Review
Biochemistry & Molecular Biology
Hadla Hariri, Rene St-Arnaud
Summary: This review highlights recent research on the regulatory functions of ubiquitin-specific peptidases (USPs) in osteoblasts and provides insight into the molecular mechanisms governing their actions. It also discusses the role of USP53 in osteoblasts and the complex layers of regulation exerted by USPs on osteoblast signaling. Further studies using knockout mouse models are necessary for a full understanding of the mechanisms underpinning USPs actions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Orthopedics
Ashley R. Sweeney-Ambros, Amy E. Biggs, Nicholas D. Zimmerman, Kenneth A. Mann, Timothy A. Damron, Megan E. Oest
Summary: Post-radiotherapy bone fragility fractures are a common complication in cancer survivors. This study investigated the effects of combined delivery of parathyroid hormone and zoledronic acid on post-radiotherapy bone health and explored the potential use of parathyroid hormone as a bone marrow radioprotectant.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Biology
Tsz Long Chu, Peikai Chen, Anna Xiaodan Yu, Mingpeng Kong, Zhijia Tan, Kwok Yeung Tsang, Zhongjun Zhou, Kathryn Song Eng Cheah
Summary: This study reveals that MMP14 plays a crucial role in the regulation of PTH signaling, thus contributing to bone homeostasis. During the development of osteoblasts from HC-descendent cells, MMP14 and the PTH pathway are activated. MMP14 cleaves PTH1R to dampen PTH signaling, thereby regulating bone synthesis.
Article
Multidisciplinary Sciences
Mikkel Bo Brent, Jesper Skovhus Thomsen, Annemarie Bruel
Summary: Excessive use of glucocorticoids can decrease muscle mass and bone formation rate, but does not impact trabecular microarchitecture or bone strength; On the other hand, abaloparatide can significantly improve bone density and strength in the absence of glucocorticoid intervention, but its osteoanabolic effect is blunted when used concurrently with glucocorticoids.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jang-Woon Kim, Narae Park, Jaewoo Kang, Yena Kim, Hyerin Jung, Yeri Alice Rim, Ji Hyeon Ju
Summary: The study developed a novel delivery system for PTHrP protein regions to improve the treatment efficacy of osteoporosis. Experimental results demonstrated that the new system can enhance bone formation, reduce bone resorption, and improve bone structure quality in treated subjects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Multidisciplinary
Yi Wang, Zhuowen Hao, Yufeng Zhang, Yingkun Hu, Tianhong Chen, Feifei Yan, Minhao Wu, Chong Zhang, Renxin Chen, Beihai Li, Xinxin Wu, Hanke Li, Qixin Zheng, Xiaodong Guo, Guohui Liu, Zhenwei Zou, Jingfeng Li, Lin Cai
Summary: Bone regeneration requires the interaction of multiple factors, including osteogenesis, osteolysis, angiogenesis, and an appropriate immune microenvironment. Recombinant human parathyroid hormone (PTH1-34) has been proven effective for clinical treatment of osteoporosis. However, its use in local bone repair is limited due to net bone resorption. This study proposes a strategy using multifunctional calcium phosphate (CaP) ceramics to modulate the effects of M1 macrophages and promote bone regeneration. The functionalization of the CaP ceramic scaffold with parathyroid hormone related peptide-1 (PTHrP-1) improves the osteogenic microenvironment, retains osteogenic and angiogenic properties, and achieves slow release of PTHrP-1. The results show that PTHrP-1-TBC is more suitable for bone regeneration than the unmodified peptide or the TBC scaffold alone.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Anna Goropashnaya, Oivind Toien, Thiruvarangan Ramaraj, Anitha Sundararajan, Faye D. Schilkey, Brian M. Barnes, Seth W. Donahue, Vadim B. Fedorov
Summary: Physical inactivity leads to bone loss in most mammalian species, but hibernating bears show no bone loss during winter immobility. Gene expression analysis in hibernating bears revealed down-regulation of genes related to bone resorption, osteoclast differentiation, and apoptosis, while no significant changes were detected in genes related to bone formation and osteoblast signaling. There was also a significant induction of genes involved in aerobic energy production in hibernating bears, likely regulated by the AMPK/PGC1 alpha pathway.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Biomedical
Zhiyuan Zou, Le Wang, Zhifei Zhou, Qing Sun, Delong Liu, Yan Chen, Hao Hu, Yu Cai, Sixiong Lin, Zhengran Yu, Bizhi Tan, Wei Guo, Zemin Ling, Xuenong Zou
Summary: The use of hydrogels containing PTH and nHAP can promote cranial bone regeneration by enhancing the expression of osteogenic-related proteins and facilitating osteogenic differentiation of BMSCs through the Notch signaling pathway. Implantation of the hydrogel into a rat cranial defect model showed efficient bone regeneration compared to using the hydrogel alone or nHAP alone, indicating a promising therapeutic effect of combining nHAP and PTH for bone regeneration.
