Article
Pharmacology & Pharmacy
Brandi N. Williamson, Lizzette Perez-Perez, Benjamin Schwarz, Friederike Feldmann, Myndi G. Holbrook, Manmeet Singh, Diane S. Lye, Darius Babusis, Raju Subramanian, Elaine Haddock, Atsushi Okumura, Patrick W. Hanley, Jamie Lovaglio, Catharine M. Bosio, Danielle P. Porter, Tomas Cihlar, Richard L. Mackman, Greg Saturday, Emmie De Wit
Summary: This study demonstrates that early subcutaneous administration of remdesivir can reduce the risk of lower respiratory tract disease caused by SARS-CoV-2 infection.
ANTIVIRAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Seonghwan Moon, Minju Kim, Yeonhee Kim, Seungmin Lee
Summary: This study investigated the effects of dietary iron deficiency and non-heme iron on the development of colitis-associated colorectal cancer (CAC). It was found that both iron deficiency and iron overload diets suppressed the growth of colonic tumors in a mouse model. Long-term iron deficiency or overload may negate the progression of CAC.
Article
Immunology
Juliette Gauthier, Murielle Gregoire, Florian Reizine, Mathieu Lesouhaitier, Yoni Desvois, Gevorg Ghukasyan, Caroline Moreau, Patricia Ame, Karin Tarte, Jean-Marc Tadie, Celine Delaloy
Summary: Severe sepsis is associated with sustained immunosuppression, leading to increased vulnerability to secondary infections. Plasmablast and plasma cell subsets, which secrete antibodies, play a role in this immunosuppression. In this study, citrulline administration was found to effectively improve immunosuppression and secondary infections by restoring arginine availability and reducing B cell suppressive responses.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Joachim Schuster, Hanns-Christian Mahler, Susanne Joerg, Vinay Kamuju, Joerg Huwyler, Roman Mathaes
Summary: This study developed a physiologic in vitro model simulating the subcutaneous environment in patients to assess the stability of two monoclonal antibodies in protein-free fluids. The results showed that mAb1 was consistently more stable than mAb2, and both antibodies were less stable in bicarbonate buffers compared to phosphate-buffered saline.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Ian F. Cook
Summary: Studies show that intramuscular (IM) injection significantly reduces the likelihood of local adverse events and generates stronger immune response compared to subcutaneous (SC) injection. Therefore, it is recommended that all vaccines except for BCG and Rotavirus vaccines be administered via IM injection.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Mathematics, Applied
Saharat Tabonglek, Amir Khan, Usa Wannasingha Humphries
Summary: This paper extends the spore dispersal model to the HLIR epidemic model for evaluating rice blast disease severity. The model is solved using the FDM. Comparison with data from PRRC shows good agreement, indicated by Willmott's index of agreement (d). The optimal parameter for spores deposited on the crop is determined as 0.173 and 0.016 for two different beds. The model can be used for simulating and analyzing rice blast outbreaks for educational purposes.
Review
Neurosciences
Mayala Thayrine de Jesus Santos Oliveira, Talita Araujo Barbosa da Silva Santana, Marcela Camara Machado Costa, Grasiely Faccin Borges, Felipe Silva de Miranda, Jose Slaibi-Filho, Wilson Barros Luiz, Luciene Cristina Gastalho Campos
Summary: Limb-girdle muscular dystrophies (LGMD) are a group of neuromuscular disorders characterized by alterations in muscle architecture and function. This study investigates the correlation between the expression of microRNAs and the severity, progression, and therapeutic response of LGMD animal models. miR-1, 133a, and 206 are found to be differentially expressed in serum and muscle, reflecting inflammation, fibrosis, muscle regeneration, and dystrophic progression. The findings suggest that miRNAs play a crucial role in LGMD models and may serve as useful biomarkers in clinical research and prognosis.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Veterinary Sciences
Steven R. Talbot, Birgitta Struve, Laura Wassermann, Miriam Heider, Nora Weegh, Tilo Knape, Martine C. J. Hofmann, Andreas von Knethen, Paulin Jirkof, Christine Haeger, Andre Bleich
Summary: Good science in translational research requires good animal welfare based on the principles of 3Rs. This study developed a method based on quantitative outcome measures to objectively compare the severity of animal suffering and proposed a severity grading system. This method will play an important role in improving animal welfare, data quality, and reproducibility.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Medicine, Research & Experimental
Shunnosuke Kunoki, Hideki Tatsukawa, Yukinao Sakai, Hiroshi Kinashi, Tetsuyoshi Kariya, Yasuhiro Suzuki, Masashi Mizuno, Makoto Yamaguchi, Hiroyuki Sasakura, Masashi Ikeno, Kosei Takeuchi, Takuji Ishimoto, Kiyotaka Hitomi, Yasuhiko Ito
Summary: Long-term peritoneal dialysis is often associated with peritoneal dysfunction characterized by fibrosis, inflammation, and angiogenesis. In this study, transglutaminase 2 (TG2) was identified as a potential therapeutic target for peritoneal injury. TG2 activity and protein expression were found to increase during the development of peritoneal fibrosis, and TGF-β and TG2 interaction played a role in regulating peritoneal fibrosis, angiogenesis, and inflammation. Inhibition of TG2 showed promising results in reducing peritoneal injuries associated with PD.
