Article
Ecology
Andrea Barbi, Tess Goessens, Diederik Strubbe, Arne Deknock, Robby Van Leeuwenberg, Niels De Troyer, Elin Verbrugghe, Mark Greener, Siegrid De Baere, Luc Lens, Peter Goethals, An Martel, Siska Croubels, Frank Pasmans
Summary: The sixth mass extinction is caused by various negative impacts on biodiversity. This study examines the interaction between two widespread factors contributing to amphibian declines: the fungal disease chytridiomycosis and the use of antifungal agents in agriculture. Field monitoring in agricultural landscapes shows the presence of triazole fungicides in amphibian ponds, and the application of epoxiconazole correlates negatively with chytrid infections in newts. Although the triazole concentrations in the ponds do not inhibit the growth of Batrachochytrium dendrobatids, they accumulate in the newts' skin, resulting in growth-suppressing concentrations. Consequently, a concentration of epoxiconazole, even ten times lower than the growth-inhibiting level, prevents chytrid infection in anuran tadpoles. The widespread presence of triazoles may therefore alter chytrid dynamics in agricultural landscapes.
Article
Chemistry, Organic
Haidi Li, Junyou Li, Jie Chao, Zixin Zhang, Chuanguang Qin
Summary: The liquid-phase on-support cyclization and synergistic self-cleavage strategy using BDKO and DPBA as small-molecular supports enabled the efficient synthesis of various naturally occurring cyclic peptides, with the added benefit of support recycling.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Environmental Sciences
Linda J. Paetow, Roger I. Cue, Bruce D. Pauli, David J. Marcogliese
Summary: Pesticides and pathogens have negative effects on amphibians, and their combined effects are not well understood. This study examined the individual and combined effects of two herbicides and a fungal pathogen on the growth, development, and survival of American toad larvae. The results showed that high concentrations of glyphosate caused 100% mortality, while lower doses had a monotonic effect on growth. The herbicides did not interact with the fungal pathogen on survival, but exposure to the pathogen increased survival. Atrazine had long-term effects on growth, while glyphosate's effects disappeared. Overall, both herbicides and the fungal pathogen can modulate larval toad growth and development.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Microbiology
Arik M. Hartmann, Sarah E. McGrath-Blaser, Zuania Colon-Pineiro, Ana Longo
Summary: Skin-associated bacteria in amphibians can inhibit pathogen infection, but their composition changes across developmental stages. Metamorphosis is a major driver of host-associated microbes in amphibians. Infection does not disrupt the microbiome.
Article
Chemistry, Analytical
Yuqiu Wang, Maoze Guo, Bingfang He, Bingbing Gao
Summary: Intelligent wound patches have potential properties such as ultra-adhesion, self-healing ability, biosensing, antibacterial, and anti-inflammatory effects. There is a need for further exploration in in situ sensing and intelligent drug delivery, and new strategies are crucial in this regard. Challenges exist in this field, but there are promising opportunities for future developments.
ANALYTICAL CHEMISTRY
(2021)
Article
Infectious Diseases
Timothy M. Rawson, David B. Antcliffe, Richard C. Wilson, Alireza Abdolrasouli, Luke S. P. Moore
Summary: Bacterial and fungal infections are common in ICU patients, and are associated with worse clinical outcomes. This article reviews the epidemiology of bacterial and fungal infection in the ICU, discussing risk factors, diagnosis and management approaches, as well as common strategies for infection prevention.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Ecology
Andrew Furness, Isabella Capellini
Summary: Based on our study on amphibians, we found that terrestrial egg deposition, hidden egg locations, and direct development promote the evolution of female egg attendance, while male egg attendance is associated with hidden eggs and terrestrial egg deposition but not with direct development. This indicates that egg attendance, particularly by females, evolves following changes in reproductive ecology, which may increase egg survival, select for small clutches of large eggs, and/or expose eggs to new environmental challenges.
Article
Ecology
Spencer R. Siddons, Catherine L. Searle
Summary: Exposure to the virulent fungal pathogen Bd was found to increase the CTmin for frogs and decrease their righting response, with Hyla versicolor showing a higher CTmin than Lithobates palustris. This reduced cold tolerance in Bd-exposed frogs may lead to increased overwintering mortality.
