Article
Endocrinology & Metabolism
Jennifer C. Coulombe, Blayne A. Sarazin, Zachary Mullen, Alicia M. Ortega, Eric W. Livingston, Ted A. Bateman, Louis S. Stodieck, Maureen E. Lynch, Virginia L. Ferguson
Summary: Research shows that microgravity has a greater impact on bone changes in older mice, especially in terms of trabecular bone, while there was no significant change in trabecular thickness in young mice.
Article
Endocrinology & Metabolism
Sara Oliviero, Vee San Cheong, Bryant C. Roberts, Carlos Amnael Orozco Diaz, William Griffiths, Ilaria Bellantuono, Enrico Dall'Ara
Summary: The aim of this study was to evaluate the intra- and inter-operator reproducibility of several bone parameters measured from microCT images. The results showed that both intra- and inter-operator reproducibility were acceptable, although there were slight differences in some parameters. MicroCT and microFE models provide reproducible measurements for non-invasive assessment of the mouse tibia properties.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Kevin F. Hoffseth, Jennifer Simkin, Emily Busse, Kennon Stewart, James Watt, Andrew Chapple, Aaron Hargrove, Mimi C. Sammarco
Summary: Bone regeneration is a critical area of research that impacts the treatment of diseases like osteoporosis and age-related bone decline. A new analysis approach based on open-source semi-automatic methods has been developed to analyze bone tissue at a granular level using mu CT image data, offering insights into structural quality and mineral distribution in regenerated bone. Results from applying this approach to mouse digits before and after amputation injury show differences in inner void fraction, patterning, mineral distribution, and density between regenerated and unamputated bone.
Article
Endocrinology & Metabolism
Wenzheng Wang, Tala Azar, Wei-Ju Tseng, Shaopeng Pei, Yilu Zhou, Xi Jiang, Nathaniel Dyment, X. Sherry Liu
Summary: This study investigated the temporal response of newly formed bone tissue and preexisting bone tissue to withdrawal from intermittent parathyroid hormone (PTH) treatment in an ovariectomized rat model. The results showed that modeling-based bone formation (MBF) sites had a greater contribution to the extended anabolic effect upon early withdrawal from PTH compared to remodeling-based bone formation (RBF) sites. Furthermore, newly formed bone tissue from MBF had greater resistance to PTH discontinuation-induced bone loss than those from RBF and preexisting bone.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Jennifer A. McKenzie, Ian M. Galbreath, Andre F. Coello, Katherine R. Hixon, Matthew J. Silva
Summary: The relationship between osteogenesis and angiogenesis is complex. While angiogenesis is necessary for normal bone development, the role of vascular endothelial growth factor A (VEGFA) in supporting bone formation is still being studied. It has been suggested that VEGFA may have a direct role in bone formation, independent of angiogenesis.
Article
Endocrinology & Metabolism
P. L. Salmon, S. Monzem, B. Javaheri, L. Oste, G. Kerckhofs, A. A. Pitsillides
Summary: Histomorphometry of rodent metaphyseal trabecular bone is often limited to the secondary spongiosa and excludes the primary spongiosa. This study explores the value of spatially resolved trabecular morphometry based on the distance from the growth plate and the inclusion of mixed primary-secondary spongiosal bone. The findings suggest that spatial resolution and the inclusion of primary spongiosal bone enhance the sensitivity of trabecular analysis and reveal significant differences in bone changes at different distances from the growth plate.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Upneet K. Sokhi, Yunwei Xia, Branden Sosa, Kathleen Turajane, Sita N. Nishtala, Tania Pannellini, Mathias P. Bostrom, Alberto Carli, Xu Yang, Lionel B. Ivashkiv
Summary: This study characterized the immune response in orthopedic periprosthetic joint infection (PJI) using histology, flow cytometry, and gene expression analysis. The results showed that persistent S. aureus infection leads to robust activation of both innate and adaptive immunity, as well as ongoing inflammation and lymph node and bone marrow reactions. However, there are feedback mechanisms that suppress immune cell activation and inhibit T-cell proliferation and tissue infiltration. These findings provide insights into the immune response to persistent S. aureus PJI and suggest potential targets for immunotherapeutic strategies.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Orthopedics
Nikola Stokovic, Natalia Ivanjko, Viktorija Rumenovic, Anita Breski, Kuber T. Sampath, Mihaela Peric, Marko Pecina, Slobodan Vukicevic
Summary: This study evaluated different commercially available synthetic ceramic particles as compression-resistant matrix (CRM) added to Osteogrow implants. The results showed that Osteogrow-C implants with different ceramic particles induced the formation of bone-ceramic structure and promoted bone formation. Highly porous Vitoss ceramic demonstrated the highest bone volume, while Vitoss and ChronOs ceramics increased the number of trabeculae, and BAM and Dongbo ceramics increased the thickness of trabeculae.
