Article
Biochemistry & Molecular Biology
Yuh-Fung Chen, Kuo-Jen Wu, Lian-Ru Siao, Huei-Yann Tsai
Summary: Cerebrovascular disease is a leading cause of disability and death worldwide. Trilinolein (TriL), a natural compound, has protective effects and can potentially prevent cerebral ischemia and cerebrovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Zeyang Li, Minghui Zhao, Xiaoqian Zhang, Yiran Lu, Yang Yang, Yalong Xie, Zhimiao Zou, Liang Zhou, Runshi Shang, Limin Zhang, Fengchao Jiang, Dunfeng Du, Ping Zhou
Summary: The MyD88 inhibitor TJ-M2010-5 has shown neuroprotective and anti-neuroinflammatory effects on cerebral ischemia-reperfusion injury (CIRI) in the central nervous system. It inhibits inflammatory cytokines, microglia activation, and peripheral myeloid cell infiltration, while downregulating the MyD88/NF-kappa B and ERK pathway. TJ-M2010-5 also demonstrates good blood-brain barrier permeability and no neurotoxicity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chuntian Huang, Ruijuan Du, Xuechao Jia, Kangdong Liu, Yan Qiao, Qiong Wu, Ning Yao, Lu Yang, Liting Zhou, Xuejiao Liu, Pu Xiang, Mingxia Xin, Yan Wang, Xiaojie Chen, Dong Joon Kim, Zigang Dong, Xiang Li
Summary: The study revealed that CDK15 plays a pivotal role in colorectal cancer progression by phosphorylating PAK4 to promote tumor growth. The CDK15-PAK4 axis may serve as a novel therapeutic target for colorectal cancer.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Biochemistry & Molecular Biology
Zining Yu, Guangjun Su, Limei Zhang, Gaigai Liu, Yonggang Zhou, Shicai Fang, Qian Zhang, Tianyun Wang, Cheng Huang, Zhihua Huang, Liangdong Li
Summary: The study found that ICT can inhibit microglial activation and M1 polarization, promote M2 polarization, and alleviate inflammatory response and achieve neuroprotection by regulating the GPER-ERK-NF-kappa B signaling pathway.
MOLECULAR MEDICINE
(2022)
Article
Oncology
Rahim Ullah, Qing Yin, Aidan H. Snell, Lixin Wan
Summary: The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway that plays a critical role in cell proliferation and survival. Genetic alterations in this pathway are highly prevalent in human cancers and can lead to uncontrolled cell growth and tumor formation. The crosstalk between the RAF-MEK-ERK axis and other signaling pathways further enhances its proliferative potential in human cancers.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Shinji Takai, Denan Jin
Summary: Chymase-activated MMP-9 is closely related to the pathogenesis of various diseases, especially inflammation-related diseases. Upregulated chymase and MMP-9 have been observed in tissues from patients and animal models of these diseases. Chymase inhibitors attenuate MMP-9 formation and reduce inflammatory cell numbers, thereby ameliorating the development and progression of these disorders.
Article
Biochemistry & Molecular Biology
Jiaping Zhou, Guoqing Wang, Ran Han, Ruhua Wang, Yu Kong, Rui Zhang, Lihua Hou, Meng Meng
Summary: The study investigated the immunomodulatory effect of glycopeptides from Paecilomyces sinensis on ethanol-induced ulcers in mice. Results showed that CPS-II has immunoregulation and anti-ulcer properties, reducing oxidative stress and inflammatory response by regulating the miR-9-5p-MEK/ERK signaling pathway, thus protecting the gastric mucosa and improving stress gastric ulcers.
Article
Immunology
Helen Hoffmann, Marina Ebensperger, Annika Schoensiegel, Hazem Hamza, Julia Koch-Heier, Andre Schreiber, Stephan Ludwig, Michael Schindler, Oliver Planz
Summary: The urgent need for broad-spectrum antivirals has been highlighted by the COVID-19 pandemic. In this study, the antiviral efficacy of zapnometinib was compared between influenza A virus (IAV) and SARS-CoV-2, revealing that IAV is more susceptible to treatment with zapnometinib compared to SARS-CoV-2.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Plant Sciences
Guowei Gong, Yuzhong Zheng, Xiangpeng Kong, Zhen Wen
Summary: Ononin, a bioactive compound found in functional foods or plants, has been shown to exhibit anticancer properties in both in vitro and in vivo studies. In this study, ononin was also found to inhibit endothelial cell angiogenesis and suppress tumor cell proliferation. The potential role of ononin as a candidate for prevention and treatment of angiogenesis-related diseases was highlighted in this research.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Oncology
Sara J. Hamis, Yury Kapelyukh, Aileen McLaren, Colin J. Henderson, C. Roland Wolf, Mark A. J. Chaplain
Summary: The study developed a mechanistic mathematical model to describe the synergistic action of dabrafenib and trametinib on ERK activity in BRAFV600E-mutant melanoma cells, elucidating the molecular mechanism underlying vertical inhibition of the BRAF-MEK-ERK cascade.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Weijing Liu, An Xie, Chunhua Tu, Weipeng Liu
Summary: REX-1 is overexpressed in prostate cancer tissues and closely correlated with patient prognosis. It affects prostate tumor growth through MEK/ERK phosphorylation, recruits DNMT3b to regulate the methylation of RASSF1a, potentially providing a new therapeutic approach for prostate cancer treatment.
