Article
Neurosciences
Youichi Shinozaki, Kozo Saito, Kenji Kashiwagi, Schuichi Koizumi
Summary: ATP, the energy source in cells, can be released to the extracellular space and serve as a signaling molecule. In the eye, ATP release in response to physiological stimuli regulates intraocular pressure, and dysregulated ATP signaling may contribute to elevated intraocular pressure and glaucoma pathogenesis.
Review
Biochemistry & Molecular Biology
Adel E. E. Khairullin, Sergey N. N. Grishin, Ayrat U. U. Ziganshin
Summary: The purine signaling system, represented by purine and pyrimidine nucleotides and nucleosides, plays a role through the adenosine, P2X and P2Y receptor families. While P2 receptors have a minor role in physiological conditions, they become more significant in certain pathophysiological conditions, functioning as dominant signaling molecules. The diversity and distribution of P2 receptors make them an attractive target for new mechanism drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xiaohang Gao, Xiaohui Di, Jingjing Li, Yiting Kang, Wenjun Xie, Lijun Sun, Jianbao Zhang
Summary: This study found that high extracellular calcium concentrations can promote the proliferation of MC3T3-E1 cells by triggering a calcium transient via the calcium-sensing receptor (CaSR) and activating glycolysis through AKT-related signaling pathways. These results indicate that high extracellular calcium levels can stimulate the proliferation of osteoblasts through glycolysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Sun-Hee Woo, Tran Nguyet Trinh
Summary: ATP serves as a major energy source in mammalian cells but also acts as an extracellular chemical messenger through P2 purinergic receptors. Different types of cells release ATP, including neurons, endothelial cells, and muscle cells. Studies have shown the distribution and roles of P2 receptor subtypes in cardiac cells under physiological and pathological conditions, with specific genetic alterations and pharmacological approaches revealing distinct functions of P2 receptors in the heart.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Valentina Vultaggio-Poma, Francesco Di Virgilio
Summary: Extracellular ATP and P2 receptors are emerging regulators of T-lymphocyte responses, affecting T-cell energy metabolism and activation status, potentially serving as markers of immune-mediated disease conditions.
Article
Agriculture, Dairy & Animal Science
Noemi Gutierrez, Stefanie Teuber, Pablo Alarcon, Rafael A. A. Burgos, Maria A. Hidalgo
Summary: In this study, it was observed that ATP increases inflammatory responses in bovine endometrial cells, such as release of IL-8, intracellular calcium mobilization, and ERK1/2 phosphorylation. The study also discovered the presence of P2Y receptors, specifically high levels of P2Y1 and P2Y2 receptors, in bovine endometrial cells. Inhibition of P2Y receptors reduced the proinflammatory responses induced by ATP. These findings suggest that P2Y receptors play a role in endometrial inflammatory activation and could be a therapeutic target for regulating uterine inflammation.
Article
Biochemistry & Molecular Biology
Marco Rossato, Francesca Favaretto, Marnie Granzotto, Marika Crescenzi, Alessandra Boscaro, Angelo Di Vincenzo, Federico Capone, Edoardo Dalla Nora, Eva Zabeo, Roberto Vettor
Summary: Research shows that human adipocytes express various P2X and P2Y receptors, which can be functionally activated by extracellular ATP to regulate calcium levels and IL-6 secretion. Additionally, adipocytes are capable of spontaneously releasing ATP and modulating IL-6 secretion.
Article
Neurosciences
H. C. Ferreira-Neto, V. R. Antunes, J. E. Stern
Summary: The study reveals that ATP enhances extrasynaptic NMDAR function through purinergic P2 receptors in MNNs in a Ca2+-dependent manner, contributing to osmotically driven firing activity. These findings suggest a functional excitatory coupling between P2 and extrasynaptic NMDA receptors in response to acute hyperosmotic stimuli, shedding light on the precise mechanisms regulating the activity of hypothalamic magnocellular neurosecretory neurons.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Neurosciences
Olena A. Petrushenko, Anastasiiya O. Stratiievska, Mariia O. Petrushenko, Elena A. Lukyanetz
Summary: This study investigated the dynamics of calcium transients in DRG neurons associated with TRPV1 channel desensitization and the effect of P2 receptor activation on this process. It was found that TRPV1 channels are mainly present in small nociceptive neurons, while P2 receptors are present in all types of neurons. ATP application can restore the response to capsaicin in these neurons.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Janielle P. Maynard, Karen S. Sfanos
Summary: P2 purinergic receptors play a crucial role in the normal function of the kidney, bladder, and prostate, as well as in various urologic disorders. Dysregulation of these receptors is associated with disease initiation and progression. Additionally, these receptors are overexpressed in urologic cancers and have potential as therapeutic targets. Exploring the role of P2 purinergic receptors in urologic diseases can provide new mechanistic insights and potential treatment options.
