Article
Behavioral Sciences
Atefeh Zandifar, Rahim Badrfam, Fatemeh Gholamian, Arman Shafiee
Summary: Spironolactone showed promising results in improving cognitive impairment in patients with bipolar disorder in manic episodes, but did not significantly impact manic symptoms. Further studies with larger sample sizes and longer follow-ups in multicenter settings are recommended.
BRAIN AND BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Brenton T. Laing, Megan S. Anderson, Jordi Bonaventura, Aishwarya Jayan, Sarah Sarsfield, Anjali Gajendiran, Michael Michaelides, Yeka Aponte
Summary: The study identified a cluster of glutamatergic parvalbumin-expressing neurons in the anterior hypothalamic area (AHA) that play a critical role in regulating defensive behaviors, including escape responses. Activation of these AHA(PV) neurons increased during exposure to a predator and triggered aversive responses. Neurotransmission between AHA(PV) neurons and the dorsal premammillary nucleus (PMD) was found to be involved in escape responses. The ablation of AHA(PV) neurons impaired escape responses but had no effect on anxiety-like behavior. Whole-brain metabolic mapping revealed activation of downstream areas such as the amygdala and substantia nigra. This study expands our understanding of the neuronal circuits underlying fight-or-flight responses and has important implications for studying neuropsychiatric disorders like post-traumatic stress disorder (PTSD).
Article
Allergy
Wisdom Alemya Akurugu, Carel Jacobus Van Heerden, Nicola Mulder, Ekkehard Werner Zollner
Summary: This study found that some SNPs of the CRHR1 and NR3C1 genes are associated with HPAS in asthmatic children, with the C allele of rs41423247 potentially having a protective effect on HPAS, and the CC genotype being associated with the highest PMTP ACTH response.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Review
Chemistry, Medicinal
Mudan Cai, Hee Ra Park, Eun Jin Yang
Summary: Post-traumatic stress disorder (PTSD) is characterized by overwhelming fear and anxiety after exposure to traumatic events. Disturbances in the hypothalamic-pituitary-adrenal (HPA) axis play a role in the development of mood disorders, including anxiety, PTSD, and major depressive disorders. The HPA axis regulates the immune system, fear memory, and neurotransmission. Currently, selective serotonin reuptake inhibitors (SSRIs) are the only approved drugs for PTSD treatment. However, SSRIs have limitations in terms of treatment duration and response rates, necessitating additional pharmacological interventions. Complementary and alternative medicine therapies can ameliorate HPA axis disturbances by regulating gut dysbiosis, insomnia, chronic stress, and depression.
Article
Endocrinology & Metabolism
Martin Werdermann, Ilona Berger, Laura D. Scriba, Alice Santambrogio, Pia Schlinkert, Heike Brendel, Henning Morawietz, Andreas Schedl, Mirko Peitzsch, Aileen J. F. King, Cynthia L. Andoniadou, Stefan R. Bornstein, Charlotte Steenblock
Summary: This study investigated the impact of metabolic diseases on progenitor cells in the hypothalamic-pituitary-adrenal axis, showing that insulin enhances proliferation and differentiation of these cells, while chronic metabolic stress leads to hyperactivation of the axis. This suggests a potential link between early life stress and the development of metabolic syndrome in adulthood.
MOLECULAR METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Mojca Jensterle, Rok Herman, Andrej Janez, Wael Al Mahmeed, Khalid Al-Rasadi, Kamila Al-Alawi, Maciej Banach, Yajnavalka Banerjee, Antonio Ceriello, Mustafa Cesur, Francesco Cosentino, Massimo Galia, Su-Yen Goh, Sanjay Kalra, Peter Kempler, Nader Lessan, Paulo Lotufo, Nikolaos Papanas, Ali A. Rizvi, Raul D. Santos, Anca P. Stoian, Peter P. Toth, Vijay Viswanathan, Manfredi Rizzo
Summary: The article reviews the rationale for glucocorticoid use in COVID-19 and emphasizes the need to be cautious about glucocorticoid-induced adrenal insufficiency. The authors also discuss other mechanisms that may affect HPA axis function and the increased risk and severity of COVID-19 in patients with pre-existing HPA axis disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Gerard Anmella, Silvia Vilches, Jordi Espadaler-Mazo, Andrea Murru, Isabella Pacchiarotti, Miquel Tuson, Marina Garriga, Eva Sole, Merce Brat, Giovanna Fico, Eduard Vieta
Summary: This study evaluated the impact of individual genes in the response to treatment in bipolar depression, finding that pharmacogenetic variables can predict patient response to medication and tolerability. These predictors could be useful for guiding pharmacological treatment in bipolar disorder, but further clinical studies are needed to confirm these findings.
