Article
Andrology
Shaian Tavakolian, Hossein Goudarzi, Nazarian Hamid, Pourya Raee, Sarah Niakan, Ebrahim Faghihloo
Summary: Viral infections, such as Papillomaviridae and Herpesviridae, can lead to infertility. HSV-1 and VZV were found in some semen samples, while HPV infection may be eliminated through sperm washing. Further investigation is needed due to the small sample size.
Review
Microbiology
Takayuki Murata
Summary: The immune system's activation and regulated downregulation are crucial for preventing immune disorders. The PD-1/PD-L1 pathway benefits the host but can also be exploited by pathogens to evade immunity. Herpesviruses like HSV, CMV, and EBV have complex relationships with this pathway and understanding them is essential for developing effective preventative and therapeutic methods.
Review
Infectious Diseases
Ana Banko, Danijela Miljanovic, Andja Cirkovic
Summary: This study conducted a systematic review and meta-analysis of 36 publications, finding that the prevalence of active EBV, HHV6, HSV, CMV, HSV1, and VZV infection in COVID-19 patients was 41%, 3%, 28%, 25%, 22%, and 18%, respectively. The risk of active EBV infection in severe COVID-19 patients was 6 times higher than in non-COVID-19 controls. Prioritized research on co-infections of herpesviruses and SARS-CoV-2 is needed to determine who, when, and how to be tested, as well as how to effectively treat HHVs reactivations in acute and long COVID-19 patients.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Immunology
Madalina Preda, Loredana Sabina Cornelia Manolescu, Razvan Daniel Chivu
Summary: Alpha herpes simplex viruses pose a significant public health problem, affecting people of all ages. From common cold sores to severe conditions like encephalitis and newborn mortality, the virus produces varying levels of pathology. While there is an efficient vaccine for varicella-zoster virus, there is no available vaccine for herpes simplex virus 1 and 2 despite several approaches, including trivalent subunit vaccines and bioinformatic studies. However, recent promising attempts, such as a trivalent vaccine and a multivalent DNA vaccine, offer hope for future solutions.
Article
Biochemistry & Molecular Biology
Anna Majewska, Beata Mlynarczyk-Bonikowska
Summary: Herpes simplex viruses and cytomegalovirus are common pathogens with significant impact on immunocompromised patients. Drug-resistant strains and frequent recurrences pose challenges, and congenital infections are particularly concerning. This article explores anti-herpesviral agents, drug resistance mechanisms, and potential treatments like immunotherapy and vaccines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Mohamed S. Kamel, Rachel A. Munds, Mohit S. Verma
Summary: Herpesviruses, as powerful gene therapy tools, have been extensively used and developed as vaccine vectors to combat infectious diseases and develop cancer-related antigen vaccines. Better understanding of herpesvirus biology and the interactions between viruses and host cells can improve vaccine development and enhance safety and efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Virology
Angus C. Wilson
Summary: Neurotropic alpha-herpesviruses have the ability to establish latent infections in peripheral neurons and reactivate under certain conditions. In this review, the author reflects on the strengths and weaknesses of existing neuronal models to study latency and reactivation, and summarizes the important insights these models have provided. The discussion also highlights areas where prioritization can contribute to ongoing progress and integration.
Article
Virology
Richard J. Roller, Tineke Hassman, Alison Haugo-Crooks
Summary: The study found that substituting the HSV-1 UL34 coding sequence with VZV ORF24 resulted in viral defects in growth and spread, despite normal protein interaction and localization. Cell culture evolution showed that the mutated viruses grew and spread more efficiently, revealing the important roles of ICP22 and ICP4 in nuclear lamina disruption and capsid nuclear egress.
JOURNAL OF VIROLOGY
(2021)
Article
Virology
Farnaz Dayyani, Shaian Tavakolian, Hossein Goudarzi, Farzad Yazdani Biucki, Ebrahim Faghihloo
Summary: Higher prevalence of HPV and HSV-1 were detected in cancerous tissues compared to normal tissues, while no infections of EBV,CMV,HSV-2 and Varicella Zoster virus were found in the samples.
Article
Biochemical Research Methods
Karl Dichtl, Andreas Osterman, Rachel Barry, Johannes Wagener
Summary: This study evaluated the performance of a novel microarray-based multiplex PCR system (Euroarray) for the molecular detection of HSV-1, HSV-2, and VZV. The microarray proved to be a useful tool for diagnosing viral infections of the skin and mucous membranes, allowing rapid differentiation between these pathogens in a single assay.
