment options. Schwann cell transplantation plays a crucial role in resolving peripheral neuropathy, and stem cells have the potential to differentiate into Schwann-like cells. These studies provide insights into cell therapy and uncover prospective therapeutic strategies for peripheral neuropathy.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Tak-Ho Chu, Kabita Baral, Elodie Labit, Nicole Rosin, Sarthak Sinha, Daniel Umansky, Saud Alzahrani, Rohit Arora, Leslie Cao, Derrick Rancourt, Jeff Biernaskie, Rajiv Midha
Summary: Skin-derived Schwann cells (Sk-SCs) and nerve-derived Schwann cells (N-SCs) share similar gene expression profiles with subtle differences, particularly in HLA genes. In vitro experiments showed comparable functions between the two cell types, while in vivo experiments indicated that Sk-SCs may have a stronger effect on dorsal root ganglion (DRG) neurite outgrowth complexity.
Article
Biochemistry & Molecular Biology
D. A. Santiago Gonzalez, V. T. Cheli, S. L. Rosenblum, G. Denaroso, P. M. Paez
Summary: Ceruloplasmin is an essential ferroxidase enzyme for cell iron efflux and plays a crucial role in promoting the maturation of OLs and SCs by regulating iron balance and preventing oxidative stress and neurodegeneration in the central and peripheral nervous systems.
Article
Neurosciences
John W. McLean, Julie A. Wilson, Tina Tian, Jennifer A. Watson, Mary VanHart, Andrew J. Bean, Steven S. Scherer, David K. Crossman, Eroboghene Ubogu, Scott M. Wilson
Summary: Endosomal sorting is crucial for neural development by regulating membrane receptor distribution and signaling pathways. Inactivation of the HGS protein in Schwann cells leads to peripheral neuropathy with deficits in motor and sensory functions, delayed myelination, and altered gene expression related to Schwann cell maturation. This study suggests that HGS is essential for endosomal sorting of ERBB2/3 receptors during Schwann cell development, implicating endosomal dysfunction in inherited peripheral neuropathies.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Nicole M. Procacci, Robert Louis Hastings, Aamir A. Aziz, Nina M. Christiansen, Jie Zhao, Claire DeAngeli, Normand LeBlanc, Lucia Notterpek, Gregorio Valdez, Thomas W. Gould
Summary: This study identified Kir4.1 as a specifically expressed and active channel in non-myelinating Schwann cells (NMSC). The expression of Kir4.1 is downregulated selectively in myelinating Schwann cells (MSC). The findings suggest that Kir4.1 could serve as a potential modulator of immature Schwann cells and NMSC function.
Article
Neurosciences
Jiang-Hu Huang, Yong-Neng Chen, Hang He, Chun-Hui Fu, Zhao-Yi Xu, Fei-Yue Lin
Summary: This study demonstrates that Schwann cells-derived exosomes (SCs-Exos) can promote proliferation, migration, and tube formation of brain-derived endothelial cells (bEnd.3 cells). It is found that SCs-Exos express high levels of the pro-angiogenesis molecules, Integrin-beta 1. The angiogenic effect of SCs-Exos on bEnd.3 cells is dependent on Integrin-beta 1 expression. In an spinal cord injury (SCI) model, treatment with SCs-Exos attenuates tissue damage and enhances functional recovery by promoting angiogenesis, which requires the involvement of Integrin-beta 1.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Akihiro Ishii, Miki Furusho, Rashmi Bansal
Summary: Multiple intracellular signaling pathways, including Mek/ERK1/2-MAPK and PI3K/Akt/mTOR, are involved in regulating myelination in the peripheral nervous system. The roles of these pathways may differ during development and adulthood, highlighting the complexity of their interactions in Schwann cells.
Article
Biotechnology & Applied Microbiology
Peng Yu, Guanhua Zhang, Bo Hou, Enpeng Song, Jiaming Wen, Yueyang Ba, Donglin Zhu, Gangwei Wang, Feng Qin
Summary: Complete myelination and formation of myelinated fibers are essential for functional nerve regeneration after peripheral nerve injury. Suboptimal myelin regeneration is common and can hinder ideal nerve regeneration. Therefore, closely monitoring and supporting myelin regeneration in patients with PNI is important for optimal outcomes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Neurosciences
Bin Zhang, Wenfeng Su, Junxia Hu, Jinghui Xu, Parizat Askar, Shuangxi Bao, Songlin Zhou, Gang Chen, Yun Gu
Summary: Enhancing remyelination after injury is crucial for nerve function recovery. This study reveals the importance of Sin3A and other transcription factors and chromatin regulators in the process of myelination by Schwann cells (SCs). Sin3A affects SC migration, differentiation, and proliferation, as well as the remyelination of regenerating axons. These findings provide insights for developing new treatments to enhance remyelination and nerve regeneration.