MOLECULAR CANCER RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Jen-Chun Wang, Shih-Hung Tsai, Hsiao-Ya Tsai, Shing-Jong Lin, Po-Hsun Huang
Summary: This study aimed to elucidate the relationship between hyperuricemia and abdominal aortic aneurysm (AAA). Retrospective study and mouse model revealed that hyperuricemia exacerbates AAA formation and activates the URAT1/ERK1/2/ROS/MMP-9 pathway in human aortic smooth muscle cells (HASMCs).
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Anna Marcinkowska-Gapinska, Izabela Siemieniak, Weronika Kawalkiewicz, Olgierd Stieler, Dorota Hojan-Jezierska, Leszek Kubisz
Summary: This study aimed to analyze the interdependencies between rheological and biochemical parameters of blood, by analyzing hemorheological profiles and biochemical tests in patients with clinically silent multifocal vascular cerebral lesions. The study found correlations between red blood cell deformability and fibrinogen level.
Article
Cardiac & Cardiovascular Systems
Prachi Umbarkar, Sultan Tousif, Anand P. Singh, Joshua C. Anderson, Qinkun Zhang, Michelle D. Tallquist, James Woodgett, Hind Lal
Summary: This study reveals the important role of cardiac fibroblast-GSK-3 alpha in myocardial fibrosis and heart failure, and identifies the molecular mechanism underlying this role through fibroblast kinome mapping. The results suggest that GSK-3 alpha plays a critical role in fibroblast transformation and fibrotic remodeling, independently of the canonical TGF-beta 1-SMAD3 pathway.
CIRCULATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Kyuhee Park, Yoonkyoung Shin, Gyeongbeen Lee, Hwantae Park, Yongmun Choi
Summary: The small molecule dabrafenib has been identified to promote Schwann cell differentiation by inhibiting ERK phosphorylation and enhancing ErbB2 and Akt phosphorylation. However, MEK and ERK inhibitors have no effect on key transcription factor expression, while pharmacological inhibition of PI3K interferes with dabrafenib-induced differentiation. This suggests that the ErbB2-PI3K-Akt axis is essential for Schwann cell differentiation induced by dabrafenib in vitro.
Review
Pharmacology & Pharmacy
Lars Edvinsson, Jacob C. A. Edvinsson, Kristian A. Haanes
Summary: Migraine is a common neurological disorder affecting up to 15% of the global population. Recent pharmacological treatments targeting CGRP signaling molecules have provided safe and effective options for migraine patients, offering new hope for migraine therapy.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Simon Bentsen, Anette Sams, Philip Hasbak, Lars Edvinsson, Andreas Kjaer, Rasmus S. Ripa
Summary: The study found that the CGRP analogue, SAX, has a cardioprotective effect in a rat model of myocardial infarction, improving myocardial perfusion recovery after chronic occlusion of the coronary artery.
JOURNAL OF NUCLEAR CARDIOLOGY
(2022)
Editorial Material
Pharmacology & Pharmacy
Lars Edvinsson, Amynah Pradhan
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Mimmi Rehnstrom, Hilda Ahnstedt, Diana N. Krause, Marie Louise Edvinsson, Kristian Agmund Haanes, Lars Edvinsson
Summary: The effects of sex hormones on post-stroke vascular responses are not fully understood. This study found that loss of ovarian function affects vascular contractile responses after cerebral ischemia, suggesting that sex hormones do not directly influence these alterations.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Clinical Neurology
Jacob C. A. Edvinsson, Aida Maddahi, Isabella M. Christiansen, Philip Reducha, Karin Warfvinge, Majid Sheykhzade, Lars Edvinsson, Kristian A. Haanes
Summary: This study reveals the presence of a subgroup of C-fibres that store 5-HT and shows high expression of 5-HT1B/1D receptors. The study suggests that the 5-HT1F receptor is a relatively unlikely target in the rat trigeminal system. Furthermore, Lasmiditan works as a partial agonist on 5-HT1B/1D receptors in clinically relevant dose regiments.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Clinical Neurology
Isabella Mai Christiansen, Jacob C. A. Edvinsson, Philip Reducha, Lars Edvinsson, Kristian Agmund Haanes
Summary: The present study demonstrates that ACEA alone does not exhibit antimigraine potential due to its dual agonistic properties, resulting in activation of both CB1 and TRPV1.
