Article
Infectious Diseases
Alessia G. Servidio, Roberto Simeone, Davide Zanon, Egidio Barbi, Natalia Maximova
Summary: The efficacy between levofloxacin and ciprofloxacin prophylaxis in pediatric recipients undergoing allogeneic hematopoietic stem cell transplantation for hematological malignancies is similar, but levofloxacin prophylaxis is associated with significantly lower cumulative antibiotic exposure.
Article
Infectious Diseases
Mobil Akhmedov, Galina Klyasova, Larisa Kuzmina, Elena Parovichnikova
Summary: This study aimed to analyze the rate and etiology of recurrent bloodstream infection (BSI) in allogeneic hematopoietic cell transplant (allo-HCT) recipients. The results showed that recurrent BSI is rarely caused by the same pathogen, therefore empirical antimicrobial therapy should not be based solely on previous BSI data.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2023)
Article
Infectious Diseases
Thais Guimaraes, Igor Carmo Borges, Fernanda de Souza Spadao, Livia Mariano, Marina de Mattos Nascimento, Hermes Higashino, Flavia Rossi, Vanderson Rocha, Silvia Figueiredo Costa
Summary: The non-use of fluoroquinolone prophylaxis during neutropenia can reduce antibiotic resistance in Gram-negative bacteria causing bloodstream infections (BSIs) in hematopoietic stem cell transplantation (HSCT) patients. However, it may also increase BSI incidence and mortality rates.
Article
Microbiology
Jessica Gill, Alessandro Busca, Natascia Cinatti, Roberto Passera, Chiara Maria Dellacasa, Luisa Giaccone, Irene Dogliotti, Sara Manetta, Silvia Corcione, Francesco Giuseppe De Rosa
Summary: This study retrospectively observed allo-HSCT recipients and found that bacterial bloodstream infections pose a major risk to these patients, with multidrug-resistant organisms being a significant cause of morbidity and mortality. Independent risk factors for BSI occurrence include high and very high disease risk index, haploidentical transplant, and antibacterial prophylaxis.
Article
Infectious Diseases
Weijie Cao, Lina Guan, Xiaoning Li, Ran Zhang, Li Li, Suping Zhang, Chong Wang, Xinsheng Xie, Zhongxing Jiang, Dingming Wan, Xiaohui Chi
Summary: This retrospective study analyzed the occurrence of bloodstream infections (BSI) in 397 patients who underwent allogeneic hematopoietic stem cell transplantation. The study revealed a BSI incidence rate of 17.7%, primarily caused by Gram-negative bacteria with high resistance to carbapenem drugs. Risk factors for BSI included pre-treatment with ATG, duration of agranulocytosis, and stem cell source.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Microbiology
Nadine Rouphael, Patricia Winokur, Michael C. Keefer, Jessica Traenkner, Ana Drobeniuc, Yohei Doi, Sonal Munsiff, Vance G. Fowler, Scott Evans, Randolph E. Oler, Bonifride Tuyishimire, Marina Lee, Varduhi Ghazaryan, Henry F. Chambers
Summary: Concerns over resistance and safety have been identified in the current treatment regimen for complicated urinary tract infections. Fosfomycin is a drug that is routinely used for the treatment of uncomplicated cystitis. This study shows that fosfomycin could be an oral alternative as step-down therapy for the treatment of complicated urinary tract infections, with a clinical cure rate comparable to levofloxacin but a lower microbiological success rate 3 weeks from start of antibiotics.
Article
Microbiology
Carmine Liberatore, Francesca Farina, Raffaella Greco, Fabio Giglio, Daniela Clerici, Chiara Oltolini, Maria Teresa Lupo Stanghellini, Federica Barzaghi, Paolo Vezzulli, Elena Orsenigo, Consuelo Corti, Fabio Ciceri, Jacopo Peccatori
Summary: Despite the introduction of mold-active antifungal prophylaxis, breakthrough invasive fungal infections remain a possible complication for hematological patients and hematopoietic stem-cell transplantation recipients. Management of these infections is challenging and requires individualized antifungal treatment based on risk factors, ongoing prophylaxis, and local epidemiology. Early broad-spectrum preemptive therapy is advisable to cover against rare fungal strains and atypical infection sites.
