Editorial Material
Medicine, General & Internal
Kristine E. Ensrud, John T. Schousboe
Summary: Medications used to reduce the risk of osteoporosis-related fractures are classified as antiresorptive agents or anabolic therapies. This article focuses on anabolic medications, including specific drugs like teriparatide, abaloparatide, and romosozumab.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Alvaro del Real, Sergio Ciordia, Carolina Sanudo, Carmen Garcia-Ibarbia, Adriel Roa-Bautista, Javier G. Ocejo-Vinals, Fernando Corrales, Jose A. Riancho
Summary: The aim of this study was to explore new markers in serum proteome associated with the response to antiosteoporosis drugs. The results showed significant differences in protein levels, particularly those related to the innate immune system, in the serum after treatment with teriparatide and denosumab.
Article
Endocrinology & Metabolism
Akito Makino, Tomoka Hasegawa, Hideko Takagi, Yoshimasa Takahashi, Naoki Hase, Norio Amizuka
Summary: In this study, the effects of ABL and TPTD were compared in mice, with frequent administration of ABL showing significantly higher bone density and improvement in bone structure compared to TPTD. ABL increased bone formation markers levels more than TPTD with more frequent regimens, while bone resorption markers levels were similar between ABL and TPTD in all regimens.
Article
Endocrinology & Metabolism
F. Cosman, C. Cooper, Y. Wang, B. Mitlak, S. Varughese, S. A. Williams
Summary: This study evaluates the real-world effectiveness of abaloparatide versus teriparatide in terms of nonvertebral fracture (NVF) incidence and cardiovascular safety during a 19-month period after treatment initiation. The results show that after 18 months of treatment, abaloparatide is comparable to teriparatide in terms of preventing NVF and has similar cardiovascular safety.
OSTEOPOROSIS INTERNATIONAL
(2022)
Review
Endocrinology & Metabolism
Felicia Cosman, David W. Dempster
Summary: There are three anabolic agents available for postmenopausal women at high risk for fracture, and studies show that they are more effective than antiresorptive agents. There is no definitive answer on how to choose which agent to use at different stages of a woman's life.
CURRENT OSTEOPOROSIS REPORTS
(2021)
Review
Endocrinology & Metabolism
Leonardo Bandeira, E. Michael Lewiecki
Summary: Anabolic agents increase bone density, improve bone strength, and reduce fracture risk. They work by increasing osteoblastic bone formation, distinguishing them from antiresorptive drugs. However, the bone forming effects of anabolic therapy are self-limited, necessitating the use of antiresorptive therapy to enhance the benefits achieved.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2022)
Review
Medicine, General & Internal
Barbara Hauser, Nerea Alonso, Philip L. Riches
Summary: Teriparatide has been shown to effectively reduce vertebral and non-vertebral fractures in post-menopausal and glucocorticoid-induced osteoporosis in clinical trials. The real-world experience of Teriparatide confirms the benefits seen in clinical trials, with similar outcomes observed in male and glucocorticoid-induced osteoporosis. Limited experience has been reported in pre-menopausal osteoporosis or in using Teriparatide in combination with other therapies, and surveillance studies have not found any safety signals relating to Teriparatide and osteosarcoma. Additionally, there is evidence on predicting response to Teriparatide in order to guide its optimal use in therapy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Emily G. Atkinson, Michele Adaway, Daniel J. Horan, Crystal Korff, Angela Klunk, Ashley L. Orr, Katherine Ratz, Teresita Bellido, Lilian I. Plotkin, Alexander G. Robling, Joseph P. Bidwell
Summary: Activation of bone anabolic pathways is a promising strategy for treating severe osteoporosis. The inactivation of the Nmp4 gene enhances the bone anabolic effects of parathyroid hormone (PTH). The Prx1-expressing mesenchymal stem/progenitor cells (MSPCs) play a crucial role in the efficacy of PTH therapy.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Multidisciplinary Sciences
Zhi-Ming Liu, Min Zhang, Yuan Zong, Ding Zhang, Zhu-Bin Shen, Xiao-Qing Guan, Fei Yin
Summary: This study aimed to compare the efficacy of alendronate and teriparatide in the treatment of glucocorticoid-induced osteoporosis. The study found that compared to alendronate, teriparatide could reduce the rate of new vertebral fractures and increase the bone mineral density of the lumbar spine, femoral neck, and total hip. There was no significant difference in the incidence of non-vertebral fractures and adverse events between the two groups.