NEUROSCIENCE BULLETIN
(2022)
Article
Oncology
Erik A. Williams, Ajay Ravindranathan, Rohit Gupta, Nicholas O. Stevers, Abigail K. Suwala, Chibo Hong, Somang Kim, Jimmy Bo Yuan, Jasper Wu, Jairo Barreto, Calixto-Hope G. Lucas, Emily Chan, Melike Pekmezci, Philip E. LeBoit, Thaddeus Mully, Arie Perry, Andrew Bollen, Jessica Van Ziffle, W. Patrick Devine, Alyssa T. Reddy, Nalin Gupta, Kristen M. Basnet, Robert J. B. Macaulay, Patrick Malafronte, Han Lee, William H. Yong, Kevin Jon Williams, Tareq A. Juratli, Douglas A. Mata, Richard S. P. Huang, Matthew C. Hiemenz, Dean C. Pavlick, Garrett M. Frampton, Tyler Janovitz, Jeffrey S. Ross, Susan M. Chang, Mitchel S. Berger, Line Jacques, Jun S. Song, Joseph F. Costello, David A. Solomon
Summary: In this study, comprehensive genomic profiling and DNA methylation profiling were performed on 96 human schwannomas. The researchers identified novel recurrent in-frame insertion/deletion mutations in the SOX10 gene in a subset of sporadic schwannomas. Functional studies showed that these mutations impaired the differentiation of immature Schwann cells, suggesting they may drive a unique subtype of schwannomas.
Article
Clinical Neurology
Joseph F. Bohlen, Colin M. Cleary, Debamitra Das, Srinidhi Rao Sripathy, Norah Sadowski, Gina Shim, Rakaia F. Kenney, Ingrid P. Buchler, Tapasree Banerji, Thomas S. Scanlan, Daniel K. Mulkey, Brady J. Maher
Summary: In this study, the researchers found that three promyelinating compounds can restore myelination defects in a Pitt-Hopkins syndrome mouse model. Clemastine treatment reduced excess oligodendrocyte precursor cells and normalized oligodendrocyte density. Treatment with sobetirome or Sob-AM2 also effectively normalized oligodendrocyte precursor cell and oligodendrocyte densities and improved behavior in the Pitt-Hopkins syndrome mouse model. These findings suggest that promyelinating therapies may be beneficial in Pitt-Hopkins syndrome and other neurodevelopmental disorders characterized by dysmyelination.
Article
Chemistry, Multidisciplinary
Zhiyuan Wang, Shuaijun Jia, Hailiang Xu, Botao Lu, Weidong Wu, Yixiang Ai, Youjun Liu, Renfeng Liu, Yulin Cao, Shixiang Cheng, Chunping Hu, Zhimou Yang, Lei Zhu, Dingjun Hao
Summary: A new strategy involving IGF1c-PHM has been proposed to improve the efficiency of IGF1c and promote the proliferation and neuronal differentiation of NSCs for the treatment of SCI.
