期刊
JOURNAL OF CLINICAL PERIODONTOLOGY
卷 42, 期 9, 页码 807-816出版社
WILEY
DOI: 10.1111/jcpe.12442
关键词
animal models; obese diabetic Zucker rats; periodontitis; TNF-alpha; Type 2 diabetes
资金
- Danish Medical Research Council
- Simon Spies Foundation
- Colgate
- Danish Diabetes Association
- Danish Dental Association
- Danish Diabetes Academy by the Novo Nordisk Foundation
- Horslev-Fonden
ObjectiveTumour necrosis factor (TNF-) is considered a key signalling modulator in the pathogenesis of both periodontitis (PD) and type 2 diabetes mellitus (DM2). This study aims at elucidating the effect of TNF- blocking on the interplay between PD and DM2. MethodsObese diabetic Zucker rats and their lean littermates were divided into five treatment groups with or without periodontitis. Anti-TNF- treatment was provided with Etanercept injections. Diabetic state was evaluated by oral glucose tolerance test, the homeostatic model assessment, free fatty acids and blood glucose. Systemic inflammation was assessed by measurement of interleukin (IL)-1, IL-6 and TNF- in plasma. Kidney complications were evaluated by real-time rtPCR, creatinine clearance rate, urinary albumin excretion and increase in weight. PD was evaluated by registration of alveolar bone level. ResultsAfter 4weeks the diabetic state was modified by Etanercept treatment with lower insulin levels and lower homeostatic model assessment. Furthermore, while kidney complications were reduced by Etanercept treatment, PD had no effect. PD was influenced by diabetic state, but the impact was attenuated by Etanercept treatment. ConclusionIn this study anti-TNF- treatment improved glucose tolerance and compensated for the increased periodontal disease in obese diabetic Zucker. PD did not influence diabetic parameters assessed including complications of the rats kidneys.
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