INTERNATIONAL ORTHOPAEDICS
(2022)
Article
Endocrinology & Metabolism
Robert Brommage, Sabrina Jeter-Jones, Wendy Xiong, Jeff Liu
Summary: Analysis of mouse femoral neck structure provides valuable information for studying osteoporosis therapies, with variations observed among different mouse strains. Age, genetic factors, and treatments influence BV/TV in the femoral neck of mice.
Article
Engineering, Biomedical
Rodrigue Caron, Lama Seoud, Irene Londono, Isabelle Villemure
Summary: This study evaluates the potential of using deep learning models, YOLOv4 and Unet, for linear microcrack detection and segmentation in trabecular bone samples. The YOLOv4p5 model performs the best among the four versions, and Unet provides better segmentation performance on sample 2 compared to sample 1. The comparison between deep learning and contrast agent approaches shows different regions segmented. Overall, the accuracy of both neural networks is acceptable for their first application in this field with limited data.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Environmental Sciences
Deiweson Souza-Monteiro, Railson de Oliveira Ferreira, Luciana Guimaraes Eiro, Leidiane Alencar de Oliveira Lima, Gabriela Souza Balbinot, Simone Patricia Aranha da Paz, Alan Rodrigo Leal Albuquerque, Fabricio Mezzomo Collares, Romulo Simoes Angelica, Sofia Pessanha, Cristiane do Socorro Ferraz Maia, Rafael Rodrigues Lima
Summary: The study investigated the toxicological effects of aluminum chloride on the alveolar bone of rats, finding that aluminum chloride increased aluminum levels in blood and triggered significant changes in the bone microstructure.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Medicine, General & Internal
Luis Gracia-Marco, Sheila Gonzalez-Salvatierra, Antonia Garcia-Martin, Esther Ubago-Guisado, Beatriz Garcia-Fontana, Jose Juan Gil-Cosano, Manuel Munoz-Torres
Summary: This study analyzed differences in 3D DXA parameters at the hip site among patients with acromegaly or AGHD and healthy controls. The study found cortical bone impairment in AGHD patients and highlighted the trochanter as the site with greater cortical bone differences between acromegaly patients and controls. 3D-DXA provided useful information about bone involvement in GH-related disorders, with AGHD patients showing distinct involvement of the cortical structure.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Karin A. Payne, Nichole M. Shaw, Christopher B. Erickson, Peter Yarger, Yangyi Yu, Todd Baldini, Christopher J. Kleck, Vikas V. Patel, Evalina L. Burger
Summary: The study found that administration of osteoprotegerin (OPG) in a rat spine fusion model increased bone volume and decreased osteoclasts in the fusion mass. OPG, as a soluble RANK-ligand inhibitor, can block osteoclast differentiation and activation, which control the remodeling process during spinal fusion.
Article
Endocrinology & Metabolism
Joseph D. Gardinier, Amit Chougule, Devin Mendez, Conor Daly-Seiler, Chunbin Zhang
Summary: Periostin is a matricellular protein predominantly expressed at the periosteum of bone, and it plays an important role in facilitating osteoblast differentiation and mineralization. It is involved in maintaining bone mass and tissue strength during growth and development, but its function during advanced aging is relatively unknown.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Hasmik Jasmine Samvelyan, John Cummings Mathers, Timothy Michael Skerry
Summary: The study suggests that fasting/feeding interventions can enhance bone response to mechanical loading in young mice, but not in older mice. The endocrine responses to feeding timing differ between older and young mice, which may affect bone adaptation to loading.
