Article
Biochemistry & Molecular Biology
Gareth S. A. Wright
Summary: The internalization of a bacteria by an archaeal cell accelerated eukaryotic evolution by utilizing a specific copper chaperone to activate CuZnSOD for combating oxidative stress. The adoption of a single protein interface with structural characteristics necessary for homodimerization and heterodimerization played a crucial role in evolution.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Microbiology
Huiping Liao, Yuchao Zhang, Wei Guo, Xi Wang, Hailong Wang, Haocheng Ye, Kai Wu, Yu-Hang Zhang, Lingyun Guo, Yufei Zhu, Yongli Guo, Landian Hu, Gang Liu, Xiangyin Kong
Summary: This study used untargeted metagenomic next-generation sequencing and bioinformatic analysis to reveal microbial compositions in children with bacterial meningitis. Patients exhibited different microbiome signatures in their blood and CSF, which were correlated with clinical parameters and could distinguish patient subsets. Blood from patients with Klebsiella pneumoniae dominance could potentially replace CSF for clinical monitoring purposes.
Article
Clinical Neurology
Yudy Fonseca, Taty Tshimanga, Stephen Ray, Helen Malhotra, Jean Pongo, Joseph Bodi Mabiala, Montfort Bernard Gushu, Tusekile Phiri, Bertha Mekiseni Chikaonda, Davin Ambitapio Musungufu, Mananu Uchama, Nicole Fortier O'Brien
Summary: This study found that abnormal TCD flow patterns were common in children with bacterial meningitis, and identified those at high risk of poor neurological outcome. The study suggests that transcranial Doppler ultrasound may be helpful in predicting neurological prognosis in children with BM.
FRONTIERS IN NEUROLOGY
(2021)
Article
Pediatrics
Jiali Pan, Wei Xu, Wenliang Song, Tao Zhang
Summary: This study investigated the causative pathogens, clinical characteristics, and outcome of bacterial meningitis in children with an abnormal craniocerebral structure. The results showed that patients with an abnormal craniocerebral structure had fewer bloodstream infections, lower mortality rates, and higher incidence rates of neurological sequelae. Pathogens were more likely to be nosocomial and multidrug-resistant bacteria.
FRONTIERS IN PEDIATRICS
(2023)
Article
Immunology
Tuula Pelkonen, Irmeli Roine, Luis Bernardino, Kirsi Jahnukainen, Heikki Peltola
Summary: The prevalence of sickle cell disease (SCD) in children with bacterial meningitis (BM) was found to be 10% in Luanda, five times higher than the general population. BM children with SCD had higher inflammatory markers, were more often diagnosed with pneumococcal meningitis (71% vs. 39%), and had higher mortality rates (39% vs. 22%) or longer hospital stays (15 vs. 11 days) compared to BM children without SCD.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Emilie Rugemalira, Irmeli Roine, Julia Kuligowski, Angel Sanchez-Illana, Jose David Pineiro-Ramos, Sture Andersson, Manuel Leite Cruzeiro, Maximo Vento, Tuula Pelkonen
Summary: We investigated the association between cerebrospinal fluid (CSF) biomarkers indicating oxidative damage to proteins and the course of illness and outcome in childhood bacterial meningitis (BM) in Angola. We found that children with a lower o-Tyr/Phe ratio in their CSF upon admission were more likely to experience focal convulsions and secondary fever during recovery and have a suboptimal outcome at Day 7 and one month after discharge. The most common sequelae observed in these children were ataxia. This suggests that a higher admission CSF o-Tyr/Phe ratio is associated with a better course and outcome in pediatric BM.
Review
Biochemistry & Molecular Biology
Inesa Navasardyan, Stephanie Yeganyan, Helena Nguyen, Payal Vaghashia, Selvakumar Subbian, Vishwanath Venketaraman
Summary: Tuberculosis meningitis (TBM) occurs when Mycobacterium tuberculosis bacteria invade the meninges, leading to inflammation. Oxidative stress, caused by reactive oxygen species, plays a significant role in TBM by impairing the body's defense mechanisms. Diabetes mellitus (DM) increases susceptibility to TBM due to heightened oxidative stress. This review summarizes the role of oxidative stress in TBM and DM, and discusses potential therapeutic approaches.
