Article
Pharmacology & Pharmacy
Farah Hanan Fathihah Jaffar, Khairul Osman, Chua Kien Hui, Aini Farzana Zulkefli, Siti Fatimah Ibrahim
Summary: The study found that supplementation with 250 mg/kg BW/d of EBN showed a significant increase in sperm concentration, sperm motility, FSH, and LH levels compared to the group receiving 10 mg/kg BW/d. There was a dose-dependent increase in testosterone level, but it was not significant between groups. In conclusion, EBN was found to have significant effects on male reproductive parameters.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Plant Sciences
An Yong Hu, Shu Nan Xu, Dong Ni Qin, Wen Li, Xue Qiang Zhao
Summary: The article reviews the important role of silicon in mediating phosphorus imbalance in plants, including silicon uptake and accumulation, the role of phosphate transporters, and the effects of silicon under phosphorus deficiency and excess phosphorus stress. The results show that silicon plays a significant role in regulating phosphorus imbalance in plants.
Article
Biochemistry & Molecular Biology
Louise M. Arildsen Jakobsen, Weiwei He, Nicholas Ditzel, Marianne Danielsen, Trine K. Dalsgaard, Niklas Rye Jorgensen, Peter Bollen, Hanne C. Bertram
Summary: This study investigated the effects of whey protein complexation of vitamin D-3 supplements on bone health in rats. The results showed that complexation did not improve the bioavailability of vitamin D-3 or have any significant impact on bone strength or microstructure.
Article
Nutrition & Dietetics
Michael D. McAlpine, Jenalyn L. Yumol, Wendy E. Ward
Summary: The study found that consuming polyphenols through red rooibos tea before and after pregnancy can partially improve bone density and structure in lactating rats. However, the impact of red rooibos tea on bone strength post-lactation was not confirmed.
FRONTIERS IN NUTRITION
(2021)
Article
Pharmacology & Pharmacy
Ebrahim Bani Hassan, Nancy Doyle, Jean-Guy Bienvenu, Andrew Stent, Gilles J. Guillemin, Gustavo Duque
Summary: The study tested the effects of escalating and very high doses of oral PIC on rats, showing that high doses (500 or 1000 mg/kg/day) were vascular-neurotoxic, while lower doses (125 or 250 mg/kg/day) did not cause apparent adverse events. Future experiments should consider significantly lower doses.
Article
Nutrition & Dietetics
Nosheen Naz, Moazzam Rafiq Khan, Muhammad Asim Shabbir, Muhammad Naeem Faisal
Summary: This study investigated the anti-anaemic effect of fortified jamun leather on anaemia biomarkers and haematology in anaemic female Sprague Dawley rats. The results showed significant improvement in iron deficiency biomarkers after treatment with iron-fortified leather for 60 days. Additionally, the treatments had no toxic effects on the kidney and liver tissues except in the diseased group.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Hitomi Maruta, Reina Abe, Hiromi Yamashita
Summary: Acetic acid can improve age-related changes in skeletal muscle of aging rats by activating AMP-activated protein kinase, including decreasing the expression of atrophy-related genes, activating AMP-activated protein kinase, promoting mitochondrial proliferation, and affecting the expression of type I fiber-related molecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Masood Sadiq Butt, Iahtisham-Ul-Haq, Komal Javed, Urwa Tariq
Summary: This study found that combined supplementation of zinc and calcium can reduce the concentration of lead in the blood and organs, and have a better protective effect on the liver and kidney.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Medicine, Research & Experimental
Bo Wang, Di Pan, Yong Ban, Zhaolin Sun, Ye Tian, Guangheng Luo
Summary: This study found that androgens play an important role in regulating prostatic microvessel density in SD rats, and a decrease in DHT concentration can lead to a decrease in prostatic MVD, while increasing DHT concentration can lead to an increase in prostatic MVD. Additionally, prostatic MVD can gradually increase with increasing estrogen concentration.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Food Science & Technology
Abdul Momin Rizwan Ahmad, Umar Farooq, Mariam Anees, Riffat Aysha Anis, Summer Rashid, Waqas Ahmed
Summary: This study investigates the efficacy of co-administration of inulin and iron fortificants on iron deficiency biomarkers in Sprague Dawley rats. The results suggest that the combined use of inulin and iron fortificants significantly improves serum iron levels and iron stores.
FOOD SCIENCE & NUTRITION
(2022)
Article
Agriculture, Dairy & Animal Science
Su A. Lee, L. Vanessa Lagos, Mike R. Bedford, Hans H. Stein
Summary: The study aimed to determine correlations between individual bones and total body bone ash in growing pigs. Results showed that metacarpals, metatarsals, and tibia were more representative of total body bone ash, and that dietary calcium and phosphorus ratio did not significantly affect calcium and phosphorus concentrations in bone ash.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Ayme Oliva Cardenas, Blanca C. Zamora-Rodriguez, Kevin A. Batalla-Garcia, Alejandro Avalos-Rodriguez, Alejandra Contreras-Ramos, Clara Ortega-Camarillo
Summary: Adult mesenchymal cells have remarkable abilities in molecular and cell biology. Adipose tissue, a less invasive and easily accessible source of mesenchymal cells, has shown superior immunomodulatory properties and high yields. This study proposed a standardized methodology for obtaining optimal and functional adipose-derived stem cell (ASC) cultures, and confirmed their capability to differentiate into adipocytes.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Article
Agriculture, Dairy & Animal Science
Jia Zhou, Jianxun Zhang, Benchu Xue, Shuangming Yue, Chao Yang, Bai Xue
Summary: This study aimed to investigate the effects of calcium chloride (CaCl) and monocalcium phosphate (MCP) supplementation on the reproductive efficiency of grazing yak heifers. The results showed that supplementation with MCP significantly improved reproductive performance by improving body weight and bone phosphorus storage. This study may provide insights for enhancing the reproductive efficiency of yaks on the Qinghai Tibet Plateau.