Review
Physiology
Derek Schaeuble, Brent Myers
Summary: This article reviews the emerging literature on how specific cortical and hypothalamic nuclei regulate cardiovascular and neuroendocrine stress responses, as well as the cellular and circuit mechanisms mediating physiological stress responses. The reviewed literature highlights the current state of stress integration research and raises unanswered questions about the brain basis of CVD risk.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Flaminia Coluzzi, Jo Ann K. LeQuang, Salvatore Sciacchitano, Maria Sole Scerpa, Monica Rocco, Joseph Pergolizzi
Summary: Opioid-associated adrenal insufficiency (OIAI) is a common condition caused by long-term opioid use, but is not well understood by most clinicians. Diagnosis of OIAI can be challenging due to the lack of established cutoff values for tests. Better guidance for diagnosis and treatment of OIAI is urgently needed, especially considering the high prevalence of chronic opioid therapy in the United States.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Bei Zhou, Qilong Xu, Junjie Guo, Qinliang Chen, Qingqing Lv, Kan Xiao, Huiling Zhu, Jiangchao Zhao, Yulan Liu
Summary: This study investigates the role of necroptosis in the activation of the hypothalamic-pituitary-adrenal (HPA) axis in a stress model induced by Escherichia coli lipopolysaccharide (LPS). The findings indicate that necroptosis is present and contributes to HPA axis activation induced by LPS. Necroptosis may serve as a potential intervention target for alleviating HPA axis activation and stress responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Jody A. Rusch, Brian T. Layden, Lara R. Dugas
Summary: Cognitive function in humans relies on the complex interplay between multiple body systems, including the HPA axis. The gut microbiota, which outnumbers human cells and has a greater genetic potential, plays a crucial role through the MGB axis, a bidirectional communication pathway. Stress can affect the MGB axis through the HPA axis and other pathways, and animal research has contributed to a paradigm shift in understanding the influence of microbiota on human health and disease. Preclinical and human trials are currently investigating the applicability of these findings in humans.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Letter
Clinical Neurology
Mustafa Akkus
Summary: This case suggests that lithium-induced tardive dyskinesia may be reversible in a dose-dependent manner.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Xing Chen, Fei Jiang, Qun Yang, Peiyun Zhang, Haijiao Zhu, Chao Liu, Tongtong Zhang, Weijun Li, Jian Xu, Hongmei Shen
Summary: The study showed that bilateral rTMS had a certain effectiveness on depressive symptoms and dysfunction of HPA axis in MDD patients, alleviating depression by improving sleep disorders, and plasma ACTH levels can predict the efficacy of rTMS, especially in male patients.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Endocrinology & Metabolism
Jian Zhong Yang, Chuan Yuan Kang, Jing Yuan, Yan Zhang, Yu Jun Wei, Li Xu, Fang Zhou, Xinxin Fan
Summary: This study highlighted that patients with major depressive disorder (MDD) who experienced adverse childhood experiences (ACEs) showed differences in hypothalamic-pituitary-adrenal (HPA) axis function and symptom severity compared to those without ACEs. ACEs, ACTH, and COR could serve as predictors for long-term antidepressant treatment, suggesting that they may be poor prognostic indicators for MDD patients with ACEs.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Feiye Wu, Jing Zhu, Yang Wan, Subinuer Kurexi, Jia Zhou, Ke Wang, Tongyu Chen
Summary: This study aimed to investigate the effects of electroacupuncture (EA) on the hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis and its potential mechanisms. The results showed that EA treatment effectively inhibited the hyperactivity of the HPA axis and promoted postoperative recovery by activating the oxytocin/oxytocin receptor (OXT/OXTR) signaling pathway.
