Review
Neurosciences
Yiming Liu, Yong Shen
Summary: Nanoparticles offer a promising solution to the challenges posed by the blood-brain barrier, facilitating drug delivery to the central nervous system with good targeting ability.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Medicine, Research & Experimental
Joanna M. Wasielewska, Juliana C. S. Chaves, Rebecca L. Johnston, Laura A. Milton, Damian Hernandez, Liyu Chen, Jae Song, Wendy Lee, Gerhard Leinenga, Rebecca M. Nisbet, Alice Pebay, Jurgen Gotz, Anthony R. White, Lotta E. Oikari
Summary: This study established a BBB cell model using patient-derived cells to investigate the drug delivery effects of FUS+MB. The results showed that FUS+MB significantly increased drug delivery and has the potential to be a therapeutic modality in the treatment of AD.
Article
Clinical Neurology
Emily Eufaula Beaman, Anders Nissen Bonde, Sara Marie Ulv Larsen, Brice Ozenne, Terhi Johanna Lohela, Maiken Nedergaard, Gunnar Hilmar Gislason, Gitte Moos Knudsen, Sebastian Camillo Holst
Summary: Treating Alzheimer's disease with highly blood-brain barrier-permeable beta-blockers reduces the risk compared to low permeability drugs.
Review
Nanoscience & Nanotechnology
Shuo Zhang, Yishu Wang, Shuai Zhang, Chengqi Huang, Qiyang Ding, Ji Xia, Daocheng Wu, Wei Gao
Summary: Anesthetic nanomedicines play a crucial role in clinical surgery, improving anesthesia effectiveness and reducing toxic effects. However, research on anesthetic nanomedicines is still limited and requires further exploration and analysis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Instruments & Instrumentation
Na Ouyang, Chunhua Yang, Xia Li, Zhenting Zheng, Yuanyuan Xu, Yinan Wang, Wei Xiong, Haiqiang Wu
Summary: This study developed a novel nano-delivery vehicle system composed of lactoferrin-conjugated micelles, which successfully crossed the blood-brain barrier and demonstrated good biocompatibility and drug delivery capability in vivo.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Jun Zhang, Ting Yang, Wan Huang, Yao Yu, Taolei Sun
Summary: Brain diseases, such as Alzheimer's disease, brain tumors, and Parkinson's disease, present a significant burden on the public healthcare system. The blood-brain barrier (BBB) poses a major challenge in overcoming these diseases as it prevents drugs from reaching the brain. Gold nanoparticles (AuNPs) have shown promise in biomedical applications due to their adjustable size, unique optical properties, surface modification capabilities, and biocompatibility. This article reviews the structure and properties of the BBB, discusses the main transport routes through the BBB, and provides a comprehensive summary of the use of AuNPs as drug delivery platforms in various brain diseases, including brain imaging, Alzheimer's disease, brain tumors, and Parkinson's disease.
CURRENT MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Adolfo Lopez-Ornelas, Adriana Jimenez, Gilberto Perez-Sanchez, Citlali Ekaterina Rodriguez-Perez, Alejandro Corzo-Cruz, Ivan Velasco, Enrique Estudillo
Summary: Alzheimer's disease is a common neurodegenerative disorder with increasing prevalence. Understanding its pathophysiology is crucial for developing effective treatment. Despite recent efforts in drug development, the neuronal damage caused by Amyloid beta peptide and Tau protein abnormalities remains a challenge. Peripheral inflammation is closely associated with the onset and progression of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Katarzyna Potyrak, Benita Wiatrak, Edward Krzyzak, L. Lukasz Szczukowski, Piotr Swiatek, Adam Szelag
Summary: Alzheimer's disease remains a serious disorder with no effective therapy. However, certain compounds show potential for beneficial effects on damaged neuronal cells and are capable of crossing the blood-brain barrier.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Anett Hudak, Annamaria Letoha, Csaba Vizler, Tamas Letoha
Summary: Early diagnosis of Alzheimer's disease is crucial for preserving patients' health, and the expression of SDC3 in experimental models suggests it could be used as a biomarker for detecting neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Geetika Nehra, Bjoern Bauer, Anika M. S. Hartz
Summary: This review summarizes the extent and clinical relevance of barrier leakage in Alzheimer's disease (AD). By examining animal models, clinical and postmortem studies, signaling mechanisms, and potential therapeutic strategies, the review provides insights into the relationship between barrier leakage and neurodegeneration, cognitive decline, and the development of novel therapeutic targets for AD.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Neurosciences
Van Nguyen, Peter Thomas, Sarah Pemberton, Alice Babin, Cassidy Noonan, Riley Weaver, William A. Banks, Elizabeth M. Rhea
Summary: This study found that the central nervous system (CNS) can control the rate of insulin uptake by the brain, which is related to CNS insulin resistance in Alzheimer's disease. Direct injection of insulin into the brain can decrease insulin transport across the blood-brain barrier, while blocking the insulin receptor can also reduce insulin transport. These results indicate a connection between CNS insulin resistance and the rate of insulin transport across the blood-brain barrier.
