Editorial Material
Cardiac & Cardiovascular Systems
Meadhbh Ni Fhlatharta, Asad Khan, Edmund Carton, Karen C. Redmond
Summary: Tracheobronchial stent insertion is a common palliative intervention for patients with severe tracheobronchomalacia or tracheal compression due to mass effect. The stents can be placed bronchoscopically or using a rigid bronchoscope under general anaesthesia. In complex cases, awake veno-venous extracorporeal membrane oxygenation may be considered for difficult airway access.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Veterinary Sciences
Flavie Payette, Audrey Charlebois, Julie-Helene Fairbrother, Guy Beauchamp, Mathilde Leclere
Summary: The study identified Nicoletella semolina in the airways of horses and found it to be commonly present, with the potential pathogenicity remaining to be elucidated. The molecular technique developed in the study will facilitate future research on this microorganism.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Review
Medicine, General & Internal
Elaine M. Griffeth, Brian Whitson, David Huard, Brent R. Brown
Summary: Endobronchial lipomas are rare benign tumors that can be effectively managed with bronchoscopic resection, resulting in low recurrence rates.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Sana Siddiqui, Kristina Johansson, Alex Joo, Luke R. Bonser, Kyung Duk Koh, Olivier Le Tonqueze, Samaneh Bolourchi, Rodriel A. Bautista, Lorna Zlock, Theodore L. Roth, Alexander Marson, Nirav R. Bhakta, K. Mark Ansel, Walter E. Finkbeiner, David J. Erle, Prescott G. Woodruff
Summary: The study identifies miR-141 as a key regulator of pathological airway mucus production induced by IL-13, with disruption leading to decreased goblet cell frequency and reduced mucus secretion. This miRNA may offer a novel therapeutic target for airway diseases.
Article
Veterinary Sciences
S. L. Massie, R. Leguillette
Summary: This study found a high prevalence of upper airway obstructions (UAO) in barrel racing horses through a retrospective analysis. Multiple UAOs were often present simultaneously, with a higher frequency at low speeds. These findings are significant for horse health management and athletic performance.
VETERINARY JOURNAL
(2023)
Article
Veterinary Sciences
Roxane Westerfeld, Flavie Payette, Valerie Dubuc, Estelle Manguin, Khristine Picotte, Guy Beauchamp, Christian Bedard, Mathilde Leclere
Summary: Soaked hay can help control airway obstruction in horses with severe asthma. However, the strict protocol for soaking and discarding dried-out hay used in this study may be considered inconvenient by horse owners.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Veterinary Sciences
Nicolas Herteman, Martina Mosing, Andreas D. Waldmann, Vinzenz Gerber, Angelika Schoster
Summary: This study used electrical impedance tomography to compare flow variables before and after exercise in healthy horses and horses with equine asthma, finding significant differences in PIF and PEF after exercise but not before. Differences between mild-to-moderate and severe equine asthma were not observed, possibly due to the small study population.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Luca Stucchi, Francesco Ferrucci, Michela Bullone, Raffaele L. Dellaca, Jean Pierre Lavoie
Summary: This study evaluated the sensitivity of within-breath analysis and oscillometry in detecting subclinical airway obstruction in horses with asthma. The results showed that within-breath oscillometry is sensitive in discriminating horses with severe asthma from control horses, and it can identify an increase in expiratory reactance similar to that observed in human asthmatic patients. Evaluating inspiratory and expiratory reactance could be promising in distinguishing between horses with asthma in remission and control horses.
Article
Immunology
Yun Mao, Sonika Patial, Yogesh Saini
Summary: This study investigated the role of airway epithelium-specific HMGB1 in the pathogenesis of muco-obstructive lung disease in Tg+ mice. The deficiency of HMGB1 in airway epithelial cells in Tg+ mice resulted in increased inflammation and impaired bacterial clearance.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Chiara Maria Lo Feudo, Luca Stucchi, Elena Alberti, Bianca Conturba, Enrica Zucca, Francesco Ferrucci
Summary: Equine asthma is a respiratory syndrome similar to human asthma, with mild-moderate and severe classifications. Environmental allergens trigger hypersensitivity responses in asthmatic horses, with insects, Dermatophagoides spp., and dog epithelium being the most common allergens. Type-I hypersensitivity plays a major role in severe equine asthma, while type-IV hypersensitivity is more involved in milder forms. Intradermal testing is effective in identifying hypersensitivity to specific allergens in equine medicine.