ECOLOGY AND EVOLUTION
(2021)
Review
Biotechnology & Applied Microbiology
Ziyi Zhang, Junxing Shao, Yu Gao, Yuhuan Li, Te Liu, Modi Yang
Summary: Infection of the bone is a difficult problem in orthopedic diseases. The most commonly used approach for prevention and management is antibiotic bone cement, but it compromises the mechanical characteristics of bone cement and has a low antibiotic release rate. Polyetheretherketone (PEEK) and its composites have been considered as a solution due to their favorable biomechanical characteristics and diverse surface functionalizations. This article provides an overview of recent advancements in the antimicrobial modification of PEEK composites in the field of antibacterial therapy of bone infection and discusses their potential clinical applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Seyed Ebrahim Alavi, Aun Raza, Max Gholami, Michael Giles, Rayan Al-Sammak, Ali Ibrahim, Hasan Ebrahimi Shahmabadi, Lavanya A. Sharma
Summary: The oral cavity is a complex ecosystem that can be affected by various factors, leading to dysbiosis and the emergence of oral infectious diseases. Oral drug delivery systems (DDS), including nanoscopic DDS, have been developed to overcome challenges associated with systemic drug administration. This literature review highlights current therapeutic challenges and the applications of DDS for the treatment of oral infectious diseases. It also discusses the structures and therapeutic agents delivered by DDS, as well as strategies to improve treatment outcomes.
Article
Engineering, Biomedical
Weizhou Ren, Zefeng Lin, Youzhun Fan, Jun Xing, Guangyu Liu, Taizhong Xiao, Zhengao Wang, Zhengnan Zhou, Tao Zhang, Zhiguo Song, Peng Yu, Chengyun Ning
Summary: This study developed high performance photoelectric BiOCl nanosheets that can dynamically switch between tissue regrowth and antibacterial microenvironments under light stimulation. In vitro and in vivo experiments demonstrated that the nanosheets exhibit strong antibacterial performance under light illumination and promote stem cell proliferation in dark conditions.
MATERIALS TODAY BIO
(2022)
Review
Polymer Science
Mengjiao Cao, Chengcheng Liu, Mengxin Li, Xu Zhang, Li Peng, Lijia Liu, Jinfeng Liao, Jing Yang
Summary: This review summarizes the recent progress in incorporating different types of antibacterial agents into hydrogels and discusses the advantages and disadvantages of antibacterial agent hybrid hydrogels. It provides valuable insights and prospects for the treatment of infected bone defects.
Article
Chemistry, Multidisciplinary
Yi Wang, Yannan Zhao, Jiangling Wu, Ming Li, Juan Tan, Wensheng Fu, Hua Tang, Pu Zhang
Summary: The study engineered negatively charged sulfur quantum dots (SQDs) as an efficient broad-spectrum antibiotic to kill drug-resistant bacteria in vitro and in vivo. SQDs destroy bacterial membrane systems and affect their metabolism through the intrinsic antibacterial activity of elemental sulfur and catalytic generation of reactive oxygen species. Compared to traditional positively charged materials, SQDs demonstrate better hemocompatibility and lower toxicity.
Article
Chemistry, Multidisciplinary
Yi Yu, Yuxuan Zeng, Qunle Ouyang, Xiangmei Liu, Yufeng Zheng, Shuilin Wu, Lei Tan
Summary: In this study, an ultrasound-activated piezoelectric responsive heterojunction was designed to change the electron transfer path and achieve a rapid and efficient bactericidal effect. The system showed excellent therapeutic effect for the treatment of MRSA-infected osteomyelitis model.
Article
Engineering, Environmental
Guang Yang, Changrong Wang, Yaping Wang, Xiaoqing Liu, Ye Zhang, Ming Xu, Hongzhang Deng, Weiwei Wang
Summary: The study reported a method of spontaneously coassembling nanparticles to construct antibacterial agents. These nanoparticles showed significant efficacy against bacterial infections and also exhibited good antibacterial activity against drug-resistant strains. Furthermore, they were able to accelerate wound healing in infected skin.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Rita Matos, Hugo Santos Sousa, Jorge Nogueiro, Ana Magalhaes, Celso A. Reis, Fatima Carneiro, Irina Amorim, Freddy Haesebrouck, Fatima Gartner
Summary: The study shows that gastric non-Helicobacter pylori Helicobacter can bind to the human gastric mucosa, with a prevalence of chronic gastritis and chronic active gastritis among patients. Interestingly, these bacteria were found to bind to the gastric mucosa of individuals with severe chronic inflammation and intestinal metaplasia.
