期刊
ANALYTICAL CHEMISTRY
卷 87, 期 24, 页码 11967-11972出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.5b03616
关键词
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资金
- SCIEX
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- MITACS for an Accelerate Fellowship
We introduce an automated method to facilitate in-line coupling of digital microfluidics (DMF) with HPLC-MS, using a custom, 3D-printed manifold and a custom plugin to the popular open-source control system, DropBot. The method was designed to interface directly with commercial autosamplers (with no prior modification), suggesting that it will be widely accessible for end-users. The system was demonstrated to be compatible with samples dissolved in aqueous buffers and neat methanol and was validated by application to a common steroid-labeling derivatization reaction. We propose that the methods described here will be useful for a wide range of applications, combining the automated sample processing power of DMF with the resolving and analytical capacity of HPLC-MS.
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