Article
Immunology
Sophie Strasser, Christa Relly, Christoph Berger, Johannes Truck
Summary: A retrospective analysis found that a substantial proportion of children with severe bacterial infections (SBIs) had immune function impairments. Routine immunological testing can help identify these abnormalities and optimize preventive measures to avoid future SBI episodes.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Kenan Yilmaz, Gokhan Cakirca, Ozcan Erel
Summary: The study found that children with steroid-sensitive nephrotic syndrome (SSNS) shift towards oxidants in thiol/disulphide homoeostasis (TDH) during remission, indicating exposure to increased oxidative stress.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Review
Biochemistry & Molecular Biology
Leszek Rydz, Maria Wrobel, Halina Jurkowska
Summary: Mitochondria are crucial organelles for the synthesis of Fe-S clusters, with sulfurtransferases playing a key role. Fe-S clusters are essential for Fe-S proteins, susceptible to oxidative stress but capable of being resynthesized or repaired. Sulfurtransferases are involved in the formation, maturation, and reconstitution of Fe-S clusters.
Article
Medicine, Research & Experimental
Shinji Ono, Jiro Ogura, Hiroki Sugiura, Minami Yamauchi, Atsushi Tanaka, Toshihiro Sato, Masamitsu Maekawa, Hiroaki Yamaguchi, Nariyasu Mano
Summary: Protein disulfide isomerase (PDI) is involved in oxidative protein folding and S-nitrosylated PDI is considered a main cause of Alzheimer's disease. The mechanisms of PDI S-nitrosylation are not yet understood. GSH depletion is a pathological feature of Alzheimer's disease, so this study investigated the effect of GSH depletion on PDI S-nitrosylation.
Article
Pediatrics
Laura Lempinen, Anu Laulajainen-Hongisto, Antti A. Aarnisalo, Luis Bernardino, Heikki Peltola, Anne Pitkaranta, Tuula Pelkonen, Jussi Jero
Summary: This study investigated the bacterial etiology, hearing impairment, and outcome of childhood bacterial meningitis (BM) with or without otitis media (OM) in Angola. It was found that hearing impairment was common on day 7 of hospitalization, regardless of the presence of OM. Any hearing deficit on day 7 was associated with a higher risk of complicated or fatal clinical course.
Article
Pediatrics
Kushal Talukder, Rajniti Prasad, Abhisek Abhinay, Ankur Singh, Ragini Srivastava, Om P. Mishra, Tej Bali Singh
Summary: Elevated CSF LRG concentration is a sensitive and specific biomarker for bacterial meningitis, with potential for differentiation from aseptic meningitis. CSF LRG should be used for the diagnostic role in bacterial meningitis.
INDIAN JOURNAL OF PEDIATRICS
(2022)
Article
Plant Sciences
Chananwat Kortheerakul, Hakuto Kageyama, Rungaroon Waditee-Sirisattha
Summary: The study identified and characterized the GST gene family in the halotolerant cyanobacterium Halothece sp. PCC7418. One of the GSTs, H3557, showed significant upregulation under salt stress and exhibited GST activity towards CDNB and GSH with a broad range of enzymatic activity. This salt-adaptive enzyme remained catalytically active in the presence of NaCl and conferred tolerance to H2O2-induced oxidative stress and salt stress in heterologous expression systems.
PLANT CELL AND ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Y. Kalchev, P. Argirova, I. Boev, A. Yaneva, N. Vatev, M. Stoycheva, M. Murdjeva
Summary: The levels of interleukin (IL)-6, IL-8, IL-10, IL-12(p40), and tumor necrosis factor (TNF)-α are correlated with disease severity, complications, and outcome in patients with acute bacterial meningitis. The levels of IL-6, IL-8, IL-10, and TNF-α in cerebrospinal fluid (CSF) are significantly higher than in serum. Elevated serum IL-8 levels may indicate increased risk of neurological complications, severe clinical course, and fatal outcome.
