Article
Multidisciplinary Sciences
Brittany H. Scheid, Arian Ashourvan, Jennifer Stiso, Kathryn A. Davis, Fadi Mikhail, Fabio Pasqualetti, Brian Litt, Danielle S. Bassett
Summary: In the United States, over one third of the estimated 3 million epilepsy patients have medication resistance. Responsive neurostimulation from chronically implanted electrodes offers a promising alternative treatment. However, determining optimal personalized stimulation parameters is a major challenge. This study uses network neuroscience and control theory to analyze dynamic controllability during seizure events, showing that average controllability increases throughout a seizure and is negatively correlated with modal controllability.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Clinical Neurology
Barbara Ladisich, Stefan Rampp, Eugen Trinka, Nathan Weisz, Christoph Schwartz, Theo Kraus, Camillo Sherif, Franz Marhold, Gianpaolo Demarchi
Summary: By analyzing the network topology of neurooncological patients, it was found that the network topology in brain tumor patients is altered, but there is no consensus on the pattern of these changes and evidence on potential drivers is lacking.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)
Article
Multidisciplinary Sciences
Prokopis C. Prokopiou, Nina Engels-Dominguez, Kathryn Papp, Matthew R. Scott, Aaron P. Schultz, Christoph Schneider, Michelle E. Farrell, Rachel F. Buckley, Yakeel T. Quiroz, Georges El Fakhri, Dorene M. Rentz, Reisa A. Sperling, Keith A. Johnson, Heidi I. L. Jacobs
Summary: Cortical Alzheimer's Disease neuropathology is associated with cognitive decline, and the functional properties of the locus coeruleus (LC) can be used to identify individuals at risk for the disease.
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
John M. Bernabei, Nishant Sinha, T. Campbell Arnold, Erin Conrad, Ian Ong, Akash R. Pattnaik, Joel M. Stein, Russell T. Shinohara, Timothy H. Lucas, Dani S. Bassett, Kathryn A. Davis, Brian Litt
Summary: Bernabei et al. constructed an atlas of normative interictal intracranial EEG recordings and found that brain regions generating spikes and seizures have different patterns of activity and connectivity compared to the atlas. Comparing EEG recordings to the atlas can reliably identify abnormal regions and guide invasive treatment for epilepsy.
Article
Clinical Neurology
Johanna Heugenhauser, Sarah Iglseder, Armin Muigg, Johannes Kerschbaumer, Guenther Stockhammer, Martha Nowosielski, Iris Unterberger
Summary: This case series supports the growing evidence that perampanel may become a promising add-on AED for the treatment of refractory BTRE as well as for seizure control in SMART-syndrome. Overall, a reduction in seizure frequency was observed in four out of five patients, with a responder rate of 40%. Both cases with symptomatic epilepsy associated with SMART-syndrome were successfully treated with perampanel.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Fedele Dono, Stefano Consoli, Giacomo Evangelista, Annalisa Ricci, Mirella Russo, Claudia Carrarini, Angelo Di Iorio, Laura Bonanni, Francesca Anzellotti, Marco Onofrj, Stefano L. Sensi
Summary: This study evaluated the neuropsychiatric side effects of prophylactic use of levetiracetam (LEV), a third-generation anti-seizure medication, in patients with brain tumor-related epilepsy (BTRE). The results showed that compared to a group of BTRE patients, a group taking LEV as prophylaxis had higher severity of neuropsychiatric symptoms. The study emphasizes the importance of accurate epileptological evaluations in selecting patients who would benefit most from anti-seizure medication in brain tumor patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Computer Science, Artificial Intelligence
Runze Zheng, Yuanmeng Feng, Tianlei Wang, Jiuwen Cao, Duanpo Wu, Tiejia Jiang, Feng Gao
Summary: In this paper, the scalp EEG based functional connectivity and network topology parameters are comprehensively studied for the prognostic analysis of West syndrome. The study reveals that West seizures weaken connections between brain regions responsible for cognition and intelligence, while brain regions responsible for information synergy and visual reception have greater variability in connectivity during seizures.
Article
Clinical Neurology
Ioannis Vlachos, Dimitris Kugiumtzis, Dimitris G. Tsalikakis, Vasilios K. Kimiskidis
Summary: The study investigated the modulatory effects of TMS on brain connectivity in Genetic Generalized Epilepsy patients and identified potential diagnostic biomarkers. The analysis revealed significant TMS-induced modulation of connectivity at specific frequency bands and time points, indicating different effects of TMS on healthy and epileptic brain connectivity.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Kenichiro Asano, Seiko Hasegawa, Masashi Matsuzaka, Hiroki Ohkuma
Summary: This study retrospectively analyzed the incidence of BTE in 601 patients with metastatic brain tumors, finding that significant risk factors for BTE included young age, male sex, breast cancer, tumors involving eloquent areas, brain edema, dissemination, and giant tumors.
