4.7 Meeting Abstract

Combining active immunotherapy and immune checkpoint inhibitors in prostate cancer.

期刊

JOURNAL OF CLINICAL ONCOLOGY
卷 33, 期 7, 页码 -

出版社

AMER SOC CLINICAL ONCOLOGY
DOI: 10.1200/jco.2015.33.7_suppl.172

关键词

-

类别

向作者/读者索取更多资源

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Oncology

Clinical Activity of Single-Agent Cabozantinib (XL184), a Multi-receptor Tyrosine Kinase Inhibitor, in Patients with Refractory Soft-Tissue Sarcomas

Geraldine O'Sullivan Coyne, Shivaani Kummar, James Hu, Kristen Ganjoo, Warren A. Chow, Khanh T. Do, Jennifer Zlott, Ashley Bruns, Lawrence Rubinstein, Jared C. Foster, Lamin Juwara, Robert Meehan, Richard Piekarz, Howard Streicher, Elad Sharon, Naoko Takebe, Andrea Regier Voth, Donald Bottaro, Rene Costello, John J. Wright, James H. Doroshow, Alice P. Chen

Summary: In this study, the efficacy of single-agent cabozantinib in treating advanced soft-tissue sarcomas (STS) was evaluated. The results showed that cabozantinib exhibited antitumor activity in selected STS histologic subtypes, highlighting the biomolecular diversity of STS.

CLINICAL CANCER RESEARCH (2022)

Review Oncology

Dual inhibition of TGF-β and PD-L1: a novel approach to cancer treatment

James L. Gulley, Jeffrey Schlom, Mary Helen Barcellos-Hoff, Xiao-Jing Wang, Joan Seoane, Francois Audhuy, Yan Lan, Isabelle Dussault, Aristidis Moustakas

Summary: Transforming growth factor-beta (TGF-beta) and programmed death-ligand 1 (PD-L1) have immunosuppressive functions in the tumor microenvironment (TME) and inhibiting these pathways can improve clinical outcomes and reduce toxicity.

MOLECULAR ONCOLOGY (2022)

Article Oncology

A Randomized Phase II Trial of mFOLFOX6+Bevacizumab Alone or with AdCEA Vaccine plus Avelumab Immunotherapy for Untreated Metastatic Colorectal Cancer

Jason M. Redman, Yo-Ting Tsai, Benjamin A. Weinberg, Renee N. Donahue, Shruti Gandhy, Margaret E. Gatti-Mays, Houssein Abdul Sater, Marijo Bilusic, Lisa M. Cordes, Seth M. Steinberg, Jennifer L. Marte, Caroline Jochems, Sunnie S. Kim, John L. Marshall, Sheri McMahon, Erica Redmond, Jeffrey Schlom, James L. Gulley, Julius Strauss

Summary: This study compared the effectiveness of the standard of care with and without the addition of Avelumab and AdCEA vaccine in the treatment of metastatic colorectal cancer. The results showed that while the combination treatment generated a multifunctional immune response, it did not improve progression-free survival. Additional agents may be required to enhance the clinical benefit.

ONCOLOGIST (2022)

Article Oncology

Randomized Phase II Trial of Sunitinib or Cediranib in Alveolar Soft Part Sarcoma

James Nguyen, Naoko Takebe, Shivaani Kummar, Albiruni Razak, Sant P. Chawla, Suzanne George, Shreyaskumar R. Patel, Mary Louise Keohan, Sujana Movva, Geraldine O. 'Sullivan Coyne, Khanh Do, Lamin Juwara, Brooke Augustine, Seth M. Steinberg, Laura Kuhlmann, S. Percy Ivy, James H. Doroshow, Alice P. Chen

Summary: This phase II randomized trial aimed to evaluate the activity and tolerability of single-agent cediranib or sunitinib in patients with advanced metastatic alveolar soft part sarcoma (ASPS). The results showed that both drugs provided clinical benefit, but the response rates may have been affected by the time of disease progression.

