Article
Pharmacology & Pharmacy
Rachel Freid, Amira Hussein, Jennifer J. Schlezinger
Summary: The study investigated the effects of diet, ovariectomy, and TBT exposure on bone structure in mice, finding that TBT can protect against trabecular bone loss to some extent, especially under a low-fat diet.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Jianhua Zhang, Julia Griesbach, Marsel Ganeyev, Anna-Katharina Zehnder, Peng Zeng, Gian Nutal Schaedli, Anke de Leeuw, Yuxiao Lai, Marina Rubert, Ralph Mueller
Summary: The study reveals that mechanical stimulation can promote the formation of 3D bioprinted bone organoids, and long-term mechanical loading is necessary for increasing the density and stiffness of the organoids, as well as promoting osteoblast differentiation.
Article
Endocrinology & Metabolism
Adriana Lelis Carvalho, Daniel J. Brooks, Deborah Barlow, Audrie L. Langlais, Breanna Morrill, Karen L. Houseknecht, Mary L. Bouxsein, Jane B. Lian, Tamara King, Nicholas H. Farina, Katherine J. Motyl
Summary: Opioid use has negative effects on bone health by impacting bone turnover. Recent studies have shown that chronic opioid use is associated with changes in circulating miRNAs. In this study, a model of opioid-induced bone loss was developed to understand bone turnover and identify potential miRNA-mediated regulatory mechanisms. The findings suggest that sustained morphine treatment leads to lower trabecular bone formation in male mice and alters the expression of miRNAs involved in the hypoxia-inducible factor signaling pathway and fatty acid metabolism. Understanding the sex-specific mechanisms of bone loss from opioids is important for managing the adverse effects of opioids on the skeleton.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Annika Treyball, Audrey C. Bergeron, Daniel J. Brooks, Audrie L. Langlais, Hina Hashmi, Kenichi Nagano, Deborah Barlow, Ryan J. Neilson, Tyler A. Roy, Kathleen T. Nevola, Karen L. Houseknecht, Roland Baron, Mary L. Bouxsein, Anyonya R. Guntur, Katherine J. Motyl
Summary: This study investigates the mechanism of propranolol in improving bone density with parathyroid hormone (PTH) treatment. It found that propranolol enhances the effects of PTH in bone remodeling, suppresses bone resorption, and may directly impact osteoclasts.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Karin Pernold, Eric Rullman, Brun Ulfhake
Summary: The objective was to characterize the pattern of rest and physical activity (PA) of C57BL/6J mice using the raw data output from a scalable home cage monitoring system. The analysis showed that mice spend most of their time in bouts of long rest and engage in physical activity, with a significant preference for the peripheral floor area. The extraction of electrode activations density (EAD) from the raw data can serve as a proxy for PA and rest, enabling monitoring of group housed mice.
Article
Physiology
Melanie Haffner-Luntzer, Verena Fischer, Anita Ignatius
Summary: The study found that male mice demonstrated faster fracture healing with more prominent cartilaginous callus formation in diaphyseal fractures. This may be attributed to the higher body weight of male mice, resulting in increased mechanical loading at the fracture site. Additionally, male mice exhibited higher activation of osteogenic Wnt/beta-catenin signaling during the fracture healing process.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ziyan Wang, Yang Liu, Jianing Zhang, Minmin Lin, Chufan Xiao, Haoying Bai, Chao Liu
Summary: Long-term use of adrenergic medication can negatively impact bone quality and healing, but controlling the mechanical environment can help alleviate these effects.
Article
Biochemistry & Molecular Biology
Katharina Kerschan-Schindl, Maria Papageorgiou, Ursula Foeger-Samwald, Maria Butylina, Michael Weber, Peter Pietschmann
Summary: This study used micro-computed tomography to analyze the microstructural parameters of bones in female and male mice, and found that BV/TV, TbN, and TbSp in the femur can be used to distinguish male from female bones. Cortical thickness was the best parameter to detect sex differences in the cortical compartment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Francesca Manuela Johnson de Sousa Brito, Andrew Butcher, Addolorata Pisconti, Blandine Poulet, Amanda Prior, Gemma Charlesworth, Catherine Sperinck, Michele Scotto di Mase, Ke Liu, George Bou-Gharios, Robert Jurgen van 't Hof, Anna Daroszewska
Summary: Syndecan-3 promotes new bone formation in osteoblasts by enhancing WNT signaling, and its deficiency in mice results in an early osteoporosis-like phenotype due to delayed osteoblast maturation and impaired function. Overexpressing Sdc3 in osteoblasts rescues the low bone volume phenotype and increases bone mass, making SDC3 a potential target for novel bone anabolic drug development.
Article
Endocrinology & Metabolism
Zahra Chinipardaz, Min Liu, Dana Graves, Shuying Yang
Summary: This study revealed that type 1 diabetes impairs fracture healing by affecting primary cilia expression and formation in osteoblasts. Loss of primary cilia in osteoblasts due to diabetes resulted in defective fracture healing, characterized by delayed healing, reduced bone density and mechanical strength.
Article
Neurosciences
Brandon L. Oliver, Alma E. Pahua, Kristianna Hitchcock, Dionisio A. Amodeo
Summary: The study investigated the effects of 5-HT6 receptor modulation on locomotor activity and anxiety levels in mice, finding that different doses of drugs had varying impacts on female and male mice. The findings suggest that 5-HT6 receptor modulation has distinct effects on locomotor activity in C57BL/6J mice.
Article
Nutrition & Dietetics
Dean S. Ross, Tzu-Hsuan Yeh, Shalinie King, Julia Mathers, Mark S. Rybchyn, Elysia Neist, Melissa Cameron, Alexander Tacey, Christian M. Girgis, Itamar Levinger, Rebecca S. Mason, Tara C. Brennan-Speranza
Summary: This study explored the effects of a high fat diet on glucose metabolism and bone density in developing and mature male C57BL/6J mice. The results showed that high fat diet significantly impaired glucose tolerance and reduced bone density in both age groups, with more pronounced effects in the mature mice. This mature HFD mouse model accurately represents late-onset impaired glucose tolerance/pre-T2DM cases in humans and provides insights into the mechanisms of skeletal fragility in these patients.
Article
Biochemistry & Molecular Biology
Kabsun Kim, Jung Ha Kim, Inyoung Kim, Semun Seong, Jeong Eun Han, Keun-Bae Lee, Jeong-Tae Koh, Nacksung Kim
Summary: Lmx1b negatively regulates osteoblast differentiation and function through repression of Runx2, providing a molecular basis for therapeutic targets in bone diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Michela Rossi, Giulia Battafarano, Viviana De Martino, Alfredo Scillitani, Salvatore Minisola, Andrea Del Fattore
Summary: This review discusses the impact of rare disorders on bone formation, such as sclerosteosis, van Buchem disease, hypophosphatasia, and Camurati-Engelmann disease. Research on these diseases can help us understand important pathways regulating bone formation, leading to new therapeutic approaches for managing common bone diseases.
JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Jianing Zhang, Yanrong Tong, Yang Liu, Minmin Lin, Yao Xiao, Chao Liu
Summary: This study investigated the effects of chronic TDF use on bone homeostasis and defect repair in mice. The results showed that TDF inhibited bone differentiation and mineralization, reduced bone biomechanical properties and microarchitecture, and hindered bone defect repair. However, mechanical loading was able to reverse these adverse effects.
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.