期刊
BMC NEUROLOGY
卷 14, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1471-2377-14-64
关键词
Alzheimer Disease; Dementia; Cerebrospinal fluid; Blood plasma; IGF-I; IGF-II; IGFBP-2; IGFBP-3; Insulin
资金
- Swedish Research Council
- Crafoord Foundation
- Swedish Brain Foundation
- Skane University Hospital Foundation
- Johan and Jakob Soderbergs Foundation
- Swedish Alzheimer Association
- Swedish federal government under the LUA/ALF agreement
Background: The Insulin-like Growth Factor (IGF)-related system is implicated in neuroregeneration and cell repair, as well as regulating lifespan. IGF-II, one component of this system, has also been found to affect memory functions in a rat model. In this study we explored changes in the IGF-related system in patients with Alzheimer's disease (AD), including changes in IGF-II levels. Methods: We measured blood plasma and cerebrospinal fluid (CSF) levels of IGF-I, IGF-II, IGFBP-2 and IGFBP-3 in 72 healthy controls and 92 patients with AD. Results: We found significantly lower blood plasma levels of IGF-II and IGFBP-3 in patients with AD, compared with controls. The levels of IGF-II and IGFBP-2 were significantly elevated in the CSF from patients with AD. We also found correlations between established CSF biomarkers for AD (tau and P-tau) and components of the IGF system. Conclusions: CSF and blood plasma levels of IGF-II and some of its binding proteins are changed in patients with AD. Further investigation into this area may unravel important clues to the nature of this disease.
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