Article
Medicine, General & Internal
Bahram Haqi-Ashtiani, Parichehr Moghaddam, Farzaneh Barzkar, Ali Zare Mehrjerdi, Mostafa Almasi-Dooghaee
Summary: Although rare, intravascular lymphoma can present with peripheral neuropathy, making it important to consider this diagnosis to avoid delays in treatment. This case report describes a 64-year-old man who presented with asymmetric paresthesia, weakness in his feet, and significant weight loss. Biopsy results of the peroneal nerve showed intravascular proliferation of CD-20 positive lymphocytes, indicating intravascular large B-cell lymphoma.
CLINICAL CASE REPORTS
(2023)
Article
Immunology
Sai Nagaratnam, Nimalan Harinesan, Rajiv Wijesinghe, Nicole Wong-Doo, Alison Lyons, Katrina Morris, James Triplett
Summary: Neuroleukemiosis is a rare complication of leukemia, characterized by peripheral nerve involvement secondary to leukemic infiltration. It presents with various clinical manifestations, often leading to diagnostic challenges for hematologists and neurologists. We present two cases of painless progressive mononeuritis multiplex secondary to neuroleukemiosis and review the literature on previously reported cases. The diagnosis of neuroleukemiosis requires a high index of suspicion and can be aided by repeated cerebrospinal fluid analysis.
JOURNAL OF NEUROIMMUNOLOGY
(2023)
Article
Clinical Neurology
Wei-Sheng Wang, Shey-Lin Wu, Wei-Chieh Chan, Yen-Chung Chen
Summary: In this case report, a female patient with coexistence of Graves' disease and Moyamoya disease presenting with chorea is described. After treatment, her symptoms improved rapidly. We suggest that evaluating thyroid function status is important in patients with Moyamoya disease.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Alex Vicino, Stephane Cochet, Silvia Pistocchi, Curdin Conrad, Camillo Ribi, Renaud Du Pasquier, Jean-Philippe Brouland, Marie Theaudin
Summary: This article reports an exceptional case of severe mononeuritis multiplex caused by nerve infiltration from a benign chronic B cell leukemia. The patient underwent extensive evaluation and treatment, including nerve conduction study, myography, MRI, and nerve biopsy. The results highlight the importance of nerve biopsy in diagnosing and treating this rare entity.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2023)
Article
Immunology
Valentina Boz, Erica Valencic, Martina Girardelli, Alessia Pin, Laura Gamez-Diaz, Alberto Tommasini, Sara Lega, Matteo Bramuzzo
Summary: Early onset gastrointestinal autoimmune disorders may be caused by primary immunodeficiency with genetic defects increasingly recognized through next generation sequencing technologies. A genetic diagnosis is crucial for targeted treatments to significantly improve patient prognosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Anandkumar Patel, Umangkumar M. Patel, Vani Sojitra
Summary: This case report highlights the fact that neurological symptoms can be the initial manifestation of ANCA-associated vasculitis. Clinicians should be highly suspicious of AAV in patients presenting with mononeuritis multiplex, particularly after ruling out common causes.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Mutaz Albakri, Mushtaq Ahmad, Mouhand F. H. Mohamed
Summary: This case report describes a rare presentation of sarcoidosis with massive pleural effusion that was resistant to steroid treatment. Following pleural fluid drainage and pleurodesis, the patient showed no recurrence of effusion or development of other symptoms during more than 1 year of follow-up.
Review
Psychiatry
Manuel Pereira Herrera, Aphrodite Marta Zimmerman
Summary: Delirious mania, an uncommon condition often seen in patients with a history of bipolar disorder, presents challenges in diagnosis and treatment. This case study highlights the refractory nature of delirious mania to various medications, but the dramatic response to lithium therapy after 26 days of minimal improvement with other drugs. The unique actions of lithium in treating delirious mania are discussed as a potential advantage in its management.