PURINERGIC SIGNALLING
(2022)
Article
Chemistry, Multidisciplinary
Emira D'Amico, Tania Vanessa Pierfelice, Giovanna Iezzi, Natalia Di Pietro, Stefania Lepore, Felice Lorusso, Antonio Scarano, Assunta Pandolfi, Adriano Piattelli, Morena Petrini
Summary: Apigenin (APG), a natural flavonoid compound with anti-inflammatory and antioxidative properties, has the potential to promote proliferation and mineralization of human oral osteoblasts, indicating its possible usefulness in dentistry.
APPLIED SCIENCES-BASEL
(2022)
Review
Immunology
Tobias Engel, Jonathon Smith, Mariana Alves
Summary: The treatment of epilepsy remains challenging, with chronic inflammation playing a crucial role in its pathogenesis. Identifying and targeting mechanisms that regulate inflammation may be a promising strategy for future epilepsy treatment. ATP-gated receptors are considered novel drug targets for epilepsy, showing potential for anticonvulsant and antiepileptic effects.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Cell Biology
Anael Viana Pinto Alberto, Natiele Carla da Silva Ferreira, Andre Gustavo Calvano Bonavita, Oscar Kenji Nihei, Fernando Pires de Farias, Rodrigo da Cunha Bisaggio, Cristovao de Albuquerque, Wilson Savino, Robson Coutinho-Silva, Pedro Muanis Persechini, Luiz Anastacio Alves
Summary: Purinergic receptors play important roles in the immune system, particularly the P2 receptors that regulate leukocyte activity. This review examines the characteristics of P2 receptor subtypes in the immune system and their involvement in infectious diseases, inflammation, and pain.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Vera Ralevic
Summary: Geoffrey Burnstock was a legendary figure in the field of purinergic signalling, with extraordinary contributions to the discovery of ATP as a neurotransmitter and classification of purine receptors, leading the field for over 50 years.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Qihang Kong, Yue Quan, Geer Tian, Junteng Zhou, Xiaojing Liu
Summary: Mechanosensing and mechanotransduction are crucial processes in mechanobiology, with purinergic P2 receptors playing a key role in cellular mechanotransduction. Understanding the specific mechanism of P2 receptor-mediated mechanotransduction is valuable, as interactions between P2 receptors and other mechanosensitive molecules affect physiological processes in cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Heron F. Torquato, Manoel Trindade Rodrigues Junior, Caue Santos Lima, Roberto Theodoro de Araujo Junior, Fernanda Talhati, Dhebora Albuquerque Dias, Giselle Zenker Justo, Alice Teixeira Ferreira, Ronaldo Aloise Pilli, Edgar J. Paredes-Gamero
Summary: The natural product 10-methoxycanthin6-one (Mtx-C) showed high cytotoxicity in malignant AML cells Kasumi-1 and KG-1 by inducing mitochondrial-related apoptosis. Additionally, Mtx-C was able to simultaneously execute apoptotic and necrotic programs in Kasumi-1 cells, offering a promising opportunity for the development of new anti-leukemic molecules.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Engineering, Biomedical
Rafaella de S. S. Zanette, Leonara Fayer, Eduarda R. de Oliveira, Camila G. Almeida, Caue R. Oliveira, Luiz F. C. de Oliveira, Carlos M. C. Maranduba, Erika C. Alvarenga, Humberto M. Brandao, Michele Munk
Summary: Cotton CNFs have been found to have good cellulose morphology at the nanoscale, with the ability to induce stem cell differentiation, showing potential for applications in tissue engineering and regenerative medicine.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2022)
Article
Biology
