Article
Environmental Sciences
Xiang Zhou, Xu Zhang, Xuan Zhou, Gulinuer Abulimiti, Yichun Wang, Qijie Zhang, Rong Cong, Chengjian Ji, Jiaochen Luan, Liangyu Yao, Jie Yang, Ninghong Song
Summary: Hypospadias and cryptorchidism are the most common congenital malformations in male neonates, both sharing a same origin and being associated with endocrine-disrupting chemicals. This study found that they share many same highly associated EDCs and genes, possibly leading to developmental abnormalities through pathways such as steroidogenesis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Yuhao Wu, Junke Wang, Yuexin Wei, Jiadong Chen, Lian Kang, Chunlan Long, Shengde Wu, Lianju Shen, Guanghui Wei
Summary: Research suggests that prenatal exposure to endocrine-disrupting chemicals may increase the risk of hypospadias in males, though the relationship with cryptorchidism remains inconclusive.
Article
Endocrinology & Metabolism
Taotao Sun, Wenchao Xu, Hao Xu, Yinwei Chen, Yonghua Niu, Daoqi Wang, Tao Wang, Weimin Yang, Jihong Liu
Summary: This retrospective study aimed to evaluate the effectiveness of hormonal therapy in the treatment of cryptorchidism caused by idiopathic hypogonadotropic hypogonadism (IHH). The results showed that there was no significant difference in testicular descent success rate, puberty development, and spermatogenesis between hormonal therapy and surgical treatment followed by hormonal therapy. Therefore, hormonal therapy is considered to be an effective and safe treatment option for adult males with cryptorchidism caused by IHH.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medical Laboratory Technology
Cristina Collazo Abal, Maria Covadonga Fernandez Marcos, Pedro Casado Rey, Maria Pia Vazquez Caamano, Henrik Alfthan, Hannu Koistinen, Ulf-Hakan Stenman
Summary: This article describes a woman with constantly elevated levels of hCG in serum. Specific assays were used to measure the concentrations of hCG, its beta subunit (hCG beta), and its core fragment (hCG beta cf) in serum and urine. The laboratory findings suggest the presence of familial hCG syndrome, but further investigation is needed to confirm this in other family members.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Obstetrics & Gynecology
Olanrewaju Dawodu, Jessica Wu, Robert Gallop, Kurt T. Barnhart
Summary: This study investigated the relationship between delayed presentation of first-trimester ultrasound landmarks and perinatal outcomes. The findings suggest no association between delayed presentation of intrauterine landmarks and poor perinatal outcomes, but a potential association with lower birthweight.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Andrea H. Roe, Alice Abernathy, Anne N. Flynn, Arden McAllister, Nathanael C. Koelper, Mary D. Sammel, Courtney A. Schreiber, Sarita Sonalkar
Summary: This study compared different treatments for early pregnancy loss and found that treatment success was associated with a greater decline in hCG levels, but no threshold could predict success. Further research is needed to develop reliable remote follow-up protocols for early pregnancy loss.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Andrology
Carme Grande-Moreillo, Sara Fuentes-Carretero, Jaume Margarit-Mallol, Carlos Perez-Lopez, Alejandro Rodriguez-Molinero
Summary: Acquired cryptorchidism accounts for more than half of cryptorchidism cases requiring surgery in our setting, with a clearly different age of presentation than that for congenital cryptorchidism.
Editorial Material
Multidisciplinary Sciences
Cecilia Giulivi, Kezhong Zhang, Hirofumi Arakawa
Summary: In the past decade, there has been a growing recognition of the significant role mitochondria play in various cellular processes, including energy production, immune response, and signal transmission. It is now known that mitochondrial dysfunction is implicated in many diseases, such as primary mitochondrial diseases caused by mutations in mitochondrial genes, secondary mitochondrial diseases caused by mutations in non-mitochondrial genes essential for mitochondrial function, and complex diseases associated with mitochondrial dysfunction. Moreover, evidence suggests that mitochondrial dysfunction often precedes other pathological signs, with its manifestation influenced by genetics, environment, and lifestyle.