Article
Endocrinology & Metabolism
Matthew J. Silva, Jeremy D. Eekhoff, Tarpit Patel, Jane P. Kenney-Hunt, Michael D. Brodt, Karen Steger-May, Erica L. Scheller, James M. Cheverud
JOURNAL OF BONE AND MINERAL RESEARCH
(2019)
Article
Orthopedics
Jennifer A. McKenzie, Clayton Maschhoff, Xiaochen Liu, Nicole Migotsky, Matthew J. Silva, Michael J. Gardner
JOURNAL OF ORTHOPAEDIC RESEARCH
(2019)
Article
Endocrinology & Metabolism
Evan G. Buettmann, Jennifer A. McKenzie, Nicole Migotsky, David A. W. Sykes, Pei Hu, Susumu Yoneda, Matthew J. Silva
JOURNAL OF BONE AND MINERAL RESEARCH
(2019)
Article
Endocrinology & Metabolism
Jennifer McKenzie, Craig Smith, Kannan Karuppaiah, Joshua Langberg, Matthew J. Silva, David M. Ornitz
JOURNAL OF BONE AND MINERAL RESEARCH
(2019)
Review
Orthopedics
Russell P. Main, Sandra J. Shefelbine, Lee B. Meakin, Matthew J. Silva, Marjolein C. H. van der Meulen, Bettina M. Willie
JOURNAL OF ORTHOPAEDIC RESEARCH
(2020)
Article
Endocrinology & Metabolism
Brandon A. Coates, Jennifer A. McKenzie, Evan G. Buettmann, Xiaochen Liu, Paul M. Gontarz, Bo Zhang, Matthew J. Silva
Article
Biophysics
Brandon A. Coates, Matthew J. Silva
JOURNAL OF BIOMECHANICS
(2020)
Article
Endocrinology & Metabolism
Christopher J. Chermside-Scabbo, Taylor L. Harris, Michael D. Brodt, Ingrid Braenne, Bo Zhang, Charles R. Farber, Matthew J. Silva
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Article
Endocrinology & Metabolism
Brandon A. Coates, Jennifer A. McKenzie, Susumu Yoneda, Matthew J. Silva
Summary: IL-6 plays a role in the inflammatory phase of fracture repair, but its impact on successful repair is not fully understood. In experiments using IL-6 KO mice, it was found that IL-6 knockout enhanced callus formation and bone response after stress fracture injury, possibly through direct action on osteoblast function.
Article
Endocrinology & Metabolism
Pei Hu, Jennifer A. McKenzie, Evan G. Buettmann, Nicole Migotsky, Michael J. Gardner, Matthew J. Silva
Summary: Type 1 diabetes impairs bone formation and fracture healing in humans. Akita mice, with a mutation in the insulin-2 gene, showed reduced bone mass and weaker bones, as well as impaired fracture healing. Akita mice exhibited osteopenia and decreased bone mechanical properties, mimicking some skeletal features of T1DM in humans.
Article
Endocrinology & Metabolism
Taylor L. Harris, Matthew J. Silva
Summary: Using Laser Capture Microdissection, osteocytes enriched intracortical bone tissues were analyzed for gene expression, revealing differential regulation of genes like Ngf, Wnt1, and MMP13 under mechanical loading. This method provided insights into the molecular changes in osteocytes in response to mechanical stimuli.
Article
Endocrinology & Metabolism
Lisa Y. Lawson, Michael D. Brodt, Nicole Migotsky, Christopher J. Chermside-Scabbo, Ramya Palaniappan, Matthew J. Silva
Summary: The secretion of Wnt ligands is essential for adult bone homeostasis, and inhibiting their secretion results in decreased bone formation and increased resorption. Additionally, osteoblast-derived Wnts play a crucial role in mediating the bone anabolic response to tibial loading.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Mingming Yan, Xin Duan, Lei Cai, Weili Zhang, Matthew J. Silva, Robert H. Brophy, Muhammad Farooq Rai
Summary: The study revealed that KIF26B plays a crucial role in injury-induced ectopic calcification. It was found that KIF26B represses osteogenesis by modulating Wnt/β-catenin signaling, making it a potential target for mitigating ectopic calcification.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Taylor L. Harris, Matthew J. Silva
Summary: This study assessed the contribution of osteoblast lineage cells to bone formation induced by mechanical loading. Preexisting Osx and Dmp1 lineage cells were found to play a predominant role in lamellar bone formation, while recruitment of earlier osteoprogenitors and increased cell proliferation supported robust woven bone formation.
Article
Endocrinology & Metabolism
Heather M. Zannit, Matthew J. Silva
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.