期刊
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES
卷 14, 期 4, 页码 195-204出版社
ASSOC BASIC MEDICAL SCI FEDERATION BOSNIA & HERZEGOVINA SARAJEVO
DOI: 10.17305/bjbms.2014.4.91
关键词
vitamin E; tocotrienol rich fraction; alpha tocopherol; glutamate; astrocytes
资金
- Faculty of Medicine and Health Sciences Grant Scheme, University Putra Malaysia [9300337]
Tocotrienol rich fraction (TRF) is an extract of palm oil, which consists of 25% alpha tocopherol (alpha-TCP) and 75% tocotrienols. TRF has been shown to possess potent antioxidant, anti-inflammatory, anticancer, neuroprotection, and cholesterol lowering activities. Glutamate is the main excitatory amino acid neurotransmitter in the central nervous system of mammalian, which can be excitotoxic, and it has been suggested to play a key role in neurodegenerative disorders like Parkinson's and Alzheimer's diseases. In this present study, the effects of vitamin E (TRF and alpha-TCP) in protecting astrocytes against glutamate injury were elucidated. Astrocytes induced with 180 mM of glutamate lead to significant cell death. However, glutamate mediated cytotoxicity was diminished via pre and post supplementation of TRF and alpha-TCP. Hence, vitamin E acted as a potent antioxidant agent in recovering mitochondrial injury due to elevated oxidative stress, and enhanced better survivability upon glutamate toxicity
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