Amanda Nogueira-Pedro, Helena Regina Comodo Segreto, Kathryn D. Held, Antonio Francisco Gentil Ferreira Junior, Carolina Carvalho Dias, Araceli Aparecida Hastreiter, Edson Naoto Makiyama, Edgar Julian Paredes-Gamero, Primavera Borelli, Ricardo Ambrosio Fock
Summary: This study aimed to evaluate the direct and bystander responses of mesenchymal stem cells (MSCs) to radiation and characterize their radiobiological properties. The results showed that radiation mainly affected directly irradiated MSCs at higher doses, leading to cell death, cell cycle arrest, upregulation of p21, and alteration of redox status. Micronuclei formation, H2AX phosphorylation, and decreased Akt expression were also induced by radiation, regardless of the dose. Bystander effects from unirradiated MSCs were not observed.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Simone Schneider Weber, Alessandra Carla Sampaio de Souza, Denise Caroline Luiz Soares, Caroline Carvalho Lima, Ana Carolina Rabello de Moraes, Stephanie Viegas Gkionis, Tanara Arenhart, Luiz Gustavo Goncalves Rodrigues, Sandra Regina Salvador Ferreira, Rozangela Curi Pedrosa, Denise Brentan Silva, Edgar Julian Paredes-Gamero, Renata Trentin Perdomo, Eduardo Benedetti Parisotto
Summary: The study found that A. bisporus extracts obtained by supercritical fluid extraction showed excellent performance in terms of antimicrobial, antiaggregant, and anticoagulant activities.
Article
Biochemistry & Molecular Biology
Robson Araujo de Freitas Junior, Paloma Kenia de Moraes Berenguel Lossavaro, Candida Aparecida Leite Kassuya, Edgar Julian Paredes-Gamero, Nelson Carvalho Farias Junior, Maria Ines Lenz Souza, Francielli Maria de Souza Silva-Comar, Roberto Kenji Nakamura Cuman, Denise Brentan Silva, Monica Cristina Toffoli-Kadri, Saulo Euclides Silva-Filho
Summary: This study evaluated the phytochemical profile, oral acute toxicity, and the anti-inflammatory effect of ylang-ylang essential oil. The results showed that ylang-ylang essential oil affected leukocyte activation and had anti-edematogenic, anti-hyperalgesic, and anti-inflammatory properties.
Article
Materials Science, Coatings & Films
Ana Barbara Batista, Michael Stanley, Ana Carolina Ferreira de Brito, Rebecca Vasconcellos, Michele Munk, Mario Jose-Bueno, Cristina Godoy, Erika Costa de Alvarenga, Claudia Karina Barbosa de Vasconcelos, Ariete Righi, Edesia M. B. de Sousa, Alan Barros de Oliveira, Ronaldo Junio Campos Batista, Jaqueline dos Santos Soares, Bernardo Ruegger Almeida Neves, Ana Paula Moreira Barbosa, Taise Matte Manhabosco
Summary: Nano-talc was successfully incorporated in the hydroxyapatite matrix through an eco-friendly liquid-phase exfoliation process, and it significantly improves the performance of bioceramic materials, including higher stiffness, reduced friction coefficient and wear damage, as well as corrosion resistance and biocompatibility.
SURFACE & COATINGS TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gabriella Teles Burkner, Dhebora Albuquerque Dias, Kamylla Fernanda Souza de Souza, Anna Julia Papa de Araujo, Denise Caroline Luiz Soares Basilio, Fernanda Tondello Jacobsen, Ana Carolina Rabello de Moraes, Saulo Euclides Silva-Filho, Marcos Filipe de Oliveira Cavalcante, Cassio Augusto de Oliveira Moraes, Sumbal Saba, Maria Ligia Rodrigues Macedo, Edgar Julian Paredes-Gamero, Jamal Rafique, Eduardo Benedetti Parisotto
Summary: This study evaluated the antileukemic capacity of IP derivatives by screening their ability as a pro-oxidant. MRK-107 showed the best redox profile and induced cell senescence through oxidative stress in K562 cells.
