Article
Endocrinology & Metabolism
Julie-Catherine Coll, Elodie Garceau, William D. Leslie, Mathieu Genest, Laetitia Michou, S. John Weisnagel, Fabrice Mac-Way, Caroline Albert, Suzanne N. Morin, Remi Rabasa-Lhoret, Claudia Gagnon
Summary: The prevalence of vertebral fractures is comparable between individuals with well-controlled T1D and nondiabetic controls, but T1D patients have lower bone density and trabecular bone score.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
A. E. Yildiz, A. B. Ozbalci, F. B. Ergen, U. Aydingoz
Summary: The study found that the MRI prevalence of pregnancy- and lactation-associated vertebral compression fractures (PLVCFs) is approximately 0.5% in females aged 15 to 40 years, showing no distinguishing features from other vertebral insufficiency fractures.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Konstantinos D. Stathopoulos, Efstathios Chronopoulos, Andonis Galanos, Evangelia Kaskani, Tatiana Drakopoulou, Eriona Ibro, Memi Tsekoura, Christos Kosmidis
Summary: The study aimed to assess the prevalence of morphometric vertebral fractures (VFs) in osteoporotic patients in the country. Results showed that 25.4% of patients had VFs, with the majority of them (76.6%) being undiagnosed prior to inclusion in the study.
ARCHIVES OF OSTEOPOROSIS
(2021)
Article
Medicine, General & Internal
Yang Jiang, Wei Zhang, Shihao Huang, Qing Huang, Haoyi Ye, Yurong Zeng, Xin Hua, Jinhui Cai, Zhifeng Liu, Qingyu Liu
Summary: This study aimed to develop a radiomics nomogram for the preoperative prediction of new vertebral fractures (NVFs) after vertebral augmentation (VA). The radiomics features were extracted from MRI images and combined with the presence of intravertebral cleft and number of previous vertebral fractures to develop a predictive model. The nomogram showed good predictive performance, successfully categorizing patients into high- or low-risk subgroups.
Article
Endocrinology & Metabolism
P. M. Dussault, D. McCarthy, S. A. Davis, M. Thakore-James, A. A. Lazzari
Summary: In male veterans with epilepsy who are chronic users of AEDs known to cause osteoporosis, there is a high prevalence of abnormal bone density and vertebral fractures, especially in the osteopenic range. Therefore, a more comprehensive bone health assessment should be conducted for these patients to prevent future osteoporotic fractures.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Geriatrics & Gerontology
Christian Pfeifle, Petr Kohut, Jan-Sven Jarvers, Ulrich J. Spiegl, Christoph-Eckhard Heyde, Georg Osterhoff
Summary: This study assessed the impact of time to surgery on 1-year survival in patients with osteoporotic vertebral compression fractures. The findings showed that time-to-surgery had no significant effect on one-year mortality in geriatric patients with these fractures, suggesting that treatment decisions should be individualized.
Article
Endocrinology & Metabolism
N. Binkley, J. T. Schousboe, L. M. Lix, S. N. Morin, W. D. Leslie
Summary: Prior non-vertebral fractures, such as hip, humerus, pelvis, forearm, and other fractures, are associated with an increased likelihood of previously undiagnosed vertebral fracture, providing useful information for risk stratification and monitoring.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Jianlun Zhang, Feng Liu, Jingxu Xu, Qingqing Zhao, Chencui Huang, Yizhou Yu, Huishu Yuan
Summary: This study designed a multistage deep learning system for the automatic detection, localization and classification of acute thoracolumbar vertebral body fractures based on AO classification on computed tomography. The system achieved high accuracy in detecting and classifying fractures in the thoracolumbar spine on CT images.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Hiroki Iida, Yoshihito Sakai, Taisuke Seki, Tsuyoshi Watanabe, Norimitsu Wakao, Hiroki Matsui, Shiro Imagama
Summary: The study investigates the impact of bisphosphonate (BP) on mortality post osteoporotic vertebral fracture (OVF), and finds that BP medication is significantly associated with reduced all-cause mortality after OVF.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
H. L. Aaltonen, M. K. O'Reilly, K. F. Linnau, Q. Dong, S. K. Johnston, J. G. Jarvik, N. M. Cross
Summary: The study aims to establish a method with clear rules for classifying osteoporotic vertebral body fractures (OVFs), which shows moderate interobserver agreement and practical feasibility.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Diego M. Cabrera, Mijahil P. Cornejo, Rebecca Slotkin, Yvett Pinedo, Wei Yu, Wenmin Guan, Patricia J. Garcia, Evelyn Hsieh
Summary: Osteoporosis and fracture risk among women with HIV in Latin America is understudied. In a sample of Peruvian women with and without HIV, women with HIV had lower femoral neck and total hip BMD and a higher proportion of vertebral fractures. Important treatment gaps were identified across both groups.
