Article
Biochemistry & Molecular Biology
Parichart Toejing, Nithidol Sakunrangsit, Pinyada Pho-on, Chinnatam Phetkong, Asada Leelahavanichkul, Somyoth Sridurongrit, Matthew B. Greenblatt, Sutada Lotinun
Summary: In this study, transgenic mice expressing constitutively active TGF-beta receptor type I were found to have osteopenia due to increased osteoclast number and decreased osteoblast number, possibly by suppressing Hedgehog signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Xianghe Chen, Peng Sun, Aiguo Chen, Haixia Peng, Xianliang Zhang, Kang Yang, Huilin Yu, Renqing Zhao
Summary: Downhill running can promote bone formation ability and bone mineralization ability by activating the TGF-0/Smad pathway. It increases bone density and alkaline phosphatase activity, improves bone mass and bone tissue morphology, and enhances osteoblastic differentiation and mineralized nodule formation.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Cell & Tissue Engineering
Jie Zhou, Junying Yang, Yuan Dong, Yaru Shi, Endong Zhu, Hairui Yuan, Xiaoxia Li, Baoli Wang
Summary: Our study has for the first time established the direct role of OSMR in regulating osteogenic differentiation of marrow stromal progenitor cells through ERK-mediated autophagy signaling. OSMR thus contributes to bone homeostasis through dual regulation of osteoblasts and osteoclasts. It also suggests that OSMR may be a potential target for the treatment of metabolic disorders such as osteoporosis.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Toshihisa Komori
Summary: Runx2 is a crucial transcription factor in bone development, playing a key role in the maturation and proliferation of chondrocytes and osteoblasts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Richard J. Visconti, Kyle Kolaja, Jessica A. Cottrell
Summary: The study developed a three-dimensional bone organoid model for studying human myeloma bone disease (MBD) and treatment options. The model demonstrated the ability to restore the balance of bone metabolism and assess bone structure and function.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Cell & Tissue Engineering
Xiaowen Wu, Xiaochen Wang, Liying Shan, Jie Zhou, Xin Zhang, Endong Zhu, Hairui Yuan, Baoli Wang
Summary: The loss of NFIX gene affects endochondral ossification and mineralization in bone, with NFIX inducing osteoblast differentiation and impairing adipocyte formation by regulating HMGA1 expression. HMGA1 plays a role in osteoblast commitment and mediates NFIX function by activating canonical Wnt signaling pathways.
Review
Immunology
Tatjana Bordukalo-Niksic, Vera Kufner, Slobodan Vukicevic
Summary: Bone remodeling in the adult skeleton involves a continuous process of old and damaged bone removal by osteoclasts and subsequent new bone formation by osteoblasts. BMPs play a crucial role in maintaining healthy bone, affecting both bone formation and resorption, and may be involved in pathological processes related to inflammatory disorders affecting bones and joints.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Wenjing Jin, Xianfeng Lin, Haihua Pan, Chenchen Zhao, Pengcheng Qiu, Ruibo Zhao, Zihe Hu, Yanyan Zhou, Haiyan Wu, Xiao Chen, Hongwei Ouyang, Zhijian Xie, Ruikang Tang
Summary: The authors demonstrate that chemically engineered osteoclasts coated with tetracycline can improve their targeting capacity to ectopic calcifications, effectively treating heterotopic ossification.
NATURE COMMUNICATIONS
(2021)
Article
Engineering, Environmental
Wisurumuni Arachchilage Hasitha Maduranga Karunarathne, Yung Hyun Choi, Sang Rul Park, Chang-Min Lee, Gi-Young Kim
Summary: This study reveals that BPA inhibits osteoblast differentiation and bone formation by activating ROR alpha, potentially causing bone-resorptive diseases such as osteoporosis.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Endocrinology & Metabolism
Samuel D. Burciaga, Flavia Saavedra, Lori Fischer, Karen Johnstone, Eric D. Jensen
Summary: Studies using kinase inhibitors have found that PRKD is necessary for the formation and function of osteoclasts. However, the role of individual PRKD genes and their significance in skeletal dynamics is still unclear. In this study, we show that PRKD3 is the primary form expressed in osteoclasts. Knockout of Prkd3 reduces osteoclast differentiation and resorptive function, leading to increased bone mass in male mice. Protection against bone loss was not observed in a periodontal disease model. Overall, our data demonstrate that PRKD3 promotes osteoclastogenesis both in vitro and in vivo.
Article
Biochemistry & Molecular Biology
Francesca Manuela Johnson de Sousa Brito, Andrew Butcher, Addolorata Pisconti, Blandine Poulet, Amanda Prior, Gemma Charlesworth, Catherine Sperinck, Michele Scotto di Mase, Ke Liu, George Bou-Gharios, Robert Jurgen van 't Hof, Anna Daroszewska
Summary: Syndecan-3 promotes new bone formation in osteoblasts by enhancing WNT signaling, and its deficiency in mice results in an early osteoporosis-like phenotype due to delayed osteoblast maturation and impaired function. Overexpressing Sdc3 in osteoblasts rescues the low bone volume phenotype and increases bone mass, making SDC3 a potential target for novel bone anabolic drug development.
Article
Plant Sciences
Wei Peng, Wenjuan Zhang, Qici Wu, Shunyou Cai, Tingting Jia, Jiarui Sun, Zhichao Lin, Gulimiran Alitongbieke, Yixuan Chen, Yi Su, Jinmei Lin, Lisheng Cai, Yuqin Sun, Yutian Pan, Yu Xue
Summary: The study reveals that Glucosamine hydrochloride extracted from the cell wall of Agaricus bisporus plays a dose-dependent role in promoting cartilage and bone development, as well as caudal fin regeneration in adult fish, by regulating the expression of bone-related genes. Furthermore, GAH improves osteoporosis defects induced by high iron and promotes skeletal development and injury repair through bone morphogenetic protein signaling at the downstream of the receptor level.
JOURNAL OF NATURAL PRODUCTS
(2021)
Review
Pharmacology & Pharmacy
Yan Li, Lingyu Li, Xiaoyun Li, Bingjie Luo, Qianyun Ye, Haoyu Wang, Li Yang, Xiaofeng Zhu, Li Han, Ronghua Zhang, Huaqin Tian, Panpan Wang
Summary: Bone reconstruction relies on the balance between bone formation and bone absorption. Polyphenols found in Chinese herbal medicines can affect this balance and have potential therapeutic effects on bone metabolic diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
I. Saranya, R. L. Akshaya, N. Selvamurugan
Summary: Bone remodeling involves the coordination of ossification and bone resorption activities by osteoblasts and osteoclasts, regulated by various growth factors and hormones. Dysregulation in the Wnt signaling pathway can lead to bone disorders, with non-coding RNAs playing a critical role in modulating the Wnt cascade for bone homeostasis. Understanding the regulatory role of ncRNAs could provide new therapeutic strategies for bone-related disorders.
Article
Cell Biology
Xin Zhou, Allyson Beilter, Zhaohui Xu, Ruli Gao, Shunbin Xiong, Adriana Paulucci-Holthauzen, Guillermina Lozano, Benoit de Crombrugghe, Richard Gorlick
Summary: This study identified chondrocytes as an additional source for mesenchymal progenitor cells (MPCs) and showed that Wnt/ss-catenin pathway discretely regulates the development from chondrocytes to C-MPC and subsequently from C-MPC to osteoblasts. Furthermore, the study unveiled a previously unrecognized functional link between ss-catenin and p53, with p53 playing a negative role in MPC osteogenic differentiation induced by Wnt/ss-catenin signaling.
CELL DEATH & DISEASE
(2021)
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.
