Article
Respiratory System
Matthias Welsner, Sarah Dietz-Terjung, Florian Stehling, Tim Schulte, Ute Niehammer, Fatma-Ezzahra Gahbiche, Christian Taube, Svenja Strassburg, Christoph Schoebel, Gerhard Weinreich, Sivagurunathan Sutharsan
Summary: This study aimed to investigate sleep parameters, excessive daytime sleepiness (EDS), and pulmonary function in adult patients with cystic fibrosis (pwCF). The results showed that obstructive sleep apnea (OSA), nocturnal hypoxemia, and EDS were common in adult pwCF, but no strong predictors were identified. Therefore, regular sleep tests and evaluations are recommended for adult pwCF, regardless of disease severity.
BMC PULMONARY MEDICINE
(2022)
Article
Endocrinology & Metabolism
Mahmoud I. Mahmoud, Raed K. Alotaibi, Rayyan Almusally, Hanaa Shafiek, Yasir Elamin, Ziad Alhaj, Waleed AlBaker, Alaeldin Elfaki, Hatem Qutub, Suha J. Albahrani, Fatima M. Alabdrabalnabi, Zahra A. Al Saeed, Reem Al Argan, Fatima Al Rubaish, Yousef D. Alqurashi, Noor-Ahmed Jatoi, Abdullah H. Alharmaly, Zainab Z. Almubarak, Abir H. Al Said, Nada Albahrani
Summary: This study investigated the association between glycosylated hemoglobin (HbA1c) levels and nocturnal hypoxemia and apnea-hypopnea index (AHI) in Saudi patients with obstructive sleep apnea (OSA) and diabetes mellitus (DM). The findings suggest that nocturnal hypoxemia may be an important factor affecting glycemic control in patients with OSA and DM.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Ricardo L. M. Duarte, Flavio J. Magalhaes-da-Silveira, David Gozal
Summary: This study aimed to assess the influence of nocturnal symptoms of insomnia on the prevalence of obstructive sleep apnea (OSA). The results showed that individuals without insomnia had a higher prevalence of OSA compared to those with insomnia, and the number of nocturnal symptoms of insomnia was negatively associated with the diagnosis of OSA.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Article
Clinical Neurology
Aye-Thandar Aung, William Kristanto, Megan Jia-Ing Tan, Chieh-Yang Koo, Pei-Qing Xu, Calvin W. Chin, Glenn Roldan, As Tar Thant, Siew-Pang Chan, Ai-Ping Chua, Ferran Barbe, Pipin Kojodjojo, Chi-Hang Lee
Summary: Patients who underwent percutaneous coronary intervention often experience obstructive sleep apnea during REM sleep, with diabetes mellitus being identified as an independent predictor of this condition.
SLEEP AND BREATHING
(2021)
Article
Clinical Neurology
Nana Feng, Jundong Yang, Huajun Xu, Chujun Zhang, Fan Wang, Xiaolin Wu, Meizhen Gu
Summary: This study evaluated the associations between sleep architecture and metabolic parameters in 2,308 patients with suspected OSA, finding weak correlations between sleep quality and metabolic parameters such as weight, blood sugar, and cholesterol. The clinical impact of sleep structure on metabolism appears to be negligible, highlighting the need for further prospective studies to confirm these findings.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Agata Gabryelska, Jedrzej Chrzanowski, Marcin Sochal, Piotr Kaczmarski, Szymon Turkiewicz, Marta Ditmer, Filip Franciszek Karuga, Leszek Czupryniak, Piotr Bialasiewicz
Summary: The study found that in OSA patients, basal O2 saturation is independent of AHI, BMI, and age, and is a risk factor for type 2 diabetes. One-way Cox regression analysis showed a higher risk of earlier type 2 diabetes for increased BMI, AHI, decreased basal O2, and O2 nadir values, while lowered mean O2 desaturation did not show statistical significance. In CART analysis, cut-off points of 92.2%, 81.7%, and 87.1% were determined for basal O2, O2 nadir, and mean O2 desaturation, with the first two parameters being statistically significant.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Sanae Makhout, An Boudewyns, Kim Van Hoorenbeeck, Stijn Verhulst, Annelies Van Eyck
Summary: This study evaluated the validity of nocturnal oximetry as a diagnostic tool for OSA in infants with laryngomalacia. The results showed that overnight pulse oximetry has high sensitivity and positive predictive value to diagnose OSA in these infants, but low specificity and negative predictive value.