BIOACTIVE MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Rachel Freid, Amira Hussein, Jennifer J. Schlezinger
Summary: The study investigated the effects of diet, ovariectomy, and TBT exposure on bone structure in mice, finding that TBT can protect against trabecular bone loss to some extent, especially under a low-fat diet.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rene St-Arnaud, Martin Pellicelli, Mahmoud Ismail, Alice Arabian, Toghrul Jafarov, Chengji J. Zhou
Summary: PTH induces phosphorylation of NACA and LRP6, leading to their nuclear translocation and expression of the target gene Lrp6. Knockout of Naca and Lrp6 in mice abolishes the anabolic response to iPTH, indicating that NACA and LRP6 play important roles in ensuring maximal response to iPTH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lin Ma, Weicheng Chi, Howard E. Morgan, Mu-Han Lin, Mingli Chen, David Sher, Dominic Moon, Dat T. Vo, Vladimir Avkshtol, Weiguo Lu, Xuejun Gu
Summary: In this study, a registration-guided DL segmentation framework for online cone beam computed tomography (CBCT) image was proposed. By integrating image registration algorithms and DL segmentation models, this framework overcame the issues of low image quality and limited training data, resulting in more accurate segmentation.
Article
Biotechnology & Applied Microbiology
Stylianos Kechagias, Konstantinos Theodoridis, Joseph Broomfield, Kenny Malpartida-Cardenas, Ruth Reid, Pantelis Georgiou, Richard J. van Arkel, Jonathan R. T. Jeffers
Summary: This study investigates the influence of design parameters on the performance of stochastic lattice structures and finds that increasing connectivity promotes osteoblast maturation, tissue formation, and mineralization rate. This provides a new approach for designing stochastic structures with biomimetic properties and rapid ossification.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Cell & Tissue Engineering
C-H Chen, L. Kang, L-H Chang, T-L Cheng, S-Y Lin, S-C Wu, Y-S Lin, S-C Chuang, T-C Lee, J-K Chang, M-L Ho
Summary: Intra-articular injections of PTH in guinea pigs improved endurance, preserved glycosaminoglycans, and reduced OA symptoms, suggesting a potential therapeutic effect on age-related OA.
BONE & JOINT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Rodrigo Muelas-Soria, Rafael Garcia-Molla, Virginia Morillo-Macias, Jorge Bonaque-Alandi, Patricia Sorribes-Carreras, Francisco Garcia-Pinon, Carlos Ferrer-Albiach
Summary: The aim of this study was to develop an offline adaptive radiotherapy (ART) protocol based on deformable image registration (DIR), which can identify significant dosimetric changes in the initial treatment fractions. The study found that the rectal dose in some patients exceeded the dose limitation, and there were significant variations in the planned rectal volume in the first, third, and fifth treatment fractions. Furthermore, a variation rate of D50 in the third fraction could reliably identify dose changes that exceeded the rectal dose constraint.
Review
Endocrinology & Metabolism
Eugenia Bertoldo, Giovanni Adami, Maurizio Rossini, Alessandro Giollo, Giovanni Orsolini, Ombretta Viapiana, Davide Gatti, Angelo Fassio
Summary: This review discusses the interaction between endocrine hormones and the immune system in major rheumatic disorders, particularly focusing on the role of bone-related hormones and cytokines.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Yihan Li, Wei-Ju Tseng, Chantal M. J. de Bakker, Hongbo Zhao, Rebecca Chung, X. Sherry Liu
Summary: Postmenopausal osteoporosis is influenced by reduced estrogen levels during menopause, impacting bone remodeling, bone mass, and fracture risk. Peak bone mass and microstructure are important predictors of osteoporosis risk, with thicker trabeculae being associated with lower rates of bone loss in response to estrogen deficiency. Thicker trabeculae are less likely to disconnect or perforate, leading to a lower degree of bone loss.