NEUROCHEMICAL RESEARCH
(2023)
Review
Clinical Neurology
Giovanna Fico, Ulker Isayeva, Michele De Prisco, Vincenzo Oliva, Brisa Sole, Laura Montejo, Iria Grande, Nestor Arbelo, Marta Gomez-Ramiro, Luis Pintor, Bernardo Carpiniello, Mirko Manchia, Eduard Vieta, Andrea Murru
Summary: This systematic review and meta-analysis investigates the repurposing of psychotropic drugs in the treatment of COVID-19. The study finds that antidepressants do not significantly affect the risk and mortality of COVID-19, while fluvoxamine may have potential in reducing mortality risk. Antipsychotics may increase the risk of severe COVID-19 and mortality, but their use in psychiatric patients should be evaluated on a case-by-case basis.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Marco Solmi, Giovanni Croatto, Giada Piva, Stella Rosson, Paolo Fusar-Poli, Jose M. Rubio, Andre F. Carvalho, Eduard Vieta, Celso Arango, Nicole R. DeTore, Elizabeth S. Eberlin, Kim T. Mueser, Christoph U. Correll
Summary: Psychosocial interventions play an important role in schizophrenia and early psychosis. However, the literature on this topic is heterogeneous and contradictory. This umbrella review summarizes the findings from multiple meta-analyses comparing the effectiveness of different psychosocial interventions with standard treatment or other active interventions. The results suggest that early intervention services and cognitive behavioral therapy have significant effects on symptom reduction and functional improvement in early psychosis. For schizophrenia patients, cognitive behavioral therapy, psychoeducation, and any family interventions show positive effects on symptom reduction, relapse prevention, and functional improvement.
MOLECULAR PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Giovanni Croatto, Davy Vancampfort, Alessandro Miola, Miriam Olivola, Jess G. Fiedorowicz, Joseph Firth, Ovidiu Alexinschi, Marcel A. Gaina, Vladimir Makkai, Fernanda Cunha Soares, Leandro Cavaliere, Giorgia Vianello, Brendon Stubbs, Paolo Fusar-Poli, Andre F. Carvalho, Eduard Vieta, Samuele Cortese, Jae Il Shin, Christoph U. Correll, Marco Solmi
Summary: People with mood disorders are at increased risk of comorbid medical diseases. Interventions such as psychological therapies, exercise, and certain medications can improve physical health outcomes in mood disorders, but some medications may have negative effects. It is important to consider evidence from other disorders and individual RCTs when prioritizing effective treatments with beneficial or physically neutral profiles.
MOLECULAR PSYCHIATRY
(2023)
Article
Clinical Neurology
Ana M. Sanchez-Torres, Silvia Amoretti, Monica Enguita-German, Gisela Mezquida, Lucia Moreno-Izco, Rocio Panadero-Gomez, Lide Rementeria, Alba Toll, Roberto Rodriguez-Jimenez, Alexandra Roldan, Edith Pomarol-Clotet, Angela Ibanez, Judith Usall, Fernando Contreras, Eduard Vieta, Jose M. Lopez-Ilundain, Jessica Merchan-Naranjo, Ana Gonzalez-Pinto, Esther Berrocoso, Miguel Bernardo, Manuel J. Cuesta