Article
Clinical Neurology
Julio Cezar Rodrigues Filho, Denise Duprat Neves, Gustavo Antonio Moreira, Alonco da C. Viana Jr, Maria Helena Araujo-Melo
Summary: This study evaluated the performance of Nocturnal Oximetry in diagnosing obstructive sleep apnea in patients with neuromuscular diseases. A sample of 41 patients showed a prevalence of OSA of 75.7%. The best four oximetric variables demonstrated good performance in identifying apnea/hypopnea index >5/h in these patients.
Article
Clinical Neurology
Layla B. Guscoth, Sarah L. Appleton, Sean A. Martin, Robert J. Adams, Yohannes A. Melaku, Gary A. Wittert
Summary: In this study, obstructive sleep apnea metrics were found to be positively associated with serum triglyceride levels in men with a normal waist circumference. Healthy weight individuals with OSA require clinical attention to improve cardiometabolic risk profiles.
NATURE AND SCIENCE OF SLEEP
(2021)
Article
Medicine, General & Internal
Cinthya Pena Orbea, Lu Wang, Vaishal Shah, Lara Jehi, Alex Milinovich, Nancy Foldvary-Schaefer, Mina K. Chung, Saif Mashaqi, Loutfi Aboussouan, Kelsey Seidel, Reena Mehra
Summary: In this case-control study, SDB and sleep-related hypoxia were not associated with increased SARS-CoV-2 positivity; however, once patients were infected with SARS-CoV-2, sleep-related hypoxia was an associated risk factor for detrimental COVID-19 outcomes.
Review
Health Care Sciences & Services
Sy Duong-Quy, Hoang Nguyen-Huu, Dinh Hoang-Chau-Bao, Si Tran-Duc, Lien Nguyen-Thi-Hong, Thai Nguyen-Duy, Tram Tang-Thi-Thao, Chandat Phan, Khue Bui-Diem, Quan Vu-Tran-Thien, Thu Nguyen-Ngoc-Phuong, Vinh Nguyen-Nhu, Huong Le-Thi-Minh, Timothy Craig
Summary: Obstructive Sleep Apnea (OSA) is a common disease that is often underestimated and undertreated in all age groups. Personalized diagnosis and treatment approaches are necessary for clinical practice due to morphological differences, clinical phenotype diversity, and variations in diagnosis and treatment of OSA in children and adults. Treatment should be based on individual tolerance to sleep-quality-related parameters, the harmful effects of hypoxia on the cardiovascular system, and patients' comorbidities.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Viseslav Popadic, Milica Brajkovic, Slobodan Klasnja, Natasa Milic, Nina Rajovic, Danica Popovic Lisulov, Anica Divac, Tatjana Ivankovic, Andrea Manojlovic, Novica Nikolic, Lidija Memon, Marija Brankovic, Maja Popovic, Ana Sekulic, Jelica Bjekic Macut, Olivera Markovic, Sinisa Djurasevic, Maja Stojkovic, Zoran Todorovic, Marija Zdravkovic
Summary: In a retrospective cohort study involving 328 patients with newly diagnosed obstructive sleep apnea, significant associations were found between lipid abnormalities, inflammatory markers, and other clinically important data with the severity of obstructive sleep apnea. These findings may contribute to a better understanding of the underlying pathophysiological processes and potential therapeutic modalities.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
M. Leentjens, Abdulmohsen Alterki, Mohamed Abu-Farha, P. F. N. Bosschieter, CAL. de Raaff, CEE. de Vries, Eman Al Shawaf, Thangavel Alphonse Thanaraj, Irina Al-Khairi, Preethi Cherian, Arshad Channanath, Sina Kavalakatt, B. A. van Wagensveld, N. de Vries, Jehad Abubaker
Summary: This study found significantly increased levels of ANGPTL7 in both the circulation and adipose tissue of patients with OSA, which were associated with increased inflammation and OSA severity. Bariatric surgery was shown to significantly reduce ANGPTL7 levels and improve OSA.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Respiratory System
Andrew E. Beaudin, Jill K. Raneri, Najib T. Ayas, Robert P. Skomro, Nurit Fox, A. J. Marcus Hirsch Allen, Matthew W. Bowen, Andrhea Nocon, Emma J. Lynch, Meng Wang, Eric E. Smith, Patrick J. Hanly
Summary: The prevalence of mild cognitive impairment (MCI) is high in patients referred to sleep clinics for obstructive sleep apnea (OSA), especially among older males with moderate to severe OSA and vascular comorbidities. Moderate to severe OSA is an independent risk factor for MCI, with higher odds for cognitive impairment compared to patients with no OSA.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Clinical Neurology
Nichlas Udholm, Christian Emil Rex, Milos Fuglsang, Soren Lundbye-Christensen, Jesper Bille, Sebastian Udholm
Summary: This nationwide study investigates the risk and severity of road traffic accidents in patients with obstructive sleep apnea (OSA). The results show that patients with OSA have an increased risk of motor vehicle accidents and greater severity of accidents compared to a reference cohort.