CLINICAL CANCER RESEARCH (2023)

Article Oncology

Phase 1 trial of CV301 in combination with anti-PD-1 therapy in nonsquamous non-small cell lung cancer

Arun Rajan, Jhanelle E. Gray, Siddhartha Devarakonda, Ruemu Birhiray, Borys Korchin, Erika Menius, Renee N. Donahue, Jeffrey Schlom, James L. Gulley

Summary: CV301 in combination with PD-1 inhibitors is safe and clinically active in advanced NSCLC patients, without an increased frequency or severity of immune-related adverse events.

INTERNATIONAL JOURNAL OF CANCER (2023)

Article Oncology

Effect of CD4+T cell count on treatment-emergent adverse events among patients with and without HIV receiving immunotherapy for advanced cancer

Thomas A. Odeny, Kathryn Lurain, Julius Strauss, Steven P. Fling, Elad Sharon, Anna Wright, Javier Martinez-Picado, Teresa Moran, James L. Gulley, Maria Gonzalez-Cao, Thomas S. Uldrick, Robert Yarchoan, Ramya Ramaswami

Summary: There was no significant difference in the baseline CD4 counts or the proportions of any TEAE and grade ≥ 3 TEAE between HIV-positive and HIV-negative patients receiving immune checkpoint inhibitor (ICI) treatment. CD4 count thresholds for cancer clinical trials should be carefully reviewed to avoid unnecessarily excluding patients with HIV and cancer.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

Review Oncology

Molecular Pathways and Mechanisms of TGFb in Cancer Therapy

Mary Helen Barcellos-Hoff, James L. Gulley

Summary: Despite the increasing number of TGFI3 inhibitors tested in cancer patients, there has been no clinical benefit achieved yet. The main obstacle to effective TGFI3 inhibition is the diverse mechanisms by which TGFI3 promotes tumor growth. TGFI3 is involved in regulating DNA repair and immune suppression, which can be used to synergize genotoxic therapy and immunotherapy for the benefit of cancer patients.

CLINICAL CANCER RESEARCH (2023)

Article Pharmacology & Pharmacy

In Silico Re-Optimization of Atezolizumab Dosing Using Population Pharmacokinetic Simulation and Exposure-Response Simulation

Cody J. Peer, Keith T. Schmidt, Oluwatobi Arisa, William J. Richardson, Koosha Paydary, Daniel A. Goldstein, James L. Gulley, William D. Figg, Mark J. Ratain

Summary: Atezolizumab, a humanized monoclonal antibody against PD-L1, was approved in 2016. Standard dose regimens result in high plasma concentrations, indicating the need for alternative dosing strategies to reduce exposure burden.

JOURNAL OF CLINICAL PHARMACOLOGY (2023)

Article Oncology

Bintrafusp Alfa: A Bifunctional Fusion Protein Targeting PD-L1 and TGF-β, in Patients with Pretreated Colorectal Cancer: Results from a Phase I Trial

Alexander Spira, Michael S. Wertheim, Edward J. Kim, Benjamin Tan, Heinz-Josef Lenz, Petros Nikolinakos, Patricia L. Rich, Genevieve Jehl, Andreas Machl, Rena Ito, James L. Gulley, Scott Kopetz

Summary: A phase I study on bintrafusp alfa in heavily pretreated patients with colorectal cancer showed promising early signs of clinical efficacy and manageable safety profile.

ONCOLOGIST (2023)

Article Oncology

A Phase I Single-Arm Study of Biweekly NHS-IL12 in Patients With Metastatic Solid Tumors

Margaret E. Gatti-Mays, Nicholas P. Tschernia, Julius Strauss, Ravi A. Madan, Fatima H. Karzai, Marijo Bilusic, Jason Redman, Houssein Abdul Sater, Charalampos S. Floudas, Nicole J. Toney, Renee N. Donahue, Caroline Jochems, Jennifer L. Marte, Deneise Francis, Sheri McMahon, Elizabeth Lamping, Lisa Cordes, Jeffrey Schlom, James L. Gulley

Summary: The results of this study showed that biweekly NHS-IL12 treatment was safe for patients with advanced cancers. NHS-IL12 is a first-in-class fusion protein used in this trial. Patients received NHS-IL12 every two weeks, and the results demonstrated stable disease status for the patients.

