Article
Engineering, Biomedical
Siyuan Pang, Henry P. Schwarcz, Iwona Jasiuk
Summary: Bone is a composite material composed of apatite mineral, collagen fibrils, non-collagenous proteins, and other organic species. The interface between mineral lamellae has been shown to affect the mechanical properties of bone. The presence of an organic glue between mineral lamellae, which survives treatment with ethylenediamine but not with sodium hypochlorite, contributes to the stiffness, strength, and energy absorption of bone.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Bader Bouzar, Mahfoud Benzerzour, Nor-Edine Abriak
Summary: This study presents a new approach to minimize waste by using hydroxyapatite as an adsorbent for stabilizing fluorides in soil. The synthesized hydroxyapatites showed promising results in reducing fluoride concentrations below the threshold level. Additionally, the sequential extraction results confirmed the formation of stable and insoluble fluorapatite.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Optics
Baojuan Yang, Yanle Li, Fangyi Li, Xiaoxia Qi, Xingfu Sun, Weiqiang Cui, Jiyu Du
Summary: The study proposes a composite texturing surface pretreatment method to improve the bonding performance of hydroxyapatite (HA) coatings. The results show that coatings on composite texturing surfaces have higher tensile and shear strengths compared to coatings on grit blasted surfaces. This is attributed to the increased surface roughness, enlarged interfacial contact area, and weakened stress concentration effect of the composite texturing surface.
OPTICS AND LASER TECHNOLOGY
(2023)
Article
Biophysics
Pei Feng, Xiang Qiu, Liuyimei Yang, Qing Liu, Can Zhou, Yongbin Hu, Cijun Shuai
Summary: Nano-HAP/PCL composite scaffolds have great potential in bone tissue engineering application. The interface bonding between nano-HAP and PCL can be enhanced by modifying nano-HAP with polydopamine. The P-HAP/PCL scaffolds loaded with P-HAP show improved tensile and compressive strength, as well as excellent bioactivity and cytocompatibility.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Environmental Sciences
Ming Qin, Yue Gao, Meichen Zhang, Junhua Wu, Yang Liu, Yuting Jiang, Xiaodi Zhang, Xin Wang, Yanmei Yang, Yanhui Gao
Summary: This study investigates the effects of fluorine and ADAMTS14_rs4747096 on bone mineral density (BMD). The findings suggest that fluoride exposure and mutation G allele in ADAMTS14_rs4747096 may be risk factors for decreased BMD, and there is an interaction between the two influencing factors.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Partha Pratim Biswas, Biqing Liang, Gordon Turner-Walker, Jagat Rathod, Yao-Chang Lee, Chun-Chieh Wang, Chung-Kai Chang
Summary: The study evaluated the applicability of bone char as a long-term phosphorus nutrient source by investigating their mineral transformation, physicochemical properties, and dissolution behavior. Results showed that higher temperatures led to mineral transformation, increasing stability, and resistance to acidic dissolution. Bone char produced at low to intermediate temperatures can be a substantial source of phosphorus for soil fertility, while higher temperatures are suitable for liming and pH adjustment in soils.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Genetics & Heredity
Maria Nethander, Sofia Moverare-Skrtic, Anders Kampe, Eivind Coward, Ene Reimann, Louise Grahnemo, Eva Borbely, Zsuzsanna Helyes, Thomas Funck-Brentano, Martine Cohen-Solal, Juha Tuukkanen, Antti Koskela, Jianyao Wu, Lei Li, Tianyuan Lu, Maiken E. Gabrielsen, Reedik Estonian Biobank Res Team, Reedik Magi, Mari Hoff, Ulf H. Lerner, Petra Henning, Henrik Ullum, Christian Erikstrup, Soren Brunak, Tiinamaija DBDS Genomic Consortium, Arnulf Langhammer, Tiinamaija Tuomi, Asmundur Oddsson, Kari Stefansson, Ulrika Pettersson-Kymmer, Sisse Rye Ostrowski, Ole Birger Vesterager Pedersen, Unnur Styrkarsdottir, Outi Makitie, Kristian Hveem, J. Brent Richards, Claes Ohlsson
Summary: This study identified 43 loci associated with forearm fracture through genome-wide association analysis, including some influencing bone quality parameters. Functional studies of one of these loci revealed that Tac4 knockout mice exhibit reduced mechanical bone strength without affecting bone mineral density.