JOURNAL OF VIROLOGICAL METHODS
(2023)
Article
Microbiology
Marie Ella Horstmann, Mohammad Al Hariri, Stephanie D. Grabitz, Julia Bing Bu, Melissa Apel, Norbert Pfeiffer, Joanna Wasielica-Poslednik
Summary: The purpose of this study was to determine the prevalence of HSV-1, HSV-2, VZV, and CMV DNA in donor corneas. The results showed a higher prevalence of HSV-1 and VZV DNA in donor corneas, with no detection of HSV-2 or CMV DNA. Postoperative complications were more common in patients with positive viral DNA.
Review
Ophthalmology
Aleksandra Radosavljevic, Mamta Agarwal, Soon Phaik Chee, Manfred Zierhut
Summary: Viral agents are the most common cause of infectious anterior uveitis worldwide, with members of the Herpesviridae family being the most frequent culprits. While HSV and VZV are prevalent globally, other viruses such as HTLV-1, Chikungunya, Dengue, and Ebola may become significant causes of VAU due to globalization and air travel. Gender and racial differences in the frequency of viral anterior uveitis (VAU) may exist in various populations.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Pathology
Maria Mostyka, Jinru Shia, William L. Neumann, Christa L. Whitney-Miller, Michael Feely, Rhonda K. Yantiss
Summary: Reactivation of latent varicella zoster virus (VZV) can lead to gastrointestinal involvement, particularly in immunocompromised patients, producing unique histologic features that differ from herpes simplex virus (HSV) infection. Recognition of gastrointestinal VZV infection is crucial due to its potential to progress to life-threatening disseminated disease.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Immunology
Leyla Mohammad, Mathias Fousse, Gentiana Wenzel, Marina Flotats Bastardas, Klaus Fassbender, Ulrich Dillmann, Bernhard Schick, Michael Zemlin, Barbara C. Gaertner, Urban Sester, David Schub, Tina Schmidt, Martina Sester
Summary: This study suggests that HSV may be underestimated as a cause of PFP, while VZV and borrelia can trigger PFPs. Specific immune phenotyping can help identify the origin of the pathogens.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Biochemistry & Molecular Biology
Soudeh Ghafouri-Fard, Bashdar Mahmud Hussen, Hazha Hadayat Jamal, Mohammad Taheri, Guive Sharifi
Summary: Non-coding RNAs, especially lncRNAs and miRNAs, play important roles in regulating viral infections and immune responses. The expression of various host and viral lncRNAs is altered during viral infection, which can either inhibit viral infection, promote viral replication, or suppress antiviral responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Microbiology
Emilio Bouza, Miguel Martin, Jose Enrique Ales, Nuria Aragones, Begona Barragan, Rafael de la Camara, Jose Luis Del Pozo, Valentin Garcia-Gutierrez, Ramon Garcia-Sanz, Diego Gracia, Vicente Guillem, Victor Jimenez-Yuste, Mari Cruz Martin-Delgado, Joaquin Martinez, Rafael Lopez, Alvaro Rodriguez-Lescure, Julian Ruiz Galiana, Ana Maria Sureda, Francisco Tejerina-Picado, Antoni Trilla, Antonio Zapatero, Esteban Palomo, Jesus San-Miguel
Summary: The exact number of solid organ tumors diagnosed each year in Spain is unknown, making it difficult to determine if the pandemic has led to a decrease in cancer diagnoses. However, indirect data suggests that the pandemic has resulted in later-stage diagnoses for some non-hematological neoplasms. Although there is a lack of strong evidence, oncology patients who contract COVID-19 appear to have poorer outcomes. The immune response to infection in cancer patients is influenced by factors such as the type of neoplasia, treatment received, and timing of treatment.
REVISTA ESPANOLA DE QUIMIOTERAPIA
(2023)
Article
Biophysics
Moshe Yeshurun, Uri Rozovski, Liat Shargian, Oren Pasvolsky, Steffie van der Werf, Gloria Tridello, Nina Knelange, Malgorzata Mikulska, Jan Styczynski, Diana Averbuch, Rafael de la Camara
Summary: We conducted a study to describe the infection prevention practices among EBMT centers. Questionnaires were sent to all 553 centers and responses from 127 centers in 32 countries were obtained. The study revealed significant variations in antimicrobial prophylaxis practices, medications employed and duration of preventive therapy among the centers.
