Article
Medicine, Research & Experimental
Yong-Qing Zhang, Hyun Kyu Min, Eunchong Hong, Eunhye Yu, Sun Mi Gu, Seong Shoon Yoon, Dohyun Lee, Jaejun Lee, Jin Tae Hong, Jaesuk Yun
Summary: The ICSS model was used to evaluate the abuse potential of 18 drugs in mice, and it was found that DAT availability and extracellular dopamine levels in the mPFC and NAc correlated with the ICSS threshold. These findings suggest a relationship between DAT availability-mediated dopamine levels and drug-induced reward-seeking behavior.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Giorgia Targa, Francesca Mottarlini, Beatrice Rizzi, Damiana Leo, Lucia Caffino, Fabio Fumagalli
Summary: Dopamine overactivity reduces the translation and localization of cortical AMPA receptors through altered vesicular sorting. The decreased expression of anchoring proteins and structural markers indicates synaptic instability. Hyperdopaminergia significantly alters the homeostatic plasticity of AMPA receptors, leading to a destabilized and depotentiated AMPA-mediated glutamatergic neurotransmission in the prefrontal cortex.
Article
Clinical Neurology
Greg C. Bristow, Tory Eisenlohr-Moul, Krista Lotesto, Monsheel S. Sodhi
Summary: This study found gender differences in the transcription of monoaminergic genes in the DLPFC in MDD patients, indicating that abnormalities in the expression of monoaminergic genes may contribute to alterations in DLPFC activity observed in major depression.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Medicine, Research & Experimental
Da Hee Jung, Hong Ju Lee, Young Whan Choi, Hwa Kyoung Shin, Byung Tae Choi
Summary: The etiology of attention-deficit hyperactivity disorder (ADHD) suggests a genetic component as the main cause, but environmental factors may interact with genetic susceptibility. A study on genetic ADHD model rats found that male rats were more sensitive to stress and exhibited more ADHD-related behaviors, and stress induced changes in dopamine-related genes and proteins. These findings could contribute to the development of gender-specific diagnostics and treatments for ADHD patients.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Placido Illiano, Damiana Leo, Raul R. Gainetdinov, Marta Pardo
Summary: The study focuses on the PFC function in early adolescent female rats with heterozygous and homozygous ablation of DAT, showing changes in neuronal and glial cell homeostasis. Genetic ablation of DAT in the early adolescent PFC leads to a hyperactive phenotype, alterations in glutamatergic neurotransmission, neurodegeneration, and glial activation. This study provides insight into neuroinflammatory pathological processes in DAT-ablated female rats, potentially offering new investigational approaches in human diseases.
Article
Neurosciences
Wen-Jing Ren, Ya-Fei Zhao, Jie Li, Patrizia Rubini, Zeng-Qiang Yuan, Yong Tang, Peter Illes
Summary: This study found that in a mouse model of major depressive disorder, depression-like behavior can be aggravated by microinjecting the P2X7R agonist ATP or its analog dibenzoyl-ATP into the medial prefrontal cortex, and this effect can be reversed by the P2X7R antagonist JNJ-47965567.
Review
Neurosciences
May Hui, Kevin T. Beier
Summary: Dysfunction in dopamine signaling contributes to various neurological disorders, and understanding the connectivity between dopamine-releasing cells and brain regions can provide insights into the underlying mechanisms of these diseases.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
David M. Bortz, Catalina M. Feistritzer, Anthony A. Grace
Summary: This study suggests that the medial prefrontal cortex (mPFC) to medial septum (MS) pathway may be involved in regulating cognitive flexibility and dopamine neuron activity. Activation of the mPFC-MS pathway improves strategy switching, while inhibition produces different effects. The pathway bidirectionally regulates dopamine neuron activity. This study reveals a potential top-down circuit from the prefrontal cortex to the midbrain that can manipulate dopamine activity to promote cognitive flexibility.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Clio Korn, Thomas Akam, Kristian H. R. Jensen, Cristiana Vagnoni, Anna Huber, Elizabeth M. Tunbridge, Mark E. Walton
Summary: Dopamine plays a crucial role in adaptive behavior, and DAT and COMT regulate specific aspects of behavioral flexibility by influencing the kinetics of striatal and cortical dopamine, respectively. However, the exact effects of these mechanisms on dopamine release in different brain areas and their impact on flexible decision making strategies remain unclear.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
James W. M. Kang, Kevin A. A. Keay, Michael D. D. Kendig, Laura H. H. Corbit, David Mor
Summary: The ability to adaptively guide behavior requires integration of external information with internal motivational factors. Acute stress and chronic pain can impair decision-making, including cognitive dysfunction. This study investigated the relationship between dopamine, serotonin, and their metabolites in brain regions regulating motivated behavior and decision-making.
NEUROCHEMICAL RESEARCH
(2023)
Article
Chemistry, Medicinal
A. Katherine Hatstat, Grace M. Kennedy, Trevor R. Squires, Gisela Xhafkollari, C. Skyler Cochrane, Mauricio Cafiero, Larryn W. Peterson
Summary: L-DOPA, a dopamine precursor, is commonly used in Parkinson's disease treatment. Inhibiting COMT can prolong the effects of L-DOPA and dopamine, increasing the efficiency of the treatment. Nitrile derivatives with a nitro substituent show the most promise as COMT inhibitors.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Behavioral Sciences
Tong Zhao, XiaoLei Gao, Guang-Biao Huang
Summary: The study found that a portion of 6-OHDA lesioned mice exhibited more prominent stress response and social cognitive impairment under chronic social defeat stress, possibly due to decreased selectivity of D1 receptors in the amygdala.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Review
Geriatrics & Gerontology
Christopher H. van Dyck, Amy F. T. Arnsten, Prasad R. Padala, Olga Brawman-Mintzer, Alan J. Lerner, Anton P. Porsteinsson, Roberta W. Scherer, Allan I. Levey, Nathan Herrmann, Nimra Jamil, Jacobo E. Mintzer, Krista L. Lanctot, Paul B. Rosenberg
Summary: Apathy is a common symptom in patients with Alzheimer's disease, and previous treatment methods have been ineffective. Methylphenidate has shown promising results in initial trials for treating apathy, possibly by boosting norepinephrine and dopamine actions in brain circuits. Understanding the role of neuronal circuits and neurotransmitters in motivated behavior may provide insight into developing more effective treatments for apathy in Alzheimer's disease.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Neurosciences
Annalise N. Binette, Jianfeng Liu, Hugo Bayer, Kennedi L. Crayton, Laila Melissari, Samantha O. Sweck, Stephen Maren
Summary: Stress has a significant impact on fear extinction and affects the activity of PV interneurons in the mPFC. PV interneurons regulate extinction learning under stress in a sex-dependent manner, and this effect is mediated by amygdaloprefrontal projections.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Behavioral Sciences
Rossella Ventura, Simona Cabib, Lucy Babicola, Diego Andolina, Matteo Di Segni, Cristina Orsini
Summary: Research shows that both genotype and sex contribute to the development of dysfunctional coping strategies, but how they interact to influence individual coping strategies is still being investigated. Additionally, there are specific effects of the interaction between early experiences, genotype, and stress on the development of functional and dysfunctional coping styles.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)