LABORATORY INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Wael Mami, Soumaya Znaidi-Marzouki, Raoudha Doghri, Melika Ben Ahmed, Sadri Znaidi, Erij Messadi
Summary: This study investigated the impact of IBD on the severity of myocardial infarction (MI) and the link between the two diseases using a mouse model.
Article
Agriculture, Dairy & Animal Science
Andrew K. Curtis, Douglas E. Jones, Michael Kleinhenz, Shawnee Montgomery, Miriam Martin, Mikaela Weeder, Alyssa Leslie, Balaji Narasimhan, Sean Kelly, Drew R. Magstadt, Alfredo Colina, Johann F. Coetzee
Summary: Male cattle are often castrated to reduce aggression and unwanted pregnancies, but this procedure causes pain and risks like hemorrhage and infection. Immunocastration using vaccines offers a less painful alternative, but current options require multiple doses. A single-dose implantable immunocastration vaccine was evaluated, showing promising results in reducing fertility and potentially improving animal welfare during livestock management.
Article
Construction & Building Technology
Caroline Fyfe, Lucy Telfar Barnard, Jeroen Douwes, Philippa Howden-Chapman, Julian Crane
Summary: This retrospective cohort study used linked data from a national intervention program to assess whether retrofitting home insulation can reduce respiratory disease incidence and exacerbation risk. The study showed that home insulation interventions significantly reduced chronic respiratory disease incidence rates and medication use for exacerbations, supporting their effectiveness in improving respiratory health outcomes.
Article
Gastroenterology & Hepatology
Ahmad Farooq, Liliana Hernandez, Sandip M. Swain, Rafiq A. Shahid, Joelle M. -J Romac, Steven R. Vigna, Rodger A. Liddle
Summary: Reduced phosphate availability impairs mitochondrial function and worsens pancreatic injury. Phosphate supplementation improves mitochondrial function and protects against experimental pancreatitis, suggesting that phosphate supplementation may be useful in treating pancreatitis.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Veterinary Sciences
Amory L. Koch, Milan Rusnak, Katherine Peachee, Akira Isaac, Elizabeth A. McCart, W. Bradley Rittase, Cara H. Olsen, Regina M. Day, Aviva J. Symes
Summary: This study compared the effects of subcutaneous needlesticks with surgical implantation of osmotic pumps on morbidity and mortality in a murine model of hematopoietic acute radiation syndrome (H-ARS), finding that surgical implantation of a drug-delivery device can adversely affect the outcome in the mice.
LABORATORY ANIMALS
(2021)
Review
Biochemistry & Molecular Biology
Won-Seok Lee, Bo-Eun Yoon
Summary: Animal models have been used to study ADHD and understand its underlying mechanisms. These models allow researchers to conduct controlled experiments and investigate the causes of ADHD. However, they do not fully replicate the complexity of the disorder and caution should be exercised in interpreting the findings. Environmental and epigenetic factors should also be considered. This review discusses the limitations of existing animal models and provides insights into a more reliable alternative for studying ADHD comprehensively.
