Article
Medicine, General & Internal
Stefan Gunawan, Tanja Elger, Johanna Loibl, Tanja Fererberger, Stefanie Sommersberger, Arne Kandulski, Martina Mueller, Hauke Christian Tews, Christa Buechler
Summary: This study found that chemerin protein was not detectable in human feces but could be detected in urine. The concentration of chemerin in urine was lower compared to serum levels. Urinary chemerin was associated with IBD activity and fecal calprotectin levels.
FRONTIERS IN MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Hee Sook Hwang, Hyosuk Kim, Geonhee Han, Jong Won Lee, Kwangmeyung Kim, Ick Chan Kwon, Yoosoo Yang, Sun Hwa Kim
Summary: Extracellular vesicles play an important role in inflammatory diseases, and can be engineered to target specific cells, making them promising nanoparticles for personalized therapeutic carriers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Medicinal
Dandan Liu, Varma Saikam, Katie A. Skrada, Didier Merlin, Suri S. Iyer
Summary: Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract, which can be diagnosed through endoscopy and biopsy. However, these methods are expensive and invasive, so alternative noninvasive biomarkers are being explored for disease management and prognosis.
MEDICINAL RESEARCH REVIEWS
(2022)
Review
Medicine, General & Internal
Cristina Bauset, Laura Gisbert-Ferrandiz, Jesus Cosin-Roger
Summary: IBD is a chronic gastrointestinal disorder characterized by disruption of epithelial barrier function and immune response, lacking biomarkers for early diagnosis. Metabolomics may reveal promising metabolites to understand pathology and identify therapeutic targets.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Joao Victor Silva-Silva, Carla J. Moragas-Tellis, Maria S. S. Chagas, Paulo Victor R. Souza, Davyson L. Moreira, Celeste S. F. de Souza, Kerolain F. Teixeira, Arthur R. Cenci, Aldo S. de Oliveira, Fernando Almeida-Souza, Maria D. Behrens, Katia S. Calabrese
Summary: This study evaluated the leishmanicidal activity of a crude extract and anthocyanidin-rich fractions from Arrabidaea chica, as well as three isolated anthocyanidins. The results showed promising anti-leishmanial effects of these compounds, indicating their potential as therapeutic agents for leishmaniasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
David Vogrinc, Milica Gregoric Kramberger, Andreja Emersic, Sasa Cucnik, Katja Goricar, Vita Dolzan
Summary: Oxidative stress and neuroinflammation are important processes involved in Alzheimer's disease and mild cognitive impairment. This study evaluated the association of polymorphisms in oxidative stress- and inflammation-related genes with cerebrospinal fluid biomarker levels and cognitive test results. The results showed that IL1B rs16944 carriers had higher CSF A beta(1-42) levels, while NFE2L2 rs35652124 carriers had lower CSF A beta(1-42) levels. Several gene variants, including CAT rs1001179, GSTP1 rs1138272, KEAP1 rs1048290 and rs9676881, and NFE2L2 rs35652124, were significantly associated with cognitive test scores.
Article
Nutrition & Dietetics
Georgiana-Emmanuela Gilca-Blanariu, Anca Trifan, Manuela Ciocoiu, Iolanda Valentina Popa, Alexandru Burlacu, Gheorghe G. Balan, Andrei Vasile Olteanu, Gabriela Stefanescu
Summary: This study found that hair magnesium concentration in IBD patients is significantly lower compared to healthy controls, and is related to disease activity, psychological status, and sleep quality. The findings suggest that magnesium may play a crucial role in IBD pathophysiology, and supplementation could potentially improve disease progression and sleep quality for patients with magnesium deficiency.
Article
Immunology
Wasuwit Wanchaitanawong, Nithi Thinrungroj, Siriporn C. Chattipakorn, Nipon Chattipakorn, Krekwit Shinlapawittayatorn
Summary: Inflammatory bowel disease (IBD) is a group of intestinal disorders with increasing global incidence. Despite existing treatments not being effective for all patients, metformin has shown significant benefits for IBD and could be a promising therapeutic option.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
Xue Guo, Chen Huang, Jing Xu, Haoming Xu, Le Liu, Hailan Zhao, Jiaqi Wang, Wenqi Huang, Wu Peng, Ye Chen, Yuqiang Nie, Yongjian Zhou, Youlian Zhou
Summary: Inflammatory bowel disease (IBD) is characterized by relapse and remission, making it challenging to diagnose and assess disease activity. Traditional biomarkers from plasma and stool lack specificity, while changes in gut microbiota are closely associated with IBD etiology and pathogenesis.