Article
Medicine, Research & Experimental
Wei Yu, Leilei Zhong, Lutian Yao, Yulong Wei, Tao Gui, Ziqing Li, Hyunsoo Kim, Nicholas Holdreith, Xi Jiang, Wei Tong, Nathaniel Dyment, X. Sherry Liu, Shuying Yang, Yongwon Choi, Jaimo Ahn, Ling Qin
Summary: Our study identified marrow adipogenic lineage precursors (MALPs) as a critical player in controlling bone remodeling during normal bone metabolism and pathological bone loss in a RANKL-dependent fashion.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Orthopedics
B. Han, Q. Li, C. Wang, P. Chandrasekaran, Y. Zhou, L. Qin, X. S. Liu, M. Enomoto-Iwamoto, D. Kong, R. V. Iozzo, D. E. Birk, L. Han
Summary: In post-traumatic osteoarthritis (PTOA), decorin plays a more crucial role than biglycan in regulating cartilage degeneration, while biglycan is more important in regulating subchondral bone structure. The two have distinct activities and modest synergy in the pathogenesis of PTOA.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Engineering, Biomedical
Wenzheng Wang, Wei-Ju Tseng, Hongbo Zhao, Tala Azar, Shaopeng Pei, Xi Jiang, Nathaniel Dyment, Sherry Liu
Summary: The study shows that MBF and RBF have similar contributions to trabecular bone homeostasis, with PTH playing a promoting role in new bone formation. Regardless of the type of bone formation, mineral deposition continues once activated by PTH.
Article
Endocrinology & Metabolism
Yihan Li, Chantal M. J. de Bakker, Xiaohan Lai, Hongbo Zhao, Ashutosh Parajuli, Wei -Ju Tseng, Shaopeng Pei, Tan Meng, Rebecca Chung, Liyun Wang, X. Sherry Liu
Summary: This study demonstrated that maternal bone undergoes improvements in structure in response to dynamic loading, regardless of reproductive status, with lactating rats showing enhanced mechano-responsiveness in both trabecular and cortical bone compartments. Additionally, lactation-induced activities in osteocyte peri-lacunar/canalicular remodeling may lead to increased mechano-responsiveness in maternal bone during lactation. Findings emphasize the importance of weightbearing exercise on maternal bone health during reproduction and postpartum.
Article
Endocrinology & Metabolism
Wei-Ju Tseng, Wonsae Lee, Hongbo Zhao, Yang Liu, Wenzheng Wang, Chantal Mj de Bakker, Yihan Li, Carlos Osuna, Wei Tong, Luqiang Wang, Xiaoyuan Ma, Ling Qin, X. Sherry Liu
Summary: Despite the potent effect of intermittent parathyroid hormone (PTH) treatment on promoting new bone formation, bone mineral density (BMD) rapidly decreases upon discontinuation of PTH administration. The responses to PTH treatment withdrawal vary in intact and estrogen-deficient rats, with the latter experiencing significant bone loss and microarchitecture deterioration. An extended anabolic period is observed in estrogen-deficient rats upon early PTH withdrawal, followed by adverse changes in bone cell activities.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Engineering, Biomedical
Wen Sang, Yihan Li, Jane Guignon, X. Sherry Liu, Ani Ural
Summary: This study examined the structural role of osteocyte lacunae on the mechanical properties of the bone matrix, revealing significant linear relationships between lacunar area, density, size, and orientation with elastic modulus and ultimate strength. Parametric studies also showed strong correlations between elastic modulus and strength with lacunar density, size, and orientation. Additionally, simulations demonstrated that osteocyte lacunae guide crack propagation through local stress concentrations.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Cell Biology
Abhishek Chandra, Anthony B. Lagnado, Joshua N. Farr, Madison Doolittle, Tamara Tchkonia, James L. Kirkland, Nathan K. LeBrasseur, Paul D. Robbins, Laura J. Niedernhofer, Yuji Ikeno, Joao F. Passos, David G. Monroe, Robert J. Pignolo, Sundeep Khosla
Summary: This study demonstrates that cellular senescence-driven radiation-induced osteoporosis is primarily mediated by p21(Cip1) rather than p16(Ink4a), based on the clearance of senescent cells using genetic models. This approach may be used to investigate the contributions of these pathways in other senescence-associated conditions, including aging across tissues.
