Article
Cell Biology
Magali Marti, Johanne E. Spreckels, Purnika Damindi Ranasinghe, Erik Wejryd, Giovanna Marchini, Eva Sverremark-Ekstrom, Maria C. Jenmalm, Thomas Abrahamsson
Summary: Probiotics may exert benefits in modulating the gut microbiota composition during the first month in extremely low birth weight infants, leading to increased bacterial diversity and abundance of Lactobacillus reuteri, while reducing the abundance of certain harmful bacterial families.
CELL REPORTS MEDICINE
(2021)
Article
Medicine, Research & Experimental
Huiyong Jiang, Ren Yan, Kaicen Wang, Qiangqiang Wang, Xiaoxiao Chen, Lifeng Chen, Lanjuan Li, Longxian Lv
Summary: The study demonstrated that pretreatment with DSM 17938 could alleviate liver failure induced by D-galactosamine in rats by regulating liver function, reducing histological abnormalities in the terminal ileum and liver, affecting gut microbiota, metabolome, and transcriptome. These findings suggest that DSM 17938 is a potential probiotic for the prevention or treatment of liver failure.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Nutrition & Dietetics
Ameer Al-Hadidi, Jason Navarro, Steven D. Goodman, Michael T. Bailey, Gail E. Besner
Summary: Necrotizing enterocolitis (NEC) is a devastating disease mainly found in premature infants, associated with gastrointestinal dysbiosis. Probiotics have been proposed as a new avenue for therapy, with a novel enterally delivered formulation showing promise in experimental models of NEC.
Article
Pediatrics
Brian A. Juber, Timothy J. Boly, Graeme J. Pitcher, Steven J. McElroy
Summary: In this study, a retrospective analysis of infants showed that routine probiotic supplementation did not significantly alter the rates of modified Bell's stage >= 2a NEC or all-cause pre-discharge mortality in very low birth weight (VLBW) infants at the institution.
FRONTIERS IN PEDIATRICS
(2021)
Article
Microbiology
Johanne E. Spreckels, Erik Wejryd, Giovanna Marchini, Baldvin Jonsson, Dylan H. de Vries, Maria C. Jenmalm, Eva Landberg, Eva Sverremark-Ekstrom, Magali Marti, Thomas Abrahamsson
Summary: The study showed that Lactobacillus reuteri DSM 17938 supplementation leads to successful colonisation in extremely low birth weight infants, with a potential improvement in head growth for preterm ELBW infants.
Review
Nutrition & Dietetics
Mangesh Deshmukh, Sanjay Patole
Summary: Probiotics have been shown to reduce the risk of necrotizing enterocolitis, late onset sepsis, and all-cause mortality in preterm neonates. Implementing routine probiotic supplementation can significantly improve outcomes in these vulnerable infants.
ADVANCES IN NUTRITION
(2021)
Review
Medicine, General & Internal
Angela Saviano, Mattia Brigida, Alessio Migneco, Gayani Gunawardena, Christian Zanza, Marcello Candelli, Francesco Franceschi, Veronica Ojetti
Summary: Lactobacillus reuteri DSM 17938 is a probiotic that has shown to be beneficial in modulating gut microbiota and alleviating gastrointestinal symptoms such as diarrhea, constipation, and abdominal pain. It is effective in shortening the duration of acute infectious diarrhea, improving abdominal pain in colitis and inflammatory bowel disease patients, and enhancing gut motility and chronic constipation.
