Has the era of individualised medicine arrived for antifungals? A review of antifungal pharmacogenomics

A post-marketing evaluation of posaconazole plasma concentrations in neutropenic patients with haematological malignancy receiving posaconazole prophylaxis

(2011) Alexander M. Bryant et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Therapeutic Drug Monitoring of Voriconazole and Posaconazole

(2011) Trana Hussaini et al.   PHARMACOTHERAPY

Modulators of Very Low Voriconazole Concentrations in Routine Therapeutic Drug Monitoring

(2011) Arwa Hassan et al.   THERAPEUTIC DRUG MONITORING

Development and validation of a quantitative assay based on tandem mass spectrometry

(2011) J. W. Honour   ANNALS OF CLINICAL BIOCHEMISTRY

Pharmacokinetic/Pharmacodynamic Profile of Posaconazole

(2010) Yanjun Li et al.   CLINICAL PHARMACOKINETICS

Exposure–Response of Posaconazole Used for Prophylaxis Against Invasive Fungal Infections: Evaluating the Need to Adjust Doses Based on Drug Concentrations in Plasma

(2010) S H Jang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

In Vitro Investigation of the Hepatobiliary Disposition Mechanisms of the Antifungal Agent Micafungin in Humans and Rats

(2010) S. B. Yanni et al.   DRUG METABOLISM AND DISPOSITION

Investigation into UDP-Glucuronosyltransferase (UGT) Enzyme Kinetics of Imidazole- and Triazole-Containing Antifungal Drugs in Human Liver Microsomes and Recombinant UGT Enzymes

(2010) K. Bourcier et al.   DRUG METABOLISM AND DISPOSITION

The promises of personalized medicine

(2010) Ingolf Cascorbi   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacokinetics, antifungal activity and clinical efficacy of anidulafungin in the treatment of fungal infections

(2010) Effie L Kuti et al.   Expert Opinion on Drug Metabolism & Toxicology

Increased Oral Bioavailability of Itraconazole and Its Active Metabolite, 7-Hydroxyitraconazole, When Coadministered With a Vitamin C Beverage in Healthy Participants

(2010) Soo Kyung Bae et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Cellular localization of the organic cation transporters, OCT1 and OCT2, in brain microvessel endothelial cells and its implication for MPTP transport across the blood-brain barrier and MPTP-induced dopaminergic toxicity in rodents

(2010) Chun-Jung Lin et al.   JOURNAL OF NEUROCHEMISTRY

In Vitro-In Vivo Extrapolation Predicts Drug-Drug Interactions Arising from Inhibition of Codeine Glucuronidation by Dextropropoxyphene, Fluconazole, Ketoconazole, and Methadone in Humans

(2010) P. Raungrut et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Acquired antifungal drug resistance inAspergillus fumigatus:epidemiology and detection

(2010) Susan Julie Howard et al.   MEDICAL MYCOLOGY

Itraconazole-Induced Cholestasis: Involvement of the Inhibition of Bile Canalicular Phospholipid Translocator MDR3/ABCB4

(2010) T. Yoshikado et al.   MOLECULAR PHARMACOLOGY

Echinocandins: The Newest Class of Antifungals

(2009) Allana J Sucher et al.   ANNALS OF PHARMACOTHERAPY

Posaconazole Therapeutic Drug Monitoring: a Reference Laboratory Experience

(2009) G. R. Thompson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Drug interactions and adverse events associated with antimycotic drugs used for invasive aspergillosis in hematopoietic SCT

(2009) S S Egger et al.   BONE MARROW TRANSPLANTATION

Drug interaction between voriconazole and calcineurin inhibitors in allogeneic hematopoietic stem cell transplant recipients

(2009) T Mori et al.   BONE MARROW TRANSPLANTATION

Impact of OATP transporters on pharmacokinetics

(2009) A Kalliokoski et al.   BRITISH JOURNAL OF PHARMACOLOGY

Clinical Relevance of the Pharmacokinetic Interactions of Azole Antifungal Drugs with Other Coadministered Agents

(2009) Roger J. M. Brüggemann et al.   CLINICAL INFECTIOUS DISEASES

Voriconazole concentrations and outcome of invasive fungal infections

(2009) S. Miyakis et al.   CLINICAL MICROBIOLOGY AND INFECTION

Drug Uptake Systems in Liver and Kidney: A Historic Perspective

(2009) B Hagenbuch   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pharmacokinetics and safety of 14 days intravenous voriconazole in allogeneic haematopoietic stem cell transplant recipients

(2009) R. J. M. Bruggemann et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Azole resistance in Aspergillus fumigatus: a side-effect of environmental fungicide use?