ONCOLOGIST (2023)

Article Oncology

Phase 1 Study of Safety and Preliminary Clinical Activity of JNJ-63898081, a PSMA and CD3 Bispecific Antibody, for Metastatic Castration-Resistant Prostate Cancer

Emerson A. Lim, Michael T. Schweizer, Kim N. Chi, Rahul Aggarwal, Neeraj Agarwal, James Gulley, Edward Attiyeh, James Greger, Shujian Wu, Pharavee Jaiprasart, John Loffredo, Nibedita Bandyopadhyay, Hong Xie, Aaron R. Hansen

Summary: PSMA expression is maintained in all stages of prostate cancer. In a phase 1 study, a bispecific antibody targeting PSMA-expressing tumor cells and CD3-expressing T cells showed manageable cytokine release syndrome and temporary decline in PSA in patients with metastatic castration-resistant prostate cancer. Treatment-related deaths and radiographic responses were not observed. PSMA is a potential therapeutic target for T-cell redirection in prostate cancer.

CLINICAL GENITOURINARY CANCER (2023)

Article Oncology

Society for Immunotherapy of Cancer (SITC) consensus definitions for resistance to combinations of immune checkpoint inhibitors with targeted therapies

Michael B. Atkins, Paolo A. Ascierto, David Feltquate, James L. Gulley, Douglas B. Johnson, Nikhil Khushalani, Jeffrey Sosman, Timonthy A. Yap, Harriet Kluger, Ryan J. Sullivan, Hussein Tawbi

Summary: Immunotherapy alone does not work for all tumors, so combining it with signal transduction inhibitors, such as antiangiogenic therapies, can enhance its effectiveness. Combination therapies with immunotherapy have shown improved antitumor activity in various solid tumor settings and have received regulatory approval for the treatment of several types of cancer. However, many patients still experience progression after combination treatment, highlighting the need for new strategies to address resistance to immunotherapy.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2023)

Review Oncology

Vaccinating against cancer: getting to prime time

Ryan Chang, James L. Gulley, Lawrence Fong

Summary: Immunotherapies, such as immune checkpoint inhibitors and cellular therapies, have revolutionized cancer treatment, but the development of successful cancer vaccines remains challenging. Only two vaccines have shown improved survival in advanced disease: sipuleucel-T and talimogene laherparepvec, which target specific antigens and utilize tumors in situ to prime responses. In this review, we examine the challenges and opportunities in developing therapeutic cancer vaccines.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2023)

Meeting Abstract Oncology

Phase II evaluation of the combination of PDS0101, M9241, and bintrafusp alfa in patients with HPV 16+malignancies

Julius Strauss, Charalampos S. Floudas, Danielle M. Pastor, Michell Manu, Elizabeth Lamping, Deneise C. Francis, Lisa M. Cordes, Jenn Marte, Renee Nicole Donahue, Caroline Jochems, Scott Norberg, Jason Redman, Fatima Karzai, Ravi Amrit Madan, Jeffrey Schlom, James L. Gulley

JOURNAL OF CLINICAL ONCOLOGY (2022)

Meeting Abstract Oncology

A phase I trial of T-cell receptor gene therapy targeting KK-LC-1 for gastric, breast, cervical, lung and other KK-LC-1 positive epithelial cancers

Scott Norberg, Erika Maria Von Euw, Gordon Parry, Steven Highfill, Zulmarie Franco, James L. Gulley, Christian S. Hinrichs

JOURNAL OF CLINICAL ONCOLOGY (2022)

暂无数据