Article
Electrochemistry
Afia Asif, Arto Heiskanen, Jenny Emneus, Stephan Sylvest Keller
Summary: Carbon microelectrodes are widely used in various applications due to their material properties. Optimized fabrication of carbon nanograss electrodes provides high surface area suitable for electrochemical applications such as biosensing or electrochemical monitoring of cells, showing an approximately 2-fold increase in electrochemical signals compared to 2D electrodes.
ELECTROCHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Shajahan Siraj, Christopher R. McRae, Danny K. Y. Wong
Summary: By hydrogenating carbon surfaces with n-butylsilane reduction, this study developed an antifouling carbon surface that significantly reduced signal interference during dopamine detection. The hydrogenated carbon electrodes demonstrated unique characteristics in vitro, minimizing interference from compounds like ascorbic acid. Additionally, these electrodes showed minimal fouling effects during dopamine detection, even in the presence of dopamine oxidation products.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Chemistry, Physical
Stephane Marinesco
Summary: Chemical transmission between neurosecretory cells is a central biological phenomenon that can be studied using electrochemical techniques. Carbon fiber microelectrodes are commonly used to detect neurotransmitters and can be modified for specific and sensitive in situ neurotransmitter detection, making them an essential tool for analyzing living cells and tissues.
CURRENT OPINION IN ELECTROCHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Vuslat B. Juska, Gediminas Juska
Summary: Carbon-based nanostructures have unique properties that make them attractive for chemical and biological sensing applications. A laser scribing approach has been developed for fabricating flexible, graphitic carbon-based substrates for electrochemical applications. The fabricated laser-scribed graphitic electrodes modified with nano copper/copper oxide species demonstrate excellent performance in detecting dopamine and glucose, with high sensitivity and reproducibility. This cost-effective and design-flexible system shows promise for developing biosensing platforms and miniaturizing electrodes for various target analytes.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2021)
Review
Chemistry, Analytical
Zouhour Hsine, Rym Mlika, Nicole Jaffrezic-Renault, Hafsa Korri-Youssoufi
Summary: Graphene and its derivatives have been widely used for electrochemical detection of dopamine due to their high surface area and good conductivity. Modified graphene and graphene-based nanocomposites show improved catalytic activity for dopamine detection. This review summarizes recent advances in graphene-based electrodes for electrochemical detection of dopamine and highlights the advantages of using polymers as linker platforms to form graphene-based nanocomposites for electrochemical dopamine sensors.
Article
Chemistry, Multidisciplinary
Hai-Yan Wang, Yi-Fan Ruan, Li-Bang Zhu, Xiao-Mei Shi, Wei-Wei Zhao, Hong-Yuan Chen, Jing-Juan Xu
Summary: Novel tools for single-cell interrogation combined with electrochemical techniques have been utilized to collect and detect intracellular RNA, enabling systematic studies on oncogenic miR-10b expression levels in different breast cells. This research expands the ability to study gene expression and cellular heterogeneity at the single-cell level.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Analytical
Xiaowei Jiang, Yuan Zhou, Yuang Chen, Yuanhua Shao, Jiandong Feng
Summary: A low-voltage nanotweezer for trapping single DNA molecules has been developed by using etching-engineered nanoelectrodes, reducing the minimum trapping voltage and improving trapping stiffness. This advancement is attributed to the increase in spatial heterogeneity and nonuniformity of electric field near the nanoelectrodes caused by etching of quartz.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Yazhou Xiong, Tao Ma, Hao Zhang, Lizhu Qiu, Shuai Chang, Yingwei Yang, Feng Liang
Summary: A sensitive nanopipette sensor is established through a unique design of host-guest recognition, which is further enhanced by the introduction of gold nanoparticles (Au NPs). The nanopipette conjugated with caboxylatopillar[5]arenes (CP[5]) or carboxylated leaning pillar[6]arene (CLP[6]) generates recognition sites and can capture pesticide molecules, resulting in a significant electronegativity change on the nanopipette's inner surface. The addition of Au NPs improves the selectivity and sensitivity of the nanopipette sensor for paraquat sensing.