Summary: This study aimed to investigate the relationship between relapse, cognitive function, and cognitive reserve in schizophrenia patients. The results showed that higher personal cognitive reserve mitigated the negative effects of relapse on attention performance, while higher cognitive reserve (both personal and familial) improved processing speed and visual memory in patients who did not relapse. These findings provide evidence for the protective effect of cognitive reserve over the course of the illness.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Editorial Material
Clinical Neurology
Cristian-Daniel Llach, Eduard Vieta
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Letter
Psychiatry
Leticia Gonzalez-Blanco, Pilar A. Saiz, Francesco Dal Santo, Leticia Garcia-Alvarez, Luis Jimenez-Trevino, Gonzalo Paniagua, Maria Teresa Bobes-Bascaran, Maria Paz Garcia-Portilla, Julio Bobes
SCHIZOPHRENIA RESEARCH
(2023)
Editorial Material
Psychiatry
Eduard Vieta
Article
Psychology, Clinical
Adrian I. Campos, Laura S. Van Velzen, Dick J. Veltman, Elena Pozzi, Sonia Ambrogi, Elizabeth D. Ballard, Nerisa Banaj, Zeynep Basgoeze, Sophie Bellow, Francesco Benedetti, Irene Bollettini, Katharina Brosch, Erick J. Canales-Rodriguez, Emily K. Clarke-Rubright, Lejla Colic, Colm G. Connolly, Philippe Courtet, Kathryn R. Cullen, Udo Dannlowski, Maria R. Dauvermann, Christopher G. Davey, Jeremy Deverdun, Katharina Dohm, Tracy Erwin-Grabner, Roberto Goya-Maldonado, Negar Fani, Lydia Fortea, Paola Fuentes-Claramonte, Ali Saffet Gonul, Ian H. Gotlib, Dominik Grotegerd, Mathew A. Harris, Ben J. Harrison, Courtney C. Haswell, Emma L. Hawkins, Dawson Hill, Yoshiyuki Hirano, Tiffany C. Ho, Fabrice Jollant, Tanja Jovanovic, Tilo Kircher, Bonnie Klimes-Dougan, Emmanuelle le Bars, Christine Lochner, Andrew M. McIntosh, Susanne Meinert, Yara Mekawi, Elisa Melloni, Philip Mitchell, Rajendra A. Morey, Akiko Nakagawa, Igor Nenadic, Emilie Olie, Fabricio Pereira, Rachel D. Phillips, Fabrizio Piras, Sara Poletti, Edith Pomarol-Clotet, Joaquim Radua, Kerry J. Ressler, Gloria Roberts, Elena Rodriguez-Cano, Matthew D. Sacchet, Raymond Salvador, Anca-Larisa Sandu, Eiji Shimizu, Aditya Singh, Gianfranco Spalletta, J. Douglas Steele, Dan J. Stein, Frederike Stein, Jennifer S. Stevens, Giana I. Teresi, Aslihan Uyar-Demir, Nic J. van der Wee, Steven J. van der Werff, Sanne J. H. van Rooij, Daniela Vecchio, Norma Verdolini, Eduard Vieta, Gordon D. Waiter, Heather Whalley, Sarah L. Whittle, Tony T. Yang, Carlos A. Zarate Jr, Paul M. Thompson, Neda Jahanshad, Anne-Laura van Harmelen, Hilary P. Blumberg, Lianne Schmaal, Miguel E. Renteria
Summary: A major limitation of current suicide research is the lack of power to identify robust correlates of suicidal thoughts or behavior. Variation in suicide risk assessment instruments used across cohorts may represent a limitation to pooling data in international consortia. Our findings suggest that multi-item instruments provide valuable information on different aspects of suicidal thoughts or behavior but share a modest core factor with single suicidal ideation items. Retrospective, multisite collaborations including distinct instruments should be feasible provided they harmonize across instruments or focus on specific constructs of suicidality.