JOURNAL OF HEADACHE AND PAIN
(2022)
Review
Physiology
Jacob C. A. Edvinsson, Kristian A. Haanes, Lars Edvinsson
Summary: This review focuses on the trigeminovascular system (TGV) and discusses the signaling between fibers, as well as the potential role of neuropeptides and their receptors in migraine pathophysiology.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Maryam Mostajeran, Lars Edvinsson, Hilda Ahnstedt, Kajsa Arkelius, Saema Ansar
Summary: This study aimed to evaluate spontaneous recovery and molecular mechanisms involved in the recovery phase two weeks after stroke in female rats. The results showed that there were differences in the expression of specific proteins in different brain regions of female rats after stroke, which may be important for future therapeutic strategies.
Article
Chemistry, Medicinal
Jesper Peter Bomers, Anne-Sofie Grell, Lars Edvinsson, Sara Ellinor Johansson, Kristian Agmund Haanes
Summary: This study investigated the effects of trametinib treatment on female rats with induced subarachnoid haemorrhage. The results showed that trametinib treatment significantly improved arterial contractility, reduced subacute increases in intracranial pressure, and improved sensorimotor and neurological outcomes in female rats.
Article
Clinical Neurology
Philip V. Reducha, Jesper P. Boemers, Lars Edvinsson, Kristian A. Haanes
Summary: This study aimed to investigate the behavioral changes similar to migraine caused by CFA application on the skull in rats, and the potential mitigating effects of the CGRP specific antibody fremanezumab after CFA application. The results showed that surgical application of CFA to the dura caused periorbital allodynia and increased CGRP positive fibers in the trigeminal ganglion. However, fremanezumab did not alleviate periorbital allodynia, although it reduced the amount of CGRP positive fibers.
FRONTIERS IN NEUROLOGY
(2023)
Editorial Material
Medicine, General & Internal
Kristian A. Haanes, Lars Edvinsson
Article
Clinical Neurology
Aida Maddahi, Karin Warfvinge, Anja Holm, Jacob C. A. Edvinsson, Philip Victor Reducha, Spyridoula Kazantzi, Kristian A. Haanes, Lars Edvinsson
Summary: This study investigated the distribution of progesterone in the trigeminovascular system and its role in modulating sensory neurotransmission. The results suggest that progesterone may modulate sensory neurotransmission and vascular responses in a complex manner, with effects varying by sex, tissue type, and the nature of the stimulus. Further research is needed to fully understand the underlying mechanisms and physiological implications of these findings.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Multidisciplinary Sciences
Lena Erlandsson, Lena Ohlsson, Zahra Masoumi, Mimmi Rehnstrom, Tina Cronqvist, Lars Edvinsson, Stefan R. Hansson
Summary: Preeclampsia (PE) is a pregnancy syndrome characterized by hypertension and organ damage. This study found that placenta-derived extracellular vesicles (STBEVs) in PE patients have negative effects on vascular contractility and cause structural damage to blood vessels. These effects can be reduced by blocking vesicle uptake. This discovery provides a new therapeutic strategy for preventing cardiovascular risks caused by PE.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Anette Sams, Kristian Agmund Haanes, Anja Holm, Spyridoula Kazantzi, Lars Friis Mikkelsen, Lars Edvinsson, Susan Brain, Majid Sheykhzade
Summary: This study characterized the vasomotor responses of isolated coronary, cerebral, and mesenteric arteries in Gottingen Minipigs (GM), and compared the responses to those obtained from parallel studies using other artery types. The results showed that different arterial sources had different responses to selected agonists of endothelial, sympathetic, parasympathetic, and sensory pathways. The study also demonstrated the robust nature of the vasomotor responses after 24 hours of cold storage of vascular tissue.
VASCULAR PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mimmi Rehnstrom, Hilda Ahnstedt, Diana N. Krause, Marie Louise Edvinsson, Kristian Agmund Haanes, Lars Edvinsson
Summary: This study found that sex hormones do not directly affect vasoconstrictive changes following ischemic stroke, but the loss of ovarian function does impact this process.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)