BONE MARROW TRANSPLANTATION
(2023)
Article
Oncology
Malgorzata Czogala, Wojciech Czogala, Katarzyna Pawinska-Wasikowska, Teofila Ksiazek, Karolina Bukowska-Strakova, Barbara Sikorska-Fic, Pawel Laguna, Jolanta Skalska-Sadowska, Jacek Wachowiak, Anna Rodziewicz-Konarska, Malgorzata Moj-Hackemer, Krzysztof Kalwak, Katarzyna Muszynska-Roslan, Maryna Krawczuk-Rybak, Anna Falkowska, Katarzyna Drabko, Marta Kozlowska, Ninela Irga-Jaworska, Katarzyna Bobeff, Wojciech Mlynarski, Renata Tomaszewska, Tomasz Szczepanski, Agnieszka Chodala-Grzywacz, Grazyna Karolczyk, Katarzyna Mycko, Wanda Badowska, Karolina Zielezinska, Tomasz Urasinski, Natalia Bartoszewicz, Jan Styczynski, Walentyna Balwierz, Szymon Skoczen
Summary: The study aimed to identify the clinical characteristics and analyze the outcomes of pediatric AML-pCT. The data of 40 children with AML-pCT treated from 2005 to 2020 were retrospectively analyzed. The most common primary malignancies were acute lymphoblastic leukemia and brain tumors. The treatment outcomes improved significantly in patients treated from 2015-2022 compared to 2005-2014, with increased probabilities of EFS and RFS.
Article
Biophysics
Jan Styczynski, Gloria Tridello, Linda Koster, Nina Knelange, Lotus Wendel, Anja van Biezen, Steffie van der Werf, Malgorzata Mikulska, Lidia Gil, Catherine Cordonnier, Per Ljungman, Diana Averbuch, Simone Cesaro, Helen Baldomero, Christian Chabannon, Selim Corbacioglu, Harry Dolstra, Bertram Glass, Raffaella Greco, Nicolaus Kroeger, Regis Peffault de Latour, Mohamad Mohty, Benedicte Neven, Zinaida Peric, John A. Snowden, Anna Sureda, Ibrahim Yakoub-Agha, Rafael de la Camara
Summary: This study analyzed the incidence and specific causes of death in HCT patients, focusing on infectious deaths. The results showed a decrease in mortality from infections in early phases but an increase in mortality from bacterial infections in the late phase.
BONE MARROW TRANSPLANTATION
(2023)
Review
Biotechnology & Applied Microbiology
Agata Marjanska, Jan Styczynski
Summary: Post-transplant lymphoproliferative disorders (PTLD) are a diverse group of diseases caused by uncontrolled proliferation of lymphoid or plasmacytic cells resulting from T-cell immunosuppression after transplantation. These are mainly caused by latent Epstein-Barr virus (EBV), and the risk of EBV recurrence depends on the level of immune system incompetency.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2023)
Article
Oncology
Tomasz Styczynski, Jagoda Sadlok, Monika Richert-Przygonska, Robert Debski, Patrycja Zalas-Wiecek, Krzysztof Czyzewski, Jan Styczynski
Summary: This paper reports two cases of pediatric patients with invasive fungal disease caused by Saprochaete clavata after allogeneic hematopoietic cell transplantation, and summarizes the literature data on this infection. With quick diagnosis and treatment, the outcome of therapy was successful.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2023)
Article
Medicine, General & Internal
Anna Dabrowska, Elzbieta Grzesk, Anna Urbanczyk, Marta Mazalon, Grzegorz Grzesk, Jan Styczynski, Sylwia Koltan
Summary: Inborn errors of immunity (IEI) are genetically determined disorders presenting with recurrent infections, autoimmunity, allergies, and malignancies. This study compared the utility of the 10 and 14 warning signs in diagnosing IEI. The results showed that the 14 warning signs are more effective in detecting IEI patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Jan Styczynski, Artur Slomka, Monika Lecka, Katarzyna Albrecht, Michal Romiszewski, Monika Pogorzala, Malgorzata Kubicka, Beata Kurylo-Rafinska, Barbara Tejza, Grazyna Gadomska, Ewelina Kolanska-Dams, Malgorzata Michalska, Ewa Zekanowska
Summary: This study analyzed the prognostic impact of 12 serum iron metabolism parameters in children after intensive chemotherapy for acute leukemias (AL) or undergoing hematopoietic cell transplantation (HCT). High levels of ferritin and low levels of soluble hemojuvelin (sHJV) were found to have an adverse prognostic impact on overall survival (OS) and event-free survival (EFS) in children after HCT. The results were confirmed when combined with AL patients after intensive chemotherapy.
Letter
Hematology
L. M. Juarez-Salcedo, S. Feijoo Monroy, C. Garcia-Herce, A. Alonso, B. Aguado, J. Ortiz, A. Figuera, de la Camara
MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES
(2023)
Article
Biophysics
Jan Styczynski, Gloria Tridello, Lotus Wendel, Nina Knelange, Simone Cesaro, Lidia Gil, Per Ljungman, Malgorzata Mikulska, Dina Averbuch, Rafael de la Camara
Summary: The aim of this study was to examine the current approach to EBV-driven post-transplant complications in EBMT transplant centers. The study found that most centers conduct routine serology testing before HCT, while some also routinely test for pretransplant EBV-DNA. Monitoring for EBV infection is feasible in almost all centers, with some using standardized PCR. Regular post-HCT monitoring is performed in the majority of centers. Prophylaxis with rituximab is used in a small percentage of centers. The prevalence of csEBV-DNA-emia was 7.4%, with higher rates in children. The frequency of EBV-PTLD was 1.6%, with higher rates in children. Rituximab and reduction of immunosuppressive therapy were the first-line treatments for EBV-driven complications. The failure rate of first-line preemptive treatment was 12.0%. EBV-specific T-lymphocytes were available in a portion of centers. Experimental therapies were given to patients with resistant/refractory PTLD. Overall, the prevalence of EBV-DNA-emia and EBV-PTLD decreased in comparison to historical data.