Article
Endocrinology & Metabolism
Alexander J. Rodriguez, Nitesh Nerlekar, Peter R. Ebeling
Summary: This study investigated the cardiovascular safety of osteoporosis medications and found that oral and intravenous bisphosphonates have certain cardiovascular risks, while the cardiovascular safety of teriparatide is unclear.
Review
Orthopedics
Chuanjian Yuan, Yanchen Liang, Kai Zhu, Wenpeng Xie
Summary: This study compared the efficacy and safety of teriparatide and denosumab with oral bisphosphonates. The results showed that teriparatide and denosumab were superior to bisphosphonates in increasing bone mineral density and preventing vertebral fractures. Therefore, teriparatide and denosumab may be considered as first-line treatments for glucocorticoid-induced osteoporosis.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Yang Sun, Yue Li, Jiangbi Li, Xiaoping Xie, Feng Gu, Zhenjiang Sui, Ke Zhang, Tiecheng Yu
Summary: The study found that a combination treatment of teriparatide and denosumab in postmenopausal osteoporosis patients leads to greater increase in bone density compared to monotherapy, without significant difference in adverse events.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Moritz Weigl, Roland Kocijan, James Ferguson, Gabriele Leinfellner, Patrick Heimel, Xaver Feichtinger, Peter Pietschmann, Johannes Grillari, Jochen Zwerina, Heinz Redl, Matthias Hackl
Summary: MicroRNAs play a regulatory role in bone homeostasis, and circulating microRNAs are considered as potential biomarkers for bone health. This study investigated the impact of anti-osteoporotic treatments on circulating microRNAs in OVX and SHAM rats, revealing that these treatments can reverse bone loss and modulate specific miRNA expressions. The findings suggest that bone-related miRNAs could serve as promising biomarkers for monitoring treatment efficacy in osteoporosis.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Jawed A. Siddiqui, Carole Le Henaff, Joshua Johnson, Zhiming He, Daniel B. Rifkin, Nicola C. Partridge
Summary: The study demonstrates that in bone tissue, MCP-1 is the most highly stimulated gene after PTH stimulation, with osteoblasts being the primary cells expressing MCP-1. The importance of MCP-1 in PTH's anabolic effects is confirmed by experiments showing that MCP-1 null mice do not respond to PTH, and that treatment with MCP-1 peptide can rescue this effect.
Article
Endocrinology & Metabolism
Steven Fenwick, Vishal Vekariya, Ronak Patel, Pallavi Hajela, Ketul Modi, Prashant Kale, Akshaya Nath
Summary: This study demonstrated the pharmacokinetic bioequivalence of the biosimilar teriparatide to EU- and US-approved teriparatide reference products. It also showed comparable pharmacodynamics, safety, and immunogenicity profiles.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Ferenc Emil Mozes, Jenny A. Lee, Emmanuel Anandraj Selvaraj, Arjun Narayan Ajmer Jayaswal, Michael Trauner, Jerome Boursier, Celine Fournier, Katharina Staufer, Rudolf E. Stauber, Elisabetta Bugianesi, Ramy Younes, Silvia Gaia, Monica Lupsor-Platon, Salvatore Petta, Toshihide Shima, Takeshi Okanoue, Sanjiv Mahadeva, Wah-Kheong Chan, Peter J. Eddowes, Gideon M. Hirschfield, Philip Noel Newsome, Vincent Wai-Sun Wong, Victor de Ledinghen, Jiangao Fan, Feng Shen, Jeremy F. Cobbold, Yoshio Sumida, Akira Okajima, Joern M. Schattenberg, Christian Labenz, Won Kim, Myoung Seok Lee, Johannes Wiegand, Thomas Karlas, Yusuf Yilmaz, Guruprasad Padur Aithal, Naaventhan Palaniyappan, Christophe Cassinotto, Sandeep Aggarwal, Harshit Garg, Geraldine J. Ooi, Atsushi Nakajima, Masato Yoneda, Marianne Ziol, Nathalie Barget, Andreas Geier, Theresa Tuthill, M. Julia Brosnan, Quentin Mark Anstee, Stefan Neubauer, Stephen A. Harrison, Patrick M. Bossuyt, Michael Pavlides
Summary: Liver biopsy is still necessary for fibrosis staging in patients with non-alcoholic fatty liver disease. This study evaluated the diagnostic performance of liver stiffness measurement, FIB-4 Index, and NAFLD Fibrosis Score, and showed that sequential combinations of markers can reduce the need for liver biopsies.