Review
Chemistry, Multidisciplinary
Fei Wang, Aftab Ullah, Xuelian Fan, Zhou Xu, Rongling Zong, Xuewen Wang, Gang Chen
Summary: An appropriate delivery system can enhance the immune effects of antigens against infections or tumors. Targeting vaccine delivery systems to APCs is a promising strategy for provoking potent immune responses.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Medicine, General & Internal
Wilmer Santiago Herrera Malpica, Paula Vanessa Munetones Hernandez, Nathalia Maria Perez Becerra, Jorge Nicolas Munoz Rodriguez, Jorge Arturo Diaz Ruiz
Summary: Hansen's disease, caused by Mycobacterium leprae, can lead to mononeuritis multiplex. Electrodiagnostic studies and ultrasound can be used to diagnose and evaluate the severity of the disease.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Pharmacology & Pharmacy
H-Q Zeng, X-P Lu, Z-B Yan, Z-Z Ye
Summary: This report presents the first successful treatment of refractory BSLE with belimumab in a 16-year-old girl, providing a new option for treating this condition.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Editorial Material
Obstetrics & Gynecology
Naourez Kolsi, Sondes Jellali, Ines Zouari, Rim Hathri, Rachida Bouattay, Jamel Koubaa
Summary: A 43-year-old female presented with nasal symptoms and exophthalmos, initially misdiagnosed as sinonasal cancer, later confirmed to be ethmoidal metastasis from breast adenocarcinoma.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Medicine, General & Internal
Safa Abdelhakim, Jonah D. Klapholz, Bhaskar Roy, Sarah A. Weiss, Declan McGuone, Zachary A. Corbin
Summary: Mononeuritis multiplex, a rare autoimmune peripheral neuropathy, has been associated with immune checkpoint inhibitor therapy. We report a case of melanoma patient who developed mononeuritis multiplex as a complication of immune checkpoint inhibitor therapy. Increased awareness, prompt recognition, and aggressive treatments are important for improving outcomes of this severe side effect.
JOURNAL OF MEDICAL CASE REPORTS
(2022)
Article
Allergy
Lam C. Tsoi, Matthew T. Patrick, Shao Shuai, Mrinal K. Sarkar, Sunyi Chi, Bethany Ruffino, Allison C. Billi, Xianying Xing, Ranjitha Uppala, Cheng Zang, Joseph Fullmer, Zhi He, Emanual Maverakis, Nehal N. Mehta, Bethany E. Perez White, Spiro Getsios, Yolanda Helfrich, John J. Voorhees, J. Michelle Kahlenberg, Stephan Weidinger, Johann E. Gudjonsson
Summary: This study evaluates the use of baseline molecular expression profiling to assess treatment outcome for patients with psoriasis. The results show a correlation between clinical response and molecular changes, particularly for genes responding to IL-17A/TNF in keratinocytes. Baseline gene expressions in nonlesional skin were found to be the best marker of treatment response, and cytokine gene signatures enriched in baseline nonlesional skin had strong correlations with treatment improvement.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Cell Biology
Tyler E. James, Leslie J. Martin, Theodore E. Warkentin, Mark A. Crowther
Summary: Catastrophic antiphospholipid syndrome (CAPS) is a rare condition characterized by sudden multiorgan dysfunction caused by thrombosis from antibodies. Treatment includes anticoagulation, corticosteroids, TPE, and IVIG. This case report is the first to document initial failure of IVIG treatment in a CAPS patient with subsequent success with TPE.
Article
Clinical Neurology
K. Allen-Philbey, A. Stennett, T. Begum, AC. Johnson, R. Dobson, G. Giovannoni, S. Gnanapavan, M. Marta, I. Smets, B. P. Turner, D. Baker, J. Mathews, K. Schmierer
Summary: Patients with multiple sclerosis receiving the AstraZeneca vaccine may experience transient symptoms including arm pain, flu-like symptoms, fever, fatigue, and headache. Most symptoms resolve within 48 hours, with some lasting longer up to 10-12 days, but no severe adverse effects were reported.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Immunology
Terrence Y-H Chan, Valentina De Zan, Alistair Gregg, Jasmini Alagaratnam, Simonetta Gerevini, Andrea Antinori, Antonella D'Arminio Monforte, Annalisa Saracino, Mattia Trunfio, Alex Everitt, Simon Rackstraw, Monica Marta, Andrea Calcagno, Paola Cinque, Alan Winston
Summary: This study characterized the clinical, laboratory, and radiological features of HIV patients with cerebrospinal fluid HIV RNA escape. Cognitive decline, confusion, and headache were the most common symptoms, with variations based on symptom onset and HIV RNA concentration in the cerebrospinal fluid.