SCIENTIFIC REPORTS
(2023)
Article
Obstetrics & Gynecology
Lizandra Moura Paravidine Sasaki, Bruno Ramalho de Carvalho, Adelino Amaral Silva, Alberto Moreno Zaconeta, Miriam da Silva Wanderley, Luiz Augusto Casulari Roxo da Motta, Adriana Lofrano-Porto
Summary: Selective LH deficiency has been described in both men and women, serving as a valuable model for studying the regulation of late-stage folliculogenesis and ovulation. A woman with LH deficiency due to a genetic mutation was successfully treated with individualized ovarian induction therapy, resulting in a healthy baby being born after an uneventful pregnancy. This case demonstrates that exogenous LH or hCG can effectively induce late-stage follicular development in women with deficient LH production or performance, once early follicular growth is assured by FSH.
HUMAN REPRODUCTION
(2021)
Article
Urology & Nephrology
Koji Shiraishi, Hiroshi Takihara, Hideyasu Matsuyama
Summary: The study showed that orchiopexy is effective in increasing undescended testicular volume and decreasing testicular temperature. In infants with nonpalpable testes treated by LSFSO, the transinguinal approach was found to be more effective in reducing testicular temperature compared to the conventional approach.
JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Rena Xu, Joseph W. McQuaid, Vera A. Paulson, Michael P. Kurtz, Tanya Logvinenko, Richard N. Yu, Richard S. Lee, Caleb P. Nelson
Summary: This retrospective study characterized the pathological findings of testis tissue specimens from older boys and adolescents with cryptorchidism. The study found a higher incidence of malignancy in intra-abdominal undescended testes compared to extra-abdominal ones. Orchiectomy or biopsy is indicated for intra-abdominal testes, while it may not be necessary for extra-abdominal undescended testes in older boys and adolescents.
JOURNAL OF UROLOGY
(2022)
Article
Andrology
Viljo Kubarsepp, Karin Varik, Heili Varendi, Anne Antson, Maie Veinla, Georgi Nellis, Mirjam Merila, Urve Salundi, Valve Astover, Margus Punab
Summary: The study revealed that cryptorchidism prevalence, especially in full-term boys, is lower in Estonia than reported in other Nordic-Baltic countries and worldwide. Spontaneous testicular descent was more common in prematurely born and low birth weight boys, while full-term and normal birth weight boys had lower prevalence rates of cryptorchidism.
Article
Endocrinology & Metabolism
Julia Rohayem, Michael Zitzmann, Sandra Laurentino, Sabine Kliesch, Eberhard Nieschlag, Paul-Martin Holterhus, Alexandra Kulle
Summary: In males with CHH, treatment with hCG/rFSH leads to similar serum steroid hormone profiles as healthy men. Gonadotropins play a role in steroid hormone production along the classic Delta 4 pathway and activate an alternative pathway of testosterone biosynthesis via androstenediol.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Urology & Nephrology
Anthony D'Oro, Ilina Rosoklija, Elizabeth B. Yerkes, Bruce W. Lindgren, Karen Rychlik, Earl Y. Cheng
Summary: Patients with proximal hypospadias have an increased risk of acquired cryptorchidism, and operative notes reveal a high rate of epididymal nonfusion with ascended testes. Close monitoring of testis position is necessary for these patients.
JOURNAL OF UROLOGY
(2021)
Article
Medicine, Research & Experimental
Hamed Hajipour, Laya Farzadi, Leila Roshangar, Zeinab Latifi, Houman Kahroba, Vahideh Shahnazi, Kobra Hamdi, Alieh Ghasemzadeh, Amir Fattahi, Mohammad Nouri
Summary: This study demonstrated the potential of uterine fluid-derived exosomes as a carrier for delivering hCG to endometrial cells, enhancing endometrial receptivity. The effect of hCG-loaded exosomes on endometrial receptivity exceeded that of hCG or exosomes alone. Furthermore, hCG-loaded exosomes showed enhanced regulation of specific gene expression compared to hCG alone.