ARCHIVES OF OSTEOPOROSIS
(2023)
Review
Endocrinology & Metabolism
Michael Kriegbaum Skjodt, Bo Abrahamsen
Summary: This article summarizes the recent advances in the understanding of vertebral fractures, with a focus on endocrine diseases, prevention, and treatment. It highlights the increased risk of vertebral fractures in patients with endocrine diseases and the current focus on invasive treatments. It also mentions that licensed treatments are effective in reducing the occurrence of vertebral fractures in osteoporosis patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Carlo Sozzi, Mirko Trentadue, Lisa Nicoli, Federica Tavani, Enrico Piovan
Summary: This study retrospectively evaluated 324 biopsies performed before vertebroplasty in 1183 patients with vertebral compression fractures, without history of neoplastic or hematologic diseases, and with no suspicious findings for secondary fractures at imaging. Results showed that 9 cases (2.8%) were non-diagnostic, 295 cases (91%) were diagnosed with osteoporosis, and 20 cases (6.2%) had positive histology for underlying pathologies including multiple myeloma, lymphoma/leukemia, spondylitis, metastasis, and hemangioma. A significantly higher incidence of positive biopsies was found in patients younger than 73, suggesting the importance of biopsy in patients with VCF.
Article
Endocrinology & Metabolism
Michael Kriegbaum Skjodt, Joeri Nicolaes, Christopher Dyer Smith, Cesar Libanati, Cyrus Cooper, Kim Rose Olsen, Bo Abrahamsen
Summary: This study examines the direct healthcare costs of subjects with vertebral fractures available for identification on routine CT scans. The results show that patients with vertebral fractures incur significantly higher healthcare costs compared to those without fractures. The study also found that the healthcare costs per day at risk were higher in the short term for patients with vertebral fractures, although this difference was not statistically significant, and the long-term healthcare costs were similar to the general population.
Review
Medicine, General & Internal
Athanasios D. Anastasilakis, Polyzois Makras, Julien Paccou, Ilias Bisbinas, Stergios A. Polyzos, Socrates E. Papapoulos
Summary: The management of patients with RVFx requires a multidisciplinary approach, including pain relief, medication administration, back protection, early mobilization, and appropriate exercise.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Fran Llopis-Cardona, Carmen Armero, Isabel Hurtado, Anibal Garcia-Sempere, Salvador Peiro, Clara L. Rodriguez-Bernal, Gabriel Sanfelix-Gimeno
Summary: Osteoporotic hip fractures in older people may increase the risk of subsequent hip fractures and death. This study estimated the cumulative incidence of recurrent hip fracture and death in the Valencia region. The findings showed that women had a higher incidence of recurrent hip fracture than men, while men had a higher risk of death.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Anibal Garcia-Sempere, Isabel Hurtado, Salvador Peiro, Francisco Sanchez-Saez, Clara Liliana Rodriguez-Bernal, Magda Puig-Ferrer, Manuel Escolano, Gabriel Sanfelix-Gimeno
Summary: This study evaluated the impact of different interventions on improving the appropriateness of off-label prescription of immediate-release formulations of fentanyl (IRF). Although the use of IRF decreased, the interventions had limited and temporary effects on off-label prescription.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Anibal Garcia-Sempere, Isabel Hurtado, Salvador Peiro, Francisco Sanchez-Saez, Yared Santaana, Clara Rodriguez-Bernal, Gabriel Sanfelix-Gimeno, Jose Sanfelix-Genoves
Summary: This study compared the performance of the fracture risk assessment tool (FRAX) and a simple age and sex model in a Spanish population. The results showed that the two models had virtually identical performance, suggesting that the simple model can provide comparable predictive ability to FRAX.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
Marcos Lopez-Vega, Julio Domenech-Fernandez, Salvador Peiro, Manuel Ridao-Lopez
Summary: This study investigated the use of arthroscopic meniscectomy in Spain from 2003 to 2018 and found an increase in the number of procedures performed during this period, particularly among older patients. The study showed that this increase is unnecessary, as previous research has shown that surgery is not superior to nonoperative treatment.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2023)
Article
Health Care Sciences & Services
Patricia Martinez-Ibanez, Irene Marco-Moreno, Salvador Peiro, Lucia Martinez-Ibanez, Ignacio Barreira-Franch, Laura Bellot-Pujalte, Eugenia Avelino-Hidalgo, Marina Escrig-Veses, Maria Boveda-Garcia, Mercedes Calleja-del-Ser, Andreu Ferrero-Gregori, Adina A. Iftimi, Isabel Hurtado, Anibal Garcia-Sempere, Clara L. Rodriguez-Bernal, Margarita Gimenez-Loreiro, Gabriel Sanfelix-Gimeno, Jose Sanfelix-Genoves
Summary: This study compared self-monitoring plus self-titration of antihypertensive medication with usual care for reducing blood pressure in hypertensive patients. The results showed that self-monitoring plus self-titration can effectively lower blood pressure, increase blood pressure control rate, and does not increase adverse events.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Letter
