期刊
BRAIN
卷 132, 期 -, 页码 1386-1395出版社
OXFORD UNIV PRESS
DOI: 10.1093/brain/awp052
关键词
Parkinsons disease; prefrontal cortex; neuropsychology; PET; executive function
资金
- Japan Society for the Promotion of Science for Young Scientists Research Fellowships [05J04930]
- Ministry of Education, Culture, Sports, Science and Technology of Japan [18020003]
- Japan Society for the Promotion of Science [20800006]
- Grants-in-Aid for Scientific Research [20800006, 18020003, 05J04930] Funding Source: KAKEN
Parkinsons disease is a common neurodegenerative disorder with both motor symptoms and cognitive deficits such as executive dysfunction. Over the past 100 years, a growing body of literature has suggested that patients with Parkinsons disease have characteristic personality traits such as industriousness, seriousness and inflexibility. They have also been described as honest, indicating that they have a tendency not to deceive others. However, these personality traits may actually be associated with dysfunction of specific brain regions affected by the disease. In the present study, we show that patients with Parkinsons disease are indeed honest, and that this personality trait might be derived from dysfunction of the prefrontal cortex. Using a novel cognitive task, we confirmed that patients with Parkinsons disease (n32) had difficulty making deceptive responses relative to healthy controls (n20). Also, using resting-state (18)F-fluorodeoxyglucose PET, we showed that this difficulty was significantly correlated with prefrontal hypometabolism. Our results are the first to demonstrate that the ostensible honesty found in patients with Parkinsons disease has a neurobiological basis, and they provide direct neuropsychological evidence of the brain mechanisms crucial for human deceptive behaviour.
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