Article
Transplantation
Nadja Sparding, Federica Genovese, Daniel Guldager Kring Rasmussen, Morten Asser Karsdal, Michaela Neprasova, Dita Maixnerova, Veronika Satrapova, Doubravka Frausova, Mads Hornum, Lenka Bartonova, Eva Honsova, Marek Kollar, Helena Koprivova, Zdenka Hruskova, Vladimir Tesar
Summary: This study found that levels of circulating and excreted ETP are associated with kidney function, CKD severity, and the extent of interstitial fibrosis, gradually increasing with higher fibrotic burden. ETP outperformed the known fibrosis biomarker Dickkopf-3 in discriminating patients with high fibrotic burden.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Orthopedics
V. B. Kraus, M. A. Karsdal
Summary: This article provides an overview of biomarkers for osteoarthritis (OA) and aims to equip non-specialists with a toolbox to understand and utilize biomarkers in the field of OA. Although the importance of molecular biomarkers in OA has been increasingly recognized, no OA-related biomarkers have been widely adopted in clinical practice. However, there is a growing compendium of OA-related biomarkers that could facilitate drug development for OA. The use of appropriate biomarkers is crucial for OA diagnosis, prognosis, drug development, and treatment.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Rheumatology
Salome Kristensen, Signe Holm Nielsen, Erik Berg Schmidt, Anne Christine Bay-Jensen, Morten A. Karsdal, Jeppe Hagstrup Christensen
Summary: The study found that there was no significant correlation between the content of fatty acids in granulocytes and disease activity in patients with psoriatic arthritis (PsA). However, marine n-3 PUFA was positively correlated with collagen degradation, while n-6 PUFA was positively correlated with collagen formation. Further investigation is needed to explore the relationship between fatty acids and biomarkers of bone and soft tissue turnover.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Liang-Jie Tang, Hong-Lei Ma, Mohammed Eslam, Grace Lai-Hung Wong, Pei-Wu Zhu, Sui-Dan Chen, Diana Julie Leeming, Morten Karsdal, Gang Li, Ou-Yang Huang, Howard Ho-Wai Leung, Yu-Jie Zhou, Qian Feng, Pei Jiang, Li-Mei Gao, Christopher D. Byrne, Giovanni Targher, Jacob George, Vincent Wai-Sun Wong, Ming-Hua Zheng
Summary: This study evaluated the performance of new biomarkers and algorithms for diagnosing advanced fibrosis in an Asian population. The results showed that the ADAPT score had good accuracy and sensitivity in diagnosing advanced fibrosis, and it outperformed other non-invasive fibrosis biomarkers. The ADAPT score also had good diagnostic performance in subgroup analyses.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Cardiac & Cardiovascular Systems
Dania Al-Sharify, Signe Holm Nielsen, Frank Matthes, Christoffer Tengryd, Jiangming Sun, Federica Genovese, Morten A. Karsdal, Jan Nilsson, Isabel Goncalves, Andreas Edsfeldt
Summary: This study investigated the association of cleaved osteoglycin with plaque phenotype and found that higher levels of cleaved osteoglycin were associated with a stable plaque phenotype and lower risk for future cardiovascular events. This association may be due to reduced cell apoptosis and the ability to retain LDL. Targeting the cleavage of osteoglycin may be a potential therapeutic strategy to stabilize plaques.
Article
Rheumatology
Signe Holm Nielsen, Andrew Stahly, Emilie H. Regner, Anne -Christine Bay-Jensen, Morten A. Karsdal, Kristine A. Kuhn
Summary: This study investigated the association between biomarkers of collagen degradation in healthy controls and patients with axSpA, CD, and CD-axSpA. The results showed that degradation of type IV collagen, quantified by C4M, could completely differentiate patients with CD-axSpA from axSpA, CD, and healthy controls, indicating excessive collagen degradation and epithelial turnover. This biomarker has the potential to identify patients affected by both diseases and guide treatment decisions.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Clinical Neurology
Edmond Teng, Paul T. Manser, Karen Pickthorn, Flavia Brunstein, Mira Blendstrup, Sandra Sanabria Bohorquez, Kristin R. Wildsmith, Bali Toth, Michael Dolton, Vidya Ramakrishnan, Ashwini Bobbala, Sietske A. M. Sikkes, Michael Ward, Reina N. Fuji, Geoffrey A. Kerchner
Summary: In this study, semorinemab did not slow clinical progression in patients with prodromal to mild AD, but demonstrated good safety. Further research is needed to determine the clinical utility of anti-tau antibody therapy.