Infectious Diseases
Jorge Camacho, Joao Zulaica, Estela Gimenez, Luciana Rusu, Sebastian Velandia-Alvarez, Eliseo Albert, Salvador Peiro, Hermelinda Vanaclocha, Ramon Limon, Ron Geller, David Navarro
JOURNAL OF INFECTION
(2023)
Article
Virology
Jorge Camacho, Estela Gimenez, Eliseo Albert, Joao Zulaica, Beatriz Alvarez-Rodriguez, Ignacio Torres, Luciana Rusu, Javier S. Burgos, Salvador Peiro, Hermelinda Vanaclocha, Ramon Limon, Maria Jesus Alcaraz, Jose Sanchez-Paya, Javier Diez-Domingo, Inaki Comas, Fernando Gonzales-Candelas, Ron Geller, David Navarro
Summary: This study investigates the cumulative incidence and immune status of SARS-CoV-2 infection, providing valuable information for public health decision-making. By April 2022, approximately half of the population in the Valencian Community had been infected with SARS-CoV-2 and displayed hybrid immunity due to extensive vaccination.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Jorge Camacho, Eliseo Albert, Beatriz Alvarez-Rodriguez, Luciana Rusu, Joao Zulaica, Alicia Rodriguez Moreno, Salvador Peiro, Ron Geller, David Navarro, Estela Gimenez
Summary: Supervised machine learning methods were used to predict antibody responses to COVID-19 vaccines. The study found that a machine learning model based on variables such as age, vaccination status, and infection status could accurately predict neutralizing antibody responses to Omicron BA.2 and BA.4/5 sublineages. This model could potentially save costs by replacing neutralization assays and anti-S serological tests.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Health Care Sciences & Services
Anibal Garcia-Sempere, Isabel Hurtado, Celia Robles, Fran Llopis-Cardona, Francisco Sanchez-Saez, Clara Rodriguez-Bernal, Salvador Peiro-Moreno, Gabriel Sanfelix-Gimeno
Summary: This cohort study conducted in Valencia, Spain, aimed to identify individual and initial prescription-related factors associated with an increased risk of opioid-related misuse, poisoning, and dependence (MPD) in patients with non-cancer pain. The study found that the use of ultrafast opioids, short-acting opioids, and long-acting opioids as initial prescriptions was associated with a higher risk of MPD. Additionally, male sex, younger age, lack of economic resources, and registered alcohol misuse were individual factors associated with an increased risk of MPD.
BMJ QUALITY & SAFETY
(2023)
Article
Pharmacology & Pharmacy
Carlos E. Duran, Judit Riera-Arnau, Shahab Abtahi, Romin Pajouheshnia, Vjola Hoxhaj, Magdalena Gamba, Ema Alsina, Mar Martin-Perez, Patricia Garcia-Poza, Ana Llorente-Garcia, Diana Gonzalez-Bermejo, Luisa Ibanez, Monica Sabate, Xavier Vidal, Elena Ballarin, Gabriel Sanfelix-Gimeno, Clara Rodriguez-Bernal, Salvador Peiro, Anibal Garcia-Sempere, Francisco Sanchez-Saez, Valentina Ientile, Ylenia Ingrasciotta, Claudio Guarneri, Matilde Tanaglia, Michele Tari, Ron Herings, Eline Houben, Karin Swart-Polinder, Emily Holthuis, Consuelo Huerta, Rosa Gini, Giuseppe Roberto, Claudia Bartolini, Olga Paoletti, Giorgio Limoncella, Anna Girardi, Giulia Hyeraci, Morten Andersen, Sarah Brogger Kristiansen, Christine Erikstrup Hallgreen, Olaf Klungel, Miriam Sturkenboom
Summary: The study found that the 2018 risk minimisation measures had limited impact on the utilization patterns of oral retinoids among females of childbearing age in four European countries. Pregnancy still occurred during retinoid use, and pregnant women were still prescribed with these drugs. Regulators, policymakers, prescribers, and researchers need to reconsider implementation strategies to prevent any temporary association between pregnancy and retinoid use.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Health Care Sciences & Services
Anibal Garcia-Sempere, Estela Gimenez, Hermelinda Vanaclocha, Ramon Limon, Salvador Peiro, David Navarro
Summary: A serosurvey conducted in the Valencian Community, Spain, in October 2022, when BA.5 was the predominant variant, revealed that the seroprevalence of anti-nucleocapsid antibodies (indicative of past infection) was 71.0%, and the seroprevalence of total receptor binding domain antibodies (indicative of past infection or vaccination) was 98.4%. The study also found that 66.7% of the population had hybrid immunity, with lower rates in the elderly population. These findings are important for public health strategies, and a second vaccination booster is recommended for the elderly population.
Article
Health Care Sciences & Services
Salvador Peiro, Ricard Meneu, Ildefonso Hernandez
Summary: Based on the meeting results in September 2022, Spain needs comprehensive reforms in state-wide health policies, including reconfiguration of governance, public health, and healthcare structures. The meeting identified and prioritized several proposals in areas such as NHS governance and funding, services and benefits, human resources reform, public health, actions against inequality and poverty, and healthcare delivery reform.
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.