Article
Psychiatry
Katharine Barnard-Kelly, Clare A. Whicher, Hermione C. Price, Peter Phiri, Shanaya Rathod, Carolyn Asher, Robert C. Peveler, Richard I. G. Holt
Summary: This study aimed to record the expectations and experiences of individuals with severe mental illness receiving daily Liraglutide injections for obesity treatment. Interviews with patients and healthcare professionals revealed that most participants had no challenges with the injections and overall, Liraglutide was considered an acceptable therapy for obesity in this population.
Article
Psychiatry
Susan R. McGurk, Michael W. Otto, Daniel Fulford, Zachary Cutler, Leonard P. Mulcahy, Sai Snigdha Talluri, Wei Qiao Qiu, Qini Gan, Ivy Tran, Laura Turner, Nicole R. DeTore, Stacey A. Zawacki, Chitra Khare, Anilkumar Pillai, Kim T. Mueser
Summary: This study found that adding aerobic exercise did not enhance the effects of cognitive remediation in individuals with severe mental illness, possibly because the cognitive remediation program itself led to significant improvements in cognitive functioning. Additionally, moderate aerobic exercise does not appear to reliably increase BDNF levels in individuals with severe mental illness.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychiatry
Frank Rohricht, Raguraman Padmanabhan, Paul Binfield, Deepa Mavji, Sally Barlow
Summary: This study evaluated the feasibility, acceptability, and potential clinical benefits of a mobile technology health management tool for enhancing community care for people with severe mental illness. Preliminary results suggested that the health technology tool was practicable and acceptable for patients, but further improvements are needed.
Article
Psychiatry
Naomi Launders, Laura Scolamiero, David P. J. Osborn, Joseph F. Hayes
Summary: This study found that patients with schizophrenia have lower rates of cancer diagnosis but higher all-cause and cancer-specific mortality rates following diagnosis. Premature mortality does not explain these differences, suggesting the presence of barriers to cancer diagnosis and treatment.
SCHIZOPHRENIA RESEARCH
(2022)
Review
Substance Abuse
Panagiotis Spanakis, Emily Peckham, Ben Young, Paul Heron, Della Bailey, Simon Gilbody
Summary: This study evaluated the effectiveness of behavioral smoking cessation interventions in adults with severe mental ill health, finding that face-to-face bespoke interventions were more effective compared to usual care.
Article
Psychiatry
Eric Granholm, Elizabeth W. Twamley, Zanjbeel Mahmood, Amber Keller, Hannah C. Lykins, Emma M. Parrish, Michael L. Thomas, Dimitri Perivoliotis, Jason L. Holden
Summary: The study examined the efficacy of an integrated intervention for individuals with schizophrenia, showing significant improvements in negative symptom severity and verbal learning. These effects appeared to be durable at the 6-month follow-up, suggesting the potential of the intervention for treating negative symptoms and cognitive impairments in this population.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Psychiatry
Charlotte Hanlon, Girmay Medhin, Michael E. Dewey, Martin Prince, Esubalew Assefa, Teshome Shibre, Dawit A. Ejigu, Hanna Negussie, Sewit Timothewos, Marguerite Schneider, Graham Thornicroft, Lawrence Wissow, Ezra Susser, Crick Lund, Abebaw Fekadu, Atalay Alem
Summary: This study evaluated the efficacy and cost-effectiveness of task-shared care using the WHO's mental health Gap Action Programme compared with specialist mental health care in low-income countries. The results showed no significant difference between the two care models in terms of the primary outcome, and task-shared care was found to be effective and safe in resource-poor settings.
Article
Medicine, General & Internal
Masayuki Katsushima, Hideki Nakamura, Hideki Hanaoka, Yuki Shiko, Hideki Komatsu, Eiji Shimizu
Summary: This study aims to evaluate whether real-time remote video-conference cognitive behavioural therapy for psychosis (vCBTp) could improve symptoms compared with usual care for patients with schizophrenia. The study will consist of an 8-week intervention and assess various outcomes to measure the patient's condition and quality of life.
Article
Psychiatry
Mario Luciano, Gaia Sampogna, Mario Amore, Alessandro Bertolino, Liliana Dell'Osso, Alessandro Rossi, Alberto Siracusano, Pietro Calcagno, Claudia Carmassi, Giorgio Di Lorenzo, Matteo Di Vincenzo, Vincenzo Giallonardo, Antonio Rampino, Rodolfo Rossi, Andrea Fiorillo
Summary: The present study aimed to examine the effects of a lifestyle group intervention compared to a brief psychoeducational intervention on physical activity levels and dietary habits in patients with severe mental disorders. The findings showed that patients who received the intervention were more likely to increase their physical activity levels and improve their dietary habits, suggesting the potential for patients to improve their lifestyle behaviors.
