Article
Endocrinology & Metabolism
Tsai-Sheng Fu, Ting-Shuo Huang, Chi-Chin Sun, Yu-Chiau Shyu, Fang-Ping Chen
Summary: The study demonstrates that bisphosphonate treatment significantly reduces the risk of second hip fracture and mortality in patients with initial hip fracture. Factors such as gender, comorbidities, and complications also play a significant role in determining the prognosis.
Article
Obstetrics & Gynecology
H. Kim, M. J. Kang, J. K. Baek, J. K. Lee, E. A. Choi, B. H. Yun, E. H. Kim, S. K. Seo
Summary: This study analyzed the effect of menopausal hormone therapy (MHT) on the incidence of spine and femur fractures in Korean women. The study found that EPT and tibolone significantly reduced the incidence of fractures, while ET only lowered the risk of femur fractures when used for more than 5 years with estradiol.
Article
Multidisciplinary Sciences
Marek Drobniewski, Marek Synder, Marek Aleksander Synder, Magdalena Krashiska, Lukasz Olewnik, Andrzej Borowski
Summary: The study demonstrates that the use of Metha stem in uncemented total hip replacement surgery can achieve good clinical and functional outcomes, with an average follow-up period of over 9 years. Patients with low preoperative Merle d'Aubigne and Postel classification scores experienced significant improvement post-surgery, with the majority of cases showing good results.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Tom W. Andrew, Lauren S. Koepke, Yuting Wang, Michael Lopez, Holly Steininger, Danielle Struck, Tatiana Boyko, Thomas H. Ambrosi, Xinming Tong, Yuxi Sun, Gunsagar S. Gulati, Matthew P. Murphy, Owen Marecic, Ruth Telvin, Katharina Schallmoser, Dirk Strunk, Jun Seita, Stuart B. Goodman, Fan Yang, Michael T. Longaker, George P. Yang, Charles K. F. Chan
Summary: This study investigates the regulation of bone-related sexually dimorphic traits at the stem cell level. The researchers find that estrogen signaling directly controls skeletal stem cells (SSCs) in female mice, but not in male mice. They also demonstrate that estrogen is necessary for the self-renewal and differentiation of SSCs, and suggest a potential clinical strategy for bone healing using localized estrogen hormone therapy.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Chor-Wing Sing, Tzu-Chieh Lin, Sharon Bartholomew, J. Simon Bell, Corina Bennett, Kebede Beyene, Pauline Bosco-Levy, Brian D. Bradbury, Amy Hai Yan Chan, Manju Chandran, Cyrus Cooper, Maria de Ridder, Caroline Y. Doyon, Cecile Droz-Perroteau, Ganga Ganesan, Sirpa Hartikainen, Jenni Ilomaki, Han Eol Jeong, Douglas P. Kiel, Kiyoshi Kubota, Edward Chia-Cheng Lai, Jeff L. Lange, E. Michael Lewiecki, Julian Lin, Jiannong Liu, Joe Maskell, Mirhelen Mendes de Abreu, James O'Kelly, Nobuhiro Ooba, Alma B. Pedersen, Albert Prats-Uribe, Daniel Prieto-Alhambra, Simon Xiwen Qin, Ju-Young Shin, Henrik T. Sorensen, Kelvin Bryan Tan, Tracy Thomas, Anna-Maija Tolppanen, Katia M. C. Verhamme, Grace Hsin-Min Wang, Sawaeng Watcharathanakij, Stephen J. Wood, Ching-Lung Cheung, Ian C. K. Wong
Summary: In this international study, the researchers analyzed the incidence of hip fractures, post-fracture treatment, and all-cause mortality following hip fractures across different countries and regions. They used patient-level healthcare data from 19 countries and identified 4,115,046 hip fractures from 2005 to 2018. The study revealed variations in the global epidemiology of hip fractures and post-fracture outcomes, highlighting the need for interventions to reduce the burden of osteoporotic fractures.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Editorial Material
Health Care Sciences & Services
Gary S. Donovitz
Summary: Hormone replacement therapy, particularly the use of testosterone in women, continues to be controversial in medicine. However, there is growing evidence to support the use of physiologic doses of testosterone to improve sexual function, prevent osteoporosis, protect the brain, and reduce the incidence of invasive breast cancer in women. The safety of testosterone use in women has been evaluated for 80 years, with recent studies showing long-term safety. It may be time for the FDA to consider approving products that would benefit testosterone-deficient women.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Obstetrics & Gynecology
C-W Park, S-J Lim, Y-W Moon, S-H Choi, M-H Shin, Y-K Min, B-K Yoon, Y-S Park
Summary: A randomized trial comparing risedronate and menopausal hormone therapy in postmenopausal women with recent hip fracture found no significant differences in fracture recurrence, mortality, or bone mineral density between the two groups. The study concluded that MHT may be as effective as risedronate in preventing secondary fractures and death in this population.