Article
Biochemistry & Molecular Biology
Atsuhiko Okura, Koichi Inoue, Eisuke Sakuma, Hiroshi Takase, Takatoshi Ueki, Mitsuhito Mase
Summary: Schwann cells are crucial for peripheral myelination and the activation of the SGK1 signaling pathway plays a significant role in determining cell fate during nerve injury and repair.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Brendan Zotter, Or Dagan, Jacob Brady, Hasna Baloui, Jayshree Samanta, James L. Salzer
Summary: Peripheral nerves are organized into compartments and Gli1 is a crucial transcriptional effector involved in nerve development, regulation of extracellular matrix production, and nerve vascular organization. Gli1 and Dhh have nonredundant roles in peripheral nerve development.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Shaline V. Fazal, Clara Mutschler, Civia Z. Chen, Mark Turmaine, Chiung-Ya Chen, Yi-Ping Hsueh, Andrea Ibanez-Grau, Andrea Loreto, Angeles Casillas-Bajo, Hugo Cabedo, Robin J. M. Franklin, Roger A. Barker, Kelly R. Monk, Benjamin J. Steventon, Michael P. Coleman, Jose A. Gomez-Sanchez, Peter Arthur-Farraj
Summary: Since SARM1 mutations have been identified in human neurological disease, inhibiting SARM1 has become an attractive therapeutic strategy to preserve axons. However, it is still unknown whether SARM1 is present and functional in myelinating glia. This study finds that oligodendrocytes express SARM1 and its activation results in cell death, while peripheral glia (Schwann cells) likely contain no functionally relevant levels of SARM1.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Peripheral Vascular Disease
Pawel Aftanski, Marcus Thieme, Friederike Klein, P. Christian Schulze, Sven Moebius-Winkler, Daniel Kretzschmar
Summary: This single-center, prospective registry provides compelling evidence for the safety and efficacy of intravascular lithotripsy (IVL) in patients with severe peripheral artery disease (PAD) and calcified lesions. Clinical follow-up data showed a sustained improvement in ankle brachial index (ABI) after 6 months.
INTERNATIONAL JOURNAL OF ANGIOLOGY
(2023)
Article
Emergency Medicine
Elly S. Oh, Paul Schulze, Frank Diaz, Kunal Shah, Jose Rios, Michael E. Silverman
Summary: This study compares the clinical and safety outcomes of andexanet alfa and 4-factor prothrombin complex concentrate for the reversal of apixaban or rivaroxaban-induced intracranial hemorrhage. The results show similar achievement of good hemostatic efficacy upon repeat CT scan between the two treatments, indicating that real-world outcomes align with clinical trial results.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Umidakhon Makhmudova, Beasat Samadifar, Aurel Maloku, Pellumb Haxhikadrija, Jens-Arndt Geiling, Robert Roemer, Bernward Lauer, Sven Moebius-Winkler, Sylvia Otto, P. Christian Schulze, Oliver Weingaertner
Summary: This study demonstrated that early combination therapy and progressive escalation of lipid-lowering treatment effectively achieved recommended LDL-C targets in patients with ST-elevation myocardial infarction, with minimal side effects.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Judith Heiss, Katja Grun, Laura Tempel, Mattia Matasci, Andrea Schrepper, Michael Schwarzer, Reinhard Bauer, Martin Forster, Alexander Berndt, Christian Jung, P. Christian Schulze, Dario Neri, Marcus Franz
Summary: This study compared two formats of immunocytokines and identified potential target cells of IL9. The results showed that targeted delivery of IL9 could have beneficial effects in a mouse model of pulmonary hypertension (PH). Furthermore, IL9 treatment increased the number of regulatory T cells (Tregs) and reduced lung tissue damage in PH mice.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Cardiac & Cardiovascular Systems
Julian G. Westphal, Paul Christian Schulze
Summary: Acute heart failure is a clinical syndrome characterized by elevated intracardiac filling pressures and systemic venous congestion. The underlying cardiac pathology and patient population are heterogeneous, leading to decreased perfusion and retrograde congestion. Therapeutic strategies aim to correct the cardiac dysfunction, reduce volume overload, and stabilize hemodynamics. However, empirical data from randomized trials in acute heart failure is less solid compared to chronic heart failure, resulting in a high mortality rate.
Article
Biochemistry & Molecular Biology
Ralf Kleene, Gabriele Loers, Melitta Schachner
Summary: Abnormal functions of L1 are associated with neural diseases. L1-55 fragment interacts with MeCP2, HP1, HistH1e, and other proteins via the KDET motif. These interactions regulate neurite outgrowth and neuronal survival, indicating the importance of L1 in neural system functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Gabriele Loers, Ralf Kleene, Ute Bork, Melitta Schachner
Summary: The L1 protein plays a crucial role in neural development, synaptic functions, and regeneration after trauma. L1-70 interacts with TOP1, PPAR gamma, and NDUFV2, and regulates neuronal growth and survival. The interaction of L1-70 with these proteins is also related to the expression of two essential autism genes and may be involved in both neurological and psychiatric dysfunctions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Cardiac & Cardiovascular Systems
P. Christian Schulze, Juergen Bogoviku, Julian Westphal, Pawel Aftanski, Franz Haertel, Sissy Grund, Stephan von Haehling, Ulrike Schumacher, Sven Moebius-Winkler, Martin Busch
Article
Cardiac & Cardiovascular Systems
T. Dung Nguyen, P. Christian Schulze
Summary: Chronic kidney disease is associated with an increased risk of cardiovascular disorders and may cause structural remodeling and impairments in cardiac function. The concept of uremic cardiomyopathy, a specific cardiomyopathic phenotype, has recently been recognized. The metabolism in the myocardium of uremic heart shows overlapping mechanisms with heart failure. Understanding the similarities and differences in cardiac metabolism between heart failure and uremic cardiomyopathy could lead to new targets for research and treatment.