(2009) Paul E Verweij et al.   LANCET INFECTIOUS DISEASES

Scientific and Regulatory Perspectives on Metabolizing Enzyme−Transporter Interplay and Its Role in Drug Interactions: Challenges in Predicting Drug Interactions†

(2009) Lei Zhang et al.   MOLECULAR PHARMACEUTICS

A pharmacogenetics study of the human glucuronosyltransferase UGT1A4

(2009) Marie-Odile Benoit-Biancamano et al.   Pharmacogenetics and Genomics

Polymorphic variants in the human bile salt export pump (BSEP; ABCB11): functional characterization and interindividual variability

(2009) Richard H. Ho et al.   Pharmacogenetics and Genomics

Next-Generation DNA Sequencing Methods

(2008) Elaine R. Mardis   Annual Review of Genomics and Human Genetics

International Interlaboratory Proficiency Testing Program for Measurement of Azole Antifungal Plasma Concentrations

(2008) R. J. M. Bruggemann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacokinetics and Absorption of Posaconazole Oral Suspension under Various Gastric Conditions in Healthy Volunteers

(2008) G. Krishna et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro and In Vivo Studies To Characterize the Clearance Mechanism and Potential Cytochrome P450 Interactions of Anidulafungin

(2008) B. D. Damle et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Comprehensive In Vitro Analysis of Voriconazole Inhibition of Eight Cytochrome P450 (CYP) Enzymes: Major Effect on CYPs 2B6, 2C9, 2C19, and 3A

(2008) S. Jeong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mechanism of decrease of oral bioavailability of cyclosporin A during immunotherapy upon coadministration of amphotericin B

(2008) Junko Ishizaki et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Reply to Cornely and Ullmann and to Jain and Pottinger

(2008) Vijayalakshmi Nagappan et al.   CLINICAL INFECTIOUS DISEASES

The Enzymatic Basis of Drug-Drug Interactions with Systemic Triazole Antifungals

(2008) Yasmine Nivoix et al.   CLINICAL PHARMACOKINETICS

The Role of Ethnicity in Variability in Response to Drugs: Focus on Clinical Pharmacology Studies

(2008) SU Yasuda et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Genetic Variation in Drug Transporters in Ethnic Populations

(2008) CD Cropp et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Role of Flavin-Containing Monooxygenase in Oxidative Metabolism of Voriconazole by Human Liver Microsomes

(2008) S. B. Yanni et al.   DRUG METABOLISM AND DISPOSITION

The CYP2C19 ultra-rapid metabolizer genotype influences the pharmacokinetics of voriconazole in healthy male volunteers

(2008) Guo Wang et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Mechanisms of renal anionic drug transport

(2008) Azza A.K. El-Sheikh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

CYP2C19Genotype Is a Major Factor Contributing to the Highly Variable Pharmacokinetics of Voriconazole

(2008) Johanna Weiss et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Toll-like Receptor 4 Polymorphisms and Aspergillosis in Stem-Cell Transplantation

(2008) Pierre-Yves Bochud et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vincristine induced peripheral neuropathy potentiated by voriconazole in a patient with previously undiagnosed CMT1X

(2008) Christopher C. Porter et al.   PEDIATRIC BLOOD & CANCER

Concomitant Use of Voriconazole and Rifabutin in a Patient with Multiple Infections

(2008) Joshua N Schwiesow et al.   PHARMACOTHERAPY

Emergence of Azole Resistance in Aspergillus fumigatus and Spread of a Single Resistance Mechanism

(2008) Eveline Snelders et al.   PLOS MEDICINE

Cytochrome P450 and Chemical Toxicology

(2007) F. Peter Guengerich   CHEMICAL RESEARCH IN TOXICOLOGY

Voriconazole Therapeutic Drug Monitoring in Patients with Invasive Mycoses Improves Efficacy and Safety Outcomes

(2007) A. Pascual et al.   CLINICAL INFECTIOUS DISEASES