Article
Endocrinology & Metabolism
Abhishek Chandra, Anthony B. Lagnado, Joshua N. Farr, Megan Schleusner, David G. Monroe, Dominik Saul, Joao F. Passos, Sundeep Khosla, Robert J. Pignolo
Summary: Oxidative stress-induced cellular senescence is associated with the accumulation of bone marrow adipocytes, but the direct link between cellular senescence and bone marrow adipocyte tissue (BMAT) remains elusive. This study demonstrates that radiation and aging induce the occurrence of BMAT through a common pathway that involves the presence of senescent cells. Clearance of senescent cells reduces BMAT in aged and radiated bones.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Gastroenterology & Hepatology
Vy Truong Thuy Nguyen, Negar Taheri, Abhishek Chandra, Yujiro Hayashi
Summary: Aging is a complex process that affects the functions of the gastrointestinal tract. Age-related GI motor disorders can negatively impact quality of life and increase the risk of other diseases. However, the mechanisms underlying these disorders and the effect of aging on GI motor functions are still not well understood, necessitating further research.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Review
Biochemistry & Molecular Biology
Shaopeng Pei, Yilu Zhou, Yihan Li, Tala Azar, Wenzheng Wang, Do-Gyoon Kim, X. Sherry Liu
Summary: This review focuses on nanoindentation testing in musculoskeletal research, discussing its application, the factors affecting testing results, and other commonly used techniques for synchronized imaging and colocalized characterization.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2022)
Article
Immunology
Zuozhen Tian, Frances S. Shofer, Alec Z. Sandroni, Lan Zhao, Carla R. Scanzello, Yejia Zhang
Summary: The study found that the expression of human interleukin (IL) 8 in mice affected their behavior, especially in reduced locomotion and climbing in male mice. Furthermore, the eating and drinking time of mice changed with age and were influenced by the expression of hIL8. These changes in natural behaviors in control mice are consistent with functional decline with age.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Endocrinology & Metabolism
Wenzheng Wang, Tala Azar, Wei-Ju Tseng, Shaopeng Pei, Yilu Zhou, Xi Jiang, Nathaniel Dyment, X. Sherry Liu
Summary: This study investigated the temporal response of newly formed bone tissue and preexisting bone tissue to withdrawal from intermittent parathyroid hormone (PTH) treatment in an ovariectomized rat model. The results showed that modeling-based bone formation (MBF) sites had a greater contribution to the extended anabolic effect upon early withdrawal from PTH compared to remodeling-based bone formation (RBF) sites. Furthermore, newly formed bone tissue from MBF had greater resistance to PTH discontinuation-induced bone loss than those from RBF and preexisting bone.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Robert J. Pignolo, Susan F. Law, Abhishek Chandra
Summary: This study focuses on the physiological changes in aging bones and the role of cellular senescence in age-related osteoporosis. It reviews different aspects of bone aging, including remodeling deficits, uncoupling phenomena, and the accumulation of senescent cells in the bone microenvironment, as major mechanisms for age-related osteoporosis. The study also discusses the potential therapeutic interventions based on clearing senescent cells or suppressing the senescence-associated secretory phenotype.
Review
Biochemistry & Molecular Biology
Hongtao Zhang, Nelson Shi, Zhuo Diao, Youhai Chen, Yejia Zhang
Summary: The availability of biological TNFa inhibitors has significantly advanced the treatment of immune diseases such as rheumatoid arthritis in the past 20 years. However, there are still unmet needs including side effects, tolerance issues, and the development of new TNFa inhibitors focusing on TNFR1-specific inhibitors.
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.