FRONTIERS IN NUTRITION
(2022)
Review
Pharmacology & Pharmacy
Xiaomei Wang, Guoliang Zhou, Wanwan Zhou, Xin Wang, Xiao Wang, Chenggui Miao
Summary: Inflammatory bowel disease (IBD) is a type of chronic relapsing inflammatory disease with unclear pathogenesis involving environmental factors, genetic factors, intestinal microbiota disorder, and abnormal immune responses. Exosomes, with sizes ranging from 30-150 nm, are involved in IBD pathogenesis by mediating intercellular communication and regulating cell activity through non-coding RNAs, proteins, and lipids. Understanding the roles of exosomes in IBD may offer new diagnostic markers and therapeutic targets.
Article
Gastroenterology & Hepatology
Omer S. Omer, Arnulf Hertweck, Luke B. Roberts, Jonathan W. Lo, Jennie N. Clough, Ian Jackson, Eirini D. Pantazi, Peter M. Irving, Tom T. MacDonald, Polychronis Pavlidis, Richard G. Jenner, Graham M. Lord
Summary: Targeting the transactivation function of T-bet using CDK9 inhibitors can improve immune-mediated colitis in IBD patients and selectively suppress genes responsible for pro-inflammatory signaling, especially those regulated by T-bet. CDK9 inhibition may also be a potential therapeutic target for anti-TNF-resistant IBD.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Cell Biology
Tetsuhiro Yoshimura, Keiichi Mitsuyama, Ryosuke Sakemi, Hidetoshi Takedatsu, Shinichiro Yoshioka, Kotaro Kuwaki, Atsushi Mori, Shuhei Fukunaga, Toshihiro Araki, Masaru Morita, Kozo Tsuruta, Hiroshi Yamasaki, Takuji Torimura
Summary: This study investigated the utility of serum leucine-rich alpha-2 glycoprotein (LRG) as an inflammatory marker for inflammatory bowel disease (IBD) including ulcerative colitis (UC) and Crohn's disease (CD). The study found that serum LRG levels were correlated with disease activity and various laboratory parameters in UC and CD, as well as with endoscopic disease activity in UC. Additionally, LRG gene expression in peripheral blood mononuclear cells (PBMCs) reflected disease activity. These findings suggest that LRG could serve as an inflammatory marker in UC and CD, warranting further large-scale studies to reveal its clinical significance.
MEDIATORS OF INFLAMMATION
(2021)
Review
Biotechnology & Applied Microbiology
Ting Zhang, Xinghui Ji, Gaochen Lu, Faming Zhang
Summary: Akkermansia muciniphila is a promising next-generation probiotic with recognized potential applications in metabolic diseases and tumor immunotherapy. Its safety and therapeutic value in human metabolic diseases have been confirmed in recent clinical trials. Additionally, A. muciniphila shows promise in the treatment of intestinal inflammatory diseases, particularly inflammatory bowel disease (IBD).
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Shinichiro Shinzaki, Katsuyoshi Matsuoka, Hiroki Tanaka, Fuminao Takeshima, Shingo Kato, Takehiro Torisu, Yuki Ohta, Kenji Watanabe, Shiro Nakamura, Naoki Yoshimura, Taku Kobayashi, Akiko Shiotani, Fumihito Hirai, Sakiko Hiraoka, Mamoru Watanabe, Minoru Matsuura, Shohei Nishimoto, Shinta Mizuno, Hideki Iijima, Tetsuo Takehara, Tetsuji Naka, Takanori Kanai, Takayuki Matsumoto
Summary: This study evaluated the usefulness of serum leucin-rich alpha-2 glycoprotein (LRG) levels in monitoring disease activity in inflammatory bowel disease (IBD) during adalimumab treatment. The results showed that serum LRG levels correlated with endoscopic activity in both Crohn's disease (CD) and ulcerative colitis (UC), and had better correlation compared to C-reactive protein (CRP) and fecal calprotectin (fCal). Serum LRG was found to be a useful biomarker for assessing endoscopic activity in IBD patients.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Matthias Zilbauer, Robert Heuschkel
Summary: Inflammatory bowel diseases like Crohn's disease and ulcerative colitis are complex conditions that require personalized treatment approaches. Developing biomarkers to predict disease course and treatment response is challenging.
JOURNAL OF CROHNS & COLITIS
(2022)