Article
Psychiatry
Lucia Sideli, Monica Aas, Diego Quattrone, Daniele La Barbera, Caterina La Cascia, Laura Ferraro, Luis Alameda, Eva Velthorst, Giulia Trotta, Giada Tripoli, Adriano Schimmenti, Andrea Fontana, Charlotte Gayer-Anderson, Simona Stilo, Fabio Seminerio, Crocettarachele Sartorio, Giovanna Marrazzo, Antonio Lasalvia, Sarah Tosato, Ilaria Tarricone, Domenico Berardi, Giuseppe D'Andrea, Celso Arango, Manuel Arrojo, Miguel Bernardo, Julio Bobes, Julio Sanjuan, Jose Luis Santos, Paulo Rossi Menezes, Cristina Marta Del-Ben, Hannah E. Jongsma, Peter B. Jones, James B. Kirkbride, Pierre-Michel Llorca, Andrea Tortell, Baptiste Pignon, Lieuwe de Haan, Jean-Paul Selten, Jim Van Os, Bart P. Rutten, Richard Bentall, Marta Di Fort, Robin M. Murray, Craig Morgan, Helen L. Fisher
Summary: This study aimed to investigate whether the relationship between childhood maltreatment and cognition in patients with psychosis and community controls was influenced by genetic factors related to psychosis. The study included first-episode psychosis patients (N=755) and unaffected controls (N=1219) from the EU-GEI study, who were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). The results showed that controlling for FH and SZ-PRS did not weaken the association between childhood maltreatment and IQ in either cases or controls, suggesting that genetic liability factors do not explain the lower levels of cognition in adults who experienced childhood maltreatment.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Psychiatry
Konstantinos N. Fountoulakis, Grigorios N. Karakatsoulis, Seri Abraham, Kristina Adorjan, Helal Uddin Ahmed, Renato D. Alarcon, Kiyomi Arai, Sani Salihu Auwal, Julio Bobes, Teresa Bobes-Bascaran, Julie Bourgin-Duchesnay, Cristina Ana Bredicean, Laurynas Bukelskis, Akaki Burkadze, Indira Indiana Cabrera Abud, Ruby Castilla-Puentes, Marcelo Cetkovich, Hector Colon-Rivera, Ricardo Corral, Carla Cortez-Vergara, Piirika Crepin, Domenico de Berardis, Sergio Zamora Delgado, David de Lucena, Avinash de Sousa, Ramona di Stefano, Seetal Dodd, Livia Priyanka Elek, Anna Elissa, Berta Erdelyi-Hamza, Gamze Erzin, Martin J. Etchevers, Peter Falkai, Adriana Farcas, Ilya Fedotov, Viktoriia Filatova, Nikolaos K. Fountoulakis, Iryna Frankova, Francesco Franza, Pedro Frias, Tatiana Galako, Cristian J. Garay, Leticia Garcia-Alvarez, Paz Garcia-Portilla, Xenia Gonda, Tomasz M. Gondek, Daniela Morera Gonzalez, Hilary Gould, Paolo Grandinetti, Arturo Grau, Violeta Groudeva, Michal Hagin, Takayuki Harada, Tasdik M. Hasan, Nurul Azreen Hashim, Jan Hilbig, Sahadat Hossain, Rossitza Iakimova, Mona Ibrahim, Felicia Iftene, Yulia Ignatenko, Matias Irarrazaval, Zaliha Ismail, Jamila Ismayilova, Asaf Jacobs, Miro Jakovljevic, Nenad Jaksic, Afzal Javed, Helin Yilmaz Kafali, Sagar Karia, Olga Kazakova, Doaa Khalifa, Olena Khaustova, Steve Koh, Svetlana Kopishinskaia, Korneliia Kosenko, Sotirios A. Koupidis, Illes Kovacs, Barbara Kulig, Alisha Lalljee, Justine Liewig, Abdul Majid, Evgeniia Malashonkova, Khamelia Malik, Najma Iqbal Malik, Gulay Mammadzada, Bilvesh Mandalia, Donatella Marazziti, Darko Marcinko, Stephanie Martinez, Eimantas Matiekus, Gabriela Mejia, Roha Saeed Memon, Xarah Elenne Meza Martinez, Dalia Mickeviciute, Roumen Milev, Muftau Mohammed, Alejandro Molina-Lopez, Petr Morozov, Nuru Suleiman Muhammad, Filip Mustac, Mika S. Naor, Amira Nassieb, Alvydas Navickas, Tarek Okasha, Milena Pandova, Anca-Livia Panfil, Liliya Panteleeva, Ion Papava, Mikaella E. Patsali, Alexey Pavlichenko, Bojana Pejuskovic, Mariana Pinto da Costa, Mikhail Popkov, Dina Popovic, Nor Jannah Nasution Raduan, Francisca Vargas Ramirez, Elmars Rancans, Salmi Razali, Federico Rebok, Anna Rewekant, Elena Ninoska Reyes Flores, Maria Teresa Rivera-Encinas, Pilar