PSYCHIATRY RESEARCH
(2022)
Article
Psychiatry
Bert-Jan Roosenschoon, Jaap van Weeghel, Mathijs L. Deen, Emmie W. van Esveld, Astrid M. Kamperman, Cornelis L. Mulder
Summary: This study found that patients who received IMR showed significant improvement in self-reported overall illness management and self-esteem. However, there were no significant effects in other questionnaire measures, and no statistically significant between-group differences in terms of hospitalizations. IMR completion was associated with stronger effects, and high IMR fidelity was associated with self-esteem.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Health Care Sciences & Services
Caspar Wiegmann, Esther Quinlivan, Twyla Michnevich, Andreas Pittrich, Petja Ivanova, Alissa Maresa Rohrbach, Jakob Kaminski
Summary: The effective treatment of patients with severe psychiatric disorders relies on subjective reporting of symptoms and side-effects, which can lead to uncertainty and non-adherence. In this study, a flexible electronic patient-reported outcome (ePRO) system was developed to allow patients to record and share their symptoms, improving outcomes and potentially reducing health service costs. Input from patients, practitioners, digital health experts, software engineers, and researchers was incorporated in the development process, leading to a trial-ready ePRO system for severe psychiatric disorders.
Article
Neurosciences
Amir Englund, Dominic Oliver, Edward Chesney, Lucy Chester, Jack Wilson, Simina Sovi, Andrea De Micheli, John Hodsoll, Paolo Fusar-Poli, John Strang, Robin M. Murray, Tom P. Freeman, Philip McGuire
Summary: As countries adopt more permissive cannabis policies, it is increasingly important to identify strategies that can reduce the harmful effects of cannabis use. This study aimed to determine if increasing the CBD content of cannabis can reduce its harmful effects. The results showed that increasing the CBD content did not reduce the harmful effects of cannabis on memory and psychotic symptoms. Therefore, CBD may not protect against the acute adverse effects of cannabis.
NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Psychiatry
Ella Pearson, Dan Siskind, Ruth E. Hubbard, Emily H. Gordon, Elizabeth J. Coulson, Nicola Warren
Summary: Emerging evidence suggests that individuals with severe mental illness (SMI) are at an increased risk of frailty. This systematic review examined the prevalence and correlates of frailty, as well as the efficacy of interventions, in this population. The findings indicate a high prevalence of frailty among individuals with SMI, with associations to physical comorbidity, cognitive deficits, falls, and mortality. However, further research is needed to develop appropriate interventions for frailty in this population.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Review
Psychiatry
Naista Zhand, Ridha Joober
Summary: This study aimed to review the impact of COVID-19 on patients with schizophrenia spectrum disorders. The results showed that this patient population may be more vulnerable to the effects of the pandemic, requiring continuous monitoring and long-term studies.
Article
Psychiatry
Muege H. Kucukaksu, Berno van Meijel, Lola Jansen, Trynke Hoekstra, Marcel C. Adriaanse
Summary: This study aims to evaluate a smoking cessation intervention in people with severe mental illness treated by FACT teams in the Netherlands. The intervention includes pharmacological treatment, behavioral counseling, and peer support. The study will also evaluate the implementation process of the intervention and the satisfaction and experiences of patients and mental health care professionals.
Letter
Gastroenterology & Hepatology
Calum D. Moulton, Emily Staite, Kirsty Winkley, Michael A. Heneghan, Khalida Ismail
JOURNAL OF HEPATOLOGY
(2023)
Review
Medicine, General & Internal
Paris Hosseini, Rebecca Whincup, Karrish Devan, Dory Anthony Ghanem, Jack B. Fanshawe, Aman Saini, Benjamin Cross, Apoorva Vijay, Tomas Mastellari, Umesh Vivekananda, Steven White, Franz Brunnhuber, Michael S. Zandi, Anthony S. David, Ben Carter, Dominic Oliver, Glyn Lewis, Charles Fry, Puja R. Mehta, Biba Stanton, Jonathan P. Rogers
Summary: This study aimed to determine the performance of EEG in determining whether catatonia has a medical or psychiatric cause. The study found that an abnormal EEG predicted a medical cause of catatonia with fair accuracy, but performed poorly in distinguishing psychiatric causes.