BONE MARROW TRANSPLANTATION
(2023)
Letter
Biophysics
Giorgia Battipaglia, Jarl E. Mooyaart, Ralf Meyer, Mohamad Mohty, Alicja Sadowska-Klasa, Oleg Goloshchapov, Franco Locatelli, Jan Styczynski, Jiri Pavlu, Jaroslaw Dybko, Gleb Bronin, Urpu Salmenniemi, Pavel Jindra, Jorinde D. Hoogenboom, Jurgen Kuball, Annalisa Ruggeri, Florent Malard
BONE MARROW TRANSPLANTATION
(2023)
Letter
Oncology
Simone Cesaro, Malgorzata Mikulska, Hans H. Hirsch, Jan Styczynski, Sylvain Meylan, Catherine Cordonnier, Davide Navarro, Marie von Lilienfeld-Toal, Varun Mehra, Francesco Marchesi, Caroline Besson, Raul Cordoba Masculano, Gernot Beutel, Herman Einsele, Johan Maertens, Rafael de la Camara, Per Ljungman, Livio Pagano
Article
Oncology
Malgorzata Czogala, Wojciech Czogala, Katarzyna Pawinska-Wasikowska, Teofila Ksiazek, Karolina Bukowska-Strakova, Barbara Sikorska-Fic, Pawel Laguna, Anna Falkowska, Katarzyna Drabko, Katarzyna Muszynska-Roslan, Maryna Krawczuk-Rybak, Marta Kozlowska, Ninela Irga-Jaworska, Karolina Zielezinska, Tomasz Urasinski, Natalia Bartoszewicz, Jan Styczynski, Jolanta Skalska-Sadowska, Jacek Wachowiak, Anna Rodziewicz-Konarska, Krzysztof Kalwak, Malgorzata Ciebiera, Radoslaw Chaber, Agnieszka Mizia-Malarz, Agnieszka Chodala-Grzywacz, Grazyna Karolczyk, Katarzyna Bobeff, Wojciech Mlynarski, Katarzyna Mycko, Wanda Badowska, Renata Tomaszewska, Tomasz Szczepanski, Katarzyna Machnik, Natalia Zamorska, Walentyna Balwierz, Szymon Skoczen
Summary: Mutations in the FLT3 gene are associated with poor outcomes in pediatric AML. A retrospective analysis of a nationwide pediatric AML database showed that FLT3-ITD-positive patients had worse survival compared to FLT3-ITD-negative patients. Treatment protocols and the use of FLT3 inhibitors and stem cell transplantation showed potential for improving outcomes. Additional genetic mutations, such as WT1 and NPM1, significantly influenced prognosis.
Article
Medicine, General & Internal
Emilia Roy-Vallejo, Sara Fernandez De Cordoba-Onate, Pablo Delgado-Wicke, Ana Triguero-Martinez, Nuria Montes, Rosa Carracedo-Rodriguez, Nelly Zurita-Cruz, Ana Marcos-Jimenez, Amalia Lamana, Jose Maria Galvan-Roman, Gonzalo Villapalos Garcia, Pablo Zubiaur, Marianela Ciudad, Laura Rabes, Marta Sanz, Carlos Rodriguez, Almudena Villa, Jesus alvarez Rodriguez, Celeste Marcos, Julia Hernando, Paula Diaz-Fernandez, Francisco Abad, Ignacio de los Santos, Diego A. Rodriguez Serrano, Rosario Garcia-Vicuna, Carmen Suarez Fernandez, Rosa P. Gomariz, Cecilia Munoz-Calleja, Elena Fernandez-Ruiz, Isidoro Gonzalez-Alvaro, Laura Cardenoso, PREDINMUN COVID Grp
Summary: This study aimed to evaluate the relationship between SARS-CoV-2 viremia and specific gene SNPs in predicting COVID-19 severity. Genetic variants in HMOX1, SERPING1, TMPRSS2, CD69, TRAF3IP2, OAS1, and VIPR1 genes could explain the heterogeneity in SARS-CoV-2 viremia in our population.
FRONTIERS IN MEDICINE
(2023)