Article
Chemistry, Medicinal
Shuwei Zhang, Siyuan Wang, Qian Zhang, Cheng-Wei Tom Chang, Jixun Zhan
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2015)
Article
Chemistry, Multidisciplinary
Qian Zhang, Xinrui Peng, Michelle Grilley, Jon Y. Takemoto, Cheng-Wei Tom Chang
Article
Chemistry, Organic
Marina Fosso, Madher N. AlFindee, Qian Zhang, Vincent de Paul Nzuwah Nziko, Yukie Kawasaki, Sanjib K. Shrestha, Jeremiah Bearss, Rylee Gregory, Jon Y. Takemoto, Cheng-Wei Tom Chang
JOURNAL OF ORGANIC CHEMISTRY
(2015)
Article
Infectious Diseases
Sanjib K. Shrestha, Michelle Grilley, Thomas Anderson, Christine Dhiman, John Oblad, Cheng-Wei T. Chang, Kevin N. Sorensen, Jon Y. Takemoto
Article
Biochemistry & Molecular Biology
Jaya P. Shrestha, Yagya Prasad Subedi, Liaohai Chen, Cheng-Wei Tom Chang
Article
Biochemistry & Molecular Biology
Lei Sun, Siyuan Wang, Shuwei Zhang, Lei Saho, Qian Zhang, Chad Skidmore, Cheng-Wei Tom Chang, Dayu Yu, Jixun Zhan
ACS CHEMICAL BIOLOGY
(2016)
Article
Chemistry, Organic
Qjan Zhang, Madher N. Alfindee, Jaya P. Shrestha, Vincent de Paul Nzuwah Nziko, Yukie Kawasaki, Xinrui Peng, Jon Y. Takemoto, Cheng-Wei Tom Chang
JOURNAL OF ORGANIC CHEMISTRY
(2016)
Article
Chemistry, Medicinal
Jaya P. Shrestha, Coleman Baker, Yukie Kawasaki, Yagya P. Subedi, Nzuwah Nziko Vincent de Paul, Jon Y. Takemoto, Cheng-Wei Tom Chang
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Review
Biochemistry & Molecular Biology
Yagya Prasad Subedi, Madher N. AlFindee, Jon Y. Takemoto, Cheng-Wei Tom Chang
Article
Chemistry, Medicinal
Madher N. AlFindee, Yagya P. Subedi, Mariana C. Fiori, Srinivasan Krishnan, Abbey Kjellgren, Guillermo A. Altenberg, Cheng-Wei T. Chang
ACS MEDICINAL CHEMISTRY LETTERS
(2018)
Article
Chemistry, Medicinal
Yagya Prasad Subedi, Madher N. Alfindee, Jaya P. Shrestha, Cheng-Wei Tom Chang
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Chemistry, Medicinal
Yagya Prasad Subedi, Paul Roberts, Michelle Grilley, Jon Y. Takemoto, Cheng-Wei Tom Chang
ACS INFECTIOUS DISEASES
(2019)
Article
Chemistry, Medicinal
Yagya Prasad Subedi, Uddav Pandey, Madher N. Alfindee, Heath Montgomery, Paul Roberts, Jeffrey Wight, Gavin Nichols, Michell Grilley, Jon Y. Takemoto, Cheng-Wei Tom Chang
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Review
Chemistry, Medicinal
Yagya P. Subedi, Guillermo A. Altenberg, Cheng-Wei T. Chang
Summary: Gap-junction channels formed by connexin hemichannels are crucial for intercellular communication, but abnormal activity can lead to diseases. Amphiphilic kanamycins, especially towards connexin 43 inhibition, show promising potential with low cytotoxicity.
FUTURE MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Cheng-Wei T. Chang, Naveena Poudyal, Daniel A. Verdugo, Francisca Pena, Jimmy Stehberg, Mauricio A. Retamal
Summary: This study aimed to test the effects of certain molecules derived from aminoglycosides on mammalian cells. It was found that KI04 is an effective inhibitor of Cx46 hemichannels, which could help in the development of future selective Cx46 inhibitors.