CIRCULATION RESEARCH
(2023)
Editorial Material
Medicine, General & Internal
Robert Roemer, P. Christian Schulze, Oliver Weingaertner
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Wilfried Mullens, Paul Christian Schulze, Julian Westphal, Juergen Bogoviku, Johann Bauersachs
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Benedikt Schrage, Jonas Sundermeyer, Benedikt Norbert Beer, Letizia Bertoldi, Alexander Bernhardt, Stefan Blankenberg, Jeroen Dauw, Zouhir Dindane, Dennis Eckner, Ingo Eitel, Tobias Graf, Patrick Horn, Paulus Kirchhof, Stefan Kluge, Axel Linke, Ulf Landmesser, Peter Luedike, Enzo Luesebrink, Norman Mangner, Octavian Maniuc, Sven Moebius Winkler, Peter Nordbeck, Martin Orban, Federico Pappalardo, Matthias Pauschinger, Michal Pazdernik, Alastair Proudfoot, Matthew Kelham, Tienush Rassaf, Hermann Reichenspurner, Clemens Scherer, Paul Christian Schulze, Robert H. G. Schwinger, Carsten Skurk, Marek Sramko, Guido Tavazzi, Holger Thiele, Luca Villanova, Nuccia Morici, Antonia Wechsler, Ralf Westenfeld, Ephraim Winzer, Dirk Westermann
Summary: This study aimed to evaluate the use of mechanical circulatory support (MCS) for the treatment of non-ischaemic cardiogenic shock (CS). The results showed that the use of MCS was associated with a lower 30-day mortality rate in patients with non-ischaemic CS. However, MCS treatment was also associated with more complications.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Biochemistry & Molecular Biology
Gabriela Guedez, Gabriele Loers, Cy M. Jeffries, Sandra Kozak, Rob Meijers, Dmitri I. Svergun, Melitta Schachner, Christian Loew
Summary: The cell adhesion molecule L1 plays crucial roles in neural development, regeneration, synaptic plasticity, and tumor cell migration. L1 is a member of the immunoglobulin superfamily and consists of Ig-like domains and fibronectin type III homologous repeats. The second Ig-like domain is involved in cell binding, and the fibronectin type III homologous repeats contribute to signal transduction.
Article
Medicine, General & Internal
Franz Haertel, Josephine Babst, Christiane Bruening, Jurgen Bogoviku, Sylvia Otto, Michael Fritzenwanger, Thomas Gecks, Henning Ebelt, Sven Moebius-Winkler, P. Christian Schulze, Ruediger Pfeifer
Summary: This study aimed to investigate the impact of hemolysis on neuron-specific enolase (NSE) levels and its prognostic value in predicting neurological outcomes in resuscitated patients without return of spontaneous circulation (ROSC) undergoing veno-arterial extracorporeal membrane oxygenation (VA-ECMO) therapy. The results showed that NSE is a reliable prognostic marker for poor neurological outcomes in resuscitated patients, and potential hemolysis during VA-ECMO does not significantly affect the prognostic value of NSE. These findings are crucial for clinical decision making and prognostic assessment in this patient population.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Franz Haertel, Thomas Lehmann, Tabitha Heller, Michael Fritzenwanger, Ruediger Pfeifer, Daniel Kretzschmar, Sylvia Otto, Jurgen Bogoviku, Julian Westphal, Christiane Bruening, Thomas Gecks, Mirko Kaluza, Sven Moebius-Winkler, P. Christian Schulze
Summary: This article presents a clinical trial on the use of a cytokine adsorber to improve treatment outcomes in patients with cardiogenic shock. The study will compare the use of a cytokine adsorber with conventional plasma separation in treating cardiogenic shock patients. The primary endpoint of the study is improvement in cardiac function, with secondary outcomes including other clinical parameters and safety evaluation.
JOURNAL OF CLINICAL MEDICINE
(2023)