Article
Biochemistry & Molecular Biology
Yuchen Feng, Shengchong Chen, Luyang Xiong, Chenli Chang, Wenliang Wu, Dian Chen, Jiali Gao, Gongqi Chen, Lingling Yi, Guohua Zhen
Summary: CDH26 serves as a key regulator of epithelial IL-4R signaling in asthma, playing a role in airway hyperresponsiveness, mucus overproduction, and eosinophilia. It modulates IL-4R signaling by regulating IL-13 binding, IL-4R alpha expression, and downstream phosphorylation of Jak1 and Stat6. CDH26 may serve as a potential therapeutic target for IL-4R-mediated allergic diseases.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Malwina Slowikowska, Joanna Bajzert, Julia Miller, Tadeusz Stefaniak, Artur Niedzwiedz
Summary: This study aimed to evaluate the dynamics of circulating immune complexes (CICs) in equine asthma patients during exacerbation, remission, and treatment. The results showed that CIC levels did not support the diagnosis of equine asthma syndrome but could be useful in monitoring patients' conditions.
Article
Medicine, Research & Experimental
Aekkacha Moonwiriyakit, Chantapol Yimnual, Rattikarn Noitem, Sasiwimol Dinsuwannakol, Jenjira Sontikun, Suchada Kaewin, Nichakorn Worakajit, Virawudh Soontornniyomkij, Chatchai Muanprasat
Summary: The activation of GPR120 can alleviate allergic inflammation and airway epithelial remodeling through the inhibition of STAT6 and Akt, suggesting that GPR120 may represent a novel therapeutic target for diseases associated with airway epithelial remodeling, including asthma.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Jihye Yoo, Jiyoung Park, Darong Kim, Yeonjoo Huh, Hea-Young Park Choo, Hyun Ae Woo
Summary: By synthesizing 12 novel compounds and evaluating their biological activities, it was found that 4 compounds exhibited strong inhibitory activities on IL-1 beta and IL-6 mRNA expression. Further in vivo activity evaluation indicated that 2 compounds significantly decreased mRNA levels of IL-1 beta, IL-6, and TNF-alpha.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rui Sun, Kaimin Jiang, Rui Zhu, Hanyu Chu, Huiyong Liu, Jingchun Du
Summary: Cytokine release syndrome, also called cytokine storm, can cause lung damage, acute respiratory distress syndrome (ARDS), and even death during SARS-CoV-2 infection. The underlying mechanisms of cytokine storm, especially the role of TNF-alpha and type I IFNs, remain unknown. This study found that the combination of TNF-alpha and IFN-beta induces death of human airway epithelial cells BEAS-2B through caspase-mediated apoptosis and gasdermin-mediated pyroptosis. Inhibiting TNF-alpha and IFN-beta-mediated death of airway epithelial cells may be a potential treatment for viral infectious diseases like COVID-19.
MOLECULAR IMMUNOLOGY
(2023)
Article
Veterinary Sciences
Janice Kritchevsky, Carla Olave, Stacy Tinkler, Melissa Tropf, Kathleen Ivester, Lauren Forsythe, Laurent Couetil
Summary: This study aimed to investigate the effects of supra-physiologic doses of levothyroxine on athletic horses. The results showed that high doses of levothyroxine resulted in increased heart rates and potential cardiac arrhythmias.
EQUINE VETERINARY JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Taehoo Chang, Semih Akin, Min Ku Kim, Laura Murray, Bongjoong Kim, Seungse Cho, Sena Huh, Sengul Teke, Laurent Couetil, Martin Byung-Guk Jun, Chi Hwan Lee
Summary: The increasing demand for wearable healthcare has led to advancements in the field of electronic textiles. A programmable spray technology allows for custom writing functional nanoparticles into fabrics at high resolution. This approach has significant implications for rapid prototyping of customized e-textiles to meet clinical needs.
ADVANCED MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Yanan Han, Galina Yurevna Zheleznyakova, Yanara Marincevic-Zuniga, Majid Pahlevan Kakhki, Amanda Raine, Maria Needhamsen, Maja Jagodic
Summary: This study compared two different DNA methylation quantification methods and found that enzymatic methyl-seq (EM-seq) performed better in terms of library and sequencing quality, especially in CpG coverage, CpG site overlap, and consistency between input series.
Article
Veterinary Sciences
Sara Frosth, Ellen Ruth A. Morris, Hayley Wilson, Lars Frykberg, Karin Jacobsson, Julian Parkhill, Jan-Ingmar Flock, Tim Wood, Bengt Guss, David M. Aanensen, Ashley G. Boyle, Miia Riihimaki, Noah D. Cohen, Andrew S. Waller
Summary: This study analysed the antigen sequences of 759 isolates of Streptococcus equi from around the world and found that the antigen sequences in the Strangvac vaccine are highly conserved.