A. Saiz, Manuel Sanchez de Carmona, David Saucedo Martinez, Jo Anne Saw, Goerkem Saygili, Patricia Schneidereit, Bhumika Shah, Tomohiro Shirasaka, Ketevan Silagadze, Satti Sitanggang, Oleg Skugarevsky, Anna Spikina, Sridevi Sira Mahalingappa, Maria Stoyanova, Anna Szczegielniak, Simona Claudia Tamasan, Giuseppe Tavormina, Maurilio Giuseppe Maria Tavormina, Pavlos N. Theodorakis, Mauricio Tohen, Eva-Maria Tsapakis, Dina Tukhvatullina, Irfan Ullah, Ratnaraj Vaidya, Johann M. Vega-Dienstmaier, Jelena Vrublevska, Olivera Vukovic, Olga Vysotska, Natalia Widiasih, Anna Yashikhina, Panagiotis E. Prezerakos, Michael Berk, Sarah Levaj, Daria Smirnova
Summary: The current study aimed to investigate the rates of anxiety, clinical depression, and suicidality and their changes in health professionals during the COVID-19 outbreak. The study found a clinical depression rate of 13.16%, with male doctors and 'non-binary genders' having the lowest rates and 'non-binary gender' nurses and administrative staff having the highest rates. The study also highlighted a deterioration in mental state, family dynamics, and everyday lifestyle for some participants.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Psychiatry
Clara Martinez-Cao, Ainoa Garcia-Fernandez, Leticia Gonzalez-Blanco, Paula Zurron-Madera, Pilar A. Saiz, Maria Paz Garcia-Portilla, Julio Bobes
Summary: The study aims to identify protective and risk factors associated with high and low functioning in patients with schizophrenia. Through collecting and analyzing information from 212 outpatients, it was found that years of education have a protective effect on high functioning, while factors such as employment status, number of antipsychotics used, and depressive and negative experiential symptoms are related to low functioning.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Diego Hidalgo-Mazzei, Tim Mantingh, Xavier Perez de Mendiola, Ludovic Samalin, Juan Undurraga, Sergio Strejilevich, Emanuel Severus, Michael Bauer, Ana Gonzalez-Pinto, Willem A. Nolen, Allan H. Young, Eduard Vieta
Summary: A global survey conducted by the ISBD Task Force on the Role of Lithium in Bipolar Disorders revealed potential factors contributing to the decline in lithium prescriptions in the past two decades. The survey received 886 responses from 43 different countries, showing that lithium remains the preferred treatment option for bipolar disorder maintenance (59%), but negative beliefs, acute side effects, tolerability problems, and intoxication risk are reasons for not choosing lithium.
INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
(2023)
Article
Neurosciences
Vivian Accardo, Stefano Barlati, Anna Ceraso, Gabriele Nibbio, Eduard Vieta, Antonio Vita
Summary: This study aims to evaluate the effectiveness of functional remediation (FR) in improving neurocognitive dysfunctions in patients with bipolar disorder (BD) compared to treatment as usual (TAU). The Brief Assessment of Cognition in Affective Disorders (BAC-A) and the Functioning Assessment Short Test (FAST) will be used to measure neurocognitive damage and overall psychosocial functioning, respectively. The expected outcome is that patients who undergo FR intervention will show improved cognitive abilities and psychosocial outcomes compared to the TAU group.
Meeting Abstract
Psychiatry
C. Cachan-Vega, E. Antuna, C. Garcia-Gonzalez, J. C. Bermejo-Millo, F. Baena-Huerta, L. Gonzalez-Blanco, B. Caballero, I. Vega-Naredo, J. Bobes, M. P. Garcia-Portilla, A. Coto-Montes, Y. Potes
EUROPEAN PSYCHIATRY
(2023)
Meeting Abstract
Psychiatry
C. Cachan, I. M. Valle, Y. Potes, A. Gonzalez Rubio, N. Menendez Coto, D. Lopez Fanjul, I. Vega Naredo, B. Caballero, P. Saiz, J. Bobes, P. Garcia Portilla, A. Coto Montes
EUROPEAN PSYCHIATRY
(2023)