Article
Infectious Diseases
Wen Song, Xiaochao Song, Yinting Zhu, Yalu Ren, Jie Xu, Qiongfang Zhu
Summary: This retrospective cohort study analyzed the microbiological characteristics and 30-day all-cause mortality in patients with bloodstream infections after hematopoietic stem cell transplantation. Gram-negative bacteria were the most common pathogens, and showed high resistance rates to common antibiotics. Fungal infections and non-Hodgkin's lymphoma were associated with higher 30-day mortality.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Immunology
Alessandro Busca, Natascia Cinatti, Jessica Gill, Roberto Passera, Chiara Maria Dellacasa, Luisa Giaccone, Irene Dogliotti, Sara Manetta, Silvia Corcione, Francesco Giuseppe De Rosa
Summary: This study aimed to assess the epidemiology and prognostic factors of invasive fungal infections (IFI) in a large cohort of allo-HSCT patients. The results showed that the presence of IFI had a significant impact on overall survival at 1 year, and donor type was significantly associated with the risk of IFI.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Omnia Elebyary, Noah Fine, Chunxiang Sun, Sourav T. Saha, Shawn Robinson, Zahra Dorna Mojdami, Nicole Khoury, Erin Watson, Bryan Coburn, Jeffrey H. Lipton, Michael Glogauer
Summary: Allogeneic stem cell transplant recipients with <10% primed polymorphonuclear neutrophils (pPMNs) exhibited a greater risk of developing bloodstream infections, highlighting the potential use of pPMN quantification in monitoring susceptibility to these infectious complications.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Ana M. Quintero, Diego A. Cruz Vidal, Brett G. Klamer, Monica Ardura, Sophonie J. Oyeniran
Summary: Implementation of LVX prophylaxis among high-risk children with underlying malignancy led to reduced rates of fluoroquinolone susceptible VGS bloodstream isolates over time, without significant differences in clinical outcomes when compared to subjects with LVX susceptible BSI isolates.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2023)
Article
Hematology
Francesca Marzuttini, Antonella Mancusi, Samanta Bonato, Mario Griselli, Sara Tricarico, Genni Casarola, Matteo Paradiso, Loredana Ruggeri, Adelmo Terenzi, Mara Merluzzi, Anna Prigitano, Anna Maria Tortorano, Lucia Pitzurra, Brunangelo Falini, Alessandra Carotti, Andrea Velardi, Antonio Pierini
Summary: The study evaluated the safety and outcomes of using rifaximin prophylaxis in patients undergoing hematopoietic stem cell transplantation, finding an increased risk of Candida spp. infections in rifaximin-treated patients compared to historical controls, highlighting the need for larger prospective studies to assess the overall impact of rifaximin prophylaxis on patient outcomes.
ANNALS OF HEMATOLOGY
(2021)
Article
Pediatrics
Michael L. Rinke, Moonseong Heo, Lisa Saiman, David G. Bundy, Rebecca E. Rosenberg, Patricia DeLaMora, Barbara Rabin, Philip Zachariah, Parsa Mirhaji, William J. H. Ford, Oghale Obaro-Best, Michael Drasher, Elizabeth Klein, Alexandre Peshansky, Suzette O. Oyeku
Summary: The study identified a substantial incidence density of ambulatory pediatric CLABSI and its association with healthcare utilization. The type of CL, patients with low albumin, prophylactic antimicrobial agents, and placement setting may be targeted for reduction efforts.
Article
Infectious Diseases
Sho Ogura, Muneyoshi Kimura, Shinsuke Takagi, Takashi Mitsuki, Mitsuhiro Yuasa, Kosei Kageyama, Daisuke Kaji, Aya Nishida, Yuki Taya, Kazuya Ishiwata, Hisashi Yamamoto, Yuki Asano-Mori, Go Yamamoto, Naoyuki Uchida, Atsushi Wake, Shuichi Taniguchi, Hideki Araoka
Summary: This study aimed to clarify the characteristics of gram-negative bacteremia among allo-HSCT recipients on LVFX prophylaxis, specifically focusing on ESBL-producing pathogens. The results showed that GNB was not a significant cause of death, and empiric CFPM administration in cases of LVFX breakthrough ESBL-EC bacteremia did not lead to significantly poor prognosis, suggesting it may be an acceptable strategy.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Review