EQUINE VETERINARY JOURNAL
(2023)
Article
Veterinary Sciences
John Pringle, Anna Aspan, Miia Riihimaki
Summary: Repeated nasopharyngeal lavage on at least 3 separate occasions can assist in predicting S. equi carrier-free status in horses after recovery from a strangles outbreak.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Veterinary Sciences
Ylva Hedberg-Alm, Eva Tyden, Lena-Mari Tamminen, Lisa Lindstrom, Karin Anlen, Maria Svensson, Miia Riihimaki
Summary: In Sweden, idiopathic peritonitis cases are more common than NSII cases associated with Strongylus vulgaris, and they have a high survival rate with antimicrobial treatment. However, horses presenting with a palpable abdominal mass and exhibiting fever and abdominal pain after 48 hours of medical treatment during the winter months are likely to suffer from NSII of the pelvic flexure and should be considered for abdominal surgery.
BMC VETERINARY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Amanda Raine, Anders Lundmark, Alva Annett, Ann-Christin Wiman, Marco Cavalli, Claes Wadelius, Claudia Bergin, Jessica Nordlund
Summary: DNA methylation is an important epigenetic mark that can be detected in single cells using bisulfite sequencing. Various strategies for single-cell DNA methylation studies have been described, but limitations in cost-efficiency and yield remain. A new method, scSPLAT, demonstrates higher scale and throughput in sample preparation compared to other scWGBS methods.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Nathalie Feiner, Reinder Radersma, Louella Vasquez, Markus Ringner, Bjorn Nystedt, Amanda Raine, Elmar W. Tobi, Bastiaan T. Heijmans, Tobias Uller
Summary: This study investigates the transgenerational inheritance of environmentally induced DNA methylation in water fleas. The results suggest that environmentally induced DNA methylation is non-random and stably inherited across generations in water fleas, potentially playing a significant role in the eco-evolutionary dynamics of freshwater communities.
Article
Biochemistry & Molecular Biology
Srinivas Akula, Miia Riihimaki, Ida Waern, Magnus Abrink, Amanda Raine, Lars Hellman, Sara Wernersson
Summary: This study provides the first insight into the phenotype of equine MCs in bronchoalveolar lavage fluid (BALF) and their potential role in the airways of asthmatic horses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Veterinary Sciences
Anneli Ryden, Lise-Lotte Fernstrom, Elin Svonni, Miia Riihimaki
Summary: This study assessed the effectiveness of cleaning and sanitation of experimentally S. equi contaminated materials and equipment found in stables. The results showed that routine cleaning and sanitation were generally effective to eliminate viable S. equi, but the survival of the bacteria varied depending on the material and strain.
JOURNAL OF EQUINE VETERINARY SCIENCE
(2023)
Article
Veterinary Sciences
Carla J. Olave, Kathleen M. Ivester, Laurent L. Couetil, John Burgess, Jae Hong Park, Abhijit Mukhopadhyay
Summary: This study found that compared to dry hay, steamed hay and haylage have significant advantages in reducing dust exposure, and only haylage improved bronchoalveolar lavage fluid cytology parameters and increased the ratio of anti-inflammatory lipids within 6 weeks.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Agriculture, Dairy & Animal Science
Denise Soderroos, Rickard Ignell, Pia Haubro Andersen, Kerstin Bergvall, Miia Riihimaki
Summary: Insect bite hypersensitivity (IBH), a common allergic skin disease in horses caused by Culicoides biting midges, reduces the welfare of affected horses. This study examined the impact of IBH on animal welfare and behavior, and evaluated a new prophylactic insect repellent. The results showed that there were no differences in movement activity and observed behavior between IBH-affected horses and control horses. However, horses displayed more itching behaviors in the evening, indicating the need for protection and the use of insect repellents when Culicoides are most active. Short periods of scratching were associated with moderate/severe inflammatory skin lesions. It was found that the new repellent tested can potentially reduce allergen exposure and prevent signs of IBH, but further studies are required.
Article
Agriculture, Dairy & Animal Science
Cornelie M. Westermann, Annelieke G. de Bie, Carla Olave, Janny C. de Grauw, Erik Teske, Laurent L. Couetil
Summary: Equine bronchoalveolar lavage (BAL) is commonly performed with isotonic saline, but the acidic pH of saline may increase airway neutrophil count. This study compared the effects of different isotonic solutions on neutrophil influx after BAL in horses and found that the type of solution used and the lung lobe sampled did not significantly affect neutrophil percentage in the lavage fluid. Saline remains an appropriate choice for BAL in horses.