MEDICINA-LITHUANIA
(2021)
Article
Medicine, General & Internal
Edward F. Bell, Susan R. Hintz, Nellie Hansen, Carla M. Bann, Myra H. Wyckoff, Sara B. DeMauro, Michele C. Walsh, Betty R. Vohr, Barbara J. Stoll, Waldemar A. Carlo, Krisa P. Van Meurs, Matthew A. Rysavy, Ravi M. Patel, Stephanie L. Merhar, Pablo J. Sanchez, Abbot R. Laptook, Anna Maria Hibbs, C. Michael Cotten, Carl T. D'Angio, Sarah Winter, Janell Fuller, Abhik Das
Summary: Despite improvements, extremely preterm infants still have a significant impact on neonatal mortality and childhood morbidity. This study reviewed the survival, in-hospital morbidities, care practices, and neurodevelopmental and functional outcomes at 22-26 months' corrected age for extremely preterm infants born at 19 US academic centers. The findings showed that survival rate has increased compared to previous years, but rehospitalizations and neurodevelopmental impairments are still common among infants born at less than 27 weeks' gestational age.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Microbiology
Jumana Samara, Shirin Moossavi, Belal Alshaikh, Van A. Ortega, Veronika Kucharova Pettersen, Tahsin Ferdous, Suzie L. Hoops, Amuchou Soraisham, Joseph Vayalumkal, Deonne Dersch-Mills, Jeffrey S. Gerber, Sagori Mukhopadhyay, Karen Puopolo, Thomas A. Tompkins, Dan Knights, Jens Walter, Harish Amin, Marie-Claire Arrieta
Summary: Probiotics have positive effects on gut microbiome assembly and immunity in premature infants, accelerating microbiome maturation and improving intestinal immune environment.
CELL HOST & MICROBE
(2022)
Article
Obstetrics & Gynecology
Zhuoli Lai, Fang Gong
Summary: LR 17938 reduces intestinal inflammation and provides protection in a neonatal mouse model of NEC by regulating oxidative stress and improving gut mucosal and immune barriers.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Review
Pediatrics
Vamsi K. K. Batta, Shripada C. C. Rao, Sanjay K. K. Patole
Summary: This study suggests that probiotic supplements containing Bifidobacterium infantis may provide greater benefits to preterm infants. Further well-designed trials are needed to confirm these findings.
PEDIATRIC RESEARCH
(2023)
Article
Medicine, General & Internal
Xuerong Tan, Yunxia Zhou, Lan Xu, Li Zhang, Jiaying Wang, Wenqiong Yang
Summary: This retrospective cohort study investigates the influencing factors of necrotizing enterocolitis (NEC) in low birth weight (LBW) newborns. The study finds that congenital heart disease, sepsis, and blood transfusion are independent risk factors for NEC, while breastfeeding and probiotics feeding are protective factors. The study also suggests that infants who undergo surgery for NEC have better prognosis. Comprehensive interventions targeting the risk and protective factors are recommended to improve the prognosis of LBW infants with NEC.
Article
Geriatrics & Gerontology
Hye-Yeon Lee, Ji-Hyeon Lee, Seung Hyung Kim, Su-Yeon Jo, Kyung-Jin Min
Summary: This study evaluated the anti-aging effects of Lactobacillus reuteri on the lifespan and physiology of fruit flies. It found that L. reuteri significantly increased the mean lifespan of fruit flies without affecting reproductive output, food intake, or locomotor activity. The study suggests that the longevity effect of L. reuteri is mediated by the reduction of the insulin/IGF-1 signaling pathway and the action of reuterin.
Review
Pediatrics
Ramaa Chitale, Kacey Ferguson, Megan Talej, Wen-Chien Yang, Siran He, Karen M. Edmond, Emily R. Smith
Summary: Early enteral feeding within 72 hours after birth is likely to reduce mortality and length of hospital stay in preterm and low birth weight infants, and may also decrease the risk of sepsis and weight at discharge. However, its effect on other outcomes such as necrotizing enterocolitis is uncertain.
Article
Geriatrics & Gerontology
Hye-Yeon Lee, Ji-Hyeon Lee, Seung Hyung Kim, Su-Yeon Jo, Kyung-Jin Min
Summary: This study found that L. reuteri has anti-aging effects and can significantly extend the average lifespan of fruit flies. Furthermore, the effects of L. reuteri do not affect the reproductive output, food intake, or locomotor activity of fruit flies. The results suggest that the anti-aging effects of L. reuteri are mediated by the reduction of the insulin/IGF-1 signaling pathway and the action of reuterin.