FLUIDS AND BARRIERS OF THE CNS
(2023)
Review
Biochemistry & Molecular Biology
Buddolla Anantha Lakshmi, Young-Joon Kim
Summary: Nanotechnology plays a crucial role in the treatment and diagnosis of glioblastoma. The multifunctional nanomaterials with specific features such as real-time tracking, in-depth tissue penetration, and drug-loading capacity offer effective theranostics for glioblastoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Rosemary J. Jackson, Jonah C. Meltzer, Huong Nguyen, Caitlin Commins, Rachel E. Bennett, Eloise Hudry, Bradley T. Hyman
Summary: The study demonstrates that APOE4 leads to a leaky blood-brain barrier, and astrocyte-produced APOE4, through its interaction with blood vessels, is a crucial regulator of blood-brain barrier integrity.
Review
Cell Biology
Liqiang Hu, Yiran Tao, Yanjiao Jiang, Feng Qin
Summary: Alzheimer's disease is the most common cause of memory disruption in elderly individuals, and the lack of effective therapy is due to low drug potency and challenges in drug delivery. Recent advances in nanomedicine have shown promising developments in Alzheimer's disease treatment, using various nano-carriers to develop successful strategies. This review comprehensively summarizes the efficacy of different nanomedicine in pre-clinical studies and provides insights and future research directions. It can guide the design and evaluation of nanomedicine in Alzheimer's disease treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Chanchal Sharma, Hanwoong Woo, Sang Ryong Kim
Summary: The blood-brain barrier is essential in maintaining the brain microenvironment, and disruptions to it can be linked to cognitive impairments such as Alzheimer's disease. By studying the mechanisms of BBB breakdown, we can better understand neurodegenerative diseases. Additionally, BBB disruption can serve as a biomarker for diagnosing cognitive impairments.
Review
Medicine, Research & Experimental
Aric F. Logsdon, Elizabeth M. Rhea, May Reed, William A. Banks, Michelle A. Erickson
Summary: The endothelial glycocalyx layer (EGL) is a crucial component of the blood-brain barrier (BBB), consisting of proteoglycans and glycosaminoglycans. It serves as the first line of defense in preventing substances from entering the brain.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Review
Endocrinology & Metabolism
Elizabeth M. Rhea, William A. Banks
Summary: Since the discovery of insulin in 1921, research has extensively investigated its role in the brain, particularly its ability to regulate peripheral glucose levels and transport across the blood-brain barrier. Advancements in technology have allowed for quantitative measurement of insulin transport rate at the blood-brain barrier, as well as exploration of the specific role of the insulin receptor through genetic mouse models and high-specificity antagonists.
JOURNAL OF NEUROENDOCRINOLOGY
(2021)
Article
Neurosciences
Elizabeth M. Rhea, Aric F. Logsdon, Kim M. Hansen, Lindsey M. Williams, May J. Reed, Kristen K. Baumann, Sarah J. Holden, Jacob Raber, William A. Banks, Michelle A. Erickson
Summary: The study demonstrates that the SARS-CoV-2 spike 1 protein can cross the mouse blood-brain barrier and be taken up by both the brain and peripheral tissues. Intravenous injection results in higher levels of protein uptake in the brain compared to intranasal administration. Genetic factors and sex have varying effects on the uptake of the spike protein in different tissues.
NATURE NEUROSCIENCE
(2021)
Article
Clinical Neurology
Aric F. Logsdon, Kendra L. Francis, Nicole E. Richardson, Shannon J. Hu, Chelsea L. Faber, Bao Anh Phan, Vy Nguyen, Naly Setthavongsack, William A. Banks, Randy L. Woltjer, C. Dirk Keene, Caitlin S. Latimer, Michael W. Schwartz, Jarrad M. Scarlett, Kimberly M. Alonge
Summary: The study found that patients with AD-related dementia experience a re-coding of their PNN-associated CS-GAGs, correlating with the progression of pathology, accumulation of p-tau, and cognitive impairment. These sulfation changes can be detected prior to classical AD pathology, potentially playing a crucial role in the development of the disease.
ALZHEIMERS & DEMENTIA
(2022)
Review
Biochemistry & Molecular Biology
Melvin R. Hayden, William A. Banks
Summary: Obesity, metabolic syndrome, type 2 diabetes, and aging are global societal problems with potential complications, causing economic burdens to individuals and families. This review focuses on the role of leptin hormone from white adipose tissue in brain remodeling in female mice with hyperphagia, obesity, or hyperglycemia, examining structural changes in various brain components.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Elizabeth M. Rhea, William A. Banks
Summary: The interactions between lipids, lipoproteins, and apolipoproteins with the blood-brain barrier (BBB) are diverse and important for both health and disease.