Article
Multidisciplinary Sciences
Mariana Freitas de Aguiar, Heron Torquato, Bruno Ramos Salu, Ana Cecilia Diniz Oliveira, Maria Luiza Vilela Oliva, Edgar Julian Paredes-Gamero, Wayel H. Abdulahad, Elisabeth Brouwer, Alexandre W. S. de Souza
Summary: This study found that individuals with Takayasu arteritis (TAK) showed abnormal levels of monocyte subsets and related chemokines. Active TAK patients had higher monocyte counts, while glucocorticoid treatment affected the proportion of monocyte subsets. CCL22 was found to have the strongest association with disease activity in TAK.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Ana Calheiros de Carvalho, Caue Santos Lima, Heron Fernandes Vieira Torquato, Andre Tarsis Domiciano, Sebastiao da Cruz Silva, Lucas Magalhaes de Abreu, Miriam Uemi, Edgar Julian Paredes-Gamero, Paulo Cezar Vieira, Thiago Andre Moura Veiga, Livia Soman de Medeiros
Summary: Penicillium setosum is a species with limited information about its metabolic and biological potential. Chemical and biological studies of P. setosum CMLD18 revealed six compounds, one of which displayed promising cytotoxic activity against a human leukemia cell line.
Article
Multidisciplinary Sciences
Bruno Henrique Costa, Alisson Kennedy Rezende, Lais Costa, Gabrielle Fernanda Monteiro Neves, Antonio Carlos Shimano, Alvaro de Oliveira Penoni, Claudia Rocha Carvalho, Raquel Alves Costa, Erika Costa de Alvarenga
Summary: Injection of zein protein can reduce inflammation and promote bone healing. The experiment showed that zein injection improved bone repair and mechanical strength.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Medicinal
Amarith R. das Neves, Diego B. Carvalho, Fernanda Silva, Rafael F. Rosalem, Bruno I. Pelizaro, Pamella F. Castilho, Kelly M. P. Oliveira, Nadla S. Cassemiro, Lucas R. Pessatto, Edgar J. Paredes-Gamero, Eliane M. Piranda, Denise B. Silva, Carla C. P. Arruda, Adriano C. M. Baroni
Summary: This study evaluated the in vivo intralesional treatment efficacy of five isoxazole derivatives and found that analogue 7 showed promising therapeutic effects and low toxicity. It could be a potential new drug candidate for CL caused by L. amazonensis.
ACS INFECTIOUS DISEASES
(2023)
Article
Immunology
Paola Mayara Valente Coronel, Indiara Correia Pereira, Denise Caroline Luiz Soares Basilio, Isabelly Teixeira Espinoca, Kamylla Fernanda Souza de Souza, Rafael Seiji Nakano Ota, Eliane Borges de Almeida, Edgar Julian Paredes-Gamero, Danilo Wilhelm Filho, Renata Trentin Perdomo, Eduardo Benedetti Parisotto
Summary: COVID-19 is a severe respiratory disease caused by the new coronavirus. Excessive release of pro-inflammatory cytokines and oxidative stress may contribute to the pathophysiology of the disease. This study found that patients with SARS-CoV-2 infection had higher levels of inflammatory cytokines and oxidative stress biomarkers, which were correlated with disease severity.
MICROBIAL PATHOGENESIS
(2023)
Article
Nutrition & Dietetics
Ed Wilson Santos, Carolina Carvalho Dias, Ricardo Ambrosio Fock, Edgar Julian Paredes-Gamero, Yun-Min Zheng, Yong-Xiao Wang, Primavera Borelli
Summary: Protein restriction leads to bone marrow hypoplasia by impairing the activation of mitogen-activated protein kinase (MAPK) signaling pathway in hematopoietic stem cells (HSCs). This results in altered proliferation and differentiation of HSCs.
NUTRITION RESEARCH
(2023)
Meeting Abstract
Rheumatology
Bruna Savioli, Heron Fernandes Vieira Torquato, Edgar Julian Paredes-Gamero, Andrea Fabiana do Vale Franco, Carolina de Oliveira Gigek, Ricardo Artigiani Neto, Alexandre Wagner de Souza
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Eveline M. Bezerra, Erika C. de Alvarenga, Ricardo P. dos Santos, Jeanlex S. de Sousa, Umberto L. Fulco, Valder N. Freire, Eudenilson L. Albuquerque, Roner F. da Costa
Summary: Losartan, a widely used hypertension medication, acts as a selective antagonist of angiotensin II receptor to reduce blood pressure. In this study, we investigated the interaction between losartan and sACE enzyme using molecular docking assays and quantum biochemistry calculations. Our findings reveal a new mechanism of action that has important implications for understanding the effects of losartan on hypertension.
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.