Article
Chemistry, Multidisciplinary
N. Norouzi, T. Averianov, J. Kuang, D. C. Bock, S. Yan, L. Wang, K. J. Takeuchi, E. S. Takeuchi, A. C. Marschilok, E. Pomerantseva
Summary: A sol-gel process involving hydrogen peroxide initiation and molybdenum transformation in the presence of excess dopamine hydrochloride led to the formation of metastable precipitate composed of polydopamine spheres coated with dopamine preintercalated molybdenum oxide. Further hydrothermal treatment and annealing processes resulted in the formation of MoO2 nanoplatelets distributed on the surface of a carbon matrix derived from dopamine. The annealed MoO2/C electrode exhibited improved electrochemical activity and stability compared to the hydrothermally treated MoO2/C electrode.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Md. Azahar Ali, Chunshan Hu, Bin Yuan, Sanjida Jahan, Mohammad S. Saleh, Zhitao Guo, Andrew J. Gellman, Rahul Panat
Summary: The authors introduce a biosensing platform with multi-length-scale electrode architecture to achieve ultra-low detection of biomolecules like dopamine, using 3D printed silver micropillars and graphene nanoflakes. This breakthrough in detection limit opens up possibilities for early detection and treatment of diseases.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Analytical
Jiaxin Zhou, Yi Xia, Zhirong Zou, Qing Yang, Xue Jiang, Xiaoli Xiong
Summary: This study presents a composite carbon nanomaterial electrode of CDs/MWCNTs, which is synthesized using liquid dielectric barrier discharge (DBD) microplasma. The electrode shows enhanced electron transfer and electrocatalytic activity for sensitive detection of dopamine (DA). The sensor exhibits good sensing performance and successfully detects DA levels in human serum samples with satisfactory selectivity and recovery rate.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Mathilde Moderne, Imad Abrao-Nemeir, Nathan Meyer, Jun Du, Saly Charles-Achille, Joan Torrent, Mathilde Lepoitevin, Sebastien Balme
Summary: In this work, we investigated two strategies for functionalizing track-etched nanopore membranes to capture and detect Aβ42 aggregates at the single molecule level. One strategy used an aptamer with three steps, while the other strategy used Lecanemab antibodies with six steps. The second strategy was found to be the most suitable for detecting Aβ42 aggregates using a quick current-voltage readout. By comparing the species present in the retentate and filtrate, we confirmed the membrane's affinity for larger Aβ42 aggregates and found that chromatographic membranes combined with an ionic diode for binary on/off readout are powerful tools for detecting rare biomarkers before single molecule analysis.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Physical
Haichao Li, Kechao Zhou, Jun Cao, Qiuping Wei, Cheng-Te Lin, Sharel E. Pei, Li Ma, Naixiu Hu, Yaohua Guo, Zejun Deng, Zhiming Yu, Sichao Zeng, Wanlin Yang, Lingcong Meng
Summary: A novel modification technique was proposed to immobilize nanoparticles on a boron-doped diamond surface via nanopores, preventing aggregation and improving stability. The modified electrode showed good selectivity, increased peak current for dopamine, and enhanced sensitivity for detection, with a wide linear range and low detection limit. Real sample tests validated the promising performance of the modified electrode in detecting dopamine in human serum and injections.
Article
Chemistry, Analytical
Simona Baluchova, Mariola Brycht, Andrew Taylor, Vincent Mortet, Jan Krusek, Ivan Dittert, Silvia Sedlakova, Ladislav Klimsa, Jaromir Kopecek, Karolina Schwarzova-Peckova
Summary: The study characterized three different thicknesses of BDDporous electrodes, finding that electrodes with more layers exhibited higher sensitivity and lower detection limits. Additionally, the presence of a poly-L-lysine coating on porous electrodes was shown to impact the detection performance of dopamine.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Wanyi Xie, Shixuan He, Shaoxi Fang, Liyuan Liang, Biao Shi, Deqiang Wang
Summary: A simple and effective fluorescence platform using nanopipette has been established for visualizing nanomaterials' protective effect on DNA, achieving sensitive detection of MC-LR and signal amplification. The interaction between aptamer/AuNPs prevents DNA cleavage at the nanoscale confinement and provides new kinetic information about dynamic chemical processes.
ANALYTICA CHIMICA ACTA
(2021)
Editorial Material
Biochemical Research Methods
B. Jill Venton, Rebecca R. Pompano
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yuanyu Chang, B. Jill Venton
Summary: Rapid adenosine signaling in the brain provides local neuromodulation but is limited in spatial resolution and regional coordination. This study used dual-channel fast-scan cyclic voltammetry to measure adenosine release in mouse brain slices, revealing localized spontaneous adenosine events and regionally extended adenosine release after mechanical stimulation.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Chemistry, Physical
Qizhang Jia, Cheng Yang, B. Jill Venton, Kateri H. DuBay
Summary: This study utilizes molecular dynamics simulations to investigate the surface diffusion of dopamine on graphene. The findings suggest that dopamine rapidly adsorbs to the surface and diffuses quickly, with its vertical placement influenced by charge.
Article
Chemistry, Physical
Qun Cao, Zijun Shao, Dale Hensley, B. Jill Venton
Summary: This study mass fabricates carbon nanoelectrodes by growing carbon nanospikes (CNSs) on metal wires, which have remarkable electrochemical properties and can be mass fabricated on almost any substrate without using catalysts. The CNS nanoelectrodes show excellent sensitivity for the detection of neurotransmitters like dopamine using fast-scan cyclic voltammetry.