Article
Genetics & Heredity
Jessica Mundy, Christopher Hubel, Brett N. N. Adey, Helena L. L. Davies, Molly R. R. Davies, Jonathan R. I. Coleman, Matthew Hotopf, Gursharan Kalsi, Sang Hyuck Lee, Andrew M. M. McIntosh, Henry C. C. Rogers, Thalia C. C. Eley, Robin M. M. Murray, Evangelos Vassos, Gerome Breen
Summary: The Mood Disorder Questionnaire (MDQ) is commonly used for screening bipolar disorder but its validity for genetic studies has not been fully examined. A study compared the MDQ to self-reported bipolar disorder and conducted genome-wide association studies to investigate genetic correlations with bipolar disorder and other traits. The MDQ showed low positive predictive value for self-reported bipolar disorder and no genetic correlations with bipolar disorder were found. The study also suggested that the MDQ may capture symptoms of general distress or psychopathology instead of specifically targeting hypomania/mania in at-risk populations.
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
(2023)
Article
Medicine, General & Internal
Jonathan P. Rogers, Michael S. Zandi, Anthony S. David
Summary: Catatonia is a severe syndrome that affects various aspects of human functioning and can be caused by different psychiatric and neurological conditions. The main treatment options are benzodiazepines and/or electroconvulsive therapy, while important investigations may include neuroimaging and assessment for neuronal autoantibodies. However, the guidelines are limited by the lack of high-quality evidence.
Article
Medicine, General & Internal
Cheng Zhang, Shanshan Wei, Yunxia Wang, Kunyao Yu, Zhe Jin, Meng Zhang, Xiaoyu Ma, Chunbo Zhang, Qi Zhang, Kunyan Sun, Peining Zhou, Yijue Zhong, Jing Ma, Jiping Liao, Guangfa Wang
Summary: This study investigated the association between obstructive sleep apnea (OSA) and preserved ratio impaired spirometry (PRISm) in a community population. The findings showed that the prevalence of high-risk OSA, waist-to-hip ratio, current smoking, and nasal allergy symptoms were independently associated with PRISm.
CURRENT MEDICAL RESEARCH AND OPINION
(2023)
Article
Endocrinology & Metabolism
Madeleine Benton, Jeni Baykoca, Khalida Ismail, Hermione Price
Summary: This study aims to explore the perspectives and experiences of healthcare professionals in identifying and supporting mental health problems in adults with type 1 diabetes in the UK. Through individual interviews with 15 healthcare professionals, barriers such as time constraints, lack of knowledge, service relationships, and stigma were identified, while facilitators included education, communication, and appropriate tools and services. The findings highlight the importance of educational tools to improve the skills and competency of healthcare professionals in identifying mental health problems in type 1 diabetes patients.
Article
Biochemistry & Molecular Biology
Dominic B. Dwyer, Ganesh B. Chand, Alessandro Pigoni, Adyasha Khuntia, Junhao Wen, Mathilde Antoniades, Gyujoon Hwang, Guray Erus, Jimit Doshi, Dhivya Srinivasan, Erdem Varol, Rene S. Kahn, Hugo G. Schnack, Eva Meisenzahl, Stephen J. Wood, Chuanjun Zhuo, Aristeidis Sotiras, Russell T. Shinohara, Haochang Shou, Yong Fan, Maristela Schaulfelberger, Pedro Rosa, Paris A. Lalousis, Rachel Upthegrove, Antonia N. Kaczkurkin, Tyler M. Moore, Barnaby Nelson, Raquel E. Gur, Ruben C. Gur, Marylyn D. Ritchie, Theodore D. Satterthwaite, Robin M. Murray, Marta Di Forti, Simone Ciufolini, Marcus V. Zanetti, Daniel H. Wolf, Christos Pantelis, Benedicto Crespo-Facorro, Geraldo F. Busatto, Christos Davatzikos, Nikolaos Koutsouleris, Paola Dazzan
Summary: Using machine learning, researchers found that schizophrenia can be decomposed into two volumetric subgroups with distinct neuroanatomical characteristics: a 'lower brain volume' subgroup and a 'higher striatal volume' subgroup. These subgroups were already present at the first episode of psychosis and were associated with different clinical presentations and remission outcomes. The findings suggest that these subgroups may be important in understanding the underlying mechanisms of schizophrenia and could be targeted in future treatment trials.