Article
Microbiology
Bruno Toledo-Silva, Lisa Beuckelaere, Anneleen De Visscher, Chloe Geeroms, Evelyne Meyer, Sofie Piepers, Damien Thiry, Freddy Haesebrouck, Sarne De Vliegher
Summary: This paper presents a new quantitative method for evaluating and quantifying the in vitro growth inhibition of mastitis-related bacteria. The method can accurately quantify the differences in growth inhibition among different NAS isolates.
Article
Health Care Sciences & Services
Rita Matos, Emily Taillieu, Sofie De Bruyckere, Chloe De Witte, Alexandra Rema, Hugo Santos-Sousa, Jorge Nogueiro, Celso A. Reis, Fatima Carneiro, Freddy Haesebrouck, Irina Amorim, Fatima Gaertner
Summary: This study reveals the presence of Helicobacter spp. in 46.3% of gastric cancer and obese patients, with 43.8% having single H. pylori infection and 2.5% having mixed infections with H. pylori and H. felis associated with dogs or cats. The effectiveness of current Helicobacter eradication treatments needs further improvement.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biotechnology & Applied Microbiology
Junhua Xie, Qiqiong Li, Freddy Haesebrouck, Lien Van Hoecke, Roosmarijn E. Vandenbroucke
Summary: This article reviews the recent advances and obstacles in the use of bacterial extracellular vesicles (bEVs) in biomedical applications, and discusses the paths towards clinical translation.
TRENDS IN BIOTECHNOLOGY
(2022)
Article
Microbiology
Robin Temmerman, Mahdi Ghanbari, Gunther Antonissen, Gerd Schatzmayr, Luc Duchateau, Freddy Haesebrouck, An Garmyn, Mathias Devreese
Summary: Fluoroquinolone agents are critical for human medicine, but their use in poultry production may contribute to the spread of antibiotic resistance genes. This study used metagenomics to investigate the effects of fluoroquinolone application in the gut microbiome of broiler chickens. The results showed that low-dose fluoroquinolone had the most significant impact on the chicken gut microbiota and resistome, while synbiotic supplementation alleviated the burden of antibiotic resistance genes.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Masahiko Nakamura, Futa Murasato, Anders Overby, Yosuke Kodama, Hirofumi Michimae, Kazuki Sasaki, Bram Flahou, Freddy Haesebrouck, Somay Y. Murayama, Shinichi Takahashi, Masayuki Uchida, Hidekazu Suzuki, Hidenori Matsui
Summary: The increased pH induced by acid suppressants affects the viability of non-Helicobacter pylori helicobacters within the cells and lumina of the stomach. Acid suppressants, such as vonoprazan, cause damage and apoptosis of the helicobacter cells by altering the pH.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Veterinary Sciences
Evelien Biebaut, Ilias Chantziaras, Filip Boyen, Bert Devriendt, Freddy Haesebrouck, Charles-Oliver Gomez-Duran, Dominiek Maes
Summary: This study investigated the presence of Mycoplasma hyopneumoniae in the breeding population of ten Belgian farrow-to-finish farms. The results showed that the prevalence of M. hyopneumoniae PCR varied greatly between farms, with gilts being more likely to be infected than sows. Positive animals were mostly found at 30-40 days of gestation. This highlights the importance of a sufficiently long quarantine period and proper gilt acclimation practices before introducing gilts to the sow herd.
PORCINE HEALTH MANAGEMENT
(2022)
Review
Biochemistry & Molecular Biology
Junhua Xie, Freddy Haesebrouck, Lien Van Hoecke, Roosmarijn E. Vandenbroucke
Summary: Bacterial extracellular vesicles (bEVs) have been shown to play a crucial role in the pathogenesis of various diseases. This article thoroughly discusses the contribution of bEVs in disease pathogenesis, their potential as diagnostic biomarkers, and their application as therapeutic targets.