JOURNAL OF NEUROSURGERY
(2022)
Article
Geriatrics & Gerontology
Shixiong Tang, Zhipeng Wu, Hengyi Cao, Xudong Chen, Guowei Wu, Wenjian Tan, Dayi Liu, Jie Yang, Yicheng Long, Zhening Liu
Summary: This study investigated whether patients with MDD experience accelerated aging of brain function. The results showed that the age-related decrease in DMN FC strength may occur at a faster rate in MDD patients than in healthy individuals. The findings provide evidence for further understanding the causation between MDD and accelerated brain aging.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Liping Pan, Yakun Wu, Jie Bao, Dandan Guo, Xin Zhang, Jiajing Wang, Meili Deng, Peiran Yu, Gaoxu Wei, Lulin Zhang, Xiao Qin, Yijun Song
Summary: The aim of this study was to investigate the alterations in neural networks during working memory encoding in patients with temporal lobe epilepsy (TLE). The results showed that functional connectivity strength decreased, and the theta network was altered in TLE patients with working memory deficits. This suggests that the theta network may serve as a sensitive measure of cognitive impairment and predict cognitive outcomes in TLE patients.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Review
Oncology
Edward K. Avila, Steven Tobochnik, Sara K. Inati, Johan A. F. Koekkoek, Guy M. Mckhann, James J. Riviello, Roberta Ruda, David Schiff, William O. Tatum, Jessica W. Templer, Michael Weller, Patrick Y. Wen
Summary: Tumor-related epilepsy (TRE) is a common and significant consequence of brain tumors, and managing TRE requires comprehensive understanding of diagnosis and treatment to improve quality of life. Complete removal of tumors is preferred for both oncologic and epilepsy reasons. Shared mechanisms between tumor growth and epilepsy offer potential for better targeted therapies.
Article
Behavioral Sciences
Ondrej Strycek, Martin Lamos, Ivan Rektor
Summary: This study investigated the impact of TLE with HS on functional connectivity between mesiotemporal structures, revealing a significant decrease in FC between the right-and left-sided mesiotemporal structures in TLE patients, particularly with correctly recognized words, at 8-to 20-Hz frequency range. The decreased FC between mesiotemporal structures in TLE is essential for successful performance of a memory retrieval task.
EPILEPSY & BEHAVIOR
(2021)
Article
Behavioral Sciences
M. Morningstar, R. C. French, W. I. Mattson, D. J. Englot, E. E. Nelson
Summary: This study found differences in brain connectivity in youth with epilepsy during a social cognitive task, suggesting disruptions in the organization of the mentalizing network related to social cognition in epilepsy patients, with variations in connectivity within this circuit depending on task demands.
Article
Oncology
Nupur Brahmbhatt, Roger Stupp, Omar Bushara, Elizabeth Bachman, Stephan U. Schuele, Jessica W. Templer
Summary: The observational study examined the effect of clobazam on seizure frequency in patients with primary CNS tumors and TRE. Results showed that 93.9% of patients had a significant response to clobazam, with 30.3% becoming seizure-free within 6 months and 63.6% reporting a significant reduction in seizure frequency. The addition of clobazam may also lead to a reduction in polypharmacy, allowing for modifications of concurrent AEDs.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Oncology
Florien W. Boele, Patricia W. M. den Otter, Jaap C. Reijneveld, Philip C. de Witt Hamer, Hinke F. van Thuijl, Linda M. C. Lorenz, Pieter Wesseling, Frank J. Lagerwaard, Martin J. B. Taphoorn, Mathilde C. M. Kouwenhoven, Tom J. Snijders, Linda Douw, Martin Klein
Summary: HRQOL and NCF do not appear greatly impacted during long-term survivorship in LGG, but depressive symptoms and fatigue are persistent.
Article
Clinical Neurology
Myrte Strik, Anand J. C. Eijlers, Iris Dekker, Tommy A. A. Broeders, Linda Douw, Joep Killestein, Scott C. Kolbe, Jeroen J. G. Geurts, Menno M. Schoonheim
Summary: This study investigated the functional network predictors and longitudinal network changes related to upper and lower limb progression in multiple sclerosis (MS). The results showed that upper and lower limb progression had unique predictors, possibly indicating different network disturbances underlying these types of progression in MS.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Editorial Material
Clinical Neurology
Linda Douw, Lucas C. Breedt, Mona L. M. Zimmermann
Article
Multidisciplinary Sciences
Jantine G. Rottgering, Vera Belgers, Mathilde C. M. Kouwenhoven, Maaike Schuur, Tjeerd J. Postma, Claudia M. Nijboer, Myra E. van Linde, Philip C. de Witt Hamer, Linda Douw, Martin Klein
Summary: This study evaluated the frequency and burden of symptoms in glioma patients with stable disease and assessed their willingness to consider treatment. Fatigue, memory problems, reduced physical fitness, concentration problems, and drowsiness were the most common and burdensome symptoms. However, patients had a relatively low inclination for symptom management interventions.