PHARMACEUTICAL RESEARCH
(2021)
Review
Chemistry, Multidisciplinary
Jia Li, Meng Zheng, Olga Shimoni, William A. Banks, Ashley I. Bush, Jennifer R. Gamble, Bingyang Shi
Summary: The blood-brain barrier is a crucial neurovascular unit that prevents harmful substances from entering the brain and maintains normal neuronal function. Disruption of BBB in diseases can contribute to disease progression, while restoration of BBB integrity is a biomarker for better clinical outcomes. The BBB also plays a role in facilitating communication between neuronal and circulatory systems, showing promising results for brain-targeted drug delivery.
Editorial Material
Biotechnology & Applied Microbiology
Jia Li, Meng Zheng, Yan Zou, Pu Chun Ke, Miqin Zhang, William A. Banks, Bingyang Shi
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Takashi Fujimoto, Yoichi Morofuji, Andrej Kovac, Michelle A. Erickson, Maria A. Deli, Masami Niwa, William A. Banks
Summary: Statins have neuroprotective effects on neurological diseases, possibly through regulating blood-brain barrier function. Pitavastatin (PTV) can ameliorate lipopolysaccharide-induced blood-brain barrier dysfunction by inhibiting cytokine production. These findings highlight the pharmacological significance of statins in the treatment of central nervous system diseases.
Article
Multidisciplinary Sciences
Elizabeth M. Rhea, Kim Hansen, Sarah Pemberton, Eileen Ruth S. Torres, Sarah Holden, Jacob Raber, William A. Banks
Summary: Independent risk factors such as age, apoE isoform, sex, and diet can impact the development of Alzheimer's disease. Synergies between some of these risk factors have been observed, but the relationship between the latter three has not been studied. Analysis of the insulin blood-brain barrier pharmacokinetics in aged male and female mice with different apoE isoforms and diets showed potential differences in insulin interactions, which may contribute to cognitive changes related to altered CNS insulin signaling.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, Research & Experimental
Michelle A. Erickson, William A. Banks
Summary: Disruption of the blood-brain barrier (BBB) can occur through different mechanisms and pathways, resulting in different neurological insults. The importance of transcellular pathways in BBB disruption has been highlighted. Transcytotic mechanisms are less clearly linked to permeability compared to membrane spanning canaliculi and fenestrations. Cellular components involved in transcellular mechanisms of BBB disruption are being discovered and measured, adding to our classic knowledge based on ultrastructural studies.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Pharmacology & Pharmacy
William A. Banks, Pericles Calias, Kim M. Hansen, Kristin M. Bullock, Kory Engelke
Summary: This study evaluated the uptake and distribution of kleptose in the brain and spinal cord after intranasal and intrathecal delivery. The results showed that intrathecal delivery resulted in higher distribution in the brain compared to intranasal delivery.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Rachel C. Knopp, Michelle A. Erickson, Elizabeth M. Rhea, May J. Reed, William A. Banks
Summary: The blood-brain barrier (BBB) is an important interface that regulates communication between the brain and blood. It is comprised of brain endothelial cells and is surrounded by supportive brain cell types. Recent studies have shown that the BBB undergoes dysfunction during aging and in diseases, and cellular senescence, one of the hallmarks of aging, is believed to play a role in these changes. This review summarizes the known age-related changes at the BBB, evaluates the impact of cellular senescence in neurodegenerative diseases, discusses insights from in vitro and in vivo studies, and explores mechanisms by which cellular senescence affects BBB function.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Geriatrics & Gerontology
Subhashis Banerjee, Sarbani Ghoshal, Clemence Girardet, Kelly M. DeMars, Changjun Yang, Michael L. Niehoff, Andrew D. Nguyen, Prerana Jayanth, Brittany A. Hoelscher, Fenglian Xu, William A. Banks, Kim M. Hansen, Jinsong Zhang, Eduardo Candelario-Jalil, Susan A. Farr, Andrew A. Butler
Summary: Studies have shown that adropin is highly expressed in the human brain and plays a crucial role in neural network development and function. In elderly individuals, adropin is positively correlated with genes related to mitochondrial function, morphogenesis, and inflammation, while cognitive decline can be reversed by increasing adropin expression.
NPJ AGING AND MECHANISMS OF DISEASE
(2021)
Review
Cell Biology
William A. Banks, May J. Reed, Aric F. Logsdon, Elizabeth M. Rhea, Michelle A. Erickson
Summary: The blood-brain barrier undergoes changes in morphology and function during healthy aging, affecting communication and homeostatic regulation between the brain and peripheral tissues, and potentially predisposing to age-related diseases.