Article
Orthopedics
Stephen M. Gillinov, Peter Y. Joo, Justin R. Zhu, Jay Moran, Lee E. Rubin, Jonathan N. Grauer
Summary: This study determined the incidence and predictors of hip dislocation within 2 years of primary THA, finding that 2.3% of patients experienced dislocation and identifying risk factors. It also showed that most patients with dislocation had recurrent episodes of instability and were more likely to require revision surgery.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2022)
Review
Critical Care Medicine
Annalisa De Cicco, Giuseppe Toro, Francesco Oliva, Umberto Tarantino, Alfredo Schiavone Panni, Nicola Maffulli
Summary: The study analyzed 17 patients with APFF, finding that all cases occurred in females with an average age of 75.9 years. Conservative management was effective for incomplete fractures, while complete fractures required open reduction and internal fixation. The study suggests that APFF shares many clinical and imaging characteristics with AFF.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2021)
Article
Geriatrics & Gerontology
Warrington W. Q. Hsu, Xiaowen Zhang, Chor-Wing Sing, Gloria H. Y. Li, Kathryn C. B. Tan, Annie W. C. Kung, Janus S. H. Wong, Ian Chi-Kei Wong, Ching-Lung Cheung
Summary: The study found that hip fracture was associated with an increased risk of dementia among older adults, especially in women. Further research on the potential role of hip fracture in the development of dementia could benefit the management of both conditions in older adults.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Orthopedics
Jhase Sniderman, Prushoth Vivekanantha, Ajay Shah, Oleg Safir, Jesse Wolfstadt, Paul Kuzyk
Summary: This study aimed to evaluate the outcome of hemiarthroplasty compared to traditional treatment of unstable intertrochanteric fractures. It was found that hemiarthroplasty may improve outcomes for patients with unstable intertrochanteric fractures, especially in type A3 fractures.
JOURNAL OF ARTHROPLASTY
(2023)
Review
Endocrinology & Metabolism
M. Barake, R. El Eid, S. Ajjour, M. Chakhtoura, L. Meho, T. Mahmoud, J. Atieh, A. M. Sibai, G. El-Hajj Fuleihan
Summary: The study revealed that Asia is projected to have the largest proportion of osteoporotic fractures worldwide, while data from the Middle East is scarce. Most patients in Arab League countries with osteoporotic fractures were not tested or treated, with high mortality rates observed at 1 to 3 years post-fracture.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Orthopedics
Mohammad N. Alswerki, Lana A. Alraie, Deema Aladwan, Yasmeen Alabed, Alia Ibrahim, Razan Aburumman, Moayad Shaf'ei, Mohammad Sharayah, Mohammad A. Qaraqesh, Mohammed A. Al-Juboori, Bassem I. Haddad, Jihad Alajlouni
Summary: This study investigated the demographics and clinical characteristics of patients undergoing total hip arthroplasty (THA) in Jordan, with a specific focus on gender differences. The findings showed that females were more likely to have degenerative and dysplastic hip arthritis, required more blood transfusions during and after surgery, and had more comorbidities. These results suggest the importance of raising awareness about comorbidity management, preoperative smoking cessation, and perioperative blood transfusion management to improve medical and surgical outcomes.
INTERNATIONAL ORTHOPAEDICS
(2023)
Article
Orthopedics
Ingrid Heuch, Ivar Heuch, Knut Hagen, Kjersti Storheim, John-Anker Zwart
Summary: This study investigated the associations between systemic MHT or OC use and the risk of chronic LBP using a large population-based dataset. The results showed that long-lasting use of systemic MHT, especially therapy based on estrogen only, is associated with an increased risk of chronic LBP. Using OC may slightly increase the risk of chronic LBP.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Obstetrics & Gynecology
Vered Rosenberg, Avital Bareket-Samish, Gabriel Chodick, Nava Siegelmann-Danieli
Summary: The study examined trends in breast cancer incidence, mammography testing rates, hormone-replacement therapy (HRT) use and breast cancer subtypes in a large Israeli health maintenance organization during 2000-2014. Results showed a decrease in breast cancer incidence that parallels the global and local decrease in HRT use. Yet, current/recent HRT exposure may contribute to the incidence of luminal breast cancer tumors in particular.
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2021)
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.