Article
Clinical Neurology
Jeff Rodgers, Tim Friede, Frederick W. Vonberg, Cris S. Constantinescu, Alasdair Coles, Jeremy Chataway, Martin Duddy, Hedley Emsley, Helen Ford, Lennora Fisniku, Ian Galea, Timothy Harrower, Jeremy Hobart, Huseyin Huseyin, Christopher M. Kipps, Monica Marta, Gavin McDonnell, Brendan McLean, Owen R. Pearson, David Rog, Klaus Schmierer, Basil Sharrack, Agne Straukiene, Heather C. Wilson, David Ford, Rod M. Middleton, Richard Nicholas
Summary: The negative impact of smoking in multiple sclerosis is well documented, but there is limited evidence on the benefits of smoking cessation for disease progression. This study found that current smokers had higher disability scores compared to those who had never smoked, and there was no improvement in scores with increasing time since quitting. However, when smokers quit, the rate of motor disability deterioration slowed down to match that of non-smokers. This suggests that smoking cessation is beneficial for people with multiple sclerosis.
Article
Medicine, General & Internal
Ruth Dobson, Matthew Craner, Ed Waddingham, Aleisha Miller, Ana Cavey, Stewart Webb, Cheryl Hemingway, Jeremy Hobart, Nikos Evangelou, Neil Scolding, David Rog, Richard Nicholas, Monica Marta, Camilla Blain, Carolyn Anne Young, Helen L. Ford, Paul M. Matthews
Summary: The study aims to characterize and compare the incidence and risk of serious adverse events in MS patients treated with DMTs. The OPTIMISE:MS database allows for electronic data capture and secure data transfer. Ethical permission has been obtained and results will be disseminated through publication, with participants' consent for sharing anonymized data for further research use.
Article
Clinical Neurology
Monica Marta, David Baker, Paul Creeke, Gareth Pryce, Sharmilee Gnanapavan, Gavin Giovannoni
Summary: The study aimed to induce antigen-specific tolerance in autoimmune diseases, using anti-drug antibodies to human therapeutic proteins as a model. The data showed promising results in one participant, but the study was terminated early due to ethical concerns and availability of alternative treatments. Further research is needed in this area.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Clinical Neurology
Ide Smets, David Holden, Lucia Bianchi, Francesca Ammoscato, Kimberley Allen-Philbey, David Baker, Benjamin Turner, Monica Marta, Gavin Giovannoni, Amy Macdougall, Klaus Schmierer, Jeremy Hobart, Sharmilee Gnanapavan
Summary: In patients with multiple sclerosis (MS), the decrease in cerebrospinal fluid (CSF) neurofilament light chain (NfL) levels is influenced by factors such as age, disability status, and MS type. However, other factors including BMI, disease duration, and sex do not have an impact on CSF NfL reduction.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
Ruth Dobson, Matthew Craner, Ed Ed Waddingham, Aleisha Miller, Jayant Pindoria, Ana Cavey, Camilla Blain, Gabriele De Luca, Nikos Evangelou, Helen Ford, Paul Gallagher, Katila George, Ruth Geraldes Ramos Dias, Paula Harman, Jeremy Hobart, Tanya King, Ruth Linighan, Niall MacDougall, Monica Marta, Stephanie Mitchell, Richard Nicholas, David Rog, Antonio Scalfari, Neil Scolding, Stewart Webb, Sarah White, Judith Wilton, Carolyn Young, Paul Matthews