Letter
Dermatology
Signe Holm Nielsen, Solveig Skovlund Groen, Yiqiu Yao, Astrid-Helene Ravn Jorgensen, Valdemar Wendelboe Nielsen, Morten Karsdal, Kristoffer Gehring, Anne-Christine Bay-Jensen, Simon Francis Thomsen
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Transplantation
Daan Kremer, Firas F. Alkaff, Adrian Post, Tim J. Knobbe, Martin Tepel, Olivier Thaunat, Stefan P. Berger, Jacob van den Born, Federica Genovese, Morten A. Karsdal, Daniel G. K. Rasmussen, Stephan J. L. Bakker, Behalf Transplant Lines Investigators
Summary: This study found a strong association between plasma endotrophin and graft failure and mortality in kidney transplant recipients. The findings suggest that abnormal extracellular matrix turnover and fibrosis play a key role in the prognosis of kidney transplant recipients and highlight the need for interventional studies targeting the profibrotic state of these patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Aruna Das Pradhan, Robert J. Glynn, Jean-Charles Fruchart, Jean G. MacFadyen, Elaine S. Zaharris, Brendan M. Everett, Stuart E. Campbell, Ryu Oshima, Pierre Amarenco, Dirk J. Blom, Eliot A. Brinton, Robert H. Eckel, Marshall B. Elam, Joao S. Felicio, Henry N. Ginsberg, Assen Goudev, Shun Ishibashi, Jacob Joseph, Tatsuhiko Kodama, Wolfgang Koenig, Lawrence A. Leiter, Alberto J. Lorenzatti, Boris Mankovsky, Nikolaus Marx, Borge G. Nordestgaard, Denes Pall, Kausik K. Ray, Raul D. Santos, Handrean Soran, Andrey Susekov, Michal Tendera, Koutaro Yokote, Nina P. Paynter, Julie E. Buring, Peter Libby, Paul M. Ridker
Summary: In patients with type 2 diabetes and high triglyceride levels, pemafibrate can reduce triglyceride, VLDL cholesterol, remnant cholesterol, and apolipoprotein C-III levels, but does not lower the incidence of cardiovascular events.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Mette J. Nielsen, Grace E. Dolman, Rebecca Harris, Peder Frederiksen, Jane Chalmers, Jane I. Grove, William L. Irving, Morten A. Karsdal, Keyur Patel, Diana Julie Leeming, Indra Neil Guha
Summary: This study investigated the prognostic value of the fibrogenesis marker PRO-C3 and the ALBI score in predicting clinical outcomes and mortality in two cohorts of compensated cirrhosis patients. The results showed that both PRO-C3 and ALBI were independently associated with liver-related clinical outcomes, suggesting that PRO-C3 may be a valuable predictor of treatment efficacy.
Article
Gastroenterology & Hepatology
Morten A. Karsdal, Kate Hallsworth, Jadine Scragg, Diana J. Leeming, Ida F. Villesen, Leah Avery, Laura Haigh, Olivier Govaere, Sarah Wichmann, Guy Taylor, Sophie Cassidy, Stuart Mcpherson, Quentin M. Anstee
Summary: The amount of fibroblast activity in patients with NAFLD can be defined by circulating biomarkers of collagen formation. The high-risk, high-fibrogenesis patient endotype with greater fibroblast activity exhibited a marked reduction in collagen fibrogenesis with a very low-calorie diet intervention, while fibrogenesis remained unchanged in the low activity group. The quantification of fibrogenesis biomarkers at baseline can predict the likelihood of treatment response.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Urology & Nephrology
Nadja Sparding, Daniel Guldager Kring Rasmussen, Federica Genovese, Morten Asser Karsda, Mads Hornum, Bo Feldt-Rasmussen, Rebecca Packington, Nicholas M. Selby
Summary: This study found that levels of plasma ETP were higher in patients with acute kidney injury (AKI) at 1 year compared to those without AKI, and ETP levels predicted kidney disease progression and mortality in AKI patients.
Article
Gastroenterology & Hepatology
Katherine Johnson, Peter J. Leary, Olivier Govaere, Matthew J. Barter, Sarah H. Charlton, Simon J. Cockell, Dina Tiniakos, Michalina Zatorska, Pierre Bedossa, M. Julia Brosnan, Jeremy F. Cobbold, Mattias Ekstedt, Guruprasad P. Aithal, Karine Clement, Joern M. Schattenberg, Jerome Boursier, Vlad Ratziu, Elisabetta Bugianesi, Quentin M. Anstee, Ann K. Daly
Summary: The study found that serum miR-193a-5p levels are strongly correlated with NAFLD activity grade and fibrosis stage. MiR-193a-5p may play a role in the hepatic response to oxidative stress and is a potential circulating biomarker for progressive NAFLD.
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.