Immunology
Sherry A. Dunbar, Christopher Gardner, Shubhagata Das
Summary: This article describes the application of two rapid, molecular bloodstream infection panels that can identify the most common pathogens and associated genetic determinants of antibiotic resistance, providing clinicians with faster information for treatment. Molecular testing methods reduce the turnaround time for diagnosing bloodstream pathogens to a few hours, helping to initiate timely and effective treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Hematology
Yao-Chung Liu, Sheng-Hsuan Chien, Nai-Wen Fan, Ming-Hung Hu, Jyh-Pyng Gau, Chia-Jen Liu, Yuan-Bin Yu, Chun-Yu Liu, Liang-Tsai Hsiao, Jin-Hwang Liu, Tzeon-Jye Chiou, Cheng-Hwai Tzeng
BRITISH JOURNAL OF HAEMATOLOGY
(2015)
Article
Medicine, General & Internal
Sheng-Hsiang Yang, Liang-Tsai Hsiao, Tzeon-Jye Chiou, Ching-Fen Yang, Yuan-Bin Yu, Chun-Yu Liu, Jyh-Pyng Gau, Jin-Hwang Liu, Po-Min Chen, Cheng-Hwai Tzeng
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2015)
Article
Medicine, General & Internal
Ming-Huang Chen, Ying-Ju Kuo, Yi-Chen Yeh, Ying-Chu Lin, Cheng-Hwai Tzeng, Chun-Yu Liu, Peter Mu-Hsin Chang, Ming-Han Chen, Yung-Ming Jeng, Yee Chao
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2015)
Article
Medicine, Research & Experimental
Chun-Yu Liu, Kuen-Feng Chen, Pei-Jer Chen
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2015)
Article
Immunology
Yao-Chung Liu, Sheng-Hsuan Chien, Nai-Wen Fan, Ming-Hung Hu, Jyh-Pyng Gau, Chia-Jen Liu, Yuan-Bin Yu, Chun-Yu Liu, Liang-Tsai Hsiao, Jin-Hwang Liu, Tzeon-Jye Chiou, Po-Min Chen, Cheng-Hwai Tzeng
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2016)
Article
Hematology
Ming-Hung Hu, Yuan-Bin Yu, Yu-Chung Huang, Jyh-Pyng Gau, Liang-Tsai Hsiao, Jin-Hwang Liu, Ming-Huang Chen, Tzeon-Jye Chiou, Po-Min Chen, Cheng-Hwai Tzeng, Chun-Yu Liu
ANNALS OF HEMATOLOGY
(2014)
Article
Biotechnology & Applied Microbiology
T-C Chao, L-C Chan, S-Y Ju, M-C Tang, C-Y Liu, P-M Chen, C-H Tzeng, Y. Su
CANCER GENE THERAPY
(2014)
Article
Oncology
Jung-Chen Su, Heng-Chieh Chiang, Ping-Hui Tseng, Wei-Tien Tai, Cheng-Yi Hsu, Yong-Shi Li, Jui-Wen Huang, Ching-Huai Ko, Mai-Wei Lin, Pei-Yi Chu, Chun-Yu Liu, Kuen-Feng Chen, Chung-Wai Shiau
Article
Oncology
Liang-Tsai Hsiao, Hwei-Fang Tien, Ching-Yuan Kuo, Jin-Hou Wu, Hsin-An Hou, Ming-Chung Wang, Chun-Yu Liu, Po-Min Chen, Tzeon-Jye Chiou
HEMATOLOGICAL ONCOLOGY
(2015)
Article
Medicine, General & Internal
Yao-Chung Liu, Jyh-Pyng Gau, Yuan-Bin Yu, Ying-Chung Hong, Chueh-Chuan Yen, Chun-Yu Liu, Ta-Chung Chao, Liang-Tsai Hsiao, Jin-Hwang Liu, Tzeon-Jye Chiou, Cheng-Hwai Tzeng
Article
Medicine, General & Internal
C-T. Huang, Y-H. Lee, K-C. Chow, C-F. Yang, P. C-H. Chen, L-T. Hsiao, J-P. Gau, C-H. Tzeng, C-Y. Liu, T-J. Chiou
INTERNAL MEDICINE JOURNAL
(2014)
Article
Oncology
Yi-Ping Hung, Chung-Jen Teng, Chia-Jen Liu, Yu-Wen Hu, Man-Hsin Hung, Cheng-Hwai Tzeng, Chun-Yu Liu, Chiu-Mei Yeh, Tzeng-Ji Chen, Tzeon-Jye Chiou
INTERNATIONAL JOURNAL OF CANCER
(2014)
Article
Medicine, General & Internal
Dai-Yin Lu, Jyh-Pyug Gau, Ying-Chung Hong, Chun-Yu Liu, Yuan-Bin Yu, Liang-Tsai Hsiao, Jin-Hwang Liu, Po-Min Chen, Tzeon-Jye Chiou, Cheng-Hwai Tzeng
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2014)
Article
Multidisciplinary Sciences
Man-Hsin Hung, Chun-Yu Liu, Cheng-Ying Shiau, Chin-Yi Hsu, Yi-Fang Tsai, Yu-Ling Wang, Ling-Chen Tai, Kuang-Liang King, Ta-Chung Chao, Jen-Hwey Chiu, Cheng-Hsi Su, Su-Shun Lo, Cheng-Hwai Tzeng, Yi-Ming Shyr, Ling-Ming Tseng
Article
Oncology
Jung-Chen Su, Ping-Hui Tseng, Szu-Hsien Wu, Cheng-Yi Hsu, Wei-Tien Tai, Yong-Shi Li, I-Ting Chen, Chun-Yu Liu, Kuen-Feng Chen, Chung-Wai Shiau