Article
Chemistry, Multidisciplinary
Hongdeok Kim, Byeonghwa Goh, Sol Lee, Kyujo Lee, Joonmyung Choi
Summary: PMMA-based bone cement is crucial in joint replacement surgery, with molecular dynamics simulations demonstrating that polymerization increases the mechanical stiffness of the material and enhances its interaction characteristics with bone ceramic hydroxyapatite (HAp) as crosslink density rises.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Multidisciplinary
Zhong-Qiu Li, Dian-Xue Ma, Fa-Feng Xu, Ti-Xiong Dan, Zhong-Liang Gong, Jiang-Yang Shao, Yong Sheng Zhao, Jiannian Yao, Yu-Wu Zhong
Summary: This research successfully implemented three different modes of polarized-photon out-coupling in active optical-waveguiding organic crystals and found that the polarization direction and degree of the out-coupled light depend on the molecular arrangement and the orientation of transition dipole moments of the crystal. This work demonstrates the promising potential of 2D emissive microcrystals in multi-channel polarized photon transport.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Materials Science, Multidisciplinary
Kai Jeat Hong, Sin Tee Tan, Kam Sheng Lau, Chi Chin Yap, Chun Hui Tan, Yiin Jian Low, Josephine Ying Chyi Liew, Chin Hua Chia, Kok-Keong Chong
Summary: Interfacial charge transfer is crucial for device performance in organic photovoltaics. Incorporating inorganic nanostructures into the photoactive layer has been reported to improve charge transfer efficiency. However, there is limited understanding of defect analysis and charge transfer mechanism. This study investigates the relationship between charge transport dynamics and defect density by incorporating different weight percentages of LiF into the mixed photoactive layers.
Article
Biochemistry & Molecular Biology
Elena Merkuryeva, Tatiana Markova, Anton Tyurin, Diana Valeeva, Vladimir Kenis, Maria Sumina, Igor Sorokin, Olga Shchagina, Mikhail Skoblov, Maria Nefedova, Rita Khusainova, Ekaterina Zakharova, Elena Dadali, Sergey Kutsev
Summary: Calvarial doughnut lesions (CDL) with bone fragility is a rare autosomal dominant skeletal disorder characterized by low bone mineral density, fractures, and specific sclerotic lesions of the cranial bones. The disease is caused by pathogenic variants in the SGMS2 gene, with a recurrent variant c.148C>T (p.Arg50Ter) identified in multiple families. The phenotypic variability in patients with this variant highlights the importance of considering it in the diagnosis of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Anatoly V. Skalny, Michael Aschner, Ekaterina V. Silina, Victor A. Stupin, Oleg N. Zaitsev, Tatiana I. Sotnikova, Serafima Ia. Tazina, Feng Zhang, Xiong Guo, Alexey A. Tinkov
Summary: The objective of this study was to review recent epidemiological and clinical data on the association between selected minerals and trace elements and osteoporosis, as well as to discuss the molecular mechanisms underlying these associations. The data show that physiological and nutritional levels of trace elements and minerals promote osteogenic differentiation and inhibit osteoclastogenesis. Both miRNA and epigenetic effects are involved in the regulation of the osteogenic effects of trace minerals. Clinical trials and epidemiological studies suggest that supplementation with Zn, Mg, F, and Sr may improve bone quality and have antiosteoporotic effects.
Article
Materials Science, Ceramics
V Dhivya, G. Rajkumar, S. Mahalaxmi, K. Rajkumar, B. Saravana Karthikeyan, S. Kavitha, R. Karpagam, K. Sakthipandi, G. K. Sathishkumar
Summary: This study discusses the effect of silver oxide on the fluorophosphate glass, and finds that glass samples containing 0.9 mol % Ag2O exhibit good antibacterial activity and apatite-forming ability, making them suitable for biomedical applications.
CERAMICS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Melody Kasher, Maxim B. Freidin, Frances Mk Williams, Stacey S. Cherny, Ida Malkin, Gregory Livshits
Summary: This study investigated the genetic association between rheumatoid arthritis (RA) and osteoporosis (OP), and found evidence of pleiotropy. Shared genetic variants associated with both RA and OP were identified.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Environmental Sciences
Partha Pratim Biswas, Gordon Turner-Walker, Jagat Rathod, Biqing Liang, Chun-Chieh Wang, Yao-Chang Lee, Hwo-Shuenn Sheu
Summary: This study explores the long-term transformation of bone in the field, revealing significant organic decomposition, secondary mineral formation, and re-mineralization processes over a span of ten years. The release and migration of phosphorus from bones, as well as the formation of secondary minerals, exhibit stage-dependent changes as microbial decomposition and mineral interplay evolve over time.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.