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Luis Alameda, Zhonghua Liu, Pak C. Sham, Monica Aas, Giulia Trotta, Victoria Rodriguez, Marta Di Forti, Simona A. Stilo, Radhika Kandaswamy, Celso Arango, Manuel Arrojo, Miguel Bernardo, Julio Bobes, Lieuwe de Haan, Cristina Marta Del-Ben, Charlotte Gayer-Anderson, Lucia Sideli, Peter B. Jones, Hannah E. Jongsma, James B. Kirkbride, Caterina La Cascia, Antonio Lasalvia, Sarah Tosato, Pierre-Michel Llorca, Paulo Rossi Menezes, Jim van Os, Diego Quattrone, Bart P. Rutten, Jose Luis Santos, Julio Sanjuan, Jean-Paul Selten, Andrei Szoke, Ilaria Tarricone, Andrea Tortelli, Eva Velthorst, Craig Morgan, Emma Dempster, Eilis Hannon, Joe Burrage, Daniella Dwir, Atheeshaan Arumuham, Jonathan Mill, Robin M. Murray, Chloe C. Y. Wong
Summary: Studies have found that DNA methylation is sensitive to childhood adversity in psychotic disorders, but it is unclear whether it mediates the association between childhood adversity and psychosis. This study found that childhood adversity was associated with psychosis, but no specific CpG sites were found to mediate the association. However, there were differentially methylated probes associated with genes previously linked to psychosis.
MOLECULAR PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Andre Zugman, Luz Maria Alliende, Vicente Medel, Richard A. I. Bethlehem, Jakob Seidlitz, Grace Ringlein, Celso Arango, Aurina Arnatkeviciute, Laila Asmal, Mark Bellgrove, Vivek Benegal, Miquel Bernardo, Pablo Billeke, Jorge Bosch-Bayard, Rodrigo Bressan, Geraldo F. Busatto, Mariana N. Castro, Tiffany Chaim-Avancini, Albert Compte, Monise Costanzi, Leticia Czepielewski, Paola Dazzan, Camilo de la Fuente-Sandoval, Marta Di Forti, Covadonga M. Diaz-Caneja, Ana Maria Diaz-Zuluaga, Stefan Du Plessis, Fabio L. S. Duran, Sol Fittipaldi, Alex Fornito, Nelson B. Freimer, Ary Gadelha, Clarissa S. Gama, Ranjini Garani, Clemente Garcia-Rizo, Cecilia Gonzalez Campo, Alfonso Gonzalez-Valderrama, Salvador Guinjoan, Bharath Holla, Agustin Ibanez, Daniza Ivanovic, Andrea Jackowski, Pablo Leon-Ortiz, Christine Lochner, Carlos Lopez-Jaramillo, Hilmar Luckhoff, Raffael Massuda, Philip McGuire, Jun Miyataaaa, Romina Mizrahi, Robin Murray, Aysegul Ozerdem, Pedro M. Pan, Mara Parellada, Lebogan Phahladira, Juan P. Ramirez-Mahalu, Ramiro Reckziegel, Tiago Reis Marques, Francisco Reyes-Madrigal, Annerine Roos, Pedro Rosa, Giovanni Salum, Freda Scheffler, Gunter Schumann, Mauricio Serpa, Dan J. Stein, Angeles Tepper, Jeggan Tiego, Tsukasa Ueno, Juan Undurraga, Eduardo A. Undurrag, Pedro Valdes-Sosaooo, Isabel Valliy, Mirta Villarrealu, Toby T. Winton-Brownrrr, Nefize Yalin, Francisco Zamorano, Marcus V. Zanetti, Anderson M. Winkler, Daniel S. Pine, Sara Evans-Lacko, Nicolas A. Crossley
Summary: Gender inequality has been linked to higher mental health risks and lower academic achievement for women globally. Differences in brain structure between men and women may be partially explained by unequal exposure to harsher conditions in gender-unequal countries, leading to worse outcomes for women. A meta-analysis of MRI scans from 139 samples across 29 countries revealed that women in gender-equal countries had no differences or even thicker cortical regions, while those in countries with greater gender inequality had thinner cortices. These findings highlight the potential negative impact of gender inequality on women's brains and the need for policies based on neuroscience for gender equality.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Psychology, Clinical