FARADAY DISCUSSIONS
(2022)
Article
Electrochemistry
Zijun Shao, B. Jill Venton
Summary: Carbon nanotube yarn microelectrodes (CNTYMEs) exhibit different trapping effects on anions and cations, and secondary peaks can be used for dopamine identification in mixtures.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Editorial Material
Chemistry, Physical
Jordi Cabana, Thomas Alaan, George W. Crabtree, Marta C. Hatzell, Karthish Manthiram, Daniel A. Steingart, Iryna Zenyuk, Feng Jiao, Aleksandra Vojvodic, Jenny Y. Yang, Nitash P. Balsara, Kristin A. Persson, Donald J. Siegel, Christy L. Haynes, Janine Mauzeroll, Mei Shen, B. Jill Venton, Nina Balke, Joaquin Rodriguez-Lopez, Debra R. Rolison, Reza Shahbazian-Yassar, Venkat Srinivasan, Santanu Chaudhuri, Adrien Couet, Jason Hattrick-Simpers
ACS ENERGY LETTERS
(2022)
Article
Biochemical Research Methods
Scott T. Lee, Yuanyu Chang, B. Jill Venton
Summary: This study investigated the role of pannexin channels, specifically pannexinl (Panx1) channels, in rapid adenosine release. The results showed that Panx1 is a release mechanism for mechanically stimulated adenosine release, but not the only mechanism.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Analytical
Zijun Shao, Yuanyu Chang, B. Jill Venton
Summary: Carbon electrodes are widely used in neurotransmitter detection due to their good electrochemical properties, high biocompatibility, and inert chemistry. Customizing the shape and nanostructuring the surface of carbon electrodes enhance their electrochemical properties, including sensitivity, selectivity, and secondary peaks. This enables new applications in neuroscience, such as distinguishing different catecholamines, detecting vesicular release in single cells, and multi-region measurements in vivo.
ANALYTICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Kelly E. Dunham, B. Jill Venton
Summary: This study provides a detailed investigation into the effects of selective serotonin reuptake inhibitors (SSRIs) on serotonin concentration and reuptake in fruit fly larvae. The results show that different types of SSRIs have varying effects on serotonin concentration and reuptake in this model, which is valuable for future studies exploring the pharmacological effects of SSRIs with different genetic mutations in fruit flies.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Qizhang Jia, B. Jill Venton, Kateri H. DuBay
Summary: This study investigates the adsorption and surface diffusion dynamics of dopamine on carbon nanotubes (CNTs) using molecular dynamics simulations. The results show that solvent affects the diffusion of adsorbates on solvated CNT surfaces, while curvature changes have minimal impact on diffusion. Furthermore, dopamine diffuses into the groove between aligned CNTs, enhancing its diffusion along the CNT axis.
Article
Chemistry, Multidisciplinary
Mimi Shin, B. Jill Venton
Summary: In this study, we developed fast-scan cyclic voltammetry (FSCV) to measure dopamine release in fruit flies during behavior. The results showed that sugar feeding induced longer dopamine release compared to acetylcholine stimulation in the mushroom body. In addition, administering dopamine transporter inhibitor or D2 receptor antagonist significantly increased sugar-evoked dopamine release.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
B. Jill Venton, Zijun Shao, Leslie Wilson, Yuanyu Chang
Summary: Nanodiamonds (NDs) are a promising material for electrochemical sensing due to their large surface area, defect sites, and functional groups. Growing thin films of ND on niobium wires and oxygen plasma etching can increase sensitivity but slightly decrease fouling resistance.
Article
Biochemistry & Molecular Biology
Eduard Dumitrescu, Jeffrey M. Copeland, B. Jill Venton
Summary: This study investigates the effect of parkin knockdown on dopamine release in Drosophila. The results show that parkin knockdown causes age-dependent reduction of dopamine release in certain brain regions, leading to impaired locomotion. The findings provide insights into the mechanism of Parkinson's disease and suggest Drosophila as a useful model for studying dopamine functionality and potential therapies.
ACS CHEMICAL NEUROSCIENCE
(2022)
Review
Chemistry, Physical
Yuanyu Chang, Qun Cao, B. Jill Venton
Summary: Traditional carbon electrodes made of glassy carbon or carbon fibers have limited shapes. 3D printing enables complete customization of shape and simultaneous fabrication of devices and electrodes. Additive manufacturing, the most common 3D printing method, involves adding carbon materials to make it conductive and applying treatments to enhance electrochemical activity. Another newer form, 2-photon lithography uses laser lithography to print electrodes in photoresist and then annealed to carbon. Applications of 3D printed carbon electrodes include nanoelectrode measurements, biosensor arrays, and integrated electrodes in microfluidic devices.
CURRENT OPINION IN ELECTROCHEMISTRY
(2023)
Article
Biochemical Research Methods
He Zhao, Kailash Shrestha, Dale K. Hensley, B. Jill Venton
Summary: Carbon nanospikes (CNSs) are a new nanomaterial that enhances the sensitivity for dopamine detection. In this study, CNS-modified electrodes (CNSMEs) were evaluated for the detection of adenosine, hydrogen peroxide ( H2O2), and histamine. The results showed that CNSMEs had higher signals compared to conventional electrodes (CFMEs), with increased sensitivity for adenosine (4.8 times), H2O2 (1.5 times), and histamine (2 times). CNSMEs also promoted the formation of secondary products for adenosine and histamine, allowing differentiation from analytes with similar oxidation potentials. CNSs selectively enhanced the sensitivity for adenosine and histamine compared to H2O2. The use of CNSMEs in brain slices and tissue measurements showed high selectivity and low fouling.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)