Article
Clinical Neurology
Hannah Scott, Bastien Lechat, Jack Manners, Nicole Lovato, Andrew Vakulin, Peter Catcheside, Danny J. Eckert, Amy C. Reynolds
Summary: Self-reported sleep difficulties are a major concern in the diagnosis and treatment of chronic insomnia. However, advancements in in-home sleep monitoring technology and the use of self-reported sleep outcomes can assist in managing insomnia. This review explores emerging techniques for objective sleep monitoring that could improve the identification and management of insomnia. Diagnostic techniques discussed include insomnia phenotyping, better detection of coexisting sleep disorders, and identifying high-risk patients. Treatment techniques examined include therapy administration, methods for assessing and improving treatment adherence, and sleep feedback. The capabilities of sleep devices and the need for further research are also discussed.
Article
Acoustics
Phuc D. Nguyen, Kristy L. Hansen, Branko Zajamsek, Peter Catcheside, Colin H. Hansen
Summary: This study investigated the uncertainty in predicting wind farm noise, including parametric and model structure uncertainty. It found that different ground impedance and wind speed profile models were significant sources of uncertainty, resulting in noise level differences of more than 10 dBA at distances greater than 3.5 km. The differences in atmospheric vertical wind speed profile models were identified as the main source of uncertainty in long-range noise prediction. Therefore, acknowledging the variability associated with different models is important to reduce the uncertainty of predicted values in wind farm noise assessment.
Article
Acoustics
Branko Zajamsek, Kristy L. Hansen, Phuc Duc Nguyen, Bastien Lechat, Gorica Micic, Peter Catcheside
Summary: This study investigated the self-reported sleep acceptability of wind farm noise containing low-frequency amplitude modulated tones. The study found that participants had lower acceptable sound pressure levels for wind farm noise with low-frequency amplitude modulated tones compared to the control group without noise disruption. Only the participants reporting road traffic noise disruption preferred lower noise levels for wind farm noise with low-frequency amplitude modulated tones.
Article
Acoustics
Branko Zajamsek, Kristy L. Hansen, Phuc Duc Nguyen, Bastien Lechat, Gorica Micic, Peter Catcheside
Summary: This study examined the ability to detect infrasound from wind farm and its impact on audible tonal noise through creating a sensation of amplitude modulation. The research found that participants were unable to detect the infrasonic content of wind turbine noise above chance, which aligns with previous studies. Infrasound was found to slightly reduce the audibility of low frequency tonal noise, indicating a small effect on the perception of such noise.
Article
Peripheral Vascular Disease
Hannah Scott, Bastien Lechat, Alisha Guyett, Amy C. Reynolds, Nicole Lovato, Ganesh Naik, Sarah Appleton, Robert Adams, Pierre Escourrou, Peter Catcheside, Danny J. Eckert
Summary: This study examined the association between irregularities in sleep duration and timing with hypertension in a large, global sample over multiple months. The findings showed that sleep irregularity is a risk marker for poor cardiovascular health.
Review
Endocrinology & Metabolism
Gary A. Wittert, Mathis Grossmann, Bu B. Yeap, David J. Handelsman
Summary: Testosterone, acting as both androgen receptor and as aromatization to oestradiol, plays important roles in adipose tissue, bone, and skeletal muscle biology. Epidemiological studies have linked lower testosterone levels with obesity, disordered glucose metabolism, and an increased risk of type 2 diabetes in men. The Testosterone for the Prevention of Type 2 Diabetes (T4DM) study found that a 2-year treatment with testosterone undecanoate reduced the likelihood of T2D diagnosis by 40% and led to favorable changes in body composition, bone mineral density, and skeletal microarchitecture, but not in glycaemic control.
JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
David J. Stevens, Sarah Appleton, Kelsey Bickley, Louis Holtzhausen, Robert Adams
Summary: The acute and subacute phases of concussion are characterized by longer and less disrupted sleep. There is an improvement in sleep quality from the acute to subacute phase.