Edoardo Spinazzola, Diego Quattrone, Victoria Rodriguez, Giulia Trotta, Luis Alameda, Giada Tripoli, Charlotte Gayer-Anderson, Tom P. Freeman, Emma C. Johnson, Hannah E. Jongsma, Simona Stilo, Caterina La Cascia, Laura Ferraro, Daniele La Barbera, Antonio Lasalvia, Sarah Tosato, Ilaria Tarricone, Giuseppe D'Andrea, Michela Galatolo, Andrea Tortelli, Ilaria Tagliabue, Marco Turco, Maurizio Pompili, Jean-Paul Selten, Lieuwe de Haan, Paulo Rossi Menezes, Cristina M. Del Ben, Jose Luis Santos, Manuel Arrojo, Julio Bobes, Julio Sanjuan, Miguel Bernardo, Celso Arango, James B. Kirkbride, Peter B. Jones, Michael O'Donovan, Bart P. Rutten, Jim Van Os, Craig Morgan, Pak C. Sham, Isabelle Austin-Zimmerman, Zhikun Li, Evangelos Vassos, Robin M. Murray, Marta Di Forti
Summary: This study found an association between reasons for first using cannabis and patterns of use and risk of psychosis. Most patients started using cannabis because of friends, but a higher proportion of patients compared to controls reported using cannabis to feel better.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Kirsty Winkley, Taru Sorsa, Qingxiu Tian, Ilse Reece, Christina Fitzgerald, Mark Chamley, Khalida Ismail, Angus Forbes, Rebecca Upsher
Summary: The objective of this study was to determine the feasibility and acceptability of a diabetes insulin self-management education (DIME) group intervention for people with type 2 diabetes starting insulin. The study found that the DIME intervention was acceptable and feasible to deliver to participants with type 2 diabetes starting insulin in South London, UK.
PILOT AND FEASIBILITY STUDIES
(2023)
Article
Substance Abuse
George Konstantakopoulos, Anna Trova, Elias Tzavellas, Pentagiotissa Stefanatou, Anthony S. David, Thomas Paparrigopoulos
Summary: The study aimed to develop a clinician-rated scale to assess impaired insight in patients with alcohol use disorder and examine its reliability and validity. The Schedule for the Assessment of Insight in Alcohol Dependence (SAI-AD) showed good convergent validity and internal consistency. Three subscales were identified, measuring different components of insight.
DRUG AND ALCOHOL DEPENDENCE
(2023)
Article
Clinical Neurology
Jonathan P. Rogers, Michael K. L. Chou, Thomas A. Pollak, Michael Eyre, Maria Krutikov, Andrew Church, Melanie S. Hart, Abid Karim, Sophia Michael, Angela Vincent, Anthony S. David, Glyn Lewis, Saiju Jacob, Michael S. Zandi
JOURNAL OF NEUROLOGY
(2023)
Article
Psychology, Clinical
Simone Farrelly, Emmanuelle Peters, Matilda Azis, Anthony S. David, Elaine C. M. Hunter
Summary: This study aimed to investigate the feasibility and acceptability of a six-session therapy protocol adapted from a Cognitive-Behavioural model of Depersonalisation-Derealisation Disorder (DDD) in individuals with psychotic symptoms. The results suggest that the intervention was feasible and acceptable to participants, with some indication of its effectiveness on clinical outcomes.
JOURNAL OF BEHAVIOR THERAPY AND EXPERIMENTAL PSYCHIATRY
(2024)
Article
Endocrinology & Metabolism
Ann-Kristin Porth, Anouk Sjoukje Huberts, Alize Rogge, Angele Helene Marie Benard, Angus Forbes, Anja Strootker, Carmen Hurtado Del Pozo, Dagmar Kownatka, David Hopkins, David Nathanson, Henk-Jan Aanstoot, Jeanette Soderberg, Katarina Eeg-Olofsson, Kathryn Hamilton, Laure Delbecque, Lyudmil Ninov, Mette Due-Christensen, Michael Leutner, Rafael Simo, Sara Vikstrom-Greve, Sophia Roessner, Vanesa Flores, Yuki Seidler, Yvonne Hasler, Tanja Stamm, Alexandra Kautzky-Willer
Summary: This study aims to develop a person-centered outcome set for Type 1 and Type 2 diabetes to facilitate precise monitoring and care. Through a Delphi study, 64 clinical and person-reported outcomes were narrowed down to 46 outcomes, providing guidance for standardized collection of meaningful results.