TRENDS IN MICROBIOLOGY
(2023)
Article
Infectious Diseases
Francisco Cortez Nunes, Emily Taillieu, Teresa Letra Mateus, Silvia Teixeira, Freddy Haesebrouck, Irina Amorim
Summary: This study aimed to assess the presence of antibiotic resistance genes previously reported in Helicobacter pylori in gastric samples from 36 pigs where DNA of H. pylori-like organisms had been detected. Based on PCR and sequencing analysis, two samples were positive for the 16S rRNA mutation gene conferring tetracycline resistance, and one sample was positive for the frxA gene conferring metronidazole resistance. These findings indicate the potential occurrence of acquired antimicrobial resistance in H. pylori-like organisms associated with pigs.
Article
Veterinary Sciences
Francisco Cortez Nunes, Teresa Letra Mateus, Emily Taillieu, Silvia Teixeira, Nuno Carolino, Alexandra Rema, Sofie De Bruyckere, Fatima Gartner, Freddy Haesebrouck, Irina Amorim
Summary: This study reveals the presence of Helicobacter species and F. gastrosuis in the stomach of pigs and wild boars, indicating a possible association with gastric disorders.
VETERINARY RESEARCH
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Emily Taillieu, Sophie Rutten, Stijn Michiels, Yuna Arnst, Sofie De Bruyckere, Koen Chiers, Frauke van Aert, Heiko De Schepper, Emma Callewaert, Christophe George, Wouter Van Moerkercke, Glenn Vanneste, Nina Van Heddegem, Erik Vanderstraeten, Freddy Haesebrouck, Christophe Van Steenkiste
Review
Veterinary Sciences
Emily Taillieu, Koen Chiers, Irina Amorim, Fatima Gaertner, Dominiek Maes, Christophe Van Steenkiste, Freddy Haesebrouck
Summary: This article discusses the importance of Helicobacter species in dogs, cats, and pigs and their potential to infect humans. The article highlights the association of Helicobacter suis with gastritis and decreased weight gain in pigs, as well as its potential to cause disease in humans. It also mentions that multiple Helicobacter species can colonize the stomachs of dogs and cats, but their pathogenic significance is likely low. The article concludes that besides H. pylori, gastric Helicobacter species associated with these animals are also clinically relevant in humans.
VETERINARY RESEARCH
(2022)
Review
Gastroenterology & Hepatology
L. Capirchio, T-D. Huang, C. De Witte, F. Haesebrouck, C. Fervaille, C. Gillain, J-F. Rahier, T. De Ronde
Summary: This article reports the first case of elevated CA 19-9 related to H. suis gastritis, which normalized after eradication. In addition to H. pylori, infection with NHPH species can also cause elevated CA 19-9.
ACTA GASTRO-ENTEROLOGICA BELGICA
(2022)
Article
Veterinary Sciences
Silvia Teixeira, Dulce Filipe, Manuela Cerqueira, Patricia Barradas, Francisco Cortez Nunes, Fatima Faria, Freddy Haesebrouck, Joao R. Mesquita, Fatima Gartner, Irina Amorim
Summary: Cats serve as a natural reservoir for many non-Helicobacter pylori Helicobacters, and close contact with animals has been identified as a risk factor for gastric diseases caused by these bacteria. The prevalence of Helicobacter species in cats was determined, with Helicobacter heilmannii and Helicobacter salomonis being the most commonly detected species. Significant histopathological alterations associated with the presence of Helicobacter spp. were not observed in most cases, suggesting potential adaptation of these bacteria to the feline gastric microenvironment.
VETERINARY SCIENCES
(2022)
Article
Veterinary Sciences
Karina Sonalio, Henrique M. S. Almeida, Marina L. Mechler-Dreibi, Gabriel Y. Storino, Freddy Haesebrouck, Dominiek Maes, Luis Guilherme de Oliveira
Summary: The study found that Mycoplasma hyopneumoniae infection affects the diversity of respiratory microbiota and facilitates colonization of other pathogens. Differences in pulmonary and nasal microbiota were observed in pigs with different infection statuses.
VETERINARY RESEARCH
(2022)