Article
Genetics & Heredity
Andrea Cortese, Yi Zhu, Adriana P. Rebelo, Sara Negri, Steve Courel, Lisa Abreu, Chelsea J. Bacon, Yunhong Bai, Dana M. Bis-Brewer, Enrico Bugiardini, Elena Buglo, Matt C. Danzi, Shawna M. E. Feely, Alkyoni Athanasiou-Fragkouli, Nourelhoda A. Haridy, Rosario Isasi, Alaa Khan, Matilde Laura, Stefania Magri, Menelaos Pipis, Chiara Pisciotta, Eric Powell, Alexander M. Rossor, Paola Saveri, Janet E. Sowden, Stefano Tozza, Jana Vandrovcova, Julia Dallman, Elena Grignani, Enrico Marchioni, Steven S. Scherer, Beisha Tang, Zhiqiang Lin, Abdullah Al-Ajmi, Rebecca Schuele, Matthis Synofzik, Thierry Maisonobe, Tanya Stojkovic, Michaela Auer-Grumbach, Mohamed A. Abdelhamed, Sherifa A. Hamed, Ruxu Zhang, Fiore Manganelli, Lucio Santoro, Franco Taroni, Davide Pareyson, Henry Houlden, David N. Herrmann, Mary M. Reilly, Michael E. Shy, R. Grace Zhai, Stephan Zuchner
Article
Genetics & Heredity
Andreea Manole, Stephanie Efthymiou, Emer O'Connor, Marisa Mendes, Matthew Jennings, Reza Maroofian, Indran Davagnanam, Kshitij Mankad, Maria Rodriguez Lopez, Vincenzo Salpietro, Ricardo Harripaul, Lauren Badalato, Jagdeep Walia, Christopher S. Francklyn, Alkyoni Athanasiou-Fragkouli, Roisin Sullivan, Sonal Desai, Kristin Baranano, Faisal Zafar, Nuzhat Rana, Muhammed Ilyas, Alejandro Horga, Majdi Kara, Francesca Mattioli, Alice Goldenberg, Helen Griffin, Amelie Piton, Lindsay B. Henderson, Benyekhlef Kara, Ayca Dilruba Aslanger, Joost Raaphorst, Rolph Pfundt, Ruben Portier, Marwan Shinawi, Amelia Kirby, Katherine M. Christensen, Lu Wang, Rasim O. Rosti, Sohail A. Paracha, Muhammad T. Sarwar, Dagan Jenkins, Jawad Ahmed, Federico A. Santoni, Emmanuelle Ranza, Justyna Iwaszkiewicz, Cheryl Cytrynbaum, Rosanna Weksberg, Ingrid M. Wentzensen, Maria J. Guillen Sacoto, Yue Si, Aida Telegrafi, Marisa Andrews, Dustin Baldridge, Heinz Gabriel, Julia Mohr, Barbara Oehl-Jaschkowitz, Sylvain Debard, Bruno Senger, Frederic Fischer, Conny van Ravenwaaij, Annemarie J. M. Fock, Servi J. C. Stevens, Jurg Bahler, Amina Nasar, John F. Mantovani, Adnan Manzur, Anna Sarkozy, Desiree E. C. Smith, Gajja S. Salomons, Zubair M. Ahmed, Shaikh Riazuddin, Saima Riazuddin, Muhammad A. Usmani, Annette Seibt, Muhammad Ansar, Stylianos E. Antonarakis, John B. Vincent, Muhammad Ayub, Mona Grimmel, Anne Marie Jelsig, Tina Duelund Hjortshoj, Helena Gasdal Karstensen, Marybeth Hummel, Tobias B. Haack, Yalda Jamshidi, Felix Distelmaier, Rita Horvath, Joseph G. Gleeson, Hubert Becker, Jean-Louis Mandel, David A. Koolen, Henry Houlden
AMERICAN JOURNAL OF HUMAN GENETICS
(2020)
Article
Clinical Neurology
Caroline Neuray, Reza Maroofian, Marcello Scala, Tipu Sultan, Gurpur S. Pai, Majid Mojarrad, Heba El Khashab, Leigh deHoll, Wyatt Yue, Hessa S. Alsaif, Maria N. Zanetti, Oscar Bello, Richard Person, Atieh Eslahi, Zaynab Khazaei, Masoumeh H. Feizabadi, Stephanie Efthymiou, Hala T. El-Bassyouni, Doaa R. Soliman, Selahattin Tekes, Leyla Ozer, Volkan Baltaci, Suliman Khan, Christian Beetz, Khalda S. Amr, Vincenzo Salpietro, Yalda Jamshidi, Fowzan S. Alkuraya, Henry Houlden
Review
Clinical Neurology
Sherifa Ahmed Hamed
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2020)
Article
Endocrinology & Metabolism
Sherifa Ahmed Hamed, Fadia Ahmed Attiah, Refaat Fathy Abd Elaal, Mohamed Fawzy
Summary: Females with CAH exhibit frequent and severe behavioral symptoms, with excess androgenization linked to suboptimal steroid therapy as a potential cause. The study highlights the importance of early optimization of CAH management to prevent psychological consequences.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Psychiatry
Sherifa Ahmed Hamed, Mohamed Fawzy, Enas Ahmed Hamed
Summary: This study found an association between PMNE and behavioral problems, particularly emotional and hyperactivity-inattention symptoms, indicating externalizing and internalizing issues. Early interventions and treatments are necessary to prevent persistent enuresis and the development of psychiatric disorders in the future.