NATURE AND SCIENCE OF SLEEP
(2023)
Article
Health Care Sciences & Services
Bastien Lechat, Kelly A. Loffler, Amy C. Reynolds, Ganesh Naik, Andrew Vakulin, Garry Jennings, Pierre Escourrou, R. Doug McEvoy, Robert J. Adams, Peter G. Catcheside, Danny J. Eckert
Summary: The severity of obstructive sleep apnea (OSA) can vary significantly from night to night. However, it is unknown how this night-to-night variability in OSA severity affects cardiovascular outcomes such as hypertension. This study aimed to determine the impact of variability in OSA severity on the likelihood of hypertension. The study involved monitoring 15,526 adults over approximately 180 nights, using an under-mattress sleep sensor device and repeated blood pressure measures. The results showed that high night-to-night variability in OSA severity is a predictor of uncontrolled hypertension, independent of the severity of OSA.
NPJ DIGITAL MEDICINE
(2023)
Article
Clinical Neurology
Jesse L. Parker, Sarah L. Appleton, Robert J. Adams, Yohannes Adama Melaku, Angela L. D'Rozario, Gary A. Wittert, Sean A. Martin, Peter G. Catcheside, Bastien Lechat, Alison J. Teare, Barbara Toson, Andrew Vakulin
Summary: This study found associations between sleep spindles and cognitive function, with obstructive sleep apnea severity moderating these associations. It highlights the potential utility of sleep spindles as cognitive function markers in obstructive sleep apnea, warranting further longitudinal investigation.
Article
Endocrinology & Metabolism
David J. Handelsman, Mathis Grossmann, Bu B. Yeap, Bronwyn G. A. Stuckey, Nandini Shankara-Narayana, Ann J. Conway, Warrick J. Inder, Robert Mclachlan, Carolyn Allan, Alicia J. Jenkins, David Jesudason, Karen Bracken, Gary A. Wittert
Summary: The T4DM study shows that testosterone treatment for men with impaired glucose tolerance or newly diagnosed diabetes reduces the risk of diabetes and improves sleep apnea diagnosis during the study period, but these effects disappear after the study. There is also evidence of androgen dependence in some men receiving prolonged injectable testosterone treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Emily Jane Meyer, Gary Allen Wittert
Summary: Obstructive sleep apnea (OSA) and obesity are closely associated; OSA is often unrecognized in women; OSA increases the risk of developing comorbid chronic disorders and impairs quality of life; appropriate treatment can improve symptoms and related diseases.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Clinical Neurology
Jesse L. Parker, Andrew Vakulin, Ganesh Naik, Yohannes Adama Melaku, David Stevens, Gary A. Wittert, Sean A. Martin, Peter G. Catcheside, Barbara Toson, Sarah L. Appleton, Robert J. Adams
Summary: This study examined the impact of obstructive sleep apnea and sleep macroarchitecture on future cognitive function. The results showed that a higher percentage of light sleep was associated with better cognitive performance, while higher mean oxygen saturation was associated with worse performance.
JOURNAL OF SLEEP RESEARCH
(2023)
Review
Clinical Neurology
Cricket Fauska, Tarun Bastiampillai, Robert J. Adams, Gary Wittert, Danny J. Eckert, Kelly A. Loffler
Summary: This article discusses the effects of quetiapine on sleep and breathing, emphasizing the importance of understanding its impact on obstructive sleep apnea and its mechanisms. It also proposes future research priorities to address the current knowledge gaps.
JOURNAL OF SLEEP RESEARCH
(2023)
Review
Psychology, Multidisciplinary
Melissa J. J. Opozda, Melissa Oxlad, Deborah Turnbull, Himanshu Gupta, Andrew D. D. Vincent, Samuel Ziesing, Murray Nankivell, Gary Wittert
Summary: This study aimed to evaluate the characteristics of psychotherapeutic e-mental health interventions for depression or anxiety in men and their effects on men's depression and anxiety symptoms. The findings indicate that e-mental health interventions are effective in improving men's depression symptoms. It is crucial to consider gender and sex in the development, evaluation, and dissemination of such interventions for men.
CURRENT PSYCHOLOGY
(2023)
Article
Clinical Neurology
Jenny Theorell-Haglow, Xingwu Zhou, Gary Wittert, Robert Adams, Sarah Appleton, Amy Reynolds, Mirjam Ljunggren, Nathaniel Marshall
Summary: This study pooled data from three community-based cohorts and found no overall increased risk of cancer or cancer mortality in relation to obstructive sleep apnea. However, the confidence limits remain wide for important diagnostic categories of sleep apnea severity. Further investigation is needed in a comprehensive multi-cohort approach with greater statistical precision.
JOURNAL OF SLEEP RESEARCH
(2023)