Article
Veterinary Sciences
C. O. Schild, F. M. Boabaid, L. G. S. Olivera, J. I. Armendano, A. Saravia, A. Custodio, J. Algorta, C. Alvarez, M. Jaurena, R. M. Dixon, F. Riet-Correa
Summary: The study evaluated the responses of two groups of cows with chronic phosphorous deficiency to phosphorous supplements, one in loose mineral mix form and the other in block form. The results showed that the group supplemented with loose mineral mix had better outcomes in terms of weight, supplement intake, and phosphorous concentration compared to the block group.
VETERINARY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Leilei Wang, Ziyang Wang, Pengna Luo, Shiping Bai, Yu Chen, Wen Chen
Summary: The study evaluates the effects of graded concentrations of zinc on bone quality in poultry. It is found that increased zinc content is associated with improved bone quality, and the recommended dosage is determined. Additionally, zinc glycine supplementation is more effective in improving bone characteristics compared to zinc sulfate, with enhanced intestinal integrity and optimized gut microbiota.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Letter
Endocrinology & Metabolism
Ravin Jugdaohsingh, Jonathan J. Powell, Simon H. C. Anderson, Richard P. H. Thompson, Mario R. Calomme, Karen Robinson, Forrest Nielsen, Patrick D'Haese, Piet Geusens, Nigel Loveridge
Article
Endocrinology & Metabolism
Kenneth E. S. Poole, Shobna Vedi, Irene Debiram, Collette Rose, Jon Power, Nigel Loveridge, Elizabeth A. Warburton, Jonathan Reeve, Juliet Compston
Article
Endocrinology & Metabolism
Simon C. F. Rawlinson, Dianne H. Murray, John R. Mosley, Chris D. P. Wright, John C. Bredl, Leanne K. Saxon, Nigel Loveridge, Christine Leterrier, Paul Constantin, Colin Farquharson, Andrew A. Pitsillides
Article
Endocrinology & Metabolism
Jon Power, Michael Doube, Rutger L. van Bezooijen, Nigel Loveridge, Jonathan Reeve
Article
Endocrinology & Metabolism
N. Fratzl-Zelman, P. Roschger, A. Gourrier, M. Weber, B. M. Misof, N. Loveridge, J. Reeve, K. Klaushofer, P. Fratzl
CALCIFIED TISSUE INTERNATIONAL
(2009)
Editorial Material
Biochemistry & Molecular Biology
Nigel Loveridge
CELL BIOCHEMISTRY AND FUNCTION
(2009)
Article
Endocrinology & Metabolism
C. David L. Thomas, Paul M. Mayhew, Jon Power, Kenneth E. S. Poole, Nigel Loveridge, John G. Clement, Chris J. Burgoyne, Jonathan Reeve
JOURNAL OF BONE AND MINERAL RESEARCH
(2009)
Article
Endocrinology & Metabolism
Jon Power, Kenneth E. S. Poole, Rutger van Bezooijen, Michael Doube, Ana M. Caballero-Alias, Clemens Lowik, Socrates Papapoulos, Jonathan Reeve, Nigel Loveridge
JOURNAL OF BONE AND MINERAL RESEARCH
(2010)
Article
Endocrinology & Metabolism
Kenneth E. S. Poole, Paul M. Mayhew, Collette M. Rose, J. Keenan Brown, Philip J. Bearcroft, Nigel Loveridge, Jonathan Reeve
JOURNAL OF BONE AND MINERAL RESEARCH
(2010)
Article
Endocrinology & Metabolism
Antoon H. van Lierop, Neveen A. T. Hamdy, Herman Hamersma, Rutger L. van Bezooijen, Jon Power, Nigel Loveridge, Socrates E. Papapoulos
JOURNAL OF BONE AND MINERAL RESEARCH
(2011)
Article
Endocrinology & Metabolism
Samuel Gourion-Arsiquaud, Lyudmilla Lukashova, Jon Power, Nigel Loveridge, Jonathan Reeve, Adele L. Boskey
JOURNAL OF BONE AND MINERAL RESEARCH
(2013)
Article
Multidisciplinary Sciences
Matthew Prideaux, Nigel Loveridge, Andrew A. Pitsillides, Colin Farquharson
Article
Chemistry, Physical
Erica R. Wise, Sergey Maltsev, M. Elisabeth Davies, Melinda J. Duer, Christian Jaeger, Nigel Loveridge, Rachel C. Murray, David G. Reid
CHEMISTRY OF MATERIALS
(2007)
Article
Endocrinology & Metabolism
S. Kaptoge, N. Dalzell, E. Folkerd, D. Doody, K. -T. Khaw, T. J. Beck, N. Loveridge, E. B. Mawer, J. L. Berry, M. J. Shearer, M. Dowsett, J. Reeve
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2007)
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.