Article
Clinical Neurology
Lucy Pointon, Robin Grant, Sharon Peoples, Sara Erridge, Paula Sherwood, Martin Klein, Florien Boele
Summary: This study aimed to identify and characterize caregivers' unmet needs, determine associations between unmet needs and wish for support, and evaluate the acceptability and feasibility of the Caregiver Needs Screen (CNS) in clinical practice. The study found that family caregivers have many unmet needs, but this is not directly related to their wish for support.
NEURO-ONCOLOGY PRACTICE
(2023)
Article
Neuroimaging
Marike R. R. van Lingen, Lucas C. C. Breedt, Jeroen J. G. Geurts, Arjan Hillebrand, Martin Klein, Mathilde C. M. Kouwenhoven, Shanna D. D. Kulik, Jaap C. C. Reijneveld, Cornelis J. J. Stam, Philip C. C. De Witt Hamer, Mona L. M. Zimmermann, Fernando A. N. Santos, Linda Douw
Summary: This study found that frontoparietal network centrality of multilayer networks is related to and predicts executive functioning in glioma patients, but it does not predict postoperative changes in executive functioning.
BRAIN IMAGING AND BEHAVIOR
(2023)
Review
Biochemistry & Molecular Biology
Florian W. Adraoui, Linda Douw, Gerard J. M. Martens, Dorien A. Maas
Summary: Schizophrenia is a devastating psychiatric disorder that affects approximately 1% of the global population. Social-cognitive impairments and abnormalities in brain activity and connectivity contribute to the development of symptoms. The molecular mechanisms underlying these impairments are still not well understood. This study proposes impaired myelination and disinhibition of local microcircuits as potential biological pathways leading to dysconnectivity and abnormal activity in the social brain, and suggests using electroencephalography as a translational technique for pre-clinical drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Oncology
Jantine Geertruida Rottgering, Martin Klein, Linda Douw
Article
Sport Sciences
Franziska Katharina Haase, Annika Prien, Linda Douw, Nina Feddermann-Demont, Astrid Junge, Claus Reinsberger
Summary: This study compared the brain cortical thickness and neurocognitive performance of retired female soccer players and non-contact sport athletes. The results showed similar cortical thickness and neurocognitive performance between the two groups, except for verbal memory and psychomotor speed. However, frequent headers had increased cortical thickness in the right inferior parietal region. Caution is needed in interpreting these results due to small sample sizes, subjective header assessment, and the case-control study design.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Review
Psychiatry
Silvia Ciampelli, Janna N. de Boer, Alban E. Voppel, Hugo Corona Hernandez, Sanne G. Brederoo, Edwin van Dellen, Natalia B. Mota, Iris E. C. Sommer
Summary: In this study, network analysis was used to examine syntactic relations in patients with schizophrenia-spectrum disorders (SSD) and healthy controls, revealing significant differences between the two groups. Factors such as age, sex, and education level were found to have significant effects on syntactic features, and there was a significant interaction between sex and group. Syntactic measures were correlated with symptoms and cognitive functioning, and a random forest classifier based on the best set of network features achieved 74% accuracy in distinguishing patients from controls. These findings suggest the validity of linguistic network analysis as a potential marker for SSD.
SCHIZOPHRENIA BULLETIN
(2023)
Letter
Psychiatry
Ilona van de Meent, Arija Maat, Mikel Boute, Edwin van Dellen, Wiepke Cahn
SCHIZOPHRENIA RESEARCH
(2023)
Article
Oncology
J. G. Rottgering, T. M. C. K. Varkevisser, M. Gorter, V. Belgers, P. C. De Witt Hamer, J. C. Reijneveld, M. Klein, T. F. Blanken, L. Douw
Summary: In this study, we used symptom network analysis to explore the relationship between symptoms and health-related quality of life in glioma patients. We found that fatigue, depression, and social functioning were highly correlated with other symptoms. Interestingly, the network connectivity was stronger in fatigued patients compared to non-fatigued patients.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Pharmacology & Pharmacy
Vera Belgers, Jantine G. Rottgering, Linda Douw, Martin Klein, Johannes C. F. Ket, Peter M. van de Ven, Thomas Wurdinger, Myra E. van Linde, Johanna M. Niers, Markus Weber, Marcel G. Olde Rikkert, Jose Lopez-Sendon, Oscar Arrieta, Kristina B. Svendsen, Marcos H. N. Chagas, Carlos M. O. de Almeida, Mathilde C. M. Kouwenhoven, Philip C. de Witt Hamer
Summary: This meta-analysis suggests that cannabinoids do not have a significant effect on HRQoL and mental well-being in patients with cancer or CNS disease.
CANNABIS AND CANNABINOID RESEARCH
(2023)