Summary: This study analyzed the risk of adverse events in multiple sclerosis (MS) patients receiving disease-modifying therapies (DMTs) through an observational study. It found that certain DMTs had a higher incidence of adverse events. This highlights the potential of routinely collected healthcare data to evaluate the safety of DMTs in real-world clinical practice.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Letter
Clinical Neurology
K. Allen-Philbey, A. Stennett, T. Begum, A. C. Johnson, A. MacDougall, S. Green, R. Dobson, G. Giovannoni, S. Gnanapavan, M. Marta, I. Smets, B. P. Turner, D. Baker, J. Mathews, K. Schmierer
Summary: This study aimed to evaluate the safety and effectiveness of COVID-19 vaccination in people with multiple sclerosis (pwMS). The results showed that the symptoms experienced after vaccination were similar to those in the non-MS population and most symptoms resolved within a short period of time. Male pwMS had a reduced risk of reporting symptoms after the first vaccination.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
Kimberley Allen-Philbey, Stefania De Trane, Zhifeng Mao, Cesar Alvarez-Gonzalez, Joela Mathews, Amy MacDougall, Andrea Stennett, Xia Zhou, Ozlem Yildiz, Ashok Adams, Lucia Bianchi, Camilla Blain, Christine Chapman, Karen Chung, Cris S. Constantinescu, Catherine Dalton, Rachel A. Farrell, Leonora Fisniku, Helen Ford, Bruno Gran, Jeremy Hobart, Zhaleh Khaleeli, Miriam Mattoscio, Sue Pavitt, Owen Pearson, Luca Peruzzotti-Jametti, Antonio Scalfari, Basil Sharrack, Eli Silber, Emma C. Tallantyre, Stewart Webb, Benjamin P. Turner, Monica Marta, Sharmilee Gnanapavan, Gunnar Juliusson, Gavin Giovannoni, David Baker, Klaus Schmierer
Summary: The study reported on the safety and effectiveness of subcutaneous cladribine in multiple sclerosis patients, showing that cladribine was generally well tolerated and effective in both relapsing and progressive MS patients, suggesting it may be a viable treatment option for MS patients at different disease stages.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2021)
Meeting Abstract
Clinical Neurology
A. Stennett, K. Allen-Philbey, T. Begum, A. Johnson, R. Dobson, G. Giovannoni, S. Gnanapavan, M. Marta, I. Smets, B. Turner, K. Schmierer
MULTIPLE SCLEROSIS JOURNAL
(2021)
Meeting Abstract
Clinical Neurology
W. J. Rodgers, T. Friede, F. W. Vonberg, C. S. Constantinescu, A. Coles, J. Chataway, H. Emsley, H. Ford, L. Fisniku, I. Galea, T. Harrower, J. Hobart, H. Huseyin, C. Kipps, M. Marta, G. McDonnell, B. McLean, O. R. Pearson, D. Rog, K. Schmierer, B. Sharrack, A. Straukiene, H. Wilson, R. Middleton, D. V. Ford, R. Nicholas
MULTIPLE SCLEROSIS JOURNAL
(2021)
Meeting Abstract
Clinical Neurology
I. Smets, D. Holden, L. Bianchi, F. Ammoscato, K. Allen-Philbey, D. Baker, B. Turner, M. Marta, G. Giovannoni, A. MacDougall, K. Schmierer, J. Hobart, S. Gnanapavan
MULTIPLE SCLEROSIS JOURNAL
(2021)
Meeting Abstract
Clinical Neurology
K. Allen-Philbey, S. De Trane, A. Stennett, O. Yildiz, A. Adams, B. Turner, M. Marta, S. Gnanapavan, L. Bianchi, J. Mathews, A. MacDougall, G. Giovannoni, D. Baker, K. Schmierer
MULTIPLE SCLEROSIS JOURNAL
(2021)
Meeting Abstract
Clinical Neurology
K. Allen-Philbey, S. De Trane, A. Stennett, O. Yildiz, A. Adams, B. Turner, M. Marta, S. Gnanapavan, L. Bianchi, J. Mathews, G. Giovannoni, D. Baker, K. Schmierer
MULTIPLE SCLEROSIS JOURNAL
(2021)
Meeting Abstract
Clinical Neurology
I. Smets, D. Holden, L. Bianchi, F. Ammoscato, B. Turner, M. Marta, K. Schmierer, G. Giovannoni, S. Gnanapavan
MULTIPLE SCLEROSIS JOURNAL
(2021)