COMPREHENSIVE PSYCHIATRY
(2021)
Article
Clinical Neurology
Manuela Wiessner, Reza Maroofian, Meng-Yuan Ni, Andrea Pedroni, Juliane S. Muller, Rolf Stucka, Christian Beetz, Stephanie Efthymiou, Filippo M. Santorelli, Ahmed A. Alfares, Changlian Zhu, Anna Uhrova Meszarosova, Elham Alehabib, Somayeh Bakhtiari, Andreas R. Janecke, Maria Gabriela Otero, Jin Yun Helen Chen, James T. Peterson, Tim M. Strom, Peter De Jonghe, Tine Deconinck, Willem De Ridder, Jonathan De Winter, Rossella Pasquariello, Ivana Ricca, Majid Alfadhel, Bart P. van de Warrenburg, Ruben Portier, Carsten Bergmann, Saghar Ghasemi Firouzabadi, Sheng Chih Jin, Kaya Bilguvar, Sherifa Hamed, Mohammed Abdelhameed, Nourelhoda A. Haridy, Shazia Maqbool, Fatima Rahman, Najwa Anwar, Jenny Carmichael, Alistair Pagnamenta, Nick W. Wood, Frederic Tran Mau-Them, Tobias Haack, Maja Di Rocco, Isabella Ceccherini, Michele Iacomino, Federico Zara, Vincenzo Salpietro, Marcello Scala, Marta Rusmini, Yiran Xu, Yinghong Wang, Yasuhiro Suzuki, Kishin Koh, Haitian Nan, Hiroyuki Ishiura, Shoji Tsuji, Laetitia Lambert, Emmanuelle Schmitt, Elodie Lacaze, Hanna Kuepper, David Dredge, Cara Skraban, Amy Goldstein, Mary J. H. Willis, Katheryn Grand, John M. Graham, Richard A. Lewis, Francisca Millan, Ozgur Duman, Nihal Dundar, Gokhan Uyanik, Ludger Schols, Peter Nuernberg, Gudrun Nuernberg, Andrea Catala Bordes, Pavel Seeman, Martin Kuchar, Hossein Darvish, Adriana Rebelo, Filipa Boucanova, Jean-Jacques Medard, Roman Chrast, Michaela Auer-Grumbach, Fowzan S. Alkuraya, Hanan Shamseldin, Saeed Al Tala, Jamileh Rezazadeh Varaghchi, Maryam Najafi, Selina Deschner, Dieter Glaeser, Wolfgang Huettel, Michael C. Kruer, Erik-Jan Kamsteeg, Yoshihisa Takiyama, Stephan Zuchner, Jonathan Baets, Matthis Synofzik, Rebecca Schuele, Rita Horvath, Henry Houlden, Luca Bartesaghi, Hwei-Jen Lee, Konstantinos Ampatzis, Tyler Mark Pierson, Jan Senderek
Summary: This study identified families with neurological diseases caused by HPDL variants, showing various phenotypes ranging from juvenile-onset pure hereditary spastic paraplegia to infantile-onset spastic tetraplegia. Experimental evidence suggested a role of HPDL in the nervous system and supported its link to neurological disease.
Article
Neurosciences
Sherifa Ahmed Hamed, Samir Kamal Abdulhamid, Ali Farrag El-Hadad, Mohamed Fawzy, Mohamed Ahmed Abd-Elhamed
Summary: This study aimed to determine the prevalence of restless leg syndrome (RLS) due to chronic kidney disease (CKD) and its predictors. A cross-sectional study was conducted on 520 patients, and RLS diagnosis was done according to International RLS Study Group criteria. The prevalence of RLS with CKD was found to be 22.31%, with higher rates in end-stage kidney disease (ESKD) patients. Factors such as ESKD, inadequate dialysis, hyperparathyroidism, and peripheral neuropathy were found to be independently associated with RLS.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Sherifa Ahmed Hamed, Fadia Ahmed Attiah, Samir Kamal Abdulhamid, Mohamed Fawzy
Summary: This study found that children with Graves' disease (GD) exhibited higher frequencies and severities of anxiety, depression, and inattention during periods of thyroid hormone elevation as well as when thyroid hormones were normalized with anti-thyroid drugs (ATDs). Early diagnosis and optimized management are necessary to improve social life for children with GD.
Article
Audiology & Speech-Language Pathology
Sherifa A. Hamed, Ali F. ElHadad, Amira M. Oseily
Summary: This study revealed that VDs are prevalent in children with T1D and correlated with the duration and severity of diabetes as well as the occurrence of hypoglycemic attacks.
AUDIOLOGY AND NEURO-OTOLOGY
(2021)
Article
Pharmacology & Pharmacy
Sherifa Ahmed Hamed, Amira Mohamed Osiely
Summary: Vestibular dysfunctions are common in children with epilepsy, with bilateral peripheral dysfunction being more prevalent than central dysfunction, suggesting a potential adverse effect of valproate on the vestibular system.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2022)
Article
Audiology & Speech-Language Pathology
Sherifa Ahmed Hamed, Dalia Fahim Mohammed Fahim
Summary: This study found that dysfunction of the saccule of the otolith organ in adults with type 1 diabetes is prevalent and correlated with the duration and severity of the disease. Therefore, optimal glycemic control is essential.
HEARING BALANCE AND COMMUNICATION
(2023)
Article
Medicine, General & Internal
Sherifa Ahmed Hamed, Hosam Abozaid Yousef
Summary: This study presents the case of a 4-year-old girl with acute stroke and recurrent seizures, who was diagnosed with Moyamoya disease. The patient exhibited bilateral fronto-parietal ischemic infarctions and occlusion of the internal carotid arteries. During the 3-year follow-up, the patient's condition improved and stabilization was observed. Revascularization surgery was postponed.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Medicine, General & Internal
Sherifa Ahmed Hamed, Fadia Ahmed Attiah, Mohamed Fawzy, Mohamed Azzam
Summary: This study is the first to evaluate the causal relationship between psychological factors and the onset, severity, and persistence of tinnitus in our culture. Tinnitus could be the earliest and dominant somatic symptom induced by life stressors and psychological vulnerabilities. Therefore, multidisciplinary consultation (psychologists, psychiatrists, and neurologists) is important to acknowledge among the audiologists and otolaryngologists who primarily consult patients.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Genetics & Heredity
Pasquelena De Nittis, Stephanie Efthymiou, Alexandre Sarre, Nicolas Guex, Jacqueline Chrast, Audrey Putoux, Tipu Sultan, Javeria Raza Alvi, Zia Ur Rahman, Faisal Zafar, Nuzhat Rana, Fatima Rahman, Najwa Anwar, Shazia Maqbool, Maha S. Zaki, Joseph G. Gleeson, David Murphy, Hamid Galehdari, Gholamreza Shariati, Neda Mazaheri, Alireza Sedaghat, Gaetan Lesca, Nicolas Chatron, Vincenzo Salpietro, Marilena Christoforou, Henry Houlden, William F. Simonds, Thierry Pedrazzini, Reza Maroofian, Alexandre Reymond
Summary: Research shows that loss of the Gnb5 gene in mice results in abnormal heart function, characterized by increased baseline heart rate and significant bradycardia. Knocking out the Gnb5 gene affects gene expression related to cardiac muscle contraction, leading to an increase in arrhythmia frequency. The study also expanded the cohort of IDDCA syndrome patients, indicating the important role of Gnb5 signaling in autonomic control of the heart.